{"id":"https://openalex.org/W45629004","doi":null,"title":"Prospective evaluation of leptin and neuropeptide Y (NPY) serum levels in girls with anorexia nervosa.","display_name":"Prospective evaluation of leptin and neuropeptide Y (NPY) serum levels in girls with anorexia nervosa.","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W45629004","mag":"45629004","pmid":"https://pubmed.ncbi.nlm.nih.gov/16136022"},"language":"en","primary_location":{"id":"pmid:16136022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16136022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042124192","display_name":"Joanna M. O\u015bwi\u0119cimska","orcid":"https://orcid.org/0000-0003-3151-0487","observed_orcids":["https://orcid.org/0000-0003-3151-0487"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Joanna O\u015bwiecimska","raw_affiliation_strings":["Department of Paediatrics, Children's Nephrology and Endocrinology, Silesian Medical University, Zabrze, Poland. endo_dz_zabrze@wp.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, Children's Nephrology and Endocrinology, Silesian Medical University, Zabrze, Poland. endo_dz_zabrze@wp.pl","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001474605","display_name":"Katarzyna T Ziora","orcid":"https://orcid.org/0000-0002-6977-6021","observed_orcids":["https://orcid.org/0000-0002-6977-6021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Ziora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015964630","display_name":"Gabriela Geisler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriela Geisler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5060130094","display_name":"Katarzyna Broll-Wa\u015bka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Broll-Wa\u015bka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.7763,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.91671068,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"26","issue":"4","first_page":"301","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.053300000727176666,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":1.0},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":1.0},{"id":"https://openalex.org/keywords/neuropeptides","display_name":"neuropeptides","score":0.7369999885559082},{"id":"https://openalex.org/keywords/amenorrhea","display_name":"amenorrhea","score":0.7440000176429749},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.5879999995231628},{"id":"https://openalex.org/keywords/appetite-regulation","display_name":"appetite regulation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/weight-management","display_name":"weight management","score":0.6439999938011169},{"id":"https://openalex.org/keywords/high-calorie-diet","display_name":"hypercaloric diet","score":0.7139999866485596},{"id":"https://openalex.org/keywords/girls","display_name":"girls","score":0.492000013589859},{"id":"https://openalex.org/keywords/endocrine-disorders","display_name":"endocrine disorders","score":0.46000000834465027},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.9262493848800659},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.877321183681488},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8580360412597656},{"id":"https://openalex.org/C93984277","wikidata":"https://www.wikidata.org/wiki/Q24782073","display_name":"Neuropeptide Y receptor","level":4,"score":0.8392856121063232},{"id":"https://openalex.org/C75908981","wikidata":"https://www.wikidata.org/wiki/Q28578","display_name":"Appetite","level":2,"score":0.6362716555595398},{"id":"https://openalex.org/C2777031586","wikidata":"https://www.wikidata.org/wiki/Q131749","display_name":"Anorexia nervosa","level":3,"score":0.6019167304039001},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5819846391677856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5489625334739685},{"id":"https://openalex.org/C2778654693","wikidata":"https://www.wikidata.org/wiki/Q254327","display_name":"Anorexia","level":2,"score":0.45142853260040283},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.4357254207134247},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.3472995162010193},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.25326985120773315},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.088917076587677},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08262810111045837},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000568","descriptor_name":"Amenorrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000856","descriptor_name":"Anorexia Nervosa","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D001066","descriptor_name":"Appetite","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007986","descriptor_name":"Luteinizing Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009478","descriptor_name":"Neuropeptide Y","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011613","descriptor_name":"Psychotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:16136022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16136022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:45629004","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16136022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2040600084","https://openalex.org/W2260980819","https://openalex.org/W7005073365","https://openalex.org/W2337212058","https://openalex.org/W1982532682","https://openalex.org/W2133333233","https://openalex.org/W2145246058","https://openalex.org/W2013456961","https://openalex.org/W2070843855","https://openalex.org/W2000011215"],"abstract_inverted_index":{"OBJECTIVES:":[0],"The":[1,100],"pathogenesis":[2],"of":[3,23,44,98,103,213,219,226,243,255],"anorexia":[4,81],"nervosa":[5,82],"(AN)":[6,83],"remains":[7],"still":[8,47],"unclear.":[9],"It":[10],"has":[11],"been":[12],"reported":[13],"that":[14],"neuropeptides":[15,257],"may":[16,262],"play":[17],"a":[18],"role":[19],"in":[20,32,71,165,192,250,269],"the":[21,35,85,88,224,256],"control":[22,248],"appetite":[24,244],"and":[25,64,91,107,157,163,179,186,203,205,216,239,245,259],"hormone":[26],"release":[27],"contributing":[28],"to":[29,87,120,136],"hormonal":[30],"disturbances":[31],"AN.":[33,251],"However":[34],"question":[36],"if":[37],"neuropeptide":[38,52],"alterations":[39],"are":[40],"consequence":[41],"or":[42],"cause":[43],"malnutrition":[45],"is":[46],"unresolved.":[48],"METHODS:":[49],"Serum":[50,211],"leptin,":[51,201],"Y":[53],"(NPY)":[54],"concentrations":[55,160,181],"as":[56,58],"well":[57],"hormones":[59],"(FSH,":[60],"LH,":[61],"estradiol,":[62],"cortisol":[63],"fT4)":[65],"serum":[66,159,217],"levels":[67],"were":[68,151,196],"prospectively":[69],"estimated":[70],"19":[72],"girls":[73],"aged":[74],"11.7-17.7":[75],"years":[76],"(mean":[77],"15.5":[78],"years)":[79],"with":[80,235,272],"at":[84,92,161,182,187],"admission":[86],"hospital":[89],"(baseline)":[90],"follow-up":[93,164,188],"after":[94,266],"7.21+":[95],"2.32":[96],"months":[97],"treatment.":[99],"treatment":[101,225],"consisted":[102],"hypercaloric":[104],"diet,":[105],"psychotherapy":[106],"vitamins":[108],"supplementation.":[109],"RESULTS:":[110],"Mean":[111],"leptin":[112,156,178,214],"concentration":[113,129,212,218],"significantly":[114,130,222],"increased":[115],"from":[116,132],"7.99":[117],"+":[118,122,134,138],"2.6":[119],"9.98":[121],"2.48":[123],"microg/ml":[124],"(p<0.01),":[125],"whereas":[126],"mean":[127],"NPY":[128,158,180,202,220],"decreased":[131],"34.10":[133],"9.81":[135],"29.6":[137],"8.04":[139],"pmol/l":[140],"(p<0.01).":[141],"Leptin/BMI":[142],"ratio":[143,148],"was":[144],"constant,":[145],"while":[146],"NPY/BMI":[147],"decreased.":[149],"There":[150,195],"no":[152,197],"significant":[153,198],"differences":[154],"between":[155,177,200],"baseline":[162,183],"eumenorrheic":[166,193],"vs.":[167],"amenorrheic":[168],"patients.":[169],"Simple":[170],"linear":[171],"correlation":[172,176],"analysis":[173],"showed":[174],"negative":[175],"(r=-0.67;":[184],"p<0.05)":[185,190],"(r=-0.76;":[189],"only":[191],"subgroup.":[194],"correlations":[199],"BMI":[204,240],"body":[206,237,246],"weight":[207,238,247,267],"values.":[208],"CONCLUSIONS:":[209],"1)":[210],"increases":[215],"decreases":[221],"during":[223],"anorectic":[227,270],"girls.":[228],"2)":[229],"These":[230],"changes":[231],"do":[232],"not":[233],"correspond":[234],"increasing":[236],"suggesting":[241],"disregulation":[242],"mechanisms":[249],"3)":[252],"Altered":[253],"neuroregulation":[254],"(leptin":[258],"NPY)":[260],"secretion":[261],"contribute":[263],"persistent":[264],"amenorrhea":[265],"gain":[268],"patients":[271],"low":[273],"initial":[274],"BMI.":[275]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
