{"id":"https://openalex.org/W46581255","doi":null,"title":"Human cytochrome P4501A2.","display_name":"Human cytochrome P4501A2.","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W46581255","mag":"46581255","pmid":"https://pubmed.ncbi.nlm.nih.gov/10493258"},"language":"en","primary_location":{"id":"pmid:10493258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10493258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IARC scientific publications","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110966805","display_name":"Maria Teresa Landi","orcid":"https://orcid.org/0000-0002-9727-7772","observed_orcids":["https://orcid.org/0000-0002-9727-7772","https://orcid.org/0000-0003-4507-329X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M T Landi","raw_affiliation_strings":["Genetic Epidemiology Branch, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Branch, Bethesda, MD 20892, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"R Sinha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Sinha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108269730","display_name":"Nicholas Patrick Lang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N P Lang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087771359","display_name":"Fred F. Kadlubar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F F Kadlubar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.6817,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.95627884,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":null,"issue":"148","first_page":"173","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.800000011920929},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8379999995231628},{"id":"https://openalex.org/keywords/carcinogen-metabolism","display_name":"carcinogen metabolism","score":0.7490000128746033},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.6140000224113464},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.7799999713897705},{"id":"https://openalex.org/keywords/caffeine-metabolites","display_name":"caffeine metabolites","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5080000162124634},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.6169999837875366},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mycotoxins","display_name":"mycotoxins","score":0.6019999980926514},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.6499999761581421},{"id":"https://openalex.org/keywords/polybrominated-biphenyls","display_name":"polybrominated biphenyls","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dioxins","display_name":"dioxins","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.9546881914138794},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.6052370667457581},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5280916094779968},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5175106525421143},{"id":"https://openalex.org/C50605568","wikidata":"https://www.wikidata.org/wiki/Q14912267","display_name":"CYP2B6","level":5,"score":0.511683464050293},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.4648664593696594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4640890955924988},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4553138017654419},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.45316991209983826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4133455753326416},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3832823634147644},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33432942628860474},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.22137024998664856}],"mesh":[{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10493258","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10493258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IARC scientific publications","raw_type":"Journal Article"},{"id":"mag:46581255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10493258","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6216570700","display_name":"ACETYLATION AND N-OXIDATION IN COLORECTAL CANCER","funder_award_id":"R01CA055751","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2079745478","https://openalex.org/W1996264650","https://openalex.org/W1997722729","https://openalex.org/W2042005699","https://openalex.org/W7099939122","https://openalex.org/W2383052404","https://openalex.org/W4312740313","https://openalex.org/W2017196000","https://openalex.org/W2027536321","https://openalex.org/W7220585614"],"abstract_inverted_index":{"CYP1A2,":[0],"a":[1,203,247,342],"member":[2],"of":[3,15,53,81,139,161,176,196,205,246,286,296,309,344,347,362],"the":[4,12,50,64,158,162,177,228,244,251,277,307,329],"cytochrome":[5],"P450":[6],"superfamily":[7],"(CYPs),":[8],"is":[9,341],"involved":[10],"in":[11,38,63,90,117,120,144,168,235,265,272,282,353,369,377],"metabolic":[13],"activation":[14],"several":[16,210],"carcinogens,":[17],"among":[18],"them":[19],"aromatic":[20],"and":[21,27,49,83,108,132,214,219,240,350],"heterocyclic":[22],"amines,":[23],"nitroaromatic":[24],"compounds,":[25],"mycotoxins":[26],"estrogens.":[28],"Several":[29,221],"drugs":[30],"are":[31,291,332,338],"also":[32,366],"metabolized":[33],"by":[34,72],"CYP1A2.":[35],"Individual":[36],"differences":[37,89,154],"CYP1A2":[39,58,91,134,163,192,197,231,252,270,297,357,374],"activity":[40,92,113,198,271],"may":[41,97],"thus":[42],"influence":[43],"individual":[44],"susceptibility":[45],"to":[46,69,100,110,148,188,216,268],"cancer":[47,241,349,352],"risk":[48,346],"therapeutic":[51],"efficacy":[52],"some":[54,310],"drugs.":[55],"In":[56,243],"humans,":[57],"has":[59,114,127,199,276,365],"been":[60,94,115,128,166,184,200,225,262,302,367],"detected":[61],"only":[62,250,335],"liver,":[65],"where":[66],"it":[67],"seems":[68,147],"be":[70,98,149,189,255],"regulated":[71],"at":[73,257],"least":[74],"two":[75,180],"mechanisms,":[76],"one":[77],"controlling":[78],"constitutive":[79],"levels":[80],"expression":[82],"another":[84],"regulating":[85],"inducibility.":[86],"Wide":[87,122],"interindividual":[88],"have":[93,165,183,224,261,301,322],"described.":[95],"They":[96],"due":[99],"factors":[101],"such":[102],"as":[103,202,264,293],"gender,":[104],"race,":[105],"genetic":[106,181],"polymorphisms,":[107],"exposure":[109,215],"inducers.":[111],"Higher":[112],"shown":[116],"men":[118],"than":[119,376],"women.":[121],"variation":[123],"across":[124],"racial/ethnic":[125],"groups":[126],"reported.":[129],"Overall,":[130],"slow":[131,380],"intermediate":[133],"metabolizers":[135],"represent":[136],"about":[137],"50%":[138],"Caucasians,":[140],"while":[141,320],"their":[142],"frequency":[143],"Japanese":[145],"subjects":[146,354,378],"much":[150],"lower.":[151],"No":[152],"nucleotide":[153],"that":[155],"could":[156],"explain":[157],"phenotypic":[159],"variability":[160],"gene":[164],"found":[167,368],"any":[169],"exons,":[170],"exon-intron":[171],"junctions,":[172],"or":[173,234,317,325],"5'-flanking":[174],"regions":[175],"gene.":[178],"However,":[179],"variants":[182],"identified":[185],"which":[186],"seem":[187],"associated":[190],"with":[191,237,304,355,372,379],"inducibility":[193],"only.":[194],"Induction":[195],"reported":[201],"consequence":[204],"cigarette":[206],"smoking,":[207],"dietary":[208],"factors,":[209],"drugs,":[211],"chronic":[212],"hepatitis,":[213],"polybrominated":[217],"biphenyls":[218],"2,3,7,8-tetrachlorodibenzo-p-dioxin.":[220],"epidemiological":[222,283,330],"studies":[223,331],"conducted":[226],"into":[227],"relationship":[229],"between":[230],"activity,":[232],"alone":[233],"combination":[236],"other":[238],"CYPs,":[239],"risk.":[242],"absence":[245],"genotypic":[248],"assay,":[249],"phenotype":[253,375],"can":[254],"assessed":[256],"present.":[258],"Many":[259],"compounds":[260],"tested":[263],"vitro":[266],"probes":[267],"assess":[269],"humans.":[273],"Currently,":[274],"caffeine":[275,287,311],"best":[278],"potential":[279],"for":[280],"use":[281,308],"studies:":[284],"metabolites":[285],"after":[288],"coffee":[289],"consumption":[290],"measured":[292],"an":[294],"index":[295],"activity.":[298,358,381],"Variable":[299],"results":[300],"obtained":[303],"caffeine-based":[305],"methods,":[306],"metabolite":[312],"ratios":[313],"having":[314],"given":[315],"bimodal":[316],"trimodal":[318],"distributions":[319],"others":[321],"suggested":[323],"normal":[324],"unimodal":[326],"distributions.":[327],"Although":[328],"limited":[333],"because":[334],"phenotyping":[336],"data":[337],"available,":[339],"there":[340],"suggestion":[343],"increased":[345],"colon":[348],"bladder":[351],"rapid":[356,373],"A":[359],"higher":[360],"level":[361],"4-aminobiphenyl-haemoglobin":[363],"adducts":[364],"moderate":[370],"smokers":[371]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}