{"id":"https://openalex.org/W47209647","doi":"https://doi.org/10.1007/978-1-4757-9640-7_37","title":"Studies on Metabolic Perturbations and Tumor Promotion: Glycine Induces the Synthesis of Orotic Acid, a Tumor Promoter and the Expression of Certain Cell Cycle Dependent Genes","display_name":"Studies on Metabolic Perturbations and Tumor Promotion: Glycine Induces the Synthesis of Orotic Acid, a Tumor Promoter and the Expression of Certain Cell Cycle Dependent Genes","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W47209647","doi":"https://doi.org/10.1007/978-1-4757-9640-7_37","mag":"47209647"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4757-9640-7_37","doi":"https://doi.org/10.1007/978-1-4757-9640-7_37","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-9640-7_37","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Carcinogenesis","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4212797196","display_name":"Chemical Carcinogenesis"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114246125","display_name":"Shanti Vasudevan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Shanti Vasudevan","raw_affiliation_strings":["Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069155531","display_name":"George Lee","orcid":"https://orcid.org/0000-0002-8705-9210","observed_orcids":["https://orcid.org/0000-0002-8705-9210"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"George Lee","raw_affiliation_strings":["Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061156986","display_name":"I A Qureshi","orcid":"https://orcid.org/0000-0001-7720-7067","observed_orcids":["https://orcid.org/0000-0001-7720-7067"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802351361","display_name":"Centre Hospitalier Universitaire Sainte-Justine","ror":"https://ror.org/01gv74p78","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801902503","https://openalex.org/I2802351361","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ijaz A. Qureshi","raw_affiliation_strings":["Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","Department of Pediatrics, Hospital Sainte-Justine, University of Montreal, Montreal, Canada","University of Montreal","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pediatrics, Hospital Sainte-Justine, University of Montreal, Montreal, Canada","institution_ids":["https://openalex.org/I2802351361","https://openalex.org/I70931966"]},{"raw_affiliation_string":"University of Montreal","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111995185","display_name":"Prema M. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Prema M. Rao","raw_affiliation_strings":["Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014841906","display_name":"S. Rajalakshmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Srinivasan Rajalakshmi","raw_affiliation_strings":["Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103540529","display_name":"Dittakavi S. R. Sarma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dittakavi S. R. Sarma","raw_affiliation_strings":["Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","University of Toronto"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Medical Sciences Building, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"University of Toronto","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02921348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"317","last_page":"322"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.8974999785423279,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orotic-acid","display_name":"orotic acid","score":0.9959999918937683},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/glycine-metabolism","display_name":"glycine metabolism","score":0.8059999942779541},{"id":"https://openalex.org/keywords/uridine-nucleotides","display_name":"uridine nucleotides","score":0.8299999833106995},{"id":"https://openalex.org/keywords/nucleotide-pool-imbalance","display_name":"nucleotide pool imbalance","score":0.8859999775886536},{"id":"https://openalex.org/keywords/adenine-nucleotides","display_name":"adenine nucleotides","score":0.8809999823570251},{"id":"https://openalex.org/keywords/pyrimidine-biosynthesis","display_name":"pyrimidine synthesis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-cycle-genes","display_name":"cell cycle genes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.7916103601455688},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6115813255310059},{"id":"https://openalex.org/C2781259782","wikidata":"https://www.wikidata.org/wiki/Q422573","display_name":"Uridine","level":4,"score":0.5922797322273254},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.5405461192131042},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5071473121643066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4784964621067047},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.4748002588748932},{"id":"https://openalex.org/C2775851010","wikidata":"https://www.wikidata.org/wiki/Q425536","display_name":"Orotic acid","level":2,"score":0.47398462891578674},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45556095242500305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4440712630748749},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38043543696403503},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34409984946250916},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.2905305027961731},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1572950780391693}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4757-9640-7_37","doi":"https://doi.org/10.1007/978-1-4757-9640-7_37","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4757-9640-7_37","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Carcinogenesis","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.550000011920929,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W594356966","https://openalex.org/W1513717105","https://openalex.org/W1524547206","https://openalex.org/W1529063085","https://openalex.org/W1876503432","https://openalex.org/W1903816797","https://openalex.org/W1935311510","https://openalex.org/W1973409056","https://openalex.org/W1990159121","https://openalex.org/W2014669590","https://openalex.org/W2020985124","https://openalex.org/W2023598183","https://openalex.org/W2051899991","https://openalex.org/W2060333964","https://openalex.org/W2060817649","https://openalex.org/W2064772456","https://openalex.org/W2066160869","https://openalex.org/W2091402668","https://openalex.org/W2094991692","https://openalex.org/W2103401029","https://openalex.org/W2144634347","https://openalex.org/W2170311598","https://openalex.org/W2418714019","https://openalex.org/W2767900201","https://openalex.org/W6698039833","https://openalex.org/W7048635666"],"related_works":["https://openalex.org/W166545231","https://openalex.org/W7098733978","https://openalex.org/W139558409","https://openalex.org/W1973409056","https://openalex.org/W2170311598","https://openalex.org/W2020905498","https://openalex.org/W2407956211","https://openalex.org/W2004536314","https://openalex.org/W2120436695","https://openalex.org/W1990724074"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}