{"id":"https://openalex.org/W47583128","doi":null,"title":"[Non-erosive gastroesophageal reflux disease. Incidence of clinical forms, characteristics of esophageal exposure to acid and symptomatic correlations].","display_name":"[Non-erosive gastroesophageal reflux disease. Incidence of clinical forms, characteristics of esophageal exposure to acid and symptomatic correlations].","publication_year":2003,"publication_date":"2003-04-01","ids":{"openalex":"https://openalex.org/W47583128","mag":"47583128","pmid":"https://pubmed.ncbi.nlm.nih.gov/15127647"},"language":"es","primary_location":{"id":"pmid:15127647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15127647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de gastroenterologia de Mexico","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055569325","display_name":"Julio C\u00e9sar Soto-P\u00e9rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Julio C\u00e9sar Soto P\u00e9rez","raw_affiliation_strings":["Laboratorio de Motilidad Gastrointestinal, Departamento de Gastroenterolog\u00eda, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga 15, Secci\u00f3n XVI, Tlalpan, C.P. 14000, M\u00e9xico, D.F"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio de Motilidad Gastrointestinal, Departamento de Gastroenterolog\u00eda, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Vasco de Quiroga 15, Secci\u00f3n XVI, Tlalpan, C.P. 14000, M\u00e9xico, D.F","institution_ids":["https://openalex.org/I4210097900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035621495","display_name":"Mar\u00eda Eugenia Icaza","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Eugenia Icaza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111423619","display_name":"Florencia Vargas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florencia Vargas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110498118","display_name":"Miguel Angel Valdovinos D\u00edaz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel A Valdovinos D\u00edaz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7457,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.73663353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"68","issue":"2","first_page":"113","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10671","display_name":"Gastroesophageal reflux and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-erosive-reflux-disease","display_name":"non-erosive reflux disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/heartburn","display_name":"heartburn","score":0.875},{"id":"https://openalex.org/keywords/esophageal-acid-exposure","display_name":"esophageal acid exposure","score":0.9120000004768372},{"id":"https://openalex.org/keywords/esophageal-ph-monitoring","display_name":"esophageal pH monitoring","score":0.8429999947547913},{"id":"https://openalex.org/keywords/symptom-index","display_name":"symptom index","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hypersensitive-esophagus","display_name":"hypersensitive esophagus","score":0.843999981880188},{"id":"https://openalex.org/keywords/symptom-reflux-correlation","display_name":"symptom-reflux correlation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/reflux-episodes","display_name":"reflux episodes","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2777683962","wikidata":"https://www.wikidata.org/wiki/Q650031","display_name":"Nerd","level":5,"score":0.9659963846206665},{"id":"https://openalex.org/C2776462128","wikidata":"https://www.wikidata.org/wiki/Q537297","display_name":"Heartburn","level":4,"score":0.8962703943252563},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.847045361995697},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.8407413959503174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8124611973762512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7818136811256409},{"id":"https://openalex.org/C2779949763","wikidata":"https://www.wikidata.org/wiki/Q4446828","display_name":"Esophageal pH monitoring","level":5,"score":0.6205245852470398},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5850467681884766},{"id":"https://openalex.org/C2780323790","wikidata":"https://www.wikidata.org/wiki/Q2912193","display_name":"Esophageal disease","level":3,"score":0.41459259390830994},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.40299955010414124},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3689979314804077},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.30227985978126526},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000897","descriptor_name":"Anti-Ulcer Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004724","descriptor_name":"Endoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005744","descriptor_name":"Gastric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005764","descriptor_name":"Gastroesophageal Reflux","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006356","descriptor_name":"Heartburn","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006356","descriptor_name":"Heartburn","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009853","descriptor_name":"Omeprazole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054328","descriptor_name":"Proton Pump Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15127647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15127647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Revista de gastroenterologia de Mexico","raw_type":"Comparative Study"},{"id":"mag:47583128","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15127647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2015114641","https://openalex.org/W2363487927","https://openalex.org/W2353857922","https://openalex.org/W2353552871","https://openalex.org/W2135287136","https://openalex.org/W2914759492","https://openalex.org/W2115478665","https://openalex.org/W2069954988","https://openalex.org/W2018968087","https://openalex.org/W2041745500"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"is":[2],"estimated":[3],"that":[4],"up":[5],"to":[6,49,60,67,113],"70%":[7],"of":[8,16,52,55,161,165,190,268,272,297],"community-based":[9],"patients":[10,29,56,110,130,136,150,273,283,289,302],"with":[11,57,87,131,137,151,262,274,284,290,294,303],"heartburn":[12,88,237],"have":[13,38],"no":[14,211,252,304],"evidence":[15],"esophageal":[17,31,61,69,116],"mucosal":[18],"injury":[19],"or":[20,42,144],"non-erosive":[21],"gastroesophageal":[22],"reflux":[23,80,162,258],"disease":[24],"(NERD).":[25],"Studies":[26],"in":[27,81,195,200,206,214,226,244],"NERD":[28,58,263,275],"using":[30],"pH":[32,169,221],"monitoring":[33],"and":[34,64,66,73,78,102,118,140,147,154,172,183,203,216,238,249,256,280,300,308],"symptom":[35],"index":[36],"(SI)":[37],"suggested":[39],"different":[40,53],"subgroups":[41,54,271],"clinical":[43],"forms.":[44],"OBJECTIVE:":[45],"Our":[46],"aim":[47],"was":[48,120,233,247,251],"investigate":[50],"frequency":[51],"according":[59],"pH-monitoring":[62],"parameters":[63,222],"SI,":[65],"determine":[68],"acid":[70,79,239,242,257,286,298,309],"exposure":[71,243],"characteristics":[72],"the":[74,99],"relationship":[75,253],"between":[76,236,306],"symptoms":[77,255,307],"NERD.":[82],"MATERIAL":[83],"AND":[84],"METHODS:":[85],"Patients":[86,122],"at":[89],"least":[90],"3":[91],"times":[92],"per":[93],"week":[94],"during":[95,98],"12":[96],"weeks":[97],"last":[100],"year":[101],"negative":[103,155],"upper":[104],"GI":[105],"endoscopy":[106],"were":[107,111,123,175,186,193,210,223,276],"studied.":[108],"All":[109,220],"submitted":[112],"24":[114],"h":[115],"pH-metry":[117,139,153,279],"SI":[119,142,156],"calculated.":[121],"classified":[124,194],"into":[125],"three":[126],"groups:":[127],"group":[128,134,148,196,201,207,227,230,245,267],"I,":[129,197],"abnormal":[132,285],"pH-metry;":[133],"II,":[135,202,231],"normal":[138,152],"positive":[141],"(>":[143],"=":[145],"50%),":[146],"III,":[149],"(<":[157],"50%).":[158],"Total":[159],"number":[160],"episodes,":[163],"length":[164],"episode,":[166],"%":[167],"time":[168],"<":[170],"4,":[171],"Johnson-DeMeester":[173],"score":[174],"evaluated.":[176],"RESULTS:":[177],"Three":[178,270],"hundred":[179],"patients,":[180],"206":[181],"women":[182],"94":[184],"men,":[185],"included.":[187],"A":[188],"total":[189],"137":[191],"(46%)":[192],"62":[198],"(21%)":[199],"101":[204],"(33%)":[205],"III.":[208],"There":[209],"significant":[212],"differences":[213],"gender":[215],"age":[217],"among":[218,254],"groups.":[219],"significantly":[224],"higher":[225],"I.":[228],"In":[229],"there":[232,250],"good":[234],"correlation":[235,305],"reflux.":[240,310],"Esophageal":[241],"III":[246],"minimal":[248],"episodes.":[259],"CONCLUSIONS:":[260],"Subjects":[261],"represent":[264],"a":[265],"heterogeneous":[266],"patients.":[269],"identified":[277],"by":[278],"SI;":[281],"a)":[282],"exposure;":[287],"b)":[288],"hypersensitive":[291],"esophagus":[292],"(heartburn":[293],"physiologic":[295],"amounts":[296],"reflux),":[299],"c)":[301]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}