{"id":"https://openalex.org/W4579962","doi":null,"title":"Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain.","display_name":"Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain.","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W4579962","mag":"4579962","pmid":"https://pubmed.ncbi.nlm.nih.gov/19405385"},"language":"en","primary_location":{"id":"pmid:19405385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19405385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051419822","display_name":"Anurag Kuhad","orcid":"https://orcid.org/0000-0002-8312-453X","observed_orcids":["https://orcid.org/0000-0002-8312-453X"]},"institutions":[{"id":"https://openalex.org/I51452335","display_name":"Panjab University","ror":"https://ror.org/04p2sbk06","country_code":"IN","type":"education","lineage":["https://openalex.org/I51452335"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Anurag Kuhad","raw_affiliation_strings":["Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University, Chandigarh 160 014, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University, Chandigarh 160 014, India","institution_ids":["https://openalex.org/I51452335"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041030221","display_name":"Mahendra Bishnoi","orcid":"https://orcid.org/0000-0002-7785-1204","observed_orcids":["https://orcid.org/0000-0002-7785-1204","https://orcid.org/0000-0001-7894-0770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahendra Bishnoi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034354976","display_name":"Kanwaljit Chopra","orcid":"https://orcid.org/0000-0001-5898-6093","observed_orcids":["https://orcid.org/0000-0001-5898-6093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kanwaljit Chopra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5321,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.8019217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"3","first_page":"193","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/duloxetine","display_name":"duloxetine","score":1.0},{"id":"https://openalex.org/keywords/painful-diabetic-neuropathy","display_name":"diabetic neuropathic pain","score":0.996999979019165},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.7860000133514404},{"id":"https://openalex.org/keywords/antinociceptive-effect","display_name":"antinociceptive effect","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":0.9319999814033508},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9319999814033508},{"id":"https://openalex.org/keywords/serotonin-norepinephrine-reuptake-inhibitors","display_name":"serotonin-norepinephrine reuptake inhibitors","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tail-immersion-test","display_name":"tail immersion test","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hot-plate-test","display_name":"hot plate test","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C2776992512","wikidata":"https://www.wikidata.org/wiki/Q28208900","display_name":"Adenosinergic","level":5,"score":0.9072521328926086},{"id":"https://openalex.org/C2780764818","wikidata":"https://www.wikidata.org/wiki/Q411932","display_name":"Duloxetine","level":3,"score":0.8575706481933594},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.726887583732605},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.6906625628471375},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.6294970512390137},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.572849690914154},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.512505292892456},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.49588117003440857},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4442847967147827},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43019410967826843},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.41048094630241394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37327906489372253},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3435978889465332},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34339937567710876},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.1873280107975006},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0677146315574646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068736","descriptor_name":"Duloxetine Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003929","descriptor_name":"Diabetic Neuropathies","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014110","descriptor_name":"Touch","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19405385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19405385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Indian journal of experimental biology","raw_type":"Journal Article"},{"id":"mag:4579962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19405385","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W51209413","https://openalex.org/W183276954","https://openalex.org/W1964841015","https://openalex.org/W1968267261","https://openalex.org/W1969040411","https://openalex.org/W1971393265","https://openalex.org/W1972030215","https://openalex.org/W1974536178","https://openalex.org/W1976374962","https://openalex.org/W1977927738","https://openalex.org/W1979388123","https://openalex.org/W1980791335","https://openalex.org/W1982089669","https://openalex.org/W1982721912","https://openalex.org/W1983072558","https://openalex.org/W1985551569","https://openalex.org/W1985888130","https://openalex.org/W1991377510","https://openalex.org/W1992634966","https://openalex.org/W1998943140","https://openalex.org/W1999086038","https://openalex.org/W2003363634","https://openalex.org/W2003491115","https://openalex.org/W2005673706","https://openalex.org/W2008894562","https://openalex.org/W2009911564","https://openalex.org/W2013295182","https://openalex.org/W2019821346","https://openalex.org/W2023322050","https://openalex.org/W2040873958","https://openalex.org/W2043993899","https://openalex.org/W2047384901","https://openalex.org/W2049363076","https://openalex.org/W2055565104","https://openalex.org/W2057668259","https://openalex.org/W2063664232","https://openalex.org/W2064972930","https://openalex.org/W2065611281","https://openalex.org/W2077939735","https://openalex.org/W2083195852","https://openalex.org/W2089801654","https://openalex.org/W2091857463","https://openalex.org/W2091906768","https://openalex.org/W2104685744","https://openalex.org/W2106059433","https://openalex.org/W2123118134","https://openalex.org/W2138969187","https://openalex.org/W2170584263","https://openalex.org/W2320542551","https://openalex.org/W2327278150","https://openalex.org/W2330101839","https://openalex.org/W2413260525"],"related_works":["https://openalex.org/W2128917484","https://openalex.org/W1977914448","https://openalex.org/W2419236553","https://openalex.org/W2966977288","https://openalex.org/W2619464124","https://openalex.org/W2886356516","https://openalex.org/W1882623085","https://openalex.org/W2006983951","https://openalex.org/W3031006767","https://openalex.org/W2026655531"],"abstract_inverted_index":{"The":[0,113],"involvement":[1,117],"of":[2,9,25,31,34,79,111,118],"adenosinergic":[3,119],"pathway":[4,120],"in":[5,18,42,94,121,125],"the":[6,43,116],"anti-nociceptive":[7,92],"effect":[8,93],"duloxetine,":[10],"a":[11],"balanced":[12],"5-HT/NE":[13],"reuptake":[14],"inhibitor,":[15],"was":[16],"evaluated":[17],"streptozotocin":[19,35],"induced":[20],"diabetic":[21,88,126],"male":[22],"albino":[23],"mice":[24,39,61,89],"Laca":[26],"strain.":[27],"After":[28],"four":[29],"weeks":[30],"single":[32],"injection":[33],"(200":[36],"mg/kg,":[37,85],"ip),":[38],"were":[40,52,102],"tested":[41],"tail":[44],"immersion":[45],"and":[46,73,83,97,105],"hot-plate":[47,98],"assays.":[48,99],"Cerebral":[49],"adenosine":[50,76],"levels":[51,101],"measured":[53],"by":[54,108],"high-performance":[55],"liquid":[56],"chromatography":[57],"(HPLC/PDA":[58],"detector).":[59],"Diabetic":[60],"exhibited":[62],"significant":[63],"hyperalgesia":[64],"along":[65],"with":[66],"increased":[67,107],"plasma":[68],"glucose,":[69],"decreased":[70],"body":[71],"weights":[72],"reduced":[74],"cerebral":[75],"levels.":[77],"Administration":[78],"duloxetine":[80,122],"(5,":[81],"10":[82],"20":[84],"ip)":[86],"to":[87],"produced":[90],"dose-dependent":[91],"both":[95],"tail-immersion":[96],"Adenosine":[100],"also":[103],"significantly":[104],"dose-dependently":[106],"different":[109],"doses":[110],"duloxetine.":[112],"results":[114],"demonstrated":[115],"mediated":[123],"anti-hyperalgesia":[124],"neuropathic":[127],"pain.":[128]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}