{"id":"https://openalex.org/W47333012","doi":"https://doi.org/10.2460/javma.1994.204.07.1053","title":"Hepatic cirrhosis and hemochromatosis in three horses","display_name":"Hepatic cirrhosis and hemochromatosis in three horses","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W47333012","doi":"https://doi.org/10.2460/javma.1994.204.07.1053","mag":"47333012","pmid":"https://pubmed.ncbi.nlm.nih.gov/8045806"},"language":"en","primary_location":{"id":"doi:10.2460/javma.1994.204.07.1053","doi":"https://doi.org/10.2460/javma.1994.204.07.1053","is_oa":true,"landing_page_url":"https://doi.org/10.2460/javma.1994.204.07.1053","pdf_url":"https://avmajournals.avma.org/downloadpdf/journals/javma/204/7/javma.1994.204.07.1053.pdf","source":{"id":"https://openalex.org/S161638509","display_name":"Journal of the American Veterinary Medical Association","issn_l":"0003-1488","issn":["0003-1488","1943-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Veterinary Medical Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://avmajournals.avma.org/downloadpdf/journals/javma/204/7/javma.1994.204.07.1053.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039375440","display_name":"Erwin G. Pearson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erwin G. Pearson","raw_affiliation_strings":["From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Pearson, Hedstrom), and the Animal Health Diagnostic Laboratory, Michigan State University, Lansing, MI 48909 (Poppenga)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Pearson, Hedstrom), and the Animal Health Diagnostic Laboratory, Michigan State University, Lansing, MI 48909 (Poppenga)","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I87216513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048238645","display_name":"Olaf R. Hedstrom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olaf R. Hedstrom","raw_affiliation_strings":["From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Pearson, Hedstrom), and the Animal Health Diagnostic Laboratory, Michigan State University, Lansing, MI 48909 (Poppenga)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Pearson, Hedstrom), and the Animal Health Diagnostic Laboratory, Michigan State University, Lansing, MI 48909 (Poppenga)","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I87216513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003605362","display_name":"Robert H. Poppenga","orcid":"https://orcid.org/0000-0002-5741-2650","observed_orcids":["https://orcid.org/0000-0002-5741-2650"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]},{"id":"https://openalex.org/I87216513","display_name":"Michigan State University","ror":"https://ror.org/05hs6h993","country_code":"US","type":"education","lineage":["https://openalex.org/I87216513"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Poppenga","raw_affiliation_strings":["From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Pearson, Hedstrom), and the Animal Health Diagnostic Laboratory, Michigan State University, Lansing, MI 48909 (Poppenga)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331 (Pearson, Hedstrom), and the Animal Health Diagnostic Laboratory, Michigan State University, Lansing, MI 48909 (Poppenga)","institution_ids":["https://openalex.org/I131249849","https://openalex.org/I87216513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6772,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.66877422,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"204","issue":"7","first_page":"1053","last_page":"1056"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10872","display_name":"Veterinary Equine Medical Research","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3402","display_name":"Equine"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemochromatosis","display_name":"hemochromatosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.9829999804496765},{"id":"https://openalex.org/keywords/horses","display_name":"horses","score":0.984000027179718},{"id":"https://openalex.org/keywords/iron-storage-disease","display_name":"iron storage disease","score":0.8130000233650208},{"id":"https://openalex.org/keywords/portal-fibrosis","display_name":"portal fibrosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/serum-iron-binding-capacity","display_name":"serum iron-binding capacity","score":0.7820000052452087},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.6710000038146973},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.9419999718666077},{"id":"https://openalex.org/keywords/secondary-hemochromatosis","display_name":"secondary hemochromatosis","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2776590208","wikidata":"https://www.wikidata.org/wiki/Q2025687","display_name":"Hemochromatosis","level":2,"score":0.9341146349906921},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.8099181652069092},{"id":"https://openalex.org/C3017702006","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Dietary iron","level":4,"score":0.7408190965652466},{"id":"https://openalex.org/C2780762169","wikidata":"https://www.wikidata.org/wiki/Q5905368","display_name":"Horse","level":2,"score":0.6156555414199829},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5445249080657959},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5295553803443909},{"id":"https://openalex.org/C3018783601","wikidata":"https://www.wikidata.org/wiki/Q3144934","display_name":"Hereditary hemochromatosis","level":3,"score":0.5199257731437683},{"id":"https://openalex.org/C2779875672","wikidata":"https://www.wikidata.org/wiki/Q2537479","display_name":"Serum iron","level":3,"score":0.46886685490608215},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.45468971133232117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4107687473297119},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4100416302680969},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3855242133140564},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3733212351799011},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3556450605392456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3301395773887634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25421252846717834},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.18262147903442383},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006432","descriptor_name":"Hemochromatosis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D006734","descriptor_name":"Horse Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006736","descriptor_name":"Horses","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2460/javma.1994.204.07.1053","doi":"https://doi.org/10.2460/javma.1994.204.07.1053","is_oa":true,"landing_page_url":"https://doi.org/10.2460/javma.1994.204.07.1053","pdf_url":"https://avmajournals.avma.org/downloadpdf/journals/javma/204/7/javma.1994.204.07.1053.pdf","source":{"id":"https://openalex.org/S161638509","display_name":"Journal of the American Veterinary Medical Association","issn_l":"0003-1488","issn":["0003-1488","1943-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Veterinary Medical Association","raw_type":"journal-article"},{"id":"pmid:8045806","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8045806","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Veterinary Medical Association","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.2460/javma.1994.204.07.1053","doi":"https://doi.org/10.2460/javma.1994.204.07.1053","is_oa":true,"landing_page_url":"https://doi.org/10.2460/javma.1994.204.07.1053","pdf_url":"https://avmajournals.avma.org/downloadpdf/journals/javma/204/7/javma.1994.204.07.1053.pdf","source":{"id":"https://openalex.org/S161638509","display_name":"Journal of the American Veterinary Medical Association","issn_l":"0003-1488","issn":["0003-1488","1943-569X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4322545313","host_organization_name":"American Veterinary Medical Association","host_organization_lineage":["https://openalex.org/P4322545313"],"host_organization_lineage_names":["American Veterinary Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Veterinary Medical Association","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W47333012.pdf","grobid_xml":"https://content.openalex.org/works/W47333012.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2073843577","https://openalex.org/W2396905834","https://openalex.org/W3137422189","https://openalex.org/W2044900143","https://openalex.org/W1940790526","https://openalex.org/W2155797675","https://openalex.org/W2892979689","https://openalex.org/W2970019845","https://openalex.org/W2441452359","https://openalex.org/W2081532870"],"abstract_inverted_index":{"Hemochromatosis,":[0],"an":[1],"iron":[2,21,41,47,67,95,107,140,156],"storage":[3,96],"disease,":[4],"was":[5,43,50,61,74,149],"diagnosed":[6],"in":[7,23,54,58,68,83,126,136],"3":[8],"horses":[9,143],"with":[10,106,138],"hepatic":[11],"cirrhosis.":[12],"Each":[13],"horse":[14,57,73],"had":[15],"bridging":[16],"portal":[17],"fibrosis":[18],"and":[19,33,46,86,125,147],"abundant":[20],"deposits":[22],"the":[24,55,64,69,77,111,123],"cytoplasm":[25],"of":[26,30,66,71,93,113,122,132,153],"hepatocytes.":[27],"Serum":[28],"concentrations":[29],"liver-derived":[31],"enzymes":[32],"total":[34],"bile":[35],"acids":[36],"were":[37,144],"high.":[38],"However,":[39,63],"serum":[40],"concentration":[42,65],"not":[44,145,150],"high,":[45],"binding":[48],"capacity":[49],"only":[51],"46%":[52],"saturated":[53],"1":[56],"which":[59],"it":[60],"measured.":[62],"liver":[70],"this":[72,94],"20":[75],"times":[76],"reference":[78],"limits.":[79],"Hemochromatosis":[80,116],"is":[81,102,134],"common":[82],"mynah":[84],"birds":[85],"human":[87,99],"beings.":[88],"There":[89],"are":[90],"several":[91],"types":[92],"disease.":[97],"In":[98],"beings,":[100],"there":[101,148],"a":[103],"familial":[104],"disease":[105],"absorption":[108],"inappropriate":[109],"for":[110],"level":[112],"stored":[114],"iron.":[115],"also":[117],"occurs":[118],"secondary":[119],"to":[120],"cirrhosis":[121],"liver,":[124],"certain":[127],"anemia":[128],"diseases.":[129],"Another":[130],"type":[131],"hemochromatosis":[133],"seen":[135],"association":[137],"dietary":[139,155],"overload.":[141],"These":[142],"related,":[146],"any":[151],"evidence":[152],"high":[154],"intake.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}