{"id":"https://openalex.org/W46516657","doi":null,"title":"IMMUNOREGULATION OF LIVER REGENERATION BY THE ARYL HYDROCARBON RECEPTOR: ROLE OF LYMPHOCYTES AND INTERFERON-GAMMA","display_name":"IMMUNOREGULATION OF LIVER REGENERATION BY THE ARYL HYDROCARBON RECEPTOR: ROLE OF LYMPHOCYTES AND INTERFERON-GAMMA","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W46516657","mag":"46516657"},"language":"en","primary_location":{"id":"pmh:oai:scholarworks.boisestate.edu:td-1204","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.boisestate.edu/td/204","pdf_url":"https://scholarworks.boisestate.edu/cgi/viewcontent.cgi?article=1204&context=td","source":{"id":"https://openalex.org/S4377196366","display_name":"Scholar Works  (Boise State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120156002","host_organization_name":"Boise State University","host_organization_lineage":["https://openalex.org/I120156002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boise State University Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarworks.boisestate.edu/cgi/viewcontent.cgi?article=1204&context=td","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040867318","display_name":"Christopher J. Horras","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christopher J. Horras","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5040867318"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00401934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-3-7-8-tetrachlorodibenzo-p-dioxin","display_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin","score":0.9760000109672546},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8519999980926514},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9700000286102295},{"id":"https://openalex.org/keywords/nkt-cells","display_name":"NKT cells","score":0.800000011920929},{"id":"https://openalex.org/keywords/immunotoxicity","display_name":"immunotoxicity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.921999990940094},{"id":"https://openalex.org/keywords/nk-cell-depletion","display_name":"NK cell depletion","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cd69","display_name":"CD69","score":0.7429999709129333},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.6538203358650208},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.591435432434082},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.591305673122406},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.5218098163604736},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44610467553138733},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4336584508419037},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.384762704372406},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38358044624328613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3831466734409332},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3390486240386963},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3005216419696808},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21247097849845886},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:scholarworks.boisestate.edu:td-1204","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.boisestate.edu/td/204","pdf_url":"https://scholarworks.boisestate.edu/cgi/viewcontent.cgi?article=1204&context=td","source":{"id":"https://openalex.org/S4377196366","display_name":"Scholar Works  (Boise State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120156002","host_organization_name":"Boise State University","host_organization_lineage":["https://openalex.org/I120156002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boise State University Theses and Dissertations","raw_type":"text"},{"id":"mag:46516657","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.boisestate.edu/cgi/viewcontent.cgi?article=1204&context=td","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:scholarworks.boisestate.edu:td-1204","doi":null,"is_oa":true,"landing_page_url":"https://scholarworks.boisestate.edu/td/204","pdf_url":"https://scholarworks.boisestate.edu/cgi/viewcontent.cgi?article=1204&context=td","source":{"id":"https://openalex.org/S4377196366","display_name":"Scholar Works  (Boise State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I120156002","host_organization_name":"Boise State University","host_organization_lineage":["https://openalex.org/I120156002"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Boise State University Theses and Dissertations","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3193252090","display_name":"Idaho INBRE Program","funder_award_id":"P20RR016454","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320309625","display_name":"Boise State University","ror":"https://ror.org/02e3zdp86"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W46516657.pdf","grobid_xml":"https://content.openalex.org/works/W46516657.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W89320799","https://openalex.org/W112390383","https://openalex.org/W1501457950","https://openalex.org/W1547266858","https://openalex.org/W1553271305","https://openalex.org/W1571858920","https://openalex.org/W1588673533","https://openalex.org/W1605480405","https://openalex.org/W1653749361","https://openalex.org/W1965697014","https://openalex.org/W1969708796","https://openalex.org/W1973891633","https://openalex.org/W1976777279","https://openalex.org/W1976846448","https://openalex.org/W1978374942","https://openalex.org/W1981983308","https://openalex.org/W1983150631","https://openalex.org/W1988290861","https://openalex.org/W1990004694","https://openalex.org/W1992294414","https://openalex.org/W1996524127","https://openalex.org/W1996555750","https://openalex.org/W1997382475","https://openalex.org/W1998420703","https://openalex.org/W1998427679","https://openalex.org/W2000174284","https://openalex.org/W2000441102","https://openalex.org/W2003747312","https://openalex.org/W2009225735","https://openalex.org/W2009896818","https://openalex.org/W2017516136","https://openalex.org/W2022484334","https://openalex.org/W2027286533","https://openalex.org/W2030665259","https://openalex.org/W2031958609","https://openalex.org/W2036374745","https://openalex.org/W2037555606","https://openalex.org/W2039176834","https://openalex.org/W2039972806","https://openalex.org/W2041070333","https://openalex.org/W2041690669","https://openalex.org/W2043964379","https://openalex.org/W2044894161","https://openalex.org/W2050092608","https://openalex.org/W2050131392","https://openalex.org/W2050453489","https://openalex.org/W2051182721","https://openalex.org/W2053032132","https://openalex.org/W2057644777","https://openalex.org/W2058558820","https://openalex.org/W2060645387","https://openalex.org/W2062461545","https://openalex.org/W2063007059","https://openalex.org/W2070103675","https://openalex.org/W2070635608","https://openalex.org/W2071311200","https://openalex.org/W2073017599","https://openalex.org/W2075794433","https://openalex.org/W2077133859","https://openalex.org/W2081536518","https://openalex.org/W2081611490","https://openalex.org/W2083563797","https://openalex.org/W2085149614","https://openalex.org/W2089040741","https://openalex.org/W2089069133","https://openalex.org/W2089536120","https://openalex.org/W2090939833","https://openalex.org/W2091965894","https://openalex.org/W2093418725","https://openalex.org/W2098684750","https://openalex.org/W2102233728","https://openalex.org/W2106999205","https://openalex.org/W2114629114","https://openalex.org/W2114994536","https://openalex.org/W2118338891","https://openalex.org/W2118688982","https://openalex.org/W2119965437","https://openalex.org/W2121477549","https://openalex.org/W2123101851","https://openalex.org/W2127624625","https://openalex.org/W2129154108","https://openalex.org/W2145992558","https://openalex.org/W2147640266","https://openalex.org/W2148300725","https://openalex.org/W2148529156","https://openalex.org/W2150109695","https://openalex.org/W2150678429","https://openalex.org/W2152618449","https://openalex.org/W2152782043","https://openalex.org/W2158320409","https://openalex.org/W2161629837","https://openalex.org/W2161831252","https://openalex.org/W2162067613","https://openalex.org/W2165627850","https://openalex.org/W2169539585","https://openalex.org/W2170264506","https://openalex.org/W2182760487","https://openalex.org/W2395377164","https://openalex.org/W2408168992","https://openalex.org/W2419035725"],"related_works":["https://openalex.org/W2087922750","https://openalex.org/W7006318206","https://openalex.org/W2152618449","https://openalex.org/W2108648711","https://openalex.org/W2055795657","https://openalex.org/W7101086375","https://openalex.org/W1519426477","https://openalex.org/W2108625184","https://openalex.org/W2006635679","https://openalex.org/W2085042732"],"abstract_inverted_index":{"2,3,7,8-Tetrachlorodibenzo-p-dioxin":[0],"(TCDD)":[1],"is":[2,66],"a":[3,48,160,329],"persistent":[4],"environmental":[5],"contaminant":[6],"that":[7,40,63,93,194,305,331],"elicits":[8],"toxicity":[9],"by":[10,55,69,73,99,175,181,185,204,235,317,328],"activating":[11],"the":[12,31,81,108,114,150,157,168,201,218,223,238,248,263,269,312],"aryl":[13],"hydrocarbon":[14],"receptor.":[15],"The":[16],"toxic":[17],"effects":[18,84,115],"associated":[19],"with":[20,80,137,189,278],"TCDD":[21,43,86,94,117,138,195,213,244,288,322],"exposure":[22,41,211,242,320],"include":[23],"immunotoxicity":[24],"and":[25,104,123,170,173,252,290],"dysregulated":[26],"cell":[27,102],"cycle":[28],"control,":[29],"although":[30],"mechanisms":[32],"are":[33,127,308],"poorly":[34],"understood.":[35],"A":[36],"previous":[37],"report":[38],"indicates":[39],"to":[42,144,208,212,243,268,282,287,321],"suppresses":[44,323],"hepatocyte":[45,198,299,326],"proliferation":[46,148,199,300,327],"in":[47,87,107,149,200,222,237,301,324],"mouse":[49],"model":[50,89],"of":[51,85,116,129,159,220,250,265,272,293,314,340],"liver":[52,64,97,152,172,203,226,273,315],"regeneration":[53,65,98,316],"induced":[54],"70%":[56],"partial":[57],"hepatectomy":[58],"(PH).":[59],"Based":[60],"on":[61,118,156,217],"reports":[62],"negatively":[67],"regulated":[68],"interferon":[70],"(IFN)-\u03b3":[71],"produced":[72],"activated":[74],"natural":[75,119],"killer":[76,120],"(NK)":[77,121],"cells,":[78,125],"along":[79],"well-established":[82],"immunotoxic":[83],"other":[88,190],"systems,":[90],"we":[91,192],"hypothesized":[92],"treatment":[95,196],"attenuates":[96],"enhancing":[100],"NK":[101,251,266,284,294,306,335],"activation":[103,259],"IFN-\u03b3":[105,131,178],"production":[106,234,339],"regenerating":[109,202,239],"liver.":[110,240],"We":[111],"also":[112],"considered":[113],"T":[122,124],"which":[126],"capable":[128],"producing":[130],"as":[132],"well.":[133],"Mice":[134],"were":[135,165,276],"treated":[136,277],"(20":[139],"\u03bcg/kg)":[140],"one":[141],"day":[142],"prior":[143,286],"surgical":[145],"PH.":[146,291],"Hepatocyte":[147],"remnant":[151,171],"was":[153,179],"measured":[154,180],"based":[155],"incorporation":[158],"thymidine":[161],"analog,":[162],"bromodeoxyuridine.":[163],"Lymphocytes":[164],"collected":[166],"from":[167],"spleen":[169,224],"analyzed":[174],"flow":[176,186],"cytometry.":[177,187],"intracellular":[182],"staining":[183],"followed":[184],"Consistent":[188],"reports,":[191],"found":[193],"suppressed":[197],"50-80%.":[205],"However,":[206],"contrary":[207],"our":[209],"hypothesis,":[210],"had":[214],"no":[215],"effect":[216],"number":[219,249],"lymphocytes":[221,236],"or":[225,337],"after":[227],"PH,":[228],"nor":[229],"did":[230,245,296],"it":[231],"increase":[232,247],"IFN-\u03b3+":[233],"Moreover,":[241],"not":[246,297,309,333],"NKT":[253],"cells":[254,267,285,295,307,336],"expressing":[255],"CD69,":[256],"an":[257,279],"early":[258],"marker.":[260],"To":[261],"determine":[262],"relevance":[264],"TCDD-mediated":[270],"suppression":[271],"regeneration,":[274],"mice":[275],"\u03b1-asialo-GM-1":[280],"antibody":[281],"deplete":[283],"administration":[289],"Depletion":[292],"restore":[298],"TCDD-treated":[302],"mice,":[303],"indicating":[304],"required":[310],"for":[311],"attenuation":[313],"TCDD.":[318],"Hence,":[319],"vivo":[325],"mechanism":[330],"does":[332],"involve":[334],"enhanced":[338],"IFN-\u03b3.":[341]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}