{"id":"https://openalex.org/W45841934","doi":null,"title":"COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise.","display_name":"COMT inhibition by high-dose entacapone does not affect hemodynamics but changes catecholamine metabolism in healthy volunteers at rest and during exercise.","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W45841934","mag":"45841934","pmid":"https://pubmed.ncbi.nlm.nih.gov/7874370"},"language":"en","primary_location":{"id":"pmid:7874370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7874370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology and therapeutics","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030190508","display_name":"Ari Illi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A Illi","raw_affiliation_strings":["Orion-Farmos Pharmaceuticals, Orion Research Center, Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orion-Farmos Pharmaceuticals, Orion Research Center, Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110178940","display_name":"S. Sundberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Sundberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048775639","display_name":"Markku Koulu","orcid":"https://orcid.org/0000-0001-5579-7705","observed_orcids":["https://orcid.org/0000-0001-5579-7705"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Koulu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078460231","display_name":"Mika Scheinin","orcid":"https://orcid.org/0000-0001-7579-9126","observed_orcids":["https://orcid.org/0000-0001-7579-9126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Scheinin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018056733","display_name":"Sirpa H. Hein\u00e4vaara","orcid":"https://orcid.org/0000-0002-8308-9922","observed_orcids":["https://orcid.org/0000-0002-8308-9922"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Hein\u00e4vaara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110300227","display_name":"A. Gordin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Gordin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7737,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.82378976,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"32","issue":"11","first_page":"582","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entacapone","display_name":"entacapone","score":0.9779999852180481},{"id":"https://openalex.org/keywords/catechol-o-methyltransferase-inhibition","display_name":"catechol-O-methyltransferase inhibition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/catecholamine-metabolism","display_name":"catecholamine metabolism","score":0.9800000190734863},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"hemodynamics","score":0.8769999742507935},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.703000009059906},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.7919999957084656},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":1.0},{"id":"https://openalex.org/keywords/dhpg","display_name":"DHPG","score":0.8240000009536743},{"id":"https://openalex.org/keywords/mhpg","display_name":"MHPG","score":0.9259999990463257},{"id":"https://openalex.org/keywords/dopac","display_name":"DOPAC","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dose-dependence","display_name":"dose dependence","score":0.5090000033378601},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2776976799","wikidata":"https://www.wikidata.org/wiki/Q416444","display_name":"Entacapone","level":5,"score":0.9464983344078064},{"id":"https://openalex.org/C185361966","wikidata":"https://www.wikidata.org/wiki/Q94291140","display_name":"Catechol-O-methyl transferase","level":4,"score":0.8181979656219482},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7074699997901917},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6516192555427551},{"id":"https://openalex.org/C2775894120","wikidata":"https://www.wikidata.org/wiki/Q271663","display_name":"Catecholamine","level":2,"score":0.6178522706031799},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5824465155601501},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5652092099189758},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5286493897438049},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.49503153562545776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4493072032928467},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.421034038066864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3609920144081116},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.2525080442428589},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.23072049021720886},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.13840115070343018},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005080","descriptor_name":"Exercise Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D008734","descriptor_name":"Methoxyhydroxyphenylglycol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015102","descriptor_name":"3,4-Dihydroxyphenylacetic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D065098","descriptor_name":"Catechol O-Methyltransferase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7874370","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7874370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of clinical pharmacology and therapeutics","raw_type":"Journal Article"},{"id":"mag:45841934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7874370","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1996187369","https://openalex.org/W2037266889","https://openalex.org/W2123924169","https://openalex.org/W2116757809","https://openalex.org/W2049128517","https://openalex.org/W1993119435","https://openalex.org/W2053943188","https://openalex.org/W2075857365","https://openalex.org/W2057232876","https://openalex.org/W2154883983"],"abstract_inverted_index":{"We":[0],"studied":[1],"the":[2,43,51,69,145,174,180,192,197],"effects":[3],"of":[4,33,64,91,114,127,132,200,214],"catechol-O-methyltransferase":[5],"(COMT)":[6],"inhibition":[7,203],"with":[8,68,173,179,191,196],"entacapone":[9,205],"on":[10,42,50,76],"hemodynamics":[11,210],"and":[12,20,49,80,85,98,111,117,124,156,168,217],"catecholamine":[13],"metabolism":[14],"in":[15,102,166,186,219],"healthy":[16,39,220],"volunteers":[17,221],"at":[18,223],"rest":[19,224],"during":[21,30,226],"a":[22,61,77],"bicycle":[23,78],"exercise":[24,58],"test.":[25],"Entacapone":[26],"was":[27,74,170,188],"given":[28],"orally":[29],"two":[31],"periods":[32],"seven":[34],"days":[35],"each":[36],"to":[37,144,208],"eleven":[38],"male":[40],"volunteers;":[41],"first":[44],"period":[45],"400":[46,181],"mg":[47,54,176,182],"t.i.d.":[48,55],"second":[52],"800":[53,175],"A":[56],"submaximal":[57],"test":[59],"giving":[60],"heart":[62,83,108],"rate":[63,84],"about":[65],"163-167":[66],"beats/min":[67],"highest":[70],"predetermined":[71],"work":[72],"load":[73],"performed":[75],"ergometer,":[79],"blood":[81],"pressure,":[82,107],"ECG":[86],"were":[87,104,119],"recorded.":[88],"The":[89,129,164,184],"concentrations":[90,113,131,213],"adrenaline,":[92],"noradrenaline,":[93],"3,4-dihydroxyphenylglycol":[94],"(DHPG),":[95],"3-methoxy-4-hydroxyphenylglycol":[96],"(MHPG)":[97],"3,4-dihydroxyphenylacetic":[99],"acid":[100],"(DOPAC)":[101],"plasma":[103,112,130,212],"determined.":[105],"Blood":[106],"rate,":[109],"ECG,":[110],"unconjugated":[115,215],"adrenaline":[116,216],"noradrenaline":[118,218],"not":[120,207],"influenced":[121],"after":[122],"single":[123,198],"repeated":[125,193],"dosing":[126,194],"entacapone.":[128,201],"DHPG":[133,167],"(a":[134,149,158],"monoamine":[135],"oxidase":[136],"(MAO)-dependent":[137],"metabolite)":[138,151,160],"increased":[139,152],"maximally":[140,153],"by":[141,154,162,204],"245%":[142],"compared":[143],"control":[146],"day.":[147],"DOPAC":[148,169],"MAO-dependent":[150],"144%":[155],"MHPG":[157,187],"COMT-dependent":[159],"decreased":[161],"54%.":[163],"increase":[165],"significantly":[171,189],"greater":[172,190],"dose":[177,199],"than":[178,195],"dose.":[183],"decrease":[185],"COMT":[202],"seems":[206],"affect":[209],"or":[211,225],"either":[222],"exercise.(ABSTRACT":[227],"TRUNCATED":[228],"AT":[229],"250":[230],"WORDS)":[231]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}