{"id":"https://openalex.org/W46337224","doi":null,"title":"Accumulation of 10B in human synovial sarcoma cells in vitro for possible use in BNCT","display_name":"Accumulation of 10B in human synovial sarcoma cells in vitro for possible use in BNCT","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W46337224","mag":"46337224"},"language":"en","primary_location":{"id":"mag:46337224","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A219687","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088798755","display_name":"Maria Dahlstr\u00f6m Wester","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Dahlstr\u00f6m Wester","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041336753","display_name":"Jacek Capala","orcid":"https://orcid.org/0000-0001-7631-0310","observed_orcids":["https://orcid.org/0000-0001-7631-0310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacek Capala","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7631-0310","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022948168","display_name":"\u00c5ke Wasteson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u00c5ke Wasteson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086311366","display_name":"Annelie Lindstr\u00f6m","orcid":"https://orcid.org/0000-0003-2130-5375","observed_orcids":["https://orcid.org/0000-0003-2130-5375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annelie Lindstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2130-5375","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00478186,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12055","display_name":"Boron Compounds in Chemistry","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12055","display_name":"Boron Compounds in Chemistry","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/boron-neutron-capture-therapy","display_name":"boron neutron capture therapy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/synovial-sarcoma","display_name":"synovial sarcoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/boronophenylalanine","display_name":"boronophenylalanine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor-receptor","display_name":"platelet-derived growth factor receptor","score":0.828000009059906},{"id":"https://openalex.org/keywords/pdgf-aa","display_name":"PDGF-AA","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dextran-conjugates","display_name":"dextran conjugates","score":0.9940000176429749},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.7149999737739563},{"id":"https://openalex.org/keywords/boron-retention","display_name":"boron retention","score":0.460999995470047},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.4050000011920929}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5535660982131958},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5487502217292786},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5196065306663513},{"id":"https://openalex.org/C2776910622","wikidata":"https://www.wikidata.org/wiki/Q2619315","display_name":"Synovial sarcoma","level":3,"score":0.48471641540527344},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.4643203616142273},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4638637900352478},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.45189571380615234},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38541126251220703},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33170467615127563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2331399917602539},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19925916194915771},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13002660870552063}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:46337224","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2%3A219687","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","score":0.6499999761581421,"display_name":"Affordable and clean energy"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382438","https://openalex.org/W6980079749","https://openalex.org/W2143048662","https://openalex.org/W2151056163","https://openalex.org/W2021649725","https://openalex.org/W268511200","https://openalex.org/W2465631216","https://openalex.org/W2033996844","https://openalex.org/W2053234665","https://openalex.org/W1582656769"],"abstract_inverted_index":{"Exclusive":[0],"eradication":[1],"of":[2,33,43,54,59,83,96,114,134,153,158,183,190,207,215,242,302,325,335,339,392,402,407,413],"tumour":[3,55,73,120,246,275,307],"cells":[4,147,236,304],"causing":[5],"minimal":[6],"damage":[7],"to":[8,14,21,37,86,124,179,186,196,213,284,298,342,364,382,396,409],"healthy":[9],"tissue,":[10],"a":[11,163,204,291,328,336],"concept":[12],"referred":[13],"as":[15,327],"targeting,":[16],"is":[17,89,122,406],"an":[18],"interesting":[19],"approach":[20],"improve":[22],"the":[23,81,132,151,181,187,194,257,262,267,272,300,306,314,323,333,375,387,400,403,411],"outcome":[24],"for":[25,127,203,313,374,419],"patients":[26],"afflicted":[27],"with":[28,225],"cancer.":[29],"The":[30,91],"general":[31],"aim":[32],"this":[34,347],"thesis":[35],"was":[36,137,168,177,211,248,372,379],"highlighten":[38],"aspects":[39],"that":[40,361],"could":[41],"be":[42,125,383,397],"importance":[44],"in":[45,77,139,148,233,237,250,346,358],"developing":[46],"novel":[47],"treatment":[48,329],"regimens":[49],"based":[50],"on":[51,108,399],"specific":[52,205],"targeting":[53,60,74],"cells.":[56,110,188],"Two":[57],"variants":[58],"strategies,":[61],"boron":[62,184,240,289],"neutron":[63],"capture":[64,87,92],"therapy":[65],"(BNCT)":[66],"and":[67,145,155,160,220,223,231,279,331],"platelet-derived":[68],"growth":[69],"factor":[70],"receptor":[71],"(PDGFR)":[72],"were":[75,362],"studied":[76],"vitro.":[78,149,238],"In":[79],"BNCT,":[80],"ability":[82],"boron-10,":[84],"10B,":[85],"neutrons":[88],"utilized.":[90],"reaction":[93],"initiate":[94],"emission":[95,174],"high":[97],"linear":[98],"energy":[99],"transfer":[100],"(LET)":[101],"particles":[102],"which":[103],"exerts":[104],"potential":[105,324,412],"damaging":[106],"effects":[107],"exposed":[109],"A":[111,239,368],"preferential":[112],"accumulation":[113,133],"at":[115,290],"least":[116],"10":[117,219,353],"\u03bcg":[118,244],"10B/g":[119,245],"tissue":[121,247],"suggested":[123],"required":[126],"effective":[128,156],"clinical":[129],"outcome.":[130],"Here,":[131],"boronophenylalanine,":[135],"BPA,":[136],"investigated":[138],"human":[140,234,252,274,315],"glioma,":[141],"synovial":[142,316],"sarcoma,":[143],"fibroblast":[144],"monocytoid":[146,280],"For":[150,256],"purpose":[152],"quick":[154],"separation":[157],"extracellular":[159],"cell-associated":[161],"boron,":[162],"rapid":[164],"cell":[165,253,260],"filtration":[166],"method":[167],"developed.":[169],"Inductively":[170],"coupled":[171],"plasma":[172],"atomic":[173],"spectroscopy,":[175],"ICP-AES,":[176],"used":[178,283],"analyse":[180],"amount":[182,294],"associated":[185],"Over-expression":[189],"PDGFRs":[191],"may":[192,296,321],"render":[193],"possibility":[195],"target":[197],"certain":[198],"tumours":[199],"using":[200],"PDGF-based":[201],"conjugates":[202,394,415],"delivery":[206,338],"cytotoxic":[208],"agents.":[209],"PDGF-AA":[210,227,378],"conjugated":[212],"dextran":[214,350,355,414],"two":[216,258,268],"different":[217],"sizes,":[218],"40":[221],"kDa,":[222],"compared":[224],"125I-radiolabelled":[226],"regarding":[228],"accumulation,":[229],"retention":[230,370],"localisation":[232],"glioma":[235,259],"concentration":[241],">10":[243],"found":[249],"all":[251],"lines":[254],"studied.":[255],"lines,":[261],"results":[263,312],"extend":[264],"differences":[265],"between":[266],"although":[269],"originating":[270],"from":[271],"same":[273],"material.":[276],"Since":[277],"fibroblasts":[278],"cells,":[281,287,318],"here":[282],"represent":[285],"normal":[286],"accumulated":[288],"clinically":[292],"relevant":[293],"one":[295],"have":[297],"consider":[299],"role":[301],"these":[303],"in/at":[305],"site":[308],"during":[309],"treatment.":[310],"Regarding":[311],"sarcoma":[317],"further":[319],"investigations":[320],"state":[322],"BNCT":[326],"modality":[330],"explore":[332,410],"possibilities":[334],"directed":[337],"boron-containing":[340],"substances":[341,418],"receptors":[343],"specifically":[344],"expressed":[345],"malignancy.":[348],"PDGF-AA-based":[349],"conjugates,":[351,356],"preferentially":[352],"kDa":[354],"showed":[357],"vitro":[359],"properties":[360],"superior":[363],"radiolabelled":[365,393],"unconjugated":[366],"PDGF-AA.":[367],"prolonged":[369],"time":[371],"observed":[373],"conjugates.":[376],"Radiolabelled":[377],"mainly":[380],"determined":[381],"located":[384],"intracellular":[385],"but":[386],"localisation,":[388],"internalised":[389],"or":[390],"membrane-associated,":[391],"seemed":[395],"dependent":[398],"composition":[401],"conjugate.":[404],"It":[405],"interest":[408],"carrying":[416],"toxic":[417],"therapeutic":[420],"purpose.":[421]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}
