{"id":"https://openalex.org/W46082034","doi":null,"title":"Virulence characteristics and proinflammatory cytokine inducing potential of Candida glabrata in oral infection","display_name":"Virulence characteristics and proinflammatory cytokine inducing potential of Candida glabrata in oral infection","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W46082034","mag":"46082034"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-4842","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3351338","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100421905","display_name":"Lulu Li","orcid":"https://orcid.org/0000-0002-7790-090X","observed_orcids":["https://orcid.org/0000-0002-7790-090X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lulu Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100421905"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-glabrata","display_name":"Candida glabrata","score":1.0},{"id":"https://openalex.org/keywords/oral-candidiasis","display_name":"oral candidiasis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.8730000257492065},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9800000190734863},{"id":"https://openalex.org/keywords/oral-epithelial-cells","display_name":"oral epithelial cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.921999990940094},{"id":"https://openalex.org/keywords/il-1alpha","display_name":"IL-1\u03b1","score":0.921999990940094},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.7110000252723694},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.6679999828338623},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.753000020980835},{"id":"https://openalex.org/keywords/host-pathogen-interaction","display_name":"host-pathogen interaction","score":0.7519999742507935},{"id":"https://openalex.org/keywords/invasive-fungal-infections","display_name":"invasive fungal infections","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.8851556777954102},{"id":"https://openalex.org/C2780670043","wikidata":"https://www.wikidata.org/wiki/Q139137","display_name":"Candida glabrata","level":3,"score":0.741992712020874},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.721131443977356},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5968813896179199},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5525559782981873},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.48555752635002136},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40626972913742065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39905989170074463},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.3677464723587036},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2956434190273285},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07055634260177612},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.lib.uconn.edu:dissertations-4842","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.lib.uconn.edu/dissertations/AAI3351338","pdf_url":null,"source":{"id":"https://openalex.org/S4306401180","display_name":"OpenCommons at University of Connecticut (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"pmh:oai:opencommons.uconn.edu:dissertations-4842","doi":null,"is_oa":false,"landing_page_url":"http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3351338","pdf_url":null,"source":{"id":"https://openalex.org/S4377196438","display_name":"OpenCommons - UConn (University of Connecticut)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I140172145","host_organization_name":"University of Connecticut","host_organization_lineage":["https://openalex.org/I140172145"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral Dissertations","raw_type":"text"},{"id":"mag:46082034","doi":null,"is_oa":false,"landing_page_url":"http://digitalcommons.uconn.edu/dissertations/AAI3351338/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011504031","https://openalex.org/W2151125586","https://openalex.org/W2062651337","https://openalex.org/W1965893642","https://openalex.org/W587943292","https://openalex.org/W2076465259","https://openalex.org/W1593066164","https://openalex.org/W2265146382","https://openalex.org/W2002836545","https://openalex.org/W2154975007"],"abstract_inverted_index":{"Oral":[0],"candidiasis":[1],"is":[2,26],"a":[3,46,114,159,216,224,277],"common":[4],"opportunistic":[5],"infection":[6],"in":[7,50,96,108,117,141,176,201,207,264],"immunocompromised":[8],"individuals,":[9],"including":[10,124],"individuals":[11],"with":[12,33,57,148,212],"HIV":[13],"infections,":[14],"transplant":[15],"recipients":[16],"and":[17,126,133,144,173,195,220,228,244,252,284],"people":[18],"receiving":[19],"cancer":[20],"therapy.":[21],"Candida":[22,41,84,111],"albicans":[23,197,222],"(C.":[24],"albicans)":[25],"the":[27,37,51,66,79,118,145,202,261,281],"most":[28],"prevalent":[29],"etiologic":[30],"agent":[31,49],"associated":[32],"this":[34],"infection.":[35,100,291],"In":[36],"past":[38],"two":[39],"decades,":[40],"glabrata":[42,64,140,156,167,194,214,236,251,290],"has":[43],"emerged":[44],"as":[45,65],"notable":[47],"pathogenic":[48],"oral":[52,71,87,89,142,177,208,287],"mucosa,":[53],"frequently":[54],"being":[55],"coioslated":[56],"C.":[58,63,139,155,166,186,193,196,213,221,235,250,289],"albicans.":[59,187],"Meanwhile,":[60],"reports":[61],"of":[62,82,102,121,138,185,268,280,286],"sole":[67],"detectable":[68],"species":[69],"from":[70,240],"lesions":[72],"have":[73,198],"also":[74,190],"been":[75],"rising":[76],"steadily.":[77],"As":[78],"first":[80],"line":[81],"defense":[83,98],"encounters":[85],"during":[86],"infection,":[88,143,178],"mucosal":[90,151,288],"epithelial":[91,209],"cells":[92,107,123,152,210],"play":[93],"important":[94],"roles":[95],"host":[97,282],"against":[99],"Production":[101],"proinflammatory":[103,134,160,203],"cytokines":[104],"by":[105,147,157,246],"these":[106],"response":[109,263,283],"to":[110,154],"pathogens":[112],"plays":[113],"critical":[115],"role":[116],"early":[119],"activation":[120,267],"immuneffector":[122],"neutrophils":[125],"macrophages.":[127],"Our":[128],"studies":[129],"investigated":[130],"virulence":[131],"characteristics":[132],"cytokine":[135,161,204],"inducing":[136],"potential":[137,175],"mechanisms":[146],"local":[149],"non-immune":[150],"respond":[153],"mounting":[158],"response.":[162,230],"We":[163],"found":[164,191],"that":[165,184,192,234],"strains":[168],"demonstrated":[169,233],"variable":[170],"tissue":[171],"damaging":[172],"invasive":[174],"which":[179],"was":[180,242],"overall":[181],"lower":[182],"than":[183],"Moreover,":[188],"we":[189,232],"significant":[199],"differences":[200],"profiles":[205],"triggered":[206],"(OECs),":[211],"triggering":[215,223],"more":[217,225],"pronounced":[218,226],"GM-CSF":[219,238,262],"IL-8":[227],"IL-1\u03b1":[229],"Finally,":[231],"induced":[237,260],"release":[239],"OECs":[241,265],"adhesion-dependent":[243],"enhanced":[245],"endocytosis.":[247],"Interaction":[248],"between":[249],"cell":[253],"surface":[254],"receptor":[255],"CDw17,":[256],"but":[257],"not":[258],"TLR4,":[259],"through":[266],"nuclear":[269],"factor":[270],"kappa":[271],"B":[272],"(NF-\u03baB).":[273],"These":[274],"data":[275],"provide":[276],"better":[278],"understanding":[279],"pathogenesis":[285],"^":[292]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}