{"id":"https://openalex.org/W45698776","doi":"https://doi.org/10.1007/10_012","title":"Tissue Assembly Guided via Substrate Biophysics: Applications to Hepatocellular Engineering","display_name":"Tissue Assembly Guided via Substrate Biophysics: Applications to Hepatocellular Engineering","publication_year":2006,"publication_date":"2006-07-17","ids":{"openalex":"https://openalex.org/W45698776","doi":"https://doi.org/10.1007/10_012","mag":"45698776","pmid":"https://pubmed.ncbi.nlm.nih.gov/17089785"},"language":"en","primary_location":{"id":"doi:10.1007/10_012","doi":"https://doi.org/10.1007/10_012","is_oa":false,"landing_page_url":"https://doi.org/10.1007/10_012","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biochemical Engineering/Biotechnology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2489151530","display_name":"Tissue Engineering I"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071568391","display_name":"Eric J. Semler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric J. Semler","raw_affiliation_strings":["Department of Biomedical Engineering, C230 Engineering, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, C230 Engineering, Piscataway, NJ 08854, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074400108","display_name":"Colette S. Ranucci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colette S. Ranucci","raw_affiliation_strings":["Department of Biomedical Engineering, Department of Chemical and Biochemical Engineering, C230 Engineering, 98 Brett Road, 08854, Piscataway, NJ, USA","C230 Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Chemical and Biochemical Engineering, C230 Engineering, 98 Brett Road, 08854, Piscataway, NJ, USA","institution_ids":[]},{"raw_affiliation_string":"C230 Engineering","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004498168","display_name":"Prabhas V. Moghe","orcid":"https://orcid.org/0000-0002-2091-5879","observed_orcids":["https://orcid.org/0000-0002-2091-5879"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Prabhas V. Moghe","raw_affiliation_strings":["Department of Biomedical Engineering, Department of Chemical and Biochemical Engineering, C230 Engineering, 98 Brett Road, 08854, Piscataway, NJ, USA","C230 Engineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Department of Chemical and Biochemical Engineering, C230 Engineering, 98 Brett Road, 08854, Piscataway, NJ, USA","institution_ids":[]},{"raw_affiliation_string":"C230 Engineering","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5004498168"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0035,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.85386221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"102","issue":null,"first_page":"1","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microtopography","display_name":"microtopography","score":0.7570000290870667},{"id":"https://openalex.org/keywords/collagen-sponge","display_name":"collagen sponge","score":0.8180000185966492},{"id":"https://openalex.org/keywords/polyacrylamide-hydrogel","display_name":"polyacrylamide hydrogel","score":0.8180000185966492},{"id":"https://openalex.org/keywords/matrigel","display_name":"Matrigel","score":0.8970000147819519},{"id":"https://openalex.org/keywords/extracellular-matrix-ligands","display_name":"extracellular matrix ligands","score":0.9589999914169312},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/liver-tissue-engineering","display_name":"liver tissue engineering","score":0.6169999837875366},{"id":"https://openalex.org/keywords/hepatocyte-function","display_name":"hepatocyte function","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.7857964634895325},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6276405453681946},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5271872282028198},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49639493227005005},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48048654198646545},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.46044668555259705},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.41296496987342834},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.36877167224884033},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35133761167526245},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.31221580505371094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27795833349227905},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2013338804244995},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/10_012","doi":"https://doi.org/10.1007/10_012","is_oa":false,"landing_page_url":"https://doi.org/10.1007/10_012","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Biochemical Engineering/Biotechnology","raw_type":"book-chapter"},{"id":"pmid:17089785","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17089785","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in biochemical engineering/biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5682547118","display_name":null,"funder_award_id":"EB000922-01","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":142,"referenced_works":["https://openalex.org/W34603191","https://openalex.org/W114135718","https://openalex.org/W1506658790","https://openalex.org/W1532411911","https://openalex.org/W1590619267","https://openalex.org/W1599356788","https://openalex.org/W1741084120","https://openalex.org/W1793177151","https://openalex.org/W1823654700","https://openalex.org/W1828476211","https://openalex.org/W1848082114","https://openalex.org/W1963756782","https://openalex.org/W1965275473","https://openalex.org/W1966497862","https://openalex.org/W1966811216","https://openalex.org/W1966968023","https://openalex.org/W1967009678","https://openalex.org/W1967913300","https://openalex.org/W1970023965","https://openalex.org/W1970287764","https://openalex.org/W1973089587","https://openalex.org/W1973366984","https://openalex.org/W1974394774","https://openalex.org/W1978983902","https://openalex.org/W1981743437","https://openalex.org/W1982096846","https://openalex.org/W1983352401","https://openalex.org/W1984669542","https://openalex.org/W1984699863","https://openalex.org/W1987134604","https://openalex.org/W1988300335","https://openalex.org/W1989167460","https://openalex.org/W1991112627","https://openalex.org/W1991442156","https://openalex.org/W1994873648","https://openalex.org/W1996389318","https://openalex.org/W1996897120","https://openalex.org/W1998803274","https://openalex.org/W2001645404","https://openalex.org/W2002450293","https://openalex.org/W2002556401","https://openalex.org/W2002807987","https://openalex.org/W2002930440","https://openalex.org/W2004897088","https://openalex.org/W2005226698","https://openalex.org/W2006482556","https://openalex.org/W2007660627","https://openalex.org/W2011751395","https://openalex.org/W2014185746","https://openalex.org/W2016285779","https://openalex.org/W2018480531","https://openalex.org/W2020046757","https://openalex.org/W2024906662","https://openalex.org/W2032127900","https://openalex.org/W2033044524","https://openalex.org/W2035760808","https://openalex.org/W2036827054","https://openalex.org/W2042776401","https://openalex.org/W2044021612","https://openalex.org/W2044568866","https://openalex.org/W2044616210","https://openalex.org/W2045174311","https://openalex.org/W2045374273","https://openalex.org/W2045856687","https://openalex.org/W2046620120","https://openalex.org/W2049734815","https://openalex.org/W2053174043","https://openalex.org/W2053473026","https://openalex.org/W2054635074","https://openalex.org/W2054862070","https://openalex.org/W2060020347","https://openalex.org/W2062652813","https://openalex.org/W2066772900","https://openalex.org/W2066922721","https://openalex.org/W2068430831","https://openalex.org/W2069697346","https://openalex.org/W2069703095","https://openalex.org/W2070190764","https://openalex.org/W2073707351","https://openalex.org/W2073884194","https://openalex.org/W2075261230","https://openalex.org/W2075898657","https://openalex.org/W2076671288","https://openalex.org/W2078655701","https://openalex.org/W2080789667","https://openalex.org/W2080934112","https://openalex.org/W2083418601","https://openalex.org/W2083433352","https://openalex.org/W2083638734","https://openalex.org/W2084951950","https://openalex.org/W2089884825","https://openalex.org/W2095301611","https://openalex.org/W2095690799","https://openalex.org/W2095701698","https://openalex.org/W2099161432","https://openalex.org/W2100884860","https://openalex.org/W2102978118","https://openalex.org/W2106085107","https://openalex.org/W2106381135","https://openalex.org/W2107334681","https://openalex.org/W2111702538","https://openalex.org/W2118161860","https://openalex.org/W2122387882","https://openalex.org/W2124094737","https://openalex.org/W2125240138","https://openalex.org/W2125644189","https://openalex.org/W2126087366","https://openalex.org/W2128884401","https://openalex.org/W2131943772","https://openalex.org/W2133049684","https://openalex.org/W2133977582","https://openalex.org/W2137390239","https://openalex.org/W2138263724","https://openalex.org/W2139818522","https://openalex.org/W2141075109","https://openalex.org/W2145640288","https://openalex.org/W2147904584","https://openalex.org/W2152032405","https://openalex.org/W2153055548","https://openalex.org/W2153287457","https://openalex.org/W2156289700","https://openalex.org/W2157859754","https://openalex.org/W2158200659","https://openalex.org/W2161054601","https://openalex.org/W2165884738","https://openalex.org/W2169341285","https://openalex.org/W2176690355","https://openalex.org/W2408856290","https://openalex.org/W2410781457","https://openalex.org/W2411776026","https://openalex.org/W2412773030","https://openalex.org/W2415242393","https://openalex.org/W2415917762","https://openalex.org/W2495407479","https://openalex.org/W2773104848","https://openalex.org/W3023818458","https://openalex.org/W4211173486","https://openalex.org/W4212810156","https://openalex.org/W4233068027","https://openalex.org/W4236779796","https://openalex.org/W4254286992","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2095690799","https://openalex.org/W1965275473","https://openalex.org/W2044021612","https://openalex.org/W1981743437","https://openalex.org/W2793433491","https://openalex.org/W2100884860","https://openalex.org/W2124094737","https://openalex.org/W2941227476","https://openalex.org/W2317232334","https://openalex.org/W7033463969"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}