{"id":"https://openalex.org/W45614617","doi":null,"title":"Marginal protein intake results in reduced plasma IGF-I levels and skeletal muscle fiber atrophy in elderly women.","display_name":"Marginal protein intake results in reduced plasma IGF-I levels and skeletal muscle fiber atrophy in elderly women.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W45614617","mag":"45614617","pmid":"https://pubmed.ncbi.nlm.nih.gov/10842420"},"language":"en","primary_location":{"id":"pmid:10842420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10842420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110669941","display_name":"Carmen Casta\u00f1eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I4210111395","display_name":"Jean Mayer Human Nutrition Research Center on Aging","ror":"https://ror.org/01d0zz505","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210111395","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Castaneda","raw_affiliation_strings":["Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St., Boston MA 02111. ccastaneda@hnrc. tufts.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington St., Boston MA 02111. ccastaneda@hnrc. tufts.edu","institution_ids":["https://openalex.org/I121934306","https://openalex.org/I4210111395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103347217","display_name":"Patricia Gordon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P L Gordon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063933818","display_name":"Roger A. Fielding","orcid":"https://orcid.org/0000-0003-2236-9020","observed_orcids":["https://orcid.org/0000-0003-2236-9020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R A Fielding","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072838105","display_name":"W J Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W J Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110276527","display_name":"Marilyn C. Crim","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M C Crim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.138,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.85448288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"4","issue":"2","first_page":"85","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.16269999742507935,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.015300000086426735,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-intake","display_name":"protein intake","score":0.8669999837875366},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8679999709129333},{"id":"https://openalex.org/keywords/type-i-muscle-fibres","display_name":"type I muscle fibers","score":0.8519999980926514},{"id":"https://openalex.org/keywords/muscle-fiber-cross-sectional-area","display_name":"muscle fiber cross-sectional area","score":0.9419999718666077},{"id":"https://openalex.org/keywords/older-women","display_name":"older women","score":0.7279999852180481},{"id":"https://openalex.org/keywords/sarcopenia","display_name":"sarcopenia","score":0.9490000009536743},{"id":"https://openalex.org/keywords/body-cell-mass","display_name":"body cell mass","score":0.7990000247955322},{"id":"https://openalex.org/keywords/muscle-loss","display_name":"muscle mass loss","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7523572444915771},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6846026182174683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6845353245735168},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.667014479637146},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.5532368421554565},{"id":"https://openalex.org/C3017897630","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Muscle fibre","level":3,"score":0.5240854620933533},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.506660521030426},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.4868852198123932}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004044","descriptor_name":"Dietary Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018753","descriptor_name":"Diet, Protein-Restricted","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:10842420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10842420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Clinical Trial"},{"id":"mag:45614617","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10842420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"},{"score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W438943543","https://openalex.org/W2890144025","https://openalex.org/W2897394565","https://openalex.org/W2014487255","https://openalex.org/W2332493691","https://openalex.org/W2091548454","https://openalex.org/W2180868877","https://openalex.org/W2921144811","https://openalex.org/W151250086","https://openalex.org/W7100796554"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,80,93,111,116,141,155],"effects":[3],"of":[4,137],"dietary":[5,130],"protein":[6,131],"on":[7],"plasma":[8,148],"IGF-I":[9,51,68,100,109,149],"levels":[10,52],"and":[11,42,53,57,63,69,84,97,101,143],"muscle":[12,54,138],"fiber":[13,55,72,121],"cross-sectional":[14],"area":[15],"(CSA).":[16],"Twelve":[17],"healthy":[18],"elderly":[19,142],"women":[20],"were":[21,59],"randomly":[22],"assigned":[23],"to":[24],"a":[25,145,151],"weight-maintaining":[26],"diet":[27,82,95],"containing":[28],"either":[29],"1.47":[30],"(marginal)":[31],"or":[32],"2.94":[33],"(adequate)":[34],"g":[35],"protein/kg":[36],"body":[37,45],"cell":[38],"mass":[39,139],"(BCM)/d,":[40],"(0.45":[41],"0.92":[43],"g/kg":[44],"weight/d,":[46],"respectively)":[47,86],"for":[48,99,147,154],"10wks.":[49,64],"Plasma":[50],"areas":[56],"distributions":[58],"evaluated":[60],"at":[61],"baseline":[62],"After":[65],"10wks,":[66],"both":[67],"type":[70,102,119],"I":[71,103,120],"CSA":[73,122],"had":[74],"declined":[75],"significantly":[76,113],"in":[77,90,108,118,135,140,158],"subjects":[78],"fed":[79,92],"marginal":[81,129],"(30.1+/-2.1%":[83],"32.7+/-7.9%,":[85],"while":[87],"they":[88],"increased":[89],"those":[91],"adequate":[94],"(19.5+/-7.0%":[96],"22.3+/-7.5%,":[98],"CSA,":[104],"respectively).":[105],"The":[106],"change":[107,117],"was":[110],"only":[112],"associated":[114],"with":[115],"(r2=0.70;":[123],"p<0.03).":[124],"These":[125],"findings":[126],"show":[127],"that":[128],"intakes":[132],"will":[133],"result":[134],"losses":[136],"suggest":[144],"role":[146],"as":[150],"biochemical":[152],"marker":[153],"histological":[156],"changes":[157],"skeletal":[159],"muscle.":[160]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
