{"id":"https://openalex.org/W46576785","doi":null,"title":"The potential role of Rac signalling and the planar cell polarity pathway in wiring of the enteric nervous system","display_name":"The potential role of Rac signalling and the planar cell polarity pathway in wiring of the enteric nervous system","publication_year":2011,"publication_date":"2011-06-28","ids":{"openalex":"https://openalex.org/W46576785","mag":"46576785"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1318135","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1318135/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071232562","display_name":"Valentina Sasselli","orcid":"https://orcid.org/0000-0002-7118-0067","observed_orcids":["https://orcid.org/0000-0002-7118-0067"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Valentina Sasselli","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7118-0067","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071232562"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.5156000256538391,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.16699999570846558,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.1534000039100647,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enteric-nervous-system-development","display_name":"enteric nervous system development","score":0.9660000205039978},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.9430000185966492},{"id":"https://openalex.org/keywords/rac3","display_name":"RAC3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9900000095367432},{"id":"https://openalex.org/keywords/planar-cell-polarity-pathway","display_name":"planar cell polarity pathway","score":0.8899999856948853},{"id":"https://openalex.org/keywords/neural-crest-migration","display_name":"neural crest migration","score":0.7630000114440918},{"id":"https://openalex.org/keywords/enteric-neurogenesis","display_name":"enteric neurogenesis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/axon-guidance","display_name":"axon guidance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.7570000290870667},{"id":"https://openalex.org/keywords/celsr3","display_name":"CELSR3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.7279999852180481},{"id":"https://openalex.org/keywords/enteric-neuropathy","display_name":"enteric neuropathy","score":0.6830000281333923},{"id":"https://openalex.org/keywords/intestinal-function","display_name":"intestinal function","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7585077881813049},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7405264973640442},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6663615107536316},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.6165555715560913},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.5748367309570312},{"id":"https://openalex.org/C2779717556","wikidata":"https://www.wikidata.org/wiki/Q15325735","display_name":"RAC1","level":3,"score":0.560447633266449},{"id":"https://openalex.org/C69125201","wikidata":"https://www.wikidata.org/wiki/Q2034716","display_name":"Axon guidance","level":3,"score":0.5472890138626099},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.504346489906311},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4698798954486847},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.44709697365760803},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.4418465793132782},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.43020206689834595},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.42508798837661743},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41810816526412964},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3581068515777588},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2481640875339508},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2028566300868988},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1327284872531891},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1318135","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1318135/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:46576785","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1318135/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1997791336","https://openalex.org/W2008127822","https://openalex.org/W2027918140","https://openalex.org/W2039247434","https://openalex.org/W2039790417","https://openalex.org/W2045636855","https://openalex.org/W2113148955","https://openalex.org/W2132289628","https://openalex.org/W2147289229","https://openalex.org/W2148993806"],"related_works":["https://openalex.org/W2139802677","https://openalex.org/W1894141023","https://openalex.org/W2025244763","https://openalex.org/W2020493895","https://openalex.org/W4389021633","https://openalex.org/W6908121237","https://openalex.org/W2105946812","https://openalex.org/W1982144815","https://openalex.org/W2767108677","https://openalex.org/W2762174393"],"abstract_inverted_index":{"The":[0],"functional":[1],"development":[2,209],"of":[3,57,63,72,75,84,102,105,117,155,202,210,216,236,250,254,291,314,322,340,353],"the":[4,36,44,69,76,95,106,118,144,153,168,220,234,251,255,260,267,338,347,351],"enteric":[5,85,113,187,203,211,240,302,356],"nervous":[6],"system":[7,121],"(ENS)":[8],"requires":[9],"newly":[10],"generated":[11,131,161],"neurons":[12,192,212,303],"and":[13,26,31,81,99,110,122,181,191,198,213,243,266,311],"their":[14,19],"progenitors":[15,86],"to":[16,18,28,172,232],"migrate":[17],"appropriate":[20,37],"sites,":[21],"extend":[22],"neurites,":[23],"guide":[24],"axons":[25],"dendrites":[27],"suitable":[29],"locations":[30],"establish":[32],"synaptic":[33],"connections":[34],"with":[35],"targets.":[38],"Very":[39],"little":[40],"is":[41,140,149],"known":[42],"about":[43],"molecular":[45],"mechanism":[46],"underlying":[47],"these":[48,330],"processes.":[49,67],"\\nRecent":[50],"studies":[51,184],"have":[52],"suggested":[53],"a":[54,123,132,173,228,289],"potential":[55],"role":[56,98],"Rho":[58],"GTPases":[59],"as":[60],"intracellular":[61],"regulators":[62],"several":[64,354],"ENS":[65,323,334],"developmental":[66],"However,":[68],"relative":[70],"participation":[71],"specific":[73,331],"members":[74,104],"family":[77],"in":[78,96,112,143,182,200,208,214,239,279,292,296,299,307,312,333,358],"migration,":[79],"neurogenesis":[80],"axonal":[82,316],"guidance":[83,242],"has":[87],"not":[88],"been":[89],"addressed":[90],"yet.":[91],"Here,":[92],"we":[93,130,160,225,285],"investigate":[94,233],"vivo":[97,180,293],"genetic":[100],"interaction":[101],"two":[103,249],"Rho-GTPase":[107],"family,":[108],"Rac1":[109,124,138,197],"Rac3":[111,175,199],"neurogenesis.":[114],"Taking":[115],"advantage":[116],"Cre/loxP":[119],"recombination":[120],"conditional":[125],"inactivation":[126],"mouse":[127,135,170],"strain":[128,177],"(Rac1flox/flox),":[129],"Sox10Cre;":[133],"Rac1flox/flox;R26ReYFP":[134],"line,":[136],"where":[137],"gene":[139,230],"specifically":[141,278],"ablated":[142],"neural":[145,188,204],"crest":[146,189,205],"population":[147],"which":[148],"also":[150,226],"labeled":[151],"by":[152,166,287],"expression":[154],"Yellow":[156],"Fluorescent":[157],"Protein.":[158],"Secondly,":[159],"double":[162],"Rac1;Rac3":[163],"mutant":[164],"animals":[165],"crossing":[167],"Sox10Cre;Rac1flox;R26ReYFP":[169],"line":[171],"constitutive":[174],"KO":[176],"(Rac3-/-).":[178],"In":[179],"vitro":[183],"on":[185],"Rac-deficient":[186],"cells":[190,206],"showed":[193],"distinctive":[194],"roles":[195],"for":[196,349],"migration":[201],"(ENCCs),":[207],"control":[215],"cell":[217],"polarity":[218],"within":[219],"developing":[221],"ENS.":[222],"\\nIn":[223],"addition,":[224],"undertook":[227],"candidate":[229],"approach":[231],"involvement":[235],"Wnt-signaling":[237],"genes":[238],"axon":[241],"circuit":[244],"formation.":[245],"We":[246],"found":[247],"that":[248,295,329],"core":[252],"components":[253],"Planar":[256],"Cell":[257],"Polarity":[258],"pathway,":[259],"Wnt":[261],"receptor":[262,273],"Frizzled":[263],"3":[264,274],"(Fzd3)":[265],"Cadherin":[268],"EGF":[269],"LAG":[270],"seven-pass":[271],"G-type":[272],"(Celsr3)":[275],"are":[276],"expressed":[277],"ENCCs":[280],"during":[281],"embryonic":[282],"development.":[283,324],"Here":[284],"show,":[286],"using":[288],"combination":[290],"approaches":[294],"mice":[297],"deficient":[298],"either":[300],"protein,":[301],"had":[304],"characteristic":[305],"defects":[306,332],"neuronal":[308],"tract":[309],"formation":[310],"patterning":[313],"individual":[315],"projections":[317],"evident":[318],"from":[319],"early":[320],"stages":[321],"Furthermore,":[325],"preliminary":[326],"data":[327],"show":[328],"wiring":[335],"might":[336],"be":[337],"cause":[339],"impaired":[341],"intestinal":[342],"function":[343],"and,":[344],"therefore,":[345],"provide":[346],"basis":[348],"understanding":[350],"aetiopathology":[352],"idiopathic":[355],"neuropathies":[357],"humans.":[359]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}
