{"id":"https://openalex.org/W46758000","doi":null,"title":"Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma.","display_name":"Prevalent expression of MHC class I chain-related molecule A in human osteosarcoma.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W46758000","mag":"46758000","pmid":"https://pubmed.ncbi.nlm.nih.gov/18348660"},"language":"en","primary_location":{"id":"pmid:18348660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18348660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112112440","display_name":"Shanming Lu","orcid":"https://orcid.org/0009-0006-5986-4112","observed_orcids":["https://orcid.org/0009-0006-5986-4112"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan-ming Lu","raw_affiliation_strings":["Department of Pathology, First Affiliated Hospital, Sun Yat-Sen University, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, First Affiliated Hospital, Sun Yat-Sen University, Guangdong, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210128921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112125867","display_name":"Ping Xiao","orcid":"https://orcid.org/0000-0002-2407-2071","observed_orcids":["https://orcid.org/0000-0002-2407-2071","https://orcid.org/0000-0002-7527-3244"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Xue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Xue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073043066","display_name":"Li-hong Che","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-hong Che","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048841778","display_name":"Ping Yang","orcid":"https://orcid.org/0000-0002-6977-8449","observed_orcids":["https://orcid.org/0000-0002-6977-8449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ping Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Yang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Hui Qiao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Qiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8033,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.69448124,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"55","issue":"3","first_page":"266","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mica","display_name":"mica","score":0.9789999723434448},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nkg2d","display_name":"NKG2D","score":0.8899999856948853},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/soluble-mica","display_name":"soluble MICA","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tumor-surveillance","display_name":"tumor surveillance","score":0.8069999814033508},{"id":"https://openalex.org/keywords/tumor-associated-antigen-expression","display_name":"tumor-associated antigen expression","score":0.4390000104904175},{"id":"https://openalex.org/keywords/serum-biomarkers","display_name":"serum biomarkers","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C2778867473","wikidata":"https://www.wikidata.org/wiki/Q17544382","display_name":"NKG2D","level":4,"score":0.8517659902572632},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.7309730648994446},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.7181233763694763},{"id":"https://openalex.org/C2776885095","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immunosurveillance","level":3,"score":0.593208909034729},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.546293318271637},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.545903742313385},{"id":"https://openalex.org/C2781038479","wikidata":"https://www.wikidata.org/wiki/Q114675","display_name":"Mica","level":2,"score":0.49589404463768005},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.4938414692878723},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49257761240005493},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4856489896774292},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4603639841079712},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4396655857563019},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3794383704662323},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3786661922931671},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35431307554244995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3398100733757019},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22935500741004944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13012537360191345},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18348660","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18348660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neoplasma","raw_type":"Journal Article"},{"id":"mag:46758000","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18348660","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2382093334","https://openalex.org/W2106677006","https://openalex.org/W2373907095","https://openalex.org/W2586836405","https://openalex.org/W2347351847","https://openalex.org/W2058708333","https://openalex.org/W2612095795","https://openalex.org/W2361380114","https://openalex.org/W2026859850","https://openalex.org/W2392662901"],"abstract_inverted_index":{"MHC":[0],"class":[1],"I":[2],"chain-related":[3],"molecule":[4],"A":[5],"(MICA)":[6],"is":[7,18,94],"one":[8],"of":[9,32,50,60,78,82,106,122,137,143,150,160],"the":[10,51,56,76,158],"major":[11],"ligands":[12],"for":[13,173],"activating":[14],"immune-receptor":[15],"NKG2D":[16,42,161],"which":[17],"expressed":[19,96],"on":[20,44,163],"NK":[21],"cells":[22,166],"and":[23,29,58,69,102,116,139],"cytotoxic":[24,38],"T":[25],"lymphocytes.":[26],"The":[27,48],"release":[28,59],"sustained":[30],"expression":[31,57,77,136,159],"MICA":[33,61,84,93,107,124,138,145],"protein":[34,103],"can":[35,127],"impair":[36],"NKG2D-mediated":[37],"activity":[39],"by":[40,87],"reducing":[41],"receptor":[43,162],"immune":[45,164],"effector":[46,165],"cells.":[47],"aim":[49],"study":[52],"was":[53,85,108],"to":[54,169],"investigate":[55],"in":[62,74,97,100,110,125,130,154],"human":[63,174],"osteosarcoma.":[64,175],"RT-PCR,":[65],"immunohistochemistry,":[66],"western":[67],"blotting":[68],"flow":[70],"cytometry":[71],"were":[72],"used":[73],"analyzing":[75],"MICA.":[79],"Serum":[80],"level":[81,121,142],"soluble":[83,123,144],"quantitated":[86],"ELISA.":[88],"Our":[89],"data":[90],"showed":[91],"that":[92],"prevalently":[95],"osteosarcoma":[98,111,131,155],"both":[99],"mRNA":[101],"level.":[104],"Upregulation":[105],"found":[109],"compared":[112],"with":[113],"benign":[114],"tumors":[115],"normal":[117],"bone":[118],"tissues.":[119],"Higher":[120],"serum":[126,141],"be":[128],"detected":[129],"patients.":[132,156],"In":[133],"conclusion,":[134],"prevalent":[135],"higher":[140],"may":[146,167],"suggest":[147],"a":[148,170],"deficiency":[149],"MICA-NKG2D":[151],"mediated":[152],"immunosurveillance":[153],"Restoring":[157],"contribute":[168],"therapeutic":[171],"strategy":[172]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
