{"id":"https://openalex.org/W45953444","doi":null,"title":"Platelet interaction with a pancreatic ascites tumor.","display_name":"Platelet interaction with a pancreatic ascites tumor.","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W45953444","mag":"45953444","pmid":"https://pubmed.ncbi.nlm.nih.gov/3510553","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888121"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888121","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"J Hamilton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Hamilton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113766153","display_name":"Vadrevu Subbarao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Subbarao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096580831","display_name":"K Granack","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Granack","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064923841","display_name":"C. Ts'ao","orcid":"https://orcid.org/0009-0002-9760-0880","observed_orcids":["https://orcid.org/0009-0002-9760-0880"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Ts'ao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.00307653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"122","issue":"1","first_page":"160","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.763700008392334,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.1679999977350235,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.7250000238418579},{"id":"https://openalex.org/keywords/ascites-tumor","display_name":"ascites tumor","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8840000033378601},{"id":"https://openalex.org/keywords/tumor-cell-induced-platelet-aggregation","display_name":"tumor cell-induced platelet aggregation","score":0.7829999923706055},{"id":"https://openalex.org/keywords/thromboxane-formation","display_name":"thromboxane formation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/serotonin-release","display_name":"serotonin release","score":0.9990000128746033},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9169999957084656},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.781000018119812},{"id":"https://openalex.org/keywords/apyrase","display_name":"apyrase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/antithrombin-iii","display_name":"antithrombin III","score":0.8619999885559082},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pulmonary-thrombosis","display_name":"pulmonary thrombosis","score":0.5440000295639038},{"id":"https://openalex.org/keywords/syrian-golden-hamster-model","display_name":"Syrian golden hamster model","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.7957868576049805},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.5132160186767578},{"id":"https://openalex.org/C2779508331","wikidata":"https://www.wikidata.org/wiki/Q24770179","display_name":"Apyrase","level":3,"score":0.4482106864452362},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.4481217861175537},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43504437804222107},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.42644965648651123},{"id":"https://openalex.org/C2780496750","wikidata":"https://www.wikidata.org/wiki/Q193889","display_name":"Ascites","level":2,"score":0.41051948070526123},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38929733633995056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3775734007358551},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36463305354118347},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36419570446014404},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34384483098983765},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3317687511444092},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32500001788139343},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30063891410827637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25063973665237427}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000990","descriptor_name":"Antithrombin III","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001081","descriptor_name":"Apyrase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001201","descriptor_name":"Ascites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010976","descriptor_name":"Platelet Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1888121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:3510553","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3510553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:45953444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3510553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1888121","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1888121","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W349983629","https://openalex.org/W1506593069","https://openalex.org/W1509886516","https://openalex.org/W1510311591","https://openalex.org/W1523486026","https://openalex.org/W1528801751","https://openalex.org/W1594676787","https://openalex.org/W1597212658","https://openalex.org/W1609871462","https://openalex.org/W1680414559","https://openalex.org/W1965918539","https://openalex.org/W1974228025","https://openalex.org/W1978039741","https://openalex.org/W1980501877","https://openalex.org/W1981175218","https://openalex.org/W1981581994","https://openalex.org/W1992094249","https://openalex.org/W1995749890","https://openalex.org/W2005342636","https://openalex.org/W2009598035","https://openalex.org/W2019314531","https://openalex.org/W2020188985","https://openalex.org/W2033378396","https://openalex.org/W2059783731","https://openalex.org/W2060297306","https://openalex.org/W2072939017","https://openalex.org/W2087482644","https://openalex.org/W2107067281","https://openalex.org/W2126449642","https://openalex.org/W2154836348","https://openalex.org/W2165743209","https://openalex.org/W2219405515","https://openalex.org/W2301963978","https://openalex.org/W2317923956","https://openalex.org/W2345063416","https://openalex.org/W2400457801","https://openalex.org/W2409102071","https://openalex.org/W2416046774","https://openalex.org/W2418965113","https://openalex.org/W2419108746","https://openalex.org/W2422948437","https://openalex.org/W2473326549","https://openalex.org/W2474455801"],"related_works":["https://openalex.org/W2089553669","https://openalex.org/W3138797151","https://openalex.org/W2884475379","https://openalex.org/W2060910797","https://openalex.org/W2001075321","https://openalex.org/W2799964844","https://openalex.org/W2419545342","https://openalex.org/W1991360744","https://openalex.org/W2091758362","https://openalex.org/W1989029992"],"abstract_inverted_index":{"The":[0,11,126],"mechanism":[1,30],"leading":[2],"to":[3,170],"the":[4,15,21,24,29,35,143,156,214,254],"hypercoagulability":[5],"in":[6,32,49,70,79,116,145,155,196,199,210,230,241,253],"pancreatic":[7],"carcinoma":[8],"is":[9],"unclear.":[10],"rapid":[12],"progress":[13],"of":[14,23,38,43,84,113,158,160,188,193,222,234,256],"disease":[16],"after":[17],"its":[18],"diagnosis":[19],"and":[20,41,58,75,94,119,124,151,184,203,237,244,248],"inaccessibility":[22],"tumor":[25,48,56,72,86,92,174,224],"make":[26],"studies":[27,68],"on":[28,69,142],"difficult":[31],"man.":[33],"With":[34],"successful":[36],"induction":[37],"this":[39,66],"malignancy":[40],"conversion":[42],"it":[44],"into":[45,226],"an":[46],"ascites":[47],"Syrian":[50],"golden":[51],"hamsters,":[52],"interactions":[53,74],"between":[54],"isolated":[55,85,91,223],"cells":[57,87,93,225],"individual":[59],"hemostatic":[60,77],"components":[61],"can":[62],"be":[63,171],"investigated.":[64],"In":[65],"paper,":[67],"vitro":[71],"cell-platelet":[73],"some":[76],"changes":[78],"hamsters":[80,228],"following":[81],"intravenous":[82],"injection":[83],"are":[88],"described.":[89],"Freshly":[90],"tumor-cell":[95],"sonicates,":[96],"but":[97,213],"not":[98,129],"those":[99],"that":[100],"had":[101,139],"been":[102],"kept":[103],"at":[104],"4":[105],"or":[106,148,162,167],"-70":[107],"C":[108],"overnight,":[109],"induced":[110],"comparable":[111],"aggregation":[112,127,144,178,209],"human":[114],"platelets":[115],"both":[117,187,211],"heparinized":[118,163],"citrated":[120,161],"platelet-rich":[121],"plasmas":[122],"(hPRP":[123],"cPRP).":[125],"was":[128,179,218],"followed":[130],"by":[131,173,181,216],"clot":[132],"formation;":[133],"a":[134,231,238],"specific":[135],"synthetic":[136],"thrombin":[137],"inhibitor":[138],"no":[140],"effect":[141],"either":[146],"hPRP":[147],"cPRP.":[149],"Washed":[150],"gel-filtered":[152],"platelets,":[153],"even":[154],"presence":[157],"5%":[159],"platelet-poor":[164],"plasma":[165],"(cPPP":[166],"hPPP)":[168],"failed":[169],"aggregated":[172],"cells.":[175],"Tumor-cell-induced":[176],"platelet":[177,208,235],"accompanied":[180],"thromboxane":[182],"formation":[183],"serotonin":[185],"release,":[186],"which":[189],"were":[190,251],"several":[191],"orders":[192],"magnitude":[194],"greater":[195],"cPPP":[197],"than":[198],"hPRP.":[200],"Aspirin,":[201],"apyrase,":[202],"PGI2":[204],"all":[205],"inhibited":[206],"tumor-cell-induced":[207],"PRPs,":[212],"inhibition":[215],"aspirin":[217],"minimal.":[219],"Intravenous":[220],"infusion":[221],"normal":[227],"resulted":[229],"50%":[232],"reduction":[233],"count":[236],"20-30%":[239],"decline":[240],"antithrombin":[242],"III":[243],"fibrinogen.":[245],"Platelet":[246],"aggregates":[247],"fibrin":[249],"strands":[250],"seen":[252],"lungs":[255],"these":[257],"animals.":[258]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
