{"id":"https://openalex.org/W46277343","doi":null,"title":"A randomized study of gemcitabine plus cisplatin and vinorelbine plus cisplatin in patients with advanced non-small-cell lung cancer.","display_name":"A randomized study of gemcitabine plus cisplatin and vinorelbine plus cisplatin in patients with advanced non-small-cell lung cancer.","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W46277343","mag":"46277343","pmid":"https://pubmed.ncbi.nlm.nih.gov/19241895"},"language":"en","primary_location":{"id":"pmid:19241895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19241895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chang Gung medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054050349","display_name":"John Wen\u2010Cheng Chang","orcid":"https://orcid.org/0000-0001-8373-5691","observed_orcids":["https://orcid.org/0000-0001-8373-5691"]},"institutions":[{"id":"https://openalex.org/I173093425","display_name":"Chang Gung University","ror":"https://ror.org/00d80zx46","country_code":"TW","type":"education","lineage":["https://openalex.org/I173093425"]},{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"John Wen-Cheng Chang","raw_affiliation_strings":["Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Chang Gung University College of Medicine, Taoyuan, Taiwan","institution_ids":["https://openalex.org/I173093425","https://openalex.org/I3020100970"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108440524","display_name":"Thomas Chang Yao Tsao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Chang-Yao Tsao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031628450","display_name":"Cheng\u2010Ta Yang","orcid":"https://orcid.org/0000-0003-1846-1027","observed_orcids":["https://orcid.org/0000-0003-1846-1027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheng-Ta Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048313601","display_name":"Meng\u2010Chih Lin","orcid":"https://orcid.org/0000-0001-8333-1494","observed_orcids":["https://orcid.org/0000-0001-8333-1494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng-Chih Lin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021613270","display_name":"Yun\u2010Chung Cheung","orcid":"https://orcid.org/0000-0002-6870-3429","observed_orcids":["https://orcid.org/0000-0002-6870-3429"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yun-Chung Cheung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113713472","display_name":"Chung-Chi Liaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3020100970","display_name":"Chang Gung Memorial Hospital","ror":"https://ror.org/02verss31","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I3020100970"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Chi Liaw","raw_affiliation_strings":["Chang Gung Medical Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chang Gung Medical Foundation","institution_ids":["https://openalex.org/I3020100970"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100759686","display_name":"Chih\u2010Hung Chen","orcid":"https://orcid.org/0000-0003-3718-2373","observed_orcids":["https://orcid.org/0000-0003-3718-2373"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chih-Hung Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5739,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73114774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"6","first_page":"559","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.46799999475479126,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9629999995231628},{"id":"https://openalex.org/keywords/vinorelbine","display_name":"vinorelbine","score":1.0},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.640999972820282},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.8130000233650208},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.6140000224113464},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8830000162124634},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7929999828338623},{"id":"https://openalex.org/keywords/treatment-costs","display_name":"treatment costs","score":0.699999988079071},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4189999997615814}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9474660158157349},{"id":"https://openalex.org/C2780350996","wikidata":"https://www.wikidata.org/wiki/Q420532","display_name":"Vinorelbine","level":4,"score":0.9401377439498901},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.9261924028396606},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7155903577804565},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6693981885910034},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6460112929344177},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.6290725469589233},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5333696603775024},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39455902576446533},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37365996837615967}],"mesh":[{"descriptor_ui":"D000077235","descriptor_name":"Vinorelbine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:19241895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19241895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chang Gung medical journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.567.5613","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.567.5613","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://memo.cgu.edu.tw/cgmj/3106/310605.pdf","raw_type":"text"},{"id":"mag:46277343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19241895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1790560776","https://openalex.org/W1837121308","https://openalex.org/W1848316250","https://openalex.org/W1857358013","https://openalex.org/W1858072261","https://openalex.org/W1935885922","https://openalex.org/W1942409573","https://openalex.org/W2016263166","https://openalex.org/W2037139573","https://openalex.org/W2043696829","https://openalex.org/W2068864761","https://openalex.org/W2106787323","https://openalex.org/W2129793485","https://openalex.org/W2138254624","https://openalex.org/W2145008730","https://openalex.org/W2153477391","https://openalex.org/W2168708405","https://openalex.org/W2172229147","https://openalex.org/W2262092684","https://openalex.org/W2410700069"],"related_works":["https://openalex.org/W2371697453","https://openalex.org/W100359536","https://openalex.org/W2391481332","https://openalex.org/W2366476662","https://openalex.org/W2072598843","https://openalex.org/W2070536874","https://openalex.org/W7095439451","https://openalex.org/W2371221506","https://openalex.org/W2354192054","https://openalex.org/W1587223989"],"abstract_inverted_index":{"BACKGROUND:":[0],"Gemcitabine":[1],"plus":[2,7,63,82,255,259],"cisplatin":[3,8,64,83,256,260],"(GC)":[4],"and":[5,12,34,61,80,141,143,148,159,175,194,220,257],"vinorelbine":[6,73,254],"(VC)":[9],"are":[10],"active":[11],"well-tolerated":[13],"regimens":[14,38],"for":[15,42,151,264],"the":[16,32,104,115,131,152,156,163,172,178,186,201,237,248],"treatment":[17,100],"of":[18,36,99,109,117],"patients":[19,43,48,123,134,154,161],"with":[20,44],"advanced":[21],"non-small-cell":[22],"lung":[23],"cancer":[24],"(NSCLC).":[25],"We":[26],"conducted":[27],"this":[28],"study":[29],"to":[30,51],"compare":[31],"safety":[33],"efficacy":[35],"these":[37],"as":[39],"front-line":[40],"chemotherapy":[41],"NSCLC.":[45,265],"METHODS:":[46],"Eligible":[47],"were":[49,92,101,128,135,139,146,207],"randomized":[50],"receive":[52],"either":[53],"gemcitabine":[54,258],"(1000":[55],"mg/m2)":[56,66,75,85],"on":[57,67,76,86],"days":[58,77],"1,":[59,78],"8,":[60,79],"15":[62,69,81,88],"(80":[65,84],"day":[68,87],"(arm":[70,89],"GC),":[71],"or":[72],"(20":[74],"VC).":[90],"Treatments":[91],"repeated":[93],"every":[94],"28":[95],"days.":[96],"The":[97,240],"costs":[98],"retrieved":[102],"from":[103],"Health":[105],"Care":[106],"Reporting":[107],"System":[108],"Chang":[110],"Gung":[111],"Memorial":[112],"Hospital":[113],"at":[114],"time":[116],"final":[118],"data":[119],"analysis.":[120],"RESULTS:":[121],"Eighty-three":[122],"(GC,":[124],"n=39;":[125],"VC,":[126],"n=44)":[127],"enrolled":[129],"in":[130,155,162,171,177,185,232,236],"study.":[132],"Seventy-three":[133],"analyzed.":[136],"Response":[137],"rates":[138],"38%":[140],"31%":[142],"median":[144,195],"survivals":[145],"12.9":[147],"9.0":[149],"months":[150],"34":[153],"GC":[157,173,238,241],"arm":[158,174,242,250],"39":[160],"VC":[164,179,249],"arm,":[165],"respectively.":[166],"One-year":[167],"survival":[168,192,196],"was":[169,182,228],"55.9%":[170],"33.3%":[176],"arm.":[180,239],"There":[181,227],"no":[183],"difference":[184],"response":[187],"rate":[188],"(p=0.622),":[189],"progression":[190],"free":[191],"(p=0.443)":[193],"(p":[197],"=":[198],"0.4197)":[199],"between":[200],"two":[202],"arms.":[203],"Grade":[204],"3-4":[205],"toxicities":[206],"vomiting":[208],"(GC:":[209,215,222],"16.3%":[210],"vs.":[211,217,224],"VC:":[212,218,225],"36.3%),":[213],"neutropenia":[214],"14.7%":[216],"20%),":[219],"thrombocytopenia":[221,234],"8.68%":[223],"5%).":[226],"a":[229],"significant":[230],"increase":[231],"all-grade":[233],"(p=0.002)":[235],"had":[243],"higher":[244],"total":[245],"expenses":[246],"than":[247],"(p=0.020).":[251],"CONCLUSIONS:":[252],"Both":[253],"yielded":[261],"similar":[262],"efficacies":[263]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}