{"id":"https://openalex.org/W47397205","doi":null,"title":"The spatial and temporal regulatory code of transcription initiation in Drosophila melanogaster","display_name":"The spatial and temporal regulatory code of transcription initiation in Drosophila melanogaster","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W47397205","mag":"47397205"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/2454","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/2454","pdf_url":"http://hdl.handle.net/10161/2454","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/2454","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022934902","display_name":"Elizabeth A. Rach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Elizabeth A. Rach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5022934902"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-initiation","display_name":"transcription initiation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.8209999799728394},{"id":"https://openalex.org/keywords/alternative-promoter-usage","display_name":"alternative promoters","score":0.7630000114440918},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9549999833106995},{"id":"https://openalex.org/keywords/promoter-architecture","display_name":"promoter architecture","score":0.6539999842643738},{"id":"https://openalex.org/keywords/nucleosome-organization","display_name":"nucleosome organization","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chromatin-structure","display_name":"chromatin structure","score":0.6430000066757202},{"id":"https://openalex.org/keywords/insulation-materials","display_name":"insulators","score":0.7599999904632568},{"id":"https://openalex.org/keywords/rna-polymerase-ii-pausing","display_name":"RNA polymerase II pausing","score":0.722000002861023},{"id":"https://openalex.org/keywords/h2a-z","display_name":"H2A.Z","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.5830000042915344},{"id":"https://openalex.org/keywords/trf2","display_name":"TRF2","score":0.8740000128746033},{"id":"https://openalex.org/keywords/paired-end-sequencing","display_name":"paired-end sequencing","score":0.5770000219345093},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.829582929611206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49065080285072327},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4887711703777313},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.45202940702438354},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.43082353472709656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37720656394958496},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3555331826210022},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3346521258354187},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20028764009475708},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.05539047718048096},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/2454","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/2454","pdf_url":"http://hdl.handle.net/10161/2454","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:47397205","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/2454/1/D_Rach_Elizabeth_a_201005.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/2454","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/2454","pdf_url":"http://hdl.handle.net/10161/2454","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W47397205.pdf","grobid_xml":"https://content.openalex.org/works/W47397205.grobid-xml"},"referenced_works_count":236,"referenced_works":["https://openalex.org/W2101898","https://openalex.org/W144423133","https://openalex.org/W179887338","https://openalex.org/W626356915","https://openalex.org/W1487964420","https://openalex.org/W1496357020","https://openalex.org/W1502617758","https://openalex.org/W1509785790","https://openalex.org/W1511730061","https://openalex.org/W1584704387","https://openalex.org/W1592870802","https://openalex.org/W1664008877","https://openalex.org/W1665428902","https://openalex.org/W1911065410","https://openalex.org/W1962959036","https://openalex.org/W1965100590","https://openalex.org/W1965471102","https://openalex.org/W1968055625","https://openalex.org/W1969460352","https://openalex.org/W1970749509","https://openalex.org/W1973536007","https://openalex.org/W1978677326","https://openalex.org/W1979028385","https://openalex.org/W1979119703","https://openalex.org/W1980645953","https://openalex.org/W1984053739","https://openalex.org/W1985457007","https://openalex.org/W1987078237","https://openalex.org/W1987637982","https://openalex.org/W1987919833","https://openalex.org/W1989115298","https://openalex.org/W1989741361","https://openalex.org/W1992776893","https://openalex.org/W1993827187","https://openalex.org/W1994777926","https://openalex.org/W2001891766","https://openalex.org/W2003967338","https://openalex.org/W2004377729","https://openalex.org/W2004469916","https://openalex.org/W2004993130","https://openalex.org/W2007771322","https://openalex.org/W2007844697","https://openalex.org/W2008130441","https://openalex.org/W2008444931","https://openalex.org/W2008543992","https://openalex.org/W2010226312","https://openalex.org/W2013925438","https://openalex.org/W2015009994","https://openalex.org/W2015068085","https://openalex.org/W2015416439","https://openalex.org/W2016597274","https://openalex.org/W2016923471","https://openalex.org/W2018198956","https://openalex.org/W2019462186","https://openalex.org/W2025843107","https://openalex.org/W2026059246","https://openalex.org/W2029144080","https://openalex.org/W2030027182","https://openalex.org/W2031540808","https://openalex.org/W2031710534","https://openalex.org/W2032870665","https://openalex.org/W2035307362","https://openalex.org/W2037686178","https://openalex.org/W2038010573","https://openalex.org/W2039564969","https://openalex.org/W2039598215","https://openalex.org/W2041877620","https://openalex.org/W2041956242","https://openalex.org/W2042259515","https://openalex.org/W2043457799","https://openalex.org/W2043472480","https://openalex.org/W2043556230","https://openalex.org/W2043740911","https://openalex.org/W2045319488","https://openalex.org/W2045847295","https://openalex.org/W2047765648","https://openalex.org/W2047784091","https://openalex.org/W2050234082","https://openalex.org/W2055043387","https://openalex.org/W2057692691","https://openalex.org/W2058157728","https://openalex.org/W2063679723","https://openalex.org/W2064171951","https://openalex.org/W2064390432","https://openalex.org/W2066785029","https://openalex.org/W2067116931","https://openalex.org/W2067582764","https://openalex.org/W2068248220","https://openalex.org/W2070083583","https://openalex.org/W2070168243","https://openalex.org/W2070280762","https://openalex.org/W2071984843","https://openalex.org/W2072152932","https://openalex.org/W2073168126","https://openalex.org/W2073374533","https://openalex.org/W2075485921","https://openalex.org/W2077562320","https://openalex.org/W2077827481","https://openalex.org/W2078068395","https://openalex.org/W2078481156","https://openalex.org/W2078498837","https://openalex.org/W2079700496","https://openalex.org/W2081910903","https://openalex.org/W2082768601","https://openalex.org/W2083245183","https://openalex.org/W2084458818","https://openalex.org/W2084508749","https://openalex.org/W2086038224","https://openalex.org/W2086164759","https://openalex.org/W2086814185","https://openalex.org/W2087573417","https://openalex.org/W2088016816","https://openalex.org/W2088839833","https://openalex.org/W2089208780","https://openalex.org/W2089869601","https://openalex.org/W2092390808","https://openalex.org/W2094074349","https://openalex.org/W2094604037","https://openalex.org/W2095718954","https://openalex.org/W2096054562","https://openalex.org/W2096296961","https://openalex.org/W2096824423","https://openalex.org/W2097311877","https://openalex.org/W2097353028","https://openalex.org/W2097469177","https://openalex.org/W2097851830","https://openalex.org/W2097920884","https://openalex.org/W2098891914","https://openalex.org/W2099468911","https://openalex.org/W2099762535","https://openalex.org/W2099848436","https://openalex.org/W2099961908","https://openalex.org/W2101079676","https://openalex.org/W2101617498","https://openalex.org/W2101791006","https://openalex.org/W2102159699","https://openalex.org/W2102711634","https://openalex.org/W2103017472","https://openalex.org/W2104337184","https://openalex.org/W2104687412","https://openalex.org/W2106554405","https://openalex.org/W2106581226","https://openalex.org/W2107594198","https://openalex.org/W2107895168","https://openalex.org/W2108145648","https://openalex.org/W2108712717","https://openalex.org/W2110251865","https://openalex.org/W2112001233","https://openalex.org/W2112762570","https://openalex.org/W2113174377","https://openalex.org/W2114090084","https://openalex.org/W2114100577","https://openalex.org/W2114401337","https://openalex.org/W2114703458","https://openalex.org/W2115219137","https://openalex.org/W2115358825","https://openalex.org/W2116015974","https://openalex.org/W2117248014","https://openalex.org/W2117704072","https://openalex.org/W2118151959","https://openalex.org/W2118515267","https://openalex.org/W2118533197","https://openalex.org/W2119804413","https://openalex.org/W2120941188","https://openalex.org/W2121070314","https://openalex.org/W2121116352","https://openalex.org/W2122440217","https://openalex.org/W2123909876","https://openalex.org/W2124738784","https://openalex.org/W2125427542","https://openalex.org/W2125515637","https://openalex.org/W2126466006","https://openalex.org/W2128888061","https://openalex.org/W2129061533","https://openalex.org/W2129656350","https://openalex.org/W2130198725","https://openalex.org/W2131000278","https://openalex.org/W2132327671","https://openalex.org/W2134087142","https://openalex.org/W2134193442","https://openalex.org/W2136674643","https://openalex.org/W2136785696","https://openalex.org/W2138197117","https://openalex.org/W2139212933","https://openalex.org/W2139245692","https://openalex.org/W2139516179","https://openalex.org/W2140485864","https://openalex.org/W2140523271","https://openalex.org/W2143593381","https://openalex.org/W2143658931","https://openalex.org/W2145283451","https://openalex.org/W2145483178","https://openalex.org/W2146849272","https://openalex.org/W2147415348","https://openalex.org/W2148592476","https://openalex.org/W2149137857","https://openalex.org/W2150402790","https://openalex.org/W2150904790","https://openalex.org/W2151299977","https://openalex.org/W2151658462","https://openalex.org/W2152399502","https://openalex.org/W2153009644","https://openalex.org/W2153392439","https://openalex.org/W2154259718","https://openalex.org/W2154514071","https://openalex.org/W2155237411","https://openalex.org/W2157076973","https://openalex.org/W2157215359","https://openalex.org/W2157835438","https://openalex.org/W2158092584","https://openalex.org/W2158455118","https://openalex.org/W2158874089","https://openalex.org/W2159807777","https://openalex.org/W2160075393","https://openalex.org/W2161566669","https://openalex.org/W2161888246","https://openalex.org/W2161929259","https://openalex.org/W2162026806","https://openalex.org/W2162304711","https://openalex.org/W2163965551","https://openalex.org/W2165890696","https://openalex.org/W2166187656","https://openalex.org/W2168157737","https://openalex.org/W2168546553","https://openalex.org/W2168909179","https://openalex.org/W2170033314","https://openalex.org/W2170628952","https://openalex.org/W2170698318","https://openalex.org/W2171167107","https://openalex.org/W2171338385","https://openalex.org/W2172186301","https://openalex.org/W2413273374","https://openalex.org/W2465323322","https://openalex.org/W2580627695","https://openalex.org/W2765633603","https://openalex.org/W7099918793"],"related_works":["https://openalex.org/W7098948090","https://openalex.org/W2162026806","https://openalex.org/W2075485921","https://openalex.org/W2064390432","https://openalex.org/W4300940257","https://openalex.org/W2100894340","https://openalex.org/W7096758805","https://openalex.org/W2106627269","https://openalex.org/W6945718360","https://openalex.org/W4299474556"],"abstract_inverted_index":{"Transcription":[0,34],"initiation":[1,35,94,139,148,431],"is":[2,36,106,354],"a":[3,117,213,269,416,427],"key":[4],"component":[5],"in":[6,53,82,87,327,376,441,466],"the":[7,39,54,57,62,73,79,83,137,142,173,187,203,237,283,290,328,339,349,372,377,434,457,473],"regulation":[8,105,465],"of":[9,20,29,41,47,56,72,78,99,141,169,189,232,239,272,285,292,343,418,430,446,459,463,477],"gene":[10,100],"expression.":[11],"Recent":[12],"high-throughput":[13],"sequencing":[14,133,266],"techniques":[15],"have":[16,95],"enhanced":[17],"our":[18,70],"understanding":[19,71],"mammalian":[21],"transcription":[22,30,48,93,138,478],"by":[23,181,202,322],"revealing":[24],"narrow":[25],"and":[26,75,92,128,158,178,199,212,229,251,307,313,319,369,380,397,410,433,453],"broad":[27,190,252],"patterns":[28,81,231,375],"start":[31],"sites":[32,432],"(TSSs).":[33],"central":[37],"to":[38,61,135,220,227,247,261,304],"determination":[40],"condition":[42],"specificity,":[43],"as":[44],"distinct":[45,225],"repertoires":[46],"factors":[49],"(TFs)":[50],"that":[51,222,280,347,353],"assist":[52],"recruitment":[55],"RNA":[58,357],"polymerase":[59],"II":[60,359],"DNA":[63],"are":[64,439],"present":[65],"under":[66,436],"different":[67],"conditions.":[68],"However,":[69],"presence":[74,445],"spatiotemporal":[76],"architecture":[77],"promoter":[80,311,374,422,447],"fruit":[84,378],"fly":[85,379],"remains":[86],"its":[88],"infancy.":[89],"Nucleosome":[90],"organization":[91],"been":[96],"considered":[97],"hallmarks":[98],"expression,":[101],"but":[102,288],"their":[103],"cooperative":[104],"also":[107],"not":[108],"yet":[109],"understood.":[110],"\\n":[111,209,295,361],"In":[112],"this":[113],"work,":[114],"we":[115,363],"applied":[116,297],"hierarchical":[118],"clustering":[119],"strategy":[120,134,267],"on":[121],"available":[122],"5'":[123,273],"expressed":[124],"sequence":[125,176],"tags":[126],"(ESTs),":[127],"developed":[129],"an":[130,245,298],"improved":[131],"paired-end":[132,265],"explore":[136],"landscape":[140],"D.melanogaster":[143],"genome.":[144],"We":[145,296],"distinguished":[146],"three":[147,373],"patterns:":[149],"'Peaked":[150],"or":[151,163],"Narrow":[152],"Peak":[153,156,165],"TSSs\u201b,":[154,157],"'Broad":[155,159],"TSS":[160,191,253],"cluster":[161,192,254],"groups":[162,193],"Weak":[164],"TSSs\u201b.":[166],"The":[167,264,383,444],"promoters":[168,188,243,256,332,385,404,414],"peaked":[170],"TSSs":[171,223],"contained":[172],"location":[174,336],"specific":[175,309,330,448],"elements,":[177,198],"were":[179,194,200,257,281,333],"bound":[180,201],"TATA":[182],"Binding":[183],"Protein":[184],"(TBP),":[185],"while":[186],"associated":[195,260,355],"with":[196,356,389,408],"non-location-specific":[197],"TATA-box":[204],"related":[205],"Factor":[206],"2":[207],"(TRF2).":[208],"Available":[210],"ESTs":[211],"tiling":[214],"array":[215],"time":[216],"series":[217],"enabled":[218],"us":[219],"show":[221],"had":[224,244,405],"associations":[226,388,407],"conditions,":[228],"temporal":[230],"embryonic":[233],"activity":[234],"differed":[235],"across":[236,371],"majority":[238],"alternative":[240,286],"promoters.":[241],"Peaked":[242],"association":[246],"maternally":[248],"inherited":[249],"transcripts,":[250],"group":[255],"more":[258],"highly":[259],"zygotic":[262],"utilization.":[263],"identified":[268,314],"large":[270],"number":[271],"capped":[274],"transcripts":[275],"originating":[276],"from":[277,338,420],"coding":[278],"exons":[279],"unlikely":[282],"result":[284],"TSSs,":[287],"rather":[289],"product":[291],"post-transcriptional":[293],"modifications.":[294],"innovative":[299],"search":[300],"program":[301],"called":[302],"FREE":[303],"embryo,":[305],"head,":[306],"testes":[308],"core":[310,331],"sequences":[312],"123":[315],"motifs:":[316],"16":[317],"novel":[318],"107":[320],"supported":[321],"other":[323],"motif":[324,352],"sources.":[325],"Motifs":[326],"embryo":[329],"found":[334],"at":[335],"hotspots":[337],"TSS.":[340],"A":[341],"family":[342],"oligos":[344],"was":[345],"discovered":[346],"matched":[348],"Pause":[350],"Button":[351],"pol":[358],"stalling.":[360],"Lastly,":[362],"analyzed":[364],"nucleosome":[365],"organization,":[366],"chromatin":[367,451],"structure,":[368],"insulators":[370,400],"human":[381],"genomes.":[382],"WP":[384],"showed":[386],"higher":[387,406,467],"H2A.Z,":[390],"DNase":[391],"Hypersensitivity":[392],"Sites":[393],"(DHS),":[394],"H3K4":[395],"methylations,":[396],"Class":[398],"I":[399],"CTCF/BEAF32/CP190.":[401],"Conversely,":[402],"NP":[403],"polII":[409],"GAF":[411],"binding.":[412],"BP":[413],"exhibited":[415],"combination":[417],"features":[419],"both":[421],"patterns.":[423],"Our":[424],"study":[425],"provides":[426],"comprehensive":[428],"map":[429],"conditions":[435],"which":[437],"they":[438],"utilized":[440],"D.":[442],"melanogaster.":[443],"histone":[449],"replacements,":[450],"modifications,":[452],"insulator":[454],"elements":[455],"support":[456],"existence":[458],"two":[460],"divergent":[461],"strategies":[462],"transcriptional":[464],"eukaryotes.":[468],"Together,":[469],"these":[470],"data":[471],"illustrate":[472],"complex":[474],"regulatory":[475],"code":[476],"initiation.":[479]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}