{"id":"https://openalex.org/W47415772","doi":null,"title":"The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.","display_name":"The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W47415772","mag":"47415772","pmid":"https://pubmed.ncbi.nlm.nih.gov/9392437"},"language":"en","primary_location":{"id":"pmid:9392437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9392437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Receptors & signal transduction","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059373714","display_name":"K L Bruner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K L Bruner","raw_affiliation_strings":["Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081465158","display_name":"Assia Derfoul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Derfoul","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108204715","display_name":"Noreen M. Robertson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N M Robertson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"G Guerriero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Guerriero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069095259","display_name":"Teresa Fernandes\u2010Alnemri","orcid":"https://orcid.org/0000-0002-6598-5061","observed_orcids":["https://orcid.org/0000-0002-6598-5061"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Fernandes-Alnemri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077708146","display_name":"Emad S. Alnemri","orcid":"https://orcid.org/0000-0002-7295-3383","observed_orcids":["https://orcid.org/0000-0002-7295-3383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E S Alnemri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062814155","display_name":"Gerald Litwack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Litwack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.9482,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.72369572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"2","first_page":"85","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.5630000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.27000001072883606,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.10419999808073044,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mineralocorticoid-receptor","display_name":"mineralocorticoid receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.9440000057220459},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.996999979019165},{"id":"https://openalex.org/keywords/immunophilins","display_name":"immunophilins","score":0.9039999842643738},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.921999990940094},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.625},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.7720000147819519},{"id":"https://openalex.org/keywords/steroid-thyroid-hormone-receptor-superfamily","display_name":"steroid/thyroid hormone receptor superfamily","score":0.7789999842643738},{"id":"https://openalex.org/keywords/receptor-stoichiometry","display_name":"receptor stoichiometry","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C133956753","wikidata":"https://www.wikidata.org/wiki/Q583864","display_name":"FKBP","level":2,"score":0.7884371876716614},{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.6536120176315308},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.600395917892456},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5463824272155762},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.5176875591278076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5063153505325317},{"id":"https://openalex.org/C2776069600","wikidata":"https://www.wikidata.org/wiki/Q422519","display_name":"Mineralocorticoid","level":3,"score":0.49076971411705017},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4636339843273163},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36884605884552},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27649152278900146},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018161","descriptor_name":"Receptors, Mineralocorticoid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018411","descriptor_name":"Spodoptera","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018841","descriptor_name":"HSP90 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022021","descriptor_name":"Tacrolimus Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9392437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9392437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Receptors & signal transduction","raw_type":"Journal Article"},{"id":"mag:47415772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9392437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G537852018","display_name":"MINERALOCORTICOID RECEPTOR","funder_award_id":"5r01dk044441-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5875274835","display_name":"Training Program in Biomolecular Signal Transduction","funder_award_id":"T32DK007705","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4225840","https://openalex.org/W2037652621","https://openalex.org/W2018528917","https://openalex.org/W2059538242","https://openalex.org/W3201902114","https://openalex.org/W2089415564","https://openalex.org/W1858972768","https://openalex.org/W2027913812","https://openalex.org/W2055706332","https://openalex.org/W2039908108"],"abstract_inverted_index":{"The":[0,128],"human":[1],"mineralocorticoid":[2],"receptor":[3,12,249],"(MR)":[4],"is":[5],"a":[6,52,223,245],"member":[7],"of":[8,88,158,186,235],"the":[9,27,31,38,65,79,89,94,105,111,124,143,156,164,201,208,232,236,240,251],"steroid-thyroid":[10],"hormone":[11],"superfamily,":[13],"which":[14],"includes":[15],"receptors":[16],"for":[17,229],"retinoic":[18],"acid,":[19],"vitamin":[20],"D,":[21],"and":[22,36,44,57,104,139,147,161,169,212,215,250],"other":[23],"steroids,":[24],"such":[25],"as":[26],"glucocorticoids":[28],"(which":[29],"bind":[30],"glucocorticoid":[32],"receptor,":[33],"GR).":[34],"MR":[35,66,91,113,130,187,210,242],"GR,":[37,64],"corticosteroid":[39],"receptors,":[40],"share":[41],"significant":[42],"homology":[43],"are":[45,82,108,118,204],"activated":[46],"by":[47],"steroid":[48],"binding,":[49],"resulting":[50],"in":[51,78,110,123,134,140,163,207,222],"conformational":[53],"change,":[54],"nuclear":[55],"translocation,":[56],"DNA":[58,184,220],"binding.":[59],"Despite":[60],"these":[61,116],"similarities":[62],"with":[63,192,200],"remains":[67],"less":[68],"well":[69],"characterized.":[70],"However,":[71],"protein":[72],"components":[73,87],"known":[74,119],"to":[75,85,120,176,219,226],"be":[76,86,121],"present":[77,109,122,206,238],"unliganded":[80,125,129,165,202,209],"GR":[81,126,203],"also":[83,205],"likely":[84],"heteromeric":[90,241],"complex.":[92,127],"In":[93],"current":[95],"study,":[96],"we":[97],"investigated":[98],"whether":[99],"or":[100],"not":[101,172],"hsp70,":[102,159],"hsp90,":[103,160],"immunophilin":[106],"FKBP-52":[107,162,170,216],"nonsteroid-bound":[112],"complex,":[114,211],"because":[115],"proteins":[117,198,237],"complex":[131,243],"was":[132],"assembled":[133],"vitro":[135],"using":[136,142],"reticulocyte":[137],"lysate":[138],"vivo":[141],"baculovirus":[144],"overexpression":[145],"system":[146],"Spodoptera":[148],"frugiperda":[149],"(Sf9)":[150],"cells.":[151],"Western":[152],"blot":[153],"analysis":[154,181,234],"revealed":[155],"presence":[157],"complexes,":[166],"but":[167],"hsp90":[168,214],"were":[171],"detected":[173],"following":[174],"exposure":[175],"aldosterone.":[177,193],"Electrophoretic":[178],"mobility":[179],"shift":[180],"demonstrated":[182],"that":[183,197,213,227],"binding":[185,221],"occurred":[188],"only":[189],"after":[190],"treatment":[191],"These":[194],"studies":[195],"indicate":[196],"associated":[199],"dissociate":[217],"prior":[218],"manner":[224],"similar":[225],"described":[228],"GR.":[230,252],"Finally,":[231],"stoichiometric":[233],"within":[239],"suggests":[244],"divergence":[246],"between":[247],"this":[248]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
