{"id":"https://openalex.org/W46493756","doi":null,"title":"Neonatal hyperoxia alters the pulmonary alveolar and capillary structure of 40-day-old rats.","display_name":"Neonatal hyperoxia alters the pulmonary alveolar and capillary structure of 40-day-old rats.","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W46493756","mag":"46493756","pmid":"https://pubmed.ncbi.nlm.nih.gov/2356858","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877590"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1544951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877590","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877590","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049641668","display_name":"Scott H. Randell","orcid":"https://orcid.org/0000-0001-5351-2841","observed_orcids":["https://orcid.org/0000-0001-5351-2841"]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Randell","raw_affiliation_strings":["Department of Medicine, Durham Veterans Affairs Medical Center, North Carolina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Durham Veterans Affairs Medical Center, North Carolina","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108407637","display_name":"Robert R. Mercer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R R Mercer","raw_affiliation_strings":["Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022288550","display_name":"Stephen L. Young","orcid":"https://orcid.org/0000-0002-8642-8408","observed_orcids":["https://orcid.org/0000-0002-8642-8408"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S L Young","raw_affiliation_strings":["Duke University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke University","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7246,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.8939488,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"136","issue":"6","first_page":"1259","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-hyperoxia","display_name":"neonatal hyperoxia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alveolar-surface-area","display_name":"alveolar surface area","score":0.8479999899864197},{"id":"https://openalex.org/keywords/capillary-blood-volume","display_name":"capillary blood volume","score":0.796999990940094},{"id":"https://openalex.org/keywords/lung-development","display_name":"lung development","score":0.6850000023841858},{"id":"https://openalex.org/keywords/bronchopulmonary-dysplasia","display_name":"bronchopulmonary dysplasia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/oxygen-toxicity","display_name":"oxygen toxicity","score":0.35100001096725464},{"id":"https://openalex.org/keywords/rat-lung","display_name":"rat lung","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.9098079204559326},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.8400835394859314},{"id":"https://openalex.org/C2908807708","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Alveolar Wall","level":3,"score":0.7420783638954163},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.7252843379974365},{"id":"https://openalex.org/C2776993930","wikidata":"https://www.wikidata.org/wiki/Q1598902","display_name":"Stereology","level":2,"score":0.6809078454971313},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6449266672134399},{"id":"https://openalex.org/C2779333224","wikidata":"https://www.wikidata.org/wiki/Q809756","display_name":"Basal lamina","level":3,"score":0.5671170949935913},{"id":"https://openalex.org/C2909420118","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Alveolar Epithelium","level":3,"score":0.5556864738464355},{"id":"https://openalex.org/C2778543330","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Pulmonary alveolus","level":4,"score":0.5325091481208801},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.4473978281021118},{"id":"https://openalex.org/C2779854577","wikidata":"https://www.wikidata.org/wiki/Q191341","display_name":"Alveolar cells","level":3,"score":0.4387100636959076},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.42426756024360657},{"id":"https://openalex.org/C2778721537","wikidata":"https://www.wikidata.org/wiki/Q922640","display_name":"Bronchopulmonary dysplasia","level":4,"score":0.42031168937683105},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40045902132987976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3574312925338745},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.33862751722335815},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.3059307932853699},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27102744579315186},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17799514532089233},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.08432811498641968},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":true},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1544951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877590","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1877590","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877590","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:2356858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2356858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:46493756","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2356858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1544951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1877590","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2971974142","display_name":"Integrated Toxicology Program","funder_award_id":"T32ES007031","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G3100879669","display_name":"FETAL LUNG BIOCHEMISTRY AND MICROANATOMY","funder_award_id":"R01HL032188","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W182284833","https://openalex.org/W203737162","https://openalex.org/W1209674312","https://openalex.org/W1993464634","https://openalex.org/W2009813080","https://openalex.org/W2011137624","https://openalex.org/W2017236298","https://openalex.org/W2018916579","https://openalex.org/W2026524338","https://openalex.org/W2043135346","https://openalex.org/W2089543148","https://openalex.org/W2097229047","https://openalex.org/W2106581895","https://openalex.org/W2106875648","https://openalex.org/W2153088580","https://openalex.org/W2188088995","https://openalex.org/W2205166056","https://openalex.org/W2273766340","https://openalex.org/W2276054845","https://openalex.org/W2301439439","https://openalex.org/W2417916071","https://openalex.org/W4300486926"],"related_works":["https://openalex.org/W2587613468","https://openalex.org/W2017236298","https://openalex.org/W2380017751","https://openalex.org/W2368071882","https://openalex.org/W1993464634","https://openalex.org/W3028805725","https://openalex.org/W2009813080","https://openalex.org/W2097229047","https://openalex.org/W4254567557","https://openalex.org/W1996069421"],"abstract_inverted_index":{"High":[0],"inspired":[1],"oxygen":[2,72],"concentrations":[3],"during":[4,19],"the":[5,29,36,60,74,98,127,133,139,149,159,187,191,216,229,257],"neonatal":[6,26,181,249],"period":[7],"profoundly":[8],"inhibit":[9],"rat":[10],"lung":[11,99,147],"development,":[12],"an":[13,117,153],"effect":[14],"that":[15,65,137,248,267],"is":[16],"partly":[17],"reversed":[18],"recovery":[20],"in":[21,86,132,138,177,215,256],"air.":[22],"Persistent":[23],"effects":[24],"of":[25,33,38,56,62,97,101,120,130,144,152,190,212,228,238,263,275],"hyperoxia":[27,81,252],"on":[28,224],"size":[30,163],"and":[31,48,106,148,173,260,266],"number":[32,143],"alveoli":[34,145,176],"or":[35],"structure":[37,262],"pulmonary":[39,258],"capillaries":[40],"have":[41],"not":[42,156],"been":[43],"well":[44],"defined.":[45],"Using":[46],"light":[47],"electron":[49,185,206],"microscopic":[50],"morphometry":[51],"plus":[52],"quantitative":[53],"three-dimensional":[54],"reconstructions":[55],"alveoli,":[57,134],"we":[58],"examined":[59],"lungs":[61],"40-day-old":[63,178,264],"rats":[64,84,179],"were":[66,155,166],"exposed":[67,192],"to":[68,83,136,220,251,272],"more":[69,170],"than":[70,113],"95%":[71],"for":[73],"first":[75],"7":[76],"days":[77],"after":[78,180],"birth.":[79],"Neonatal":[80],"administered":[82],"resulted":[85],"abnormally":[87],"enlarged":[88],"air":[89,131],"spaces":[90],"at":[91],"age":[92],"40":[93],"days.":[94],"The":[95,142,245],"fraction":[96],"consisting":[100],"parenchyma":[102],"was":[103,110,116,199,242],"significantly":[104,169],"increased":[105],"alveolar":[107,121,140,162,188,203,217,239,259],"surface":[108,189],"area":[109],"13%":[111],"lower":[112],"controls.":[114],"There":[115],"abnormal":[118],"enlargement":[119],"ducts,":[122],"which":[123,198],"reduced":[124],"by":[125],"24%":[126],"relative":[128],"amount":[129],"compared":[135],"ducts.":[141,204],"per":[146,236],"mean":[150],"volume":[151,235],"alveolus":[154],"different":[157],"between":[158],"groups,":[160],"but":[161],"class":[164],"distributions":[165],"different,":[167],"with":[168],"very":[171,174],"small":[172],"large":[175],"hyperoxia.":[182],"By":[183],"scanning":[184],"microscopy,":[186],"animals":[193],"had":[194],"a":[195,209,225],"corrugated":[196],"appearance,":[197],"especially":[200],"evident":[201],"along":[202],"Transmission":[205],"microscopy":[207],"revealed":[208],"greater":[210],"density":[211],"capillaries,":[213],"particularly":[214],"regions":[218],"close":[219],"terminal":[221],"airways.":[222],"Based":[223],"random":[226],"sample":[227],"entire":[230],"parenchymal":[231],"region,":[232],"capillary":[233,261],"blood":[234],"cm2":[237],"basal":[240],"lamina":[241],"18%":[243],"greater.":[244],"results":[246],"demonstrate":[247],"exposure":[250],"can":[253],"cause":[254],"abnormalities":[255],"rats,":[265],"these":[268],"changes":[269],"are":[270],"similar":[271],"some":[273],"features":[274],"broncho-pulmonary":[276],"dysplasia.":[277]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}