{"id":"https://openalex.org/W45395735","doi":null,"title":"Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST?","display_name":"Does GDNF exert its neuroprotective effects on photoreceptors in the rd1 retina through the glial glutamate transporter GLAST?","publication_year":2005,"publication_date":"2005-09-01","ids":{"openalex":"https://openalex.org/W45395735","mag":"45395735","pmid":"https://pubmed.ncbi.nlm.nih.gov/16163265"},"language":"en","primary_location":{"id":"pmid:16163265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16163265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061223187","display_name":"Marie\u2010No\u00eblle Delyfer","orcid":"https://orcid.org/0000-0002-3127-8617","observed_orcids":["https://orcid.org/0000-0002-3127-8617"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-No\u00eblle Delyfer","raw_affiliation_strings":["Laboratoire de Physiopathologie Cellulaire et Mol\u00e9culaire de la R\u00e9tine, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm U592), Universit\u00e9 Pierre et Marie Curie, Paris, France. marie-noelle.delyfer@libertysurf.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Physiopathologie Cellulaire et Mol\u00e9culaire de la R\u00e9tine, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (Inserm U592), Universit\u00e9 Pierre et Marie Curie, Paris, France. marie-noelle.delyfer@libertysurf.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4405264447"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100308300","display_name":"Manuel Simonutti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Simonutti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009118615","display_name":"N. Neveux","orcid":"https://orcid.org/0000-0003-1406-653X","observed_orcids":["https://orcid.org/0000-0003-1406-653X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathalie Neveux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030345626","display_name":"Thierry L\u00e9veillard","orcid":"https://orcid.org/0000-0001-5692-8770","observed_orcids":["https://orcid.org/0000-0001-5692-8770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thierry L\u00e9veillard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063516832","display_name":"Jos\u00e9\u2010Alain Sahel","orcid":"https://orcid.org/0000-0002-4831-1153","observed_orcids":["https://orcid.org/0000-0002-4831-1153","https://orcid.org/0000-0003-3600-3599"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9-Alain Sahel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4453,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.87326825,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"11","issue":null,"first_page":"677","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/rd1-mouse-model","display_name":"rd1 mouse model","score":0.7179999947547913},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.7860000133514404},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9599999785423279},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.890999972820282},{"id":"https://openalex.org/keywords/glutamate-excitotoxicity","display_name":"glutamate excitotoxicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/gfralpha1","display_name":"GFR\u03b11","score":0.75},{"id":"https://openalex.org/keywords/ret-receptor","display_name":"RET receptor","score":0.8579999804496765},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.4309999942779541},{"id":"https://openalex.org/keywords/glutamine","display_name":"glutamine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/subretinal-injection","display_name":"subretinal injection","score":0.7450000047683716},{"id":"https://openalex.org/keywords/retinal-organ-culture","display_name":"retinal organ culture","score":0.5830000042915344},{"id":"https://openalex.org/keywords/gdnf-receptor","display_name":"GDNF receptor","score":0.5329999923706055},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C185856081","wikidata":"https://www.wikidata.org/wiki/Q14916286","display_name":"Glial cell line-derived neurotrophic factor","level":4,"score":0.9794536828994751},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6494641900062561},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.645699143409729},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.6359100341796875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6226699948310852},{"id":"https://openalex.org/C94296188","wikidata":"https://www.wikidata.org/wiki/Q5513091","display_name":"GDNF family of ligands","level":5,"score":0.5832297801971436},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5705369710922241},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5413896441459656},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5238276124000549},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.5080819129943848},{"id":"https://openalex.org/C2777102633","wikidata":"https://www.wikidata.org/wiki/Q735343","display_name":"Muller glia","level":4,"score":0.48437222838401794},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.37924546003341675},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3689286708831787},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.25507575273513794},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16467982530593872},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.04913511872291565},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005973","descriptor_name":"Glutamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012162","descriptor_name":"Retinal Degeneration","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018613","descriptor_name":"Microscopy, Confocal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027341","descriptor_name":"Excitatory Amino Acid Transporter 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051097","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051100","descriptor_name":"Glial Cell Line-Derived Neurotrophic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:16163265","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16163265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:40012","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/40012/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular vision , 11 677 -687. (2005)","raw_type":"Article"},{"id":"mag:45395735","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16163265","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2039390487","https://openalex.org/W7098565827","https://openalex.org/W2122565496","https://openalex.org/W1608027934","https://openalex.org/W1965315078","https://openalex.org/W7071542971","https://openalex.org/W2968147599","https://openalex.org/W1973945718","https://openalex.org/W4386865533","https://openalex.org/W138822253"],"abstract_inverted_index":{"PURPOSE:":[0],"We":[1,299],"previously":[2],"demonstrated":[3,69,198],"that":[4,199,301,323],"exogenous":[5,273],"glial":[6,83,92],"cell":[7,134],"line-derived":[8],"neurotrophic":[9],"factor":[10],"(GDNF)":[11],"induces":[12],"histological":[13],"and":[14,122,131,149,166,170,196,225,242,261,311],"functional":[15],"protection":[16],"of":[17,44,90,117,192,234,297,303,309,340],"photoreceptors":[18,80,289],"in":[19,53,57,70,175,226,238,245,251,264,280,347],"the":[20,42,54,58,62,88,91,113,207,232,265,281,295,307,315],"retinal":[21,133,146,223,239],"degeneration":[22],"(rd1)":[23],"mouse":[24,124,154,222,229,283],"model.":[25],"The":[26],"mechanisms":[27],"underlying":[28],"such":[29],"neuroprotection":[30],"remain":[31],"elusive.":[32],"In":[33,61],"parallel":[34],"to":[35,49,111,140,144,218,321],"this":[36],"work,":[37],"we":[38,65,319,329],"provided":[39],"evidence":[40],"for":[41],"occurrence":[43],"glutamate-mediated":[45,101],"excitotoxic":[46],"phenomena":[47],"contributing":[48],"rod":[50],"photoreceptor":[51,209],"death":[52],"rd1":[55,121,145,153,176,221,228,266,282],"retina":[56,267],"companion":[59],"paper.":[60],"present":[63],"study,":[64],"investigated":[66],"whether,":[67],"as":[68,126,128],"other":[71],"models,":[72],"GDNF":[73,118,137,159,179,193,200,216,285,305,324,334],"could":[74,330],"exert":[75],"its":[76],"neuroprotective":[77,98,286],"effect":[78,287],"on":[79,288],"through":[81,294],"M\u00fcller":[82],"cells":[84,210],"(MGC)":[85],"by":[86,163,206,213,236,243,272],"promoting":[87],"expression":[89,115,157,190,233,250,308],"L-glutamate/L-aspartate":[93],"transporter":[94],"(GLAST),":[95],"an":[96,184,338],"endogenous":[97],"mechanism":[99],"against":[100],"excitotoxicity.":[102],"METHODS:":[103],"Reverse":[104],"transcription-polymerase":[105],"chain":[106],"reaction":[107],"(RT-PCR)":[108],"was":[109,138,161,253],"used":[110],"compare":[112],"mRNA":[114,189],"levels":[116,172,263],"receptors":[119,201],"between":[120,129],"wild-type":[123],"retinas":[125,177,230],"well":[127],"MGC":[130,142,219,252],"mixed":[132],"cultures.":[135],"Recombinant":[136],"applied":[139],"pure":[141],"cultures,":[143,220],"organ":[147],"cultures":[148],"injected":[150],"subretinally":[151],"into":[152],"eyes.":[155],"GLAST":[156,235,248,310],"following":[158],"treatment":[160,182],"measured":[162],"RT-PCR,":[164],"immunoblotting":[165],"immunohistochemistry.":[167],"Free":[168,259],"glutamate":[169,260,327,341,348],"glutamine":[171,262],"were":[173,202,268],"quantified":[174],"after":[178],"or":[180],"control":[181],"using":[183],"amino":[185],"acid":[186],"analyzer.":[187],"RESULTS:":[188],"studies":[191],"receptors,":[194],"GFRalpha-1":[195],"Ret,":[197],"not":[203,269,331],"exclusively":[204],"expressed":[205],"degenerating":[208,316],"but":[211],"mainly":[212],"MGC.":[214,298],"Exogenous":[215],"application":[217],"explants":[224,240],"vivo":[227,246],"increased":[231,255],"48%":[237],"(p<0.005)":[241],"25%":[244],"(p<0.0005).":[247],"protein":[249],"particularly":[254,313],"around":[256,314],"degenerative":[257],"photoreceptors.":[258,317],"significantly":[270],"modified":[271],"GDNF.":[274],"CONCLUSIONS:":[275],"Our":[276],"data":[277],"suggest":[278],"that,":[279],"retina,":[284],"can":[290],"be":[291],"mediated":[292],"indirectly":[293],"activation":[296],"demonstrate":[300,322],"injection":[302],"recombinant":[304],"enhances":[306],"more":[312],"Since":[318],"failed":[320],"decreases":[325],"free":[326],"levels,":[328],"ascertain":[332],"whether":[333],"promoted":[335],"photoreceptor-survival":[336],"via":[337],"increase":[339],"uptake":[342],"and,":[343],"therefore,":[344],"a":[345],"change":[346],"distribution.":[349]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}