{"id":"https://openalex.org/W45764738","doi":null,"title":"INVESTIGATING THE ROLES OF REACTIVE OXYGEN AND NITROGEN SPECIES IN PLANT PROGRAMMED CELL DEATH, CYTOSKELETAL AND MITOCHONDRIAL DYNAMICS","display_name":"INVESTIGATING THE ROLES OF REACTIVE OXYGEN AND NITROGEN SPECIES IN PLANT PROGRAMMED CELL DEATH, CYTOSKELETAL AND MITOCHONDRIAL DYNAMICS","publication_year":2012,"publication_date":"2012-09-01","ids":{"openalex":"https://openalex.org/W45764738","mag":"45764738"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/ETD-2012-09-783","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/ETD-2012-09-783","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068950752","display_name":"Dushantha Sanjaya Ekanayake","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Dushantha Sanjaya Ekanayake","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5068950752"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.39399999380111694,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.025800000876188278,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.8579999804496765},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9399999976158142},{"id":"https://openalex.org/keywords/reactive-nitrogen-species","display_name":"reactive nitrogen species","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9020000100135803},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mitochondrial-clustering","display_name":"mitochondrial clustering","score":0.7260000109672546},{"id":"https://openalex.org/keywords/mitochondrial-motility","display_name":"mitochondrial motility","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.718999981880188},{"id":"https://openalex.org/keywords/actin","display_name":"actin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heat-shock","display_name":"heat shock","score":0.7770000100135803},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8610000014305115},{"id":"https://openalex.org/keywords/microtubule-associated-protein-4","display_name":"MAP4","score":0.6060000061988831},{"id":"https://openalex.org/keywords/talin","display_name":"talin","score":0.6660000085830688},{"id":"https://openalex.org/keywords/mitochondrial-morphology","display_name":"mitochondrial morphology","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6197333335876465},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5689411759376526},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5544841289520264},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5519718527793884},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5197672247886658},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.4845925569534302},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4169832766056061},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3756154477596283},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3572523593902588},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3423222303390503},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.31434524059295654},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26083236932754517},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/ETD-2012-09-783","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/ETD-2012-09-783","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/ETD-2012-09-783","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/ETD-2012-09-783","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:45764738","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/handle/10388/ETD-2012-09-783","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W101797952","https://openalex.org/W1489667076","https://openalex.org/W1492772967","https://openalex.org/W1493752155","https://openalex.org/W1499084166","https://openalex.org/W1504875581","https://openalex.org/W1567942385","https://openalex.org/W1574199015","https://openalex.org/W1591187753","https://openalex.org/W1594509035","https://openalex.org/W1753625049","https://openalex.org/W1936849162","https://openalex.org/W1957893438","https://openalex.org/W1964483580","https://openalex.org/W1966493111","https://openalex.org/W1966539065","https://openalex.org/W1973357972","https://openalex.org/W1976348423","https://openalex.org/W1976676780","https://openalex.org/W1981564867","https://openalex.org/W1981592463","https://openalex.org/W1982269427","https://openalex.org/W1983250864","https://openalex.org/W1983569416","https://openalex.org/W1984100427","https://openalex.org/W1984732209","https://openalex.org/W1985158993","https://openalex.org/W1988448864","https://openalex.org/W1989675697","https://openalex.org/W1989895500","https://openalex.org/W1991251241","https://openalex.org/W1995384886","https://openalex.org/W1998461840","https://openalex.org/W2004689990","https://openalex.org/W2010209292","https://openalex.org/W2011272696","https://openalex.org/W2013495163","https://openalex.org/W2015360357","https://openalex.org/W2015596353","https://openalex.org/W2024350775","https://openalex.org/W2024898335","https://openalex.org/W2028140975","https://openalex.org/W2028377541","https://openalex.org/W2028688156","https://openalex.org/W2029677502","https://openalex.org/W2030482324","https://openalex.org/W2031265159","https://openalex.org/W2031529753","https://openalex.org/W2031726991","https://openalex.org/W2032240407","https://openalex.org/W2033062319","https://openalex.org/W2034613026","https://openalex.org/W2038942260","https://openalex.org/W2039276913","https://openalex.org/W2040151760","https://openalex.org/W2043610562","https://openalex.org/W2046593879","https://openalex.org/W2046785803","https://openalex.org/W2047704490","https://openalex.org/W2048811075","https://openalex.org/W2049930483","https://openalex.org/W2050195517","https://openalex.org/W2050974084","https://openalex.org/W2051809332","https://openalex.org/W2052853635","https://openalex.org/W2055079019","https://openalex.org/W2057193930","https://openalex.org/W2058498996","https://openalex.org/W2060811345","https://openalex.org/W2062063518","https://openalex.org/W2062807784","https://openalex.org/W2063400445","https://openalex.org/W2065502699","https://openalex.org/W2065854375","https://openalex.org/W2072087702","https://openalex.org/W2072606349","https://openalex.org/W2072616898","https://openalex.org/W2074611001","https://openalex.org/W2077681275","https://openalex.org/W2079552583","https://openalex.org/W2082291161","https://openalex.org/W2085269345","https://openalex.org/W2086328360","https://openalex.org/W2087059798","https://openalex.org/W2089968862","https://openalex.org/W2091956705","https://openalex.org/W2093624570","https://openalex.org/W2093633953","https://openalex.org/W2094315949","https://openalex.org/W2096144383","https://openalex.org/W2096578215","https://openalex.org/W2099547318","https://openalex.org/W2102148704","https://openalex.org/W2105061879","https://openalex.org/W2109324504","https://openalex.org/W2109335417","https://openalex.org/W2110175799","https://openalex.org/W2110476295","https://openalex.org/W2110538281","https://openalex.org/W2110957398","https://openalex.org/W2111721032","https://openalex.org/W2114045225","https://openalex.org/W2116122104","https://openalex.org/W2118125354","https://openalex.org/W2118234380","https://openalex.org/W2121133562","https://openalex.org/W2121529113","https://openalex.org/W2121664578","https://openalex.org/W2123964098","https://openalex.org/W2124072937","https://openalex.org/W2124534459","https://openalex.org/W2126149189","https://openalex.org/W2128043021","https://openalex.org/W2128293952","https://openalex.org/W2129899796","https://openalex.org/W2129909898","https://openalex.org/W2130454895","https://openalex.org/W2131461587","https://openalex.org/W2132417094","https://openalex.org/W2133153530","https://openalex.org/W2134152363","https://openalex.org/W2134733352","https://openalex.org/W2135853075","https://openalex.org/W2136063185","https://openalex.org/W2136091231","https://openalex.org/W2140528190","https://openalex.org/W2141273467","https://openalex.org/W2143705375","https://openalex.org/W2144059282","https://openalex.org/W2144634347","https://openalex.org/W2144927380","https://openalex.org/W2145423370","https://openalex.org/W2145749956","https://openalex.org/W2146073666","https://openalex.org/W2146178850","https://openalex.org/W2147077654","https://openalex.org/W2147551208","https://openalex.org/W2150402884","https://openalex.org/W2151387311","https://openalex.org/W2151501496","https://openalex.org/W2152275638","https://openalex.org/W2154465669","https://openalex.org/W2155427225","https://openalex.org/W2157659065","https://openalex.org/W2161291398","https://openalex.org/W2162109410","https://openalex.org/W2162565336","https://openalex.org/W2163389258","https://openalex.org/W2163509416","https://openalex.org/W2163893998","https://openalex.org/W2166761952","https://openalex.org/W2167202847","https://openalex.org/W2168043381","https://openalex.org/W2168331596","https://openalex.org/W2168989251","https://openalex.org/W2169065964","https://openalex.org/W2171139225","https://openalex.org/W2181281149","https://openalex.org/W2242905599","https://openalex.org/W4245880706"],"related_works":["https://openalex.org/W7133006946","https://openalex.org/W4393060829","https://openalex.org/W2019025528","https://openalex.org/W1562357745","https://openalex.org/W2112382635","https://openalex.org/W1996550196","https://openalex.org/W2151539050","https://openalex.org/W2094273704","https://openalex.org/W7197131013","https://openalex.org/W2067489969"],"abstract_inverted_index":{"Mitochondria":[0],"are":[1,21],"usually":[2],"considered":[3],"simply":[4],"as":[5,72],"the":[6,9,76,116,144,148,159,210,231],"\u201cpowerhouses":[7],"of":[8,23,78,87,91,118,162,200,212,277],"cell\u201d,":[10],"however":[11],"in":[12,26,67,75,165],"recent":[13],"years":[14],"it":[15],"has":[16],"become":[17],"apparent":[18],"that":[19,158],"mitochondria":[20,88,122,141,260],"also":[22],"fundamental":[24],"importance":[25],"programmed":[27],"cell":[28,34],"death":[29,35],"(PCD),":[30],"which":[31,70,108],"refers":[32],"to":[33,58,114,136,142,172,209,227,272],"resulting":[36],"from":[37],"a":[38,85,196,236,266],"controlled,":[39],"genetically":[40],"defined":[41],"pathway.":[42],"In":[43,81,93],"Arabidopsis,":[44],"PCD":[45,83],"induced":[46],"by":[47],"either":[48,201],"heat":[49,197,238,268],"shock":[50],"or":[51,181,194,203,240,247],"treatment":[52,239],"with":[53,61,193,252,259,275],"strong":[54],"oxidants":[55],"is":[56,169],"found":[57,164],"be":[59,228,273],"correlated":[60],"an":[62,73],"early":[63],"and":[64,89,106,153,189,221],"irreversible":[65],"change":[66,183],"mitochondrial":[68,149,179,213],"morphology":[69,150,180,220],"manifests":[71],"increase":[74],"size":[77],"individual":[79],"mitochondria.":[80,281],"addition,":[82],"causes":[84],"clustering":[86,152],"loss":[90],"motility.":[92],"this":[94],"study,":[95],"I":[96],"have":[97,109],"used":[98,135],"two":[99],"arginase":[100,166,186],"negative":[101,167,187],"mutant":[102],"Arabidopsis":[103,128],"lines":[104,129],"(argah1-1":[105],"argah2-1)":[107],"elevated":[110,160],"cellular":[111],"NO":[112,163],"concentrations":[113],"examine":[115,143],"effect":[117],"nitrosative":[119],"stress":[120],"on":[121],"undergoing":[123],"PCD.":[124,174],"Another":[125],"three":[126],"different":[127,218],"(mito-GFP/mTalin-mCherry,":[130],"mito-GFP/MAP4-mCherry,":[131],"mito-":[132],"mCherry/EB1b-GFP)":[133],"were":[134,225],"visualize":[137],"cytoskeletal":[138,206,241],"elements":[139,207],"alongside":[140],"mechanisms":[145],"responsible":[146],"for":[147],"transition,":[151],"motility":[154],"inhibition.":[155],"Results":[156],"indicate":[157],"concentration":[161],"mutants":[168,188],"not":[170,255],"sufficient":[171],"induce":[173],"There":[175],"was":[176],"no":[177],"significant":[178],"dynamic":[182],"detected":[184],"between":[185],"wild":[190],"type":[191],"plants,":[192],"without":[195],"shock.":[198],"Disruption":[199],"actin":[202,233],"microtubule":[204],"(MT)":[205],"leads":[208],"formation":[211],"clusters,":[214],"although":[215],"they":[216],"showed":[217],"cluster":[219],"sizes.":[222],"Mitochondrial":[223],"clusters":[224,276],"observed":[226],"moving":[229],"along":[230],"remaining":[232],"cables":[234],"after":[235,265],"mild":[237,267],"depolymerizing":[242],"drug":[243],"treatment.":[244],"Intact":[245],"microtubules":[246],"MT":[248],"plus":[249],"ends":[250],"visualized":[251],"EB1b":[253,270],"did":[254],"show":[256],"any":[257],"interaction":[258],"under":[261],"normal":[262],"conditions.":[263],"However,":[264],"stress,":[269],"appeared":[271],"associated":[274],"enlarged,":[278],"possibly":[279],"swollen":[280]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
