{"id":"https://openalex.org/W47261802","doi":null,"title":"Comparative antioxidant and anti-inflammatory activity of different extracts of centella asiatica (L.) urban and its active compounds, asiaticoside and madecassoside","display_name":"Comparative antioxidant and anti-inflammatory activity of different extracts of centella asiatica (L.) urban and its active compounds, asiaticoside and madecassoside","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W47261802","mag":"47261802"},"language":"en","primary_location":{"id":"mag:47261802","doi":null,"is_oa":false,"landing_page_url":"http://journalarticle.ukm.my/6738/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medicine & health","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002101955","display_name":"Ari Pebru Nurlaily","orcid":"https://orcid.org/0000-0002-6850-7508","observed_orcids":["https://orcid.org/0000-0002-6850-7508"]},"institutions":[{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Ari Pebru Nurlaily","raw_affiliation_strings":["Universiti Kebangsaan Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiti Kebangsaan Malaysia","institution_ids":["https://openalex.org/I885383172"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026683647","display_name":"A.R. Noor Baitee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"A.R. Noor Baitee","raw_affiliation_strings":["Universiti Kebangsaan Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiti Kebangsaan Malaysia","institution_ids":["https://openalex.org/I885383172"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103395947","display_name":"Mazlan Musalmah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I885383172","display_name":"National University of Malaysia","ror":"https://ror.org/00bw8d226","country_code":"MY","type":"education","lineage":["https://openalex.org/I885383172"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"M Musalmah","raw_affiliation_strings":["Universiti Kebangsaan Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiti Kebangsaan Malaysia","institution_ids":["https://openalex.org/I885383172"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I885383172"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.00403648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/centella-asiatica","display_name":"Centella asiatica","score":1.0},{"id":"https://openalex.org/keywords/asiaticoside","display_name":"asiaticoside","score":0.9800000190734863},{"id":"https://openalex.org/keywords/madecassoside","display_name":"madecassoside","score":1.0},{"id":"https://openalex.org/keywords/extraction-methods","display_name":"extraction methods","score":0.5960000157356262},{"id":"https://openalex.org/keywords/ethanol-extraction","display_name":"ethanol extraction","score":0.8510000109672546},{"id":"https://openalex.org/keywords/methanol-extraction","display_name":"methanol extraction","score":0.996999979019165},{"id":"https://openalex.org/keywords/water-extraction","display_name":"water extraction","score":0.9700000286102295},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cox-1-inhibition","display_name":"COX-1 inhibition","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cox-2-inhibition","display_name":"COX-2 inhibition","score":1.0},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/phenolic-content","display_name":"phenolic content","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2779077069","wikidata":"https://www.wikidata.org/wiki/Q1348880","display_name":"Centella","level":2,"score":0.9760196208953857},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8096298575401306},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7810402512550354},{"id":"https://openalex.org/C2779607525","wikidata":"https://www.wikidata.org/wiki/Q14982","display_name":"Methanol","level":2,"score":0.5725979208946228},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.5532391667366028},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.44104355573654175},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4405534267425537},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.43968909978866577},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.43500828742980957},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27183860540390015},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23096802830696106},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13317924737930298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08711525797843933}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:47261802","doi":null,"is_oa":false,"landing_page_url":"http://journalarticle.ukm.my/6738/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Medicine & health","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W42539827","https://openalex.org/W573644969","https://openalex.org/W1965225492","https://openalex.org/W1968705390","https://openalex.org/W1974443261","https://openalex.org/W1981040064","https://openalex.org/W1999586472","https://openalex.org/W2006734701","https://openalex.org/W2021183792","https://openalex.org/W2051827697","https://openalex.org/W2053041957","https://openalex.org/W2054455753","https://openalex.org/W2057556421","https://openalex.org/W2057889917","https://openalex.org/W2066817189","https://openalex.org/W2067242082","https://openalex.org/W2070297469","https://openalex.org/W2073940782","https://openalex.org/W2074254026","https://openalex.org/W2077224253","https://openalex.org/W2089741924","https://openalex.org/W2106828037","https://openalex.org/W2120464591","https://openalex.org/W2125063590","https://openalex.org/W2125100006","https://openalex.org/W2143088276","https://openalex.org/W2144885000","https://openalex.org/W2150387129","https://openalex.org/W2165292984","https://openalex.org/W2346397980","https://openalex.org/W2348201917","https://openalex.org/W2410287230"],"related_works":["https://openalex.org/W4390588316","https://openalex.org/W2150387129","https://openalex.org/W3001465278","https://openalex.org/W3136454724","https://openalex.org/W3114661493","https://openalex.org/W7094472483","https://openalex.org/W3021078533","https://openalex.org/W4388960901","https://openalex.org/W3119140549","https://openalex.org/W4387389234"],"abstract_inverted_index":{"The":[0,70,200,217],"potential":[1],"of":[2,35,43,52,111,136,145,215,230,247],"Centella":[3,59,264],"asiatica":[4,60],"(CA)":[5],"as":[6,47,49,123,125],"an":[7],"antioxidant":[8,100,193,243],"and":[9,37,57,66,83,97,121,149,159,179,203,208,210,219,226,254],"anti-inflammatory":[10,45,248],"agent":[11],"has":[12],"been":[13],"well":[14,48,124],"described.":[15],"However":[16],"the":[17,22,39,50,94,109,112,116,143,154,197,212,238,250,259],"extraction":[18,68,261],"method":[19,262],"which":[20],"gives":[21],"best":[23],"yield":[24],"is":[25],"debatable.":[26],"In":[27],"this":[28],"study,":[29],"we":[30],"evaluated":[31],"three":[32],"different":[33],"methods":[34],"extractions":[36],"compared":[38,195],"extracts":[40,71,113,162,190,221],"in":[41,153,245],"terms":[42,246],"antioxidant,":[44],"activities":[46,105],"contents":[51,78],"its":[53],"bioactive":[54],"compounds,":[55],"asiaticoside":[56,148,178],"madecassoside.":[58],"was":[61,91],"extracted":[62],"using":[63,79,87,93],"ethanol,":[64,155],"methanol":[65,158,220],"aqueous":[67,161,234,239],"methods.":[69],"were":[72,85,106,151,222],"then":[73,160],"measured":[74,92],"for":[75,169,177,186,263],"their":[76,126],"phenolic":[77,146],"Folin-Ciocalteu":[80],"reagent.":[81],"Asiaticoside":[82],"madecassoside":[84,150,187,204],"determined":[86,107],"HPLC.":[88],"Antioxidant":[89],"activity":[90,194],"2,2-diphenyl-1-picrylhydrazyl":[95],"(DHPP)":[96],"ferric":[98],"reducing":[99],"power":[101],"(FRAP)":[102],"assays.":[103],"Anti-inflammatory":[104],"by":[108,157],"ability":[110,127],"to":[114,128,196,257],"inhibit":[115],"inflammatory":[117],"pathway":[118],"enzyme,":[119],"COX-1":[120,207],"COX-2":[122,209],"protect":[129],"fibroblasts":[130],"against":[131],"12-O-tetradecanoylphorbol-13-acetate":[132],"(TPA)":[133],"-induced":[134],"production":[135,214],"prostaglandin":[137],"E2":[138],"(PGE2).":[139],"Results":[140],"showed":[141,191,241],"that":[142],"level":[144],"constituents,":[147],"highest":[152],"followed":[156],"(17.76":[163],"g/100g,":[164,166],"15.52":[165],"13.16":[167],"g/100g":[168],"phenolics,":[170],"42.86":[171],"mg/g,":[172,174,181,183],"36.37":[173],"2.82":[175],"mg/g":[176,185],"18.66":[180],"15.87":[182],"3.75":[184],"respectively.":[188],"All":[189],"considerable":[192],"positive":[198],"controls.":[199],"extracts,":[201],"asiaticosside":[202],"inhibited":[205],"both":[206],"suppressed":[211],"TPA-induced":[213],"PGE2.":[216],"ethanol":[218,253],"stronger":[223],"COX":[224],"inhibitors":[225],"more":[227],"potent":[228],"suppressor":[229],"PGE2":[231],"formation":[232],"than":[233],"extract.":[235],"Thus":[236],"although":[237],"extract":[240],"higher":[242],"potential,":[244],"activities,":[249],"hydrophobic":[251],"solvents,":[252],"methanol,":[255],"proved":[256],"be":[258],"better":[260],"asiatica.":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}