{"id":"https://openalex.org/W46304590","doi":null,"title":"The interplay between RNA and DNA modifications : back to the RNA world","display_name":"The interplay between RNA and DNA modifications : back to the RNA world","publication_year":2009,"publication_date":"2009-06-11","ids":{"openalex":"https://openalex.org/W46304590","mag":"46304590"},"language":"en","primary_location":{"id":"pmh:oai:HAL:hal-00529377v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00529377","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.ncbi.nlm.nih.gov/books/NBK6338/","raw_type":"info:eu-repo/semantics/bookPart"},"volume":null,"type":"book-chapter","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091702193","display_name":"Patrick Forterre","orcid":"https://orcid.org/0000-0002-1843-7214","observed_orcids":["https://orcid.org/0000-0002-1843-7214"]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Forterre, Patrick","raw_affiliation_strings":["BMGE - Biologie Mol\u00e9culaire du G\u00e8ne chez les Extr\u00eamophiles (D\u00e9partement Microbiologie - 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)","IGM - Institut de g\u00e9n\u00e9tique et microbiologie [Orsay] (B\u00e2timents 400 et 409\r\nUFR des Sciences - Universit\u00e9 Paris-Sud 11\r\n15, rue Georges Cl\u00e9menceau - F 91405 ORSAY Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BMGE - Biologie Mol\u00e9culaire du G\u00e8ne chez les Extr\u00eamophiles (D\u00e9partement Microbiologie - 25-28 rue du Docteur Roux, F-75724 Paris Cedex 15 - France)","institution_ids":[]},{"raw_affiliation_string":"IGM - Institut de g\u00e9n\u00e9tique et microbiologie [Orsay] (B\u00e2timents 400 et 409\r\nUFR des Sciences - Universit\u00e9 Paris-Sud 11\r\n15, rue Georges Cl\u00e9menceau - F 91405 ORSAY Cedex - France)","institution_ids":["https://openalex.org/I102197404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073956638","display_name":"Henri Grosjean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404","https://openalex.org/I277688954"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Grosjean, Henri","raw_affiliation_strings":["IGM - Institut de g\u00e9n\u00e9tique et microbiologie [Orsay] (B\u00e2timents 400 et 409\r\nUFR des Sciences - Universit\u00e9 Paris-Sud 11\r\n15, rue Georges Cl\u00e9menceau - F 91405 ORSAY Cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IGM - Institut de g\u00e9n\u00e9tique et microbiologie [Orsay] (B\u00e2timents 400 et 409\r\nUFR des Sciences - Universit\u00e9 Paris-Sud 11\r\n15, rue Georges Cl\u00e9menceau - F 91405 ORSAY Cedex - France)","institution_ids":["https://openalex.org/I102197404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102197404"],"apc_list":null,"apc_paid":null,"fwci":4.0016,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.94724026,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"259","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.5839999914169312,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.20970000326633453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.04270000010728836,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rna-modification","display_name":"RNA modification","score":0.6980000138282776},{"id":"https://openalex.org/keywords/dna-modification","display_name":"DNA modification","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rna-world-hypothesis","display_name":"RNA world","score":0.8700000047683716},{"id":"https://openalex.org/keywords/origin-of-life","display_name":"origin of life","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.6380000114440918},{"id":"https://openalex.org/keywords/deaminase","display_name":"deaminase","score":0.8980000019073486}],"concepts":[{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6824741363525391},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5330027341842651},{"id":"https://openalex.org/C155242204","wikidata":"https://www.wikidata.org/wiki/Q407525","display_name":"RNA world hypothesis","level":5,"score":0.4554136097431183},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4333415925502777},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40751874446868896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3314322233200073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09511211514472961},{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.07174178957939148}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:HAL:hal-00529377v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00529377","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.ncbi.nlm.nih.gov/books/NBK6338/","raw_type":"info:eu-repo/semantics/bookPart"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W181741071","https://openalex.org/W650419191","https://openalex.org/W1172490410","https://openalex.org/W1508225465","https://openalex.org/W1510015995","https://openalex.org/W1796631315","https://openalex.org/W1802567635","https://openalex.org/W1964583257","https://openalex.org/W1965404910","https://openalex.org/W1976176794","https://openalex.org/W1979511146","https://openalex.org/W1981312008","https://openalex.org/W1983255679","https://openalex.org/W1987364769","https://openalex.org/W1991941799","https://openalex.org/W1996294023","https://openalex.org/W1998172162","https://openalex.org/W1999207703","https://openalex.org/W2002944556","https://openalex.org/W2003019599","https://openalex.org/W2005311687","https://openalex.org/W2013138671","https://openalex.org/W2014520526","https://openalex.org/W2018772285","https://openalex.org/W2020718415","https://openalex.org/W2030113297","https://openalex.org/W2036374978","https://openalex.org/W2039659321","https://openalex.org/W2040190781","https://openalex.org/W2045401515","https://openalex.org/W2045601762","https://openalex.org/W2047232029","https://openalex.org/W2047661441","https://openalex.org/W2050110866","https://openalex.org/W2059021438","https://openalex.org/W2061245152","https://openalex.org/W2065194989","https://openalex.org/W2069737643","https://openalex.org/W2083496215","https://openalex.org/W2090853404","https://openalex.org/W2100071542","https://openalex.org/W2100287154","https://openalex.org/W2113021729","https://openalex.org/W2115383070","https://openalex.org/W2116103056","https://openalex.org/W2116184895","https://openalex.org/W2117820928","https://openalex.org/W2119313530","https://openalex.org/W2124049725","https://openalex.org/W2129162844","https://openalex.org/W2132550739","https://openalex.org/W2135486654","https://openalex.org/W2135734424","https://openalex.org/W2136495792","https://openalex.org/W2136794728","https://openalex.org/W2154253535","https://openalex.org/W2157235926","https://openalex.org/W2158526038","https://openalex.org/W2164609484","https://openalex.org/W2166092226","https://openalex.org/W2169494000","https://openalex.org/W2171690009"],"related_works":["https://openalex.org/W2034271451","https://openalex.org/W2030113297","https://openalex.org/W2475393727","https://openalex.org/W2040190781","https://openalex.org/W7100349386","https://openalex.org/W2417242849","https://openalex.org/W4398781754","https://openalex.org/W2048823547","https://openalex.org/W197326121","https://openalex.org/W1967311854"],"abstract_inverted_index":{"An":[0],"RNA/protein":[1],"world":[2,168],"(probably":[3],"cellular)":[4],"is":[5,179],"widely":[6],"accepted":[7],"as":[8,44,205],"a":[9,194],"probable":[10],"step":[11],"in":[12,126,133,214],"the":[13,49,52,72,89,151,154,160,165,191,216,220],"early":[14],"evolution":[15,21],"of":[16,55,117,153,164,193,209,219],"life.":[17],"During":[18],"subsequent":[19],"life":[20],"various":[22],"enzymes":[23,78,139,183],"emerged":[24],"that":[25,107,184],"allowed":[26],"some":[27],"organisms":[28],"to":[29,36,62,66,112,144,171,187],"generate":[30],"deoxyribonucleotides":[31],"from":[32],"ribonucleotide":[33],"precursors":[34],"and":[35,59,97,105,123,128,148,157,197],"synthesize":[37,188],"DNA":[38,50,69,90,124,147,189,203],"molecules":[39],"using":[40,101],"ancestral":[41],"RNA":[42,122,167,211],"genomes":[43,70,91],"templates.":[45],"Later":[46],"on,":[47],"once":[48],"became":[51],"major":[53],"repository":[54],"genetic":[56,217],"information,":[57],"cells":[58,127],"viruses":[60,129],"had":[61],"develop":[63],"new":[64],"strategies":[65],"protect":[67],"their":[68,93],"against":[71],"aggressive":[73],"chemical":[74],"environment":[75],"and/or":[76],"destructive":[77],"produced":[79],"by":[80,86],"competitors.":[81],"This":[82],"was":[83],"performed":[84],"mainly":[85],"further":[87],"modifying":[88],"after":[92],"synthesis":[94],"through":[95],"pre":[96],"postreplicative":[98],"enzymatic":[99],"processes,":[100],"enzymes,":[102],"mostly":[103],"methyltransferases":[104],"deaminases":[106],"were":[108,169,185],"probably":[109],"initially":[110],"designated":[111,186],"modify":[113,145],"primordial":[114],"RNAs.":[115],"Relics":[116],"this":[118,201],"ancient":[119],"interplay":[120],"between":[121],"modification":[125,155],"are":[130,140],"still":[131,141],"abundant":[132],"our":[134],"modern":[135],"\u2018DNA-makes-RNA-makes-proteins\u2019":[136],"world.":[137],"Some":[138],"able":[142],"today":[143],"both":[146],"RNA,":[149],"demonstrating":[150],"versatility":[152],"apparatus":[156],"testifying":[158],"for":[159],"time":[161],"when":[162],"proteins":[163],"late":[166],"recruited":[170],"work":[172],"with":[173],"DNA.":[174],"Here,":[175],"we":[176],"review":[177],"what":[178],"known":[180],"about":[181],"these":[182],"within":[190],"framework":[192],"hypothetical":[195],"cellular":[196],"viral":[198],"co-evolution.":[199],"From":[200],"analysis,":[202],"appears":[204],"just":[206],"another":[207],"type":[208],"(hyper)modified":[210],"polymer,":[212],"specialized":[213],"storing":[215],"inheritance":[218],"living":[221],"organisms.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}