{"id":"https://openalex.org/W46529298","doi":null,"title":"Chromosomes, genes, and cancer.","display_name":"Chromosomes, genes, and cancer.","publication_year":1986,"publication_date":"1986-10-01","ids":{"openalex":"https://openalex.org/W46529298","mag":"46529298","pmid":"https://pubmed.ncbi.nlm.nih.gov/3490792","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888437"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888437","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111814791","display_name":"Peter C. Nowell\u0300","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P C Nowell","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, and the Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, and the Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079700663","display_name":"Carlo Maria Croce","orcid":"https://orcid.org/0000-0003-3788-1457","observed_orcids":["https://orcid.org/0000-0003-3788-1457"]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Croce","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, and the Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, and the Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I102322052","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.1167,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.91269756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"125","issue":"1","first_page":"7","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.49880000948905945,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.44359999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-cytogenetics","display_name":"tumor cytogenetics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/karyotypic-abnormalities","display_name":"karyotype abnormalities","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/chromosomal-translocation","display_name":"chromosomal translocation","score":0.6729999780654907},{"id":"https://openalex.org/keywords/chromosomal-instability","display_name":"chromosomal instability","score":0.3580000102519989},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.4230000078678131},{"id":"https://openalex.org/keywords/hematopoietic-cancers","display_name":"hematopoietic tumors","score":0.6330000162124634},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.8180000185966492},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chromosome-banding","display_name":"chromosome banding","score":0.4580000042915344},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8207851648330688},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6538881063461304},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6438350677490234},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6191875338554382},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.5374506115913391},{"id":"https://openalex.org/C3018593856","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Neoplastic cell","level":3,"score":0.5322055220603943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5262757539749146},{"id":"https://openalex.org/C2993273003","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Neoplastic transformation","level":4,"score":0.49344268441200256},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4883122444152832},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47813379764556885},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4300178587436676},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.42517003417015076},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4086551368236542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35017678141593933},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3001052141189575},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002051","descriptor_name":"Burkitt Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002877","descriptor_name":"Chromosomes, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1888437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:3490792","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3490792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:46529298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3490792","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W202064424","https://openalex.org/W304227101","https://openalex.org/W1527488691","https://openalex.org/W1576516151","https://openalex.org/W1825165936","https://openalex.org/W1964223564","https://openalex.org/W1966112609","https://openalex.org/W1966240406","https://openalex.org/W1966396612","https://openalex.org/W1984557292","https://openalex.org/W1999197294","https://openalex.org/W2005883417","https://openalex.org/W2008898220","https://openalex.org/W2008932177","https://openalex.org/W2010946778","https://openalex.org/W2011795445","https://openalex.org/W2012908073","https://openalex.org/W2013921702","https://openalex.org/W2016568386","https://openalex.org/W2016575124","https://openalex.org/W2016760717","https://openalex.org/W2020092689","https://openalex.org/W2021339951","https://openalex.org/W2022081023","https://openalex.org/W2028008767","https://openalex.org/W2028957701","https://openalex.org/W2030789354","https://openalex.org/W2032166136","https://openalex.org/W2032312044","https://openalex.org/W2035208645","https://openalex.org/W2042378550","https://openalex.org/W2045066046","https://openalex.org/W2050683897","https://openalex.org/W2056120923","https://openalex.org/W2062530202","https://openalex.org/W2062832392","https://openalex.org/W2062927712","https://openalex.org/W2067918086","https://openalex.org/W2071706472","https://openalex.org/W2073101093","https://openalex.org/W2073985924","https://openalex.org/W2089483984","https://openalex.org/W2092299362","https://openalex.org/W2093310753","https://openalex.org/W2147039086","https://openalex.org/W2159363679","https://openalex.org/W2164515753","https://openalex.org/W2330923897","https://openalex.org/W2418118875","https://openalex.org/W4249612925"],"related_works":["https://openalex.org/W297882882","https://openalex.org/W947587655","https://openalex.org/W2017851831","https://openalex.org/W1967304777","https://openalex.org/W2144166980","https://openalex.org/W146748601","https://openalex.org/W1526578215","https://openalex.org/W2087744627","https://openalex.org/W320013767","https://openalex.org/W4317214250"],"abstract_inverted_index":{"THE":[0],"MODERN":[1],"ERA":[2],"of":[3,16,28,35,38,54,92,130,154,157,173,181,183,213,217,254,270,304,307,341,346,384,392,404,429,434,453,467,472,480,487],"tumor":[4,39,73,158,225,265,308,314],"cytogenetics":[5,482],"began":[6],"in":[7,20,63,70,137,144,177,188,223,273,287,313,333,351,365,372,409,422,425,446,464,497],"the":[8,14,21,55,67,75,80,90,101,109,114,155,163,174,178,248,252,274,277,280,305,366,382,393,402,431,441,481],"1950s":[9],"and":[10,197,250,258,376,417,483,499],"accelerated":[11],"rapidly":[12],"with":[13,170,185,338,343,349,489],"development":[15],"so-called":[17],"banding":[18],"techniques":[19,328],"1970s.":[22],"During":[23],"this":[24,211,397,478],"period,":[25],"chromosome":[26,110,407],"studies":[27,496],"neoplasms":[29,45,166],"added":[30,149],"significantly":[31,389],"to":[32,51,88,124,151,162,205,243,293,319,380],"our":[33,152,493],"understanding":[34,153],"various":[36,410],"aspects":[37],"biology.":[40],"The":[41,133,267],"recognition":[42],"that":[43,57,69,165,221,235,261,282,322,357],"most":[44,93,216],"have":[46,79,236,297,317,329,456],"visible":[47],"cytogenetic":[48],"alterations":[49,187,332],"contributed":[50],"general":[52],"acceptance":[53],"view":[56],"somatic":[58,103],"genetic":[59,104,189,195,208,219,454],"changes":[60,361,445],"are":[61,141,198,336,374],"important":[62,371],"tumorigenesis.":[64],"In":[65,210],"addition,":[66],"demonstration":[68,135],"a":[71,96,117,127,224,458],"given":[72],"all":[74],"neoplastic":[76,128,179],"cells":[77,184,192,204],"often":[78,106],"same":[81,442],"karyotypic":[82,139,360],"change,":[83,105],"or":[84,348,451],"related":[85,318,484],"changes,":[86],"helped":[87],"indicate":[89,363],"derivation":[91],"tumors":[94,146,412],"from":[95,401],"single":[97],"altered":[98],"cell.":[99],"Presumably,":[100],"specific":[102,331,344,405],"recognizable":[107],"at":[108],"level,":[111],"confers":[112],"on":[113,477,492],"progenitor":[115],"cell":[116,226],"selective":[118,239],"growth":[119,240,257],"advantage,":[120],"allowing":[121],"its":[122],"progeny":[123],"expand":[125,242],"as":[126,264,327,379,414],"clone":[180],"unicellular":[131],"origin.":[132],"further":[134],"that,":[136],"general,":[138],"abnormalities":[140],"more":[142,168,200,255],"extensive":[143],"advanced":[145],"has":[147,323,354,399,437],"also":[148,284],"importantly":[150],"phenomenon":[156],"progression.":[159,266],"It":[160,353],"led":[161],"hypothesis":[164,398],"become":[167,244],"aggressive":[169,256],"time":[171],"because":[172],"sequential":[175],"appearance":[176],"subpopulations":[182,246,272],"additional":[186,238],"makeup.":[190],"Neoplastic":[191],"show":[193],"increased":[194,259],"instability":[196],"thus":[199],"likely":[201],"than":[202],"normal":[203],"generate":[206],"such":[207,385,413],"variants.":[209],"concept":[212],"clonal":[214],"evolution,":[215],"these":[218,294,358],"variants":[220],"arise":[222],"population":[227],"do":[228],"not":[229],"survive,":[230],"but":[231],"those":[232],"few":[233],"mutants":[234],"an":[237],"advantage":[241],"predominant":[245],"within":[247],"neoplasm,":[249],"demonstrate":[251],"characteristics":[253],"malignancy":[260],"we":[262],"recognize":[263],"continued":[268],"presence":[269],"multiple":[271],"neoplasm":[275],"provides":[276],"basis":[278],"for":[279,396,461],"heterogeneity":[281],"is":[283],"typically":[285],"observed":[286],"malignant":[288],"tumors.":[289],"Cytogenetic":[290],"data":[291],"contributing":[292],"evolving":[295],"concepts":[296],"been":[298,324,355,438],"incorporated":[299],"into":[300],"several":[301],"recent":[302,473,495],"reviews":[303],"mechanisms":[306],"progression.1I2":[309],"Most":[310],"current":[311],"developments":[312],"cytogenetics,":[315],"however,":[316],"another":[320],"aspect":[321,479],"increasingly":[325],"recognized":[326],"improved:":[330],"particular":[334,369],"chromosomes":[335],"associated,":[337],"different":[339],"degrees":[340],"consistency,":[342],"types":[345],"tumors,":[347,448],"neoplasia":[350],"general.3'4":[352],"suggested":[356,457],"nonrandom":[359],"might":[362,387],"sites":[364],"genome":[367],"where":[368],"genes":[370],"carcinogenesis":[373],"located,":[375],"provide":[377],"clues":[378],"how":[381],"function":[383,428],"oncogenes":[386],"be":[388],"altered.":[390],"Much":[391],"initial":[394],"support":[395],"come":[400],"study":[403],"reciprocal":[406],"translocations":[408],"hematopoietic":[411],"Burkitt's":[415],"lymphoma":[416],"chronic":[418],"myelogenous":[419],"leukemia":[420,498],"(CML),":[421],"which":[423],"alteration":[424],"structure":[426],"and/or":[427],"proto-oncogenes,":[430],"human":[432],"homolog":[433],"retroviral":[435],"oncogenes,":[436],"demonstrated.":[439],"At":[440],"time,":[443],"chromosomal":[444],"other":[447],"reflecting":[449],"gain":[450],"loss":[452],"material,":[455],"critical":[459],"role":[460],"oncogene":[462],"dosage":[463],"some":[465],"instances":[466],"carcinogenesis.":[468],"This":[469],"brief":[470],"review":[471],"findings":[474],"will":[475],"focus":[476],"molecular":[485],"genetics":[486],"neoplasia,":[488],"emphasis":[490],"primarily":[491],"own":[494],"lymphoma.":[500]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}