{"id":"https://openalex.org/W4690030","doi":"https://doi.org/10.13028/y5gz-q612","title":"Molecular imaging of the bioeffects of \u03b2-amyloid and metal ions on live human neuroblastoma cells: internalization, subcellular localization and induction of ROS","display_name":"Molecular imaging of the bioeffects of \u03b2-amyloid and metal ions on live human neuroblastoma cells: internalization, subcellular localization and induction of ROS","publication_year":2020,"publication_date":"2020-05-20","ids":{"openalex":"https://openalex.org/W4690030","doi":"https://doi.org/10.13028/y5gz-q612","mag":"4690030"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.umassmed.edu:cts_retreat-1067","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/cts_retreat/2012/posters/33","pdf_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1067&context=cts_retreat","source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UMass Center for Clinical and Translational Science Research Retreat","raw_type":"text"},"volume":null,"type":"article","indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1067&context=cts_retreat","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007775874","display_name":"Young Jiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiao, Young","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388269","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0003-0351-5184","observed_orcids":["https://orcid.org/0000-0003-0351-5184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang, Yi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020451831","display_name":"Maolin Guo","orcid":"https://orcid.org/0000-0002-9330-9239","observed_orcids":["https://orcid.org/0000-0002-9330-9239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guo, Maolin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10532","display_name":"Molecular Sensors and Ion Detection","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12211","display_name":"Aluminum toxicity and tolerance in plants and animals","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8370000123977661},{"id":"https://openalex.org/keywords/metal-ions","display_name":"metal ions","score":0.9660000205039978},{"id":"https://openalex.org/keywords/copper","display_name":"copper","score":0.7179999947547913},{"id":"https://openalex.org/keywords/zinc","display_name":"zinc","score":0.9990000128746033},{"id":"https://openalex.org/keywords/iron","display_name":"iron","score":0.847000002861023},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mitochondrial-ros","display_name":"mitochondrial reactive oxygen species","score":0.6629999876022339},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/endosomes","display_name":"endosomes","score":0.5350000262260437},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/live-cell-imaging","display_name":"live-cell imaging","score":0.7409999966621399},{"id":"https://openalex.org/keywords/fluorescent-probes","display_name":"fluorescent probes","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.9110165238380432},{"id":"https://openalex.org/C2776879804","wikidata":"https://www.wikidata.org/wiki/Q7630919","display_name":"Subcellular localization","level":3,"score":0.6180620789527893},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.5820751190185547},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5734847784042358},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4917800724506378},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4862469434738159},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.4636562764644623},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29927194118499756},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28150761127471924},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2550773620605469},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.23519638180732727},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.18464761972427368},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10835859179496765},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.umassmed.edu:cts_retreat-1067","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/cts_retreat/2012/posters/33","pdf_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1067&context=cts_retreat","source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UMass Center for Clinical and Translational Science Research Retreat","raw_type":"text"},{"id":"mag:4690030","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1067&context=cts_retreat","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"doi:10.13028/y5gz-q612","doi":"https://doi.org/10.13028/y5gz-q612","is_oa":true,"landing_page_url":"https://doi.org/10.13028/y5gz-q612","pdf_url":null,"source":{"id":"https://openalex.org/S7407053131","display_name":"University of Massachusetts (UMass) Chan Medical School","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:escholarship.umassmed.edu:cts_retreat-1067","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/cts_retreat/2012/posters/33","pdf_url":"https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1067&context=cts_retreat","source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"UMass Center for Clinical and Translational Science Research Retreat","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4690030.pdf","grobid_xml":"https://content.openalex.org/works/W4690030.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2975314712","https://openalex.org/W2025430645","https://openalex.org/W2029044778","https://openalex.org/W1968744610","https://openalex.org/W7161248100","https://openalex.org/W1997926662","https://openalex.org/W2093477129","https://openalex.org/W2163785699","https://openalex.org/W2087850309","https://openalex.org/W6947930804"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1,7],"(AD)":[2],"is":[3,42,73,77],"a":[4,123,136,165,168,184],"progressive":[5],"neurodegenerative":[6],"characterized":[8],"by":[9,199],"the":[10,38,78,119,152,159,177,192,195,216,242,254,260],"deposition":[11,180],"of":[12,31,40,167,181,187,194,209,218,247,256],"extracellular":[13,84],"amyloid-\u03b2(A\u03b2)":[14,240],"plaques":[15],"that":[16,51,148],"are":[17],"rich":[18],"in":[19,47,80,107,110,176,191],"metal":[20,56,210,257],"ions":[21,57,211,258],"such":[22,58,212],"as":[23,59,197,213,251,253],"zinc,":[24],"copper":[25,98],"and":[26,82,99,156,171,205,235,244],"iron.":[27],"The":[28,179],"neurotoxic":[29],"role":[30],"A\u03b2":[32,52,85,120,149,182],"has":[33],"been":[34],"well":[35,252],"established":[36],"but":[37],"mechanism":[39],"action":[41],"still":[43],"poorly":[44],"understood.":[45],"Recent":[46],"vitro":[48],"evidence":[49,237],"suggest":[50],"can":[53,86],"interact":[54],"with":[55,122,130,143],"Zn(II),":[60],"Cu(II)":[61],"or":[62],"Fe(II/III)":[63],"which":[64,126],"promote":[65],"its":[66,128,245],"aggregation":[67],"and/or":[68],"ROS":[69,100,229],"production.":[70,230],"However,":[71],"it":[72],"unclear":[74],"whether":[75],"this":[76,106],"case":[79],"cells":[81,112,131,146,160,243],"whether/how":[83],"get":[87],"into":[88,174],"cells.":[89,178],"Our":[90,138,231],"recently":[91],"developed":[92],"molecular":[93],"imaging":[94,141],"probes":[95],"for":[96],"iron,":[97],"enable":[101],"us":[102],"to":[103,132,225],"look":[104],"at":[105,113,151,263],"real":[108],"time":[109],"live":[111],"subcellular":[114,264],"resolution.":[115],"First,":[116],"we":[117],"tagged":[118],"covalently":[121],"fluorescent":[124],"dye":[125],"allows":[127],"interactions":[129],"be":[133,226],"monitored":[134],"under":[135],"microscope.":[137],"laser":[139],"confocal":[140],"experiments":[142],"human":[144],"neuroblastoma":[145],"revealed":[147,198],"accumulated":[150],"cell":[153],"surface":[154],"first":[155],"subsequently":[157],"entered":[158],"via":[161],"endocytosis":[162],"pathway":[163],"over":[164],"period":[166],"few":[169],"hours":[170],"finally":[172],"deposited":[173],"endosomes/lysosomes":[175],"induced":[183],"marked":[185],"production":[186,217,262],"oxygen":[188,201,219,248],"free":[189,202,249],"radicals":[190,220,250],"mitochondria":[193],"cells,":[196],"our":[200],"radical":[203,261],"probe":[204],"colocalization":[206],"experiments.":[207],"Incubation":[208],"copper(II)":[214],"increased":[215],"significantly":[221],"while":[222],"zinc(II)":[223],"appears":[224],"protective":[227],"against":[228],"data":[232],"provided":[233],"compelling":[234],"direct":[236],"on":[238,259],"how":[239],"entering":[241],"induction":[246],"effects":[255],"level.":[265]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}