{"id":"https://openalex.org/W45329928","doi":null,"title":"Radiation dosimetry and biodistribution of BAY86-9596 (O-([18F]fluoromethyl)-D-tyrosine)","display_name":"Radiation dosimetry and biodistribution of BAY86-9596 (O-([18F]fluoromethyl)-D-tyrosine)","publication_year":2011,"publication_date":"2011-05-01","ids":{"openalex":"https://openalex.org/W45329928","mag":"45329928"},"language":"en","primary_location":{"id":"mag:45329928","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/52/supplement_1/1455.short","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Johan de Jong","orcid":"https://orcid.org/0000-0001-8300-3861","observed_orcids":["https://orcid.org/0000-0001-8300-3861"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johan de Jong","raw_affiliation_strings":["1Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-8300-3861","affiliations":[{"raw_affiliation_string":"1Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078947296","display_name":"Kristin Kowal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kristin Kowal","raw_affiliation_strings":["2Bayer Schering Pharma AG, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Bayer Schering Pharma AG, Berlin, Germany;","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082071316","display_name":"Sabine Zitzmann-Kolbe","orcid":"https://orcid.org/0000-0002-1476-6299","observed_orcids":["https://orcid.org/0000-0002-1476-6299"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Zitzmann-Kolbe","raw_affiliation_strings":["2Bayer Schering Pharma AG, Berlin, Germany;"],"raw_orcid":"https://orcid.org/0000-0002-1476-6299","affiliations":[{"raw_affiliation_string":"2Bayer Schering Pharma AG, Berlin, Germany;","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080158343","display_name":"Claudia Bacher-Stier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claudia Bacher-Stier","raw_affiliation_strings":["2Bayer Schering Pharma AG, Berlin, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Bayer Schering Pharma AG, Berlin, Germany;","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040156033","display_name":"Irene Andrea Burger","orcid":"https://orcid.org/0000-0001-8029-8692","observed_orcids":["https://orcid.org/0000-0001-8029-8692"]},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Irene A. Burger","raw_affiliation_strings":["3Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8029-8692","affiliations":[{"raw_affiliation_string":"3Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002690933","display_name":"Erik F. J. de Vries","orcid":"https://orcid.org/0000-0002-6915-1590","observed_orcids":["https://orcid.org/0000-0002-6915-1590"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik F. J. de Vries","raw_affiliation_strings":["1Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-6915-1590","affiliations":[{"raw_affiliation_string":"1Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017680598","display_name":"Jan Pruim","orcid":"https://orcid.org/0000-0002-8323-6187","observed_orcids":["https://orcid.org/0000-0002-8323-6187"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jan Pruim","raw_affiliation_strings":["1Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-8323-6187","affiliations":[{"raw_affiliation_string":"1Nuclear Medicine & Molecular Imaging, University Medical Center Groningen, University of Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0059038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"52","issue":null,"first_page":"1455","last_page":"1455"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10844","display_name":"Radiation Dose and Imaging","score":0.05820000171661377,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-dosimetry","display_name":"radiation dosimetry","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tissue-distribution","display_name":"tissue distribution","score":0.9409999847412109},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.6660000085830688},{"id":"https://openalex.org/keywords/effective-dose","display_name":"effective dose","score":0.8500000238418579},{"id":"https://openalex.org/keywords/olinda","display_name":"Olinda","score":0.48100000619888306},{"id":"https://openalex.org/keywords/mird-method","display_name":"MIRD method","score":0.5529999732971191},{"id":"https://openalex.org/keywords/18f-fdg-comparison","display_name":"18F-FDG comparison","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tyrosine-analogues","display_name":"tyrosine analogues","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C75088862","wikidata":"https://www.wikidata.org/wiki/Q2291081","display_name":"Dosimetry","level":2,"score":0.8833476305007935},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.8061307668685913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.68021160364151},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.5512323975563049},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.5342127084732056},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13654887676239014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:45329928","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/52/supplement_1/1455.short","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2021632321","https://openalex.org/W2116730903","https://openalex.org/W90353677","https://openalex.org/W23834499","https://openalex.org/W200101118","https://openalex.org/W2885376240","https://openalex.org/W2087494622","https://openalex.org/W2239798215","https://openalex.org/W2050039554","https://openalex.org/W41957739"],"abstract_inverted_index":{"1455":[0],"Objectives":[2],"Despite":[4],"the":[5,10,116,136,143,152,166,174,178,185,193,210,214,223,244,253,262],"fact":[6],"that":[7,131,284],"FDG":[8],"is":[9,37],"\u2018workhorse\u2019":[11],"of":[12,24,50,66,146,148,235,285],"PET":[13,53,179,198,270],"in":[14,22,55,151,238],"oncology,":[15],"it":[16],"has":[17],"a":[18,48,91,201,231,274],"well":[19,221],"known":[20],"drawback":[21,30],"terms":[23],"specificity.":[25],"New":[26],"tracers":[27],"avoiding":[28],"this":[29],"are":[31],"actively":[32],"researched":[33],"for,":[34],"amongst":[35],"which":[36],"BAY86-9596.":[38,67],"Methods":[40],"Five":[42],"healthy":[43],"volunteers":[44],"were":[45,83,103,125,140,156,170,247],"subject":[46],"to":[47,227,283],"series":[49],"seven":[51],"whole-body":[52],"scans":[54],"three":[56],"time":[57],"windows":[58],"following":[59],"an":[60,279],"injection":[61],"with":[62,240,278],"approximately":[63],"200":[64],"MBq":[65],"Time-points":[68],"included":[69],"0,":[70],"10,":[71],"20,":[72],"30,":[73],"40":[74],"minutes":[75],"and":[76,78,99,110,155,181,217,256],"2":[77],"4":[79],"hours":[80],"post-injection.":[81],"Data":[82,102],"acquired":[84],"using":[85,115],"1":[86,208],"minute":[87],"per":[88],"bed-position":[89],"on":[90,192,200],"Siemens":[92],"Biograph":[93],"mCT":[94],"PET/CT":[95],"camera":[96],"featuring":[97],"TrueV":[98],"UHD":[100],"technology.":[101],"fully":[104],"corrected":[105],"for":[106,160,165,213,252,261],"decay,":[107],"randoms,":[108],"scatter":[109],"attenuation.":[111],"Dosimetry":[112],"was":[113,132,195],"performed":[114],"MIRD":[117],"scheme":[118],"as":[119,127,220,222],"implemented":[120],"by":[121,172],"OLINDA/EXM.":[122],"Source":[123],"organs":[124,128,154],"identified":[126],"showing":[129],"uptake":[130],"significantly":[133],"different":[134],"from":[135,142,177,197],"average.":[137],"Cumulated":[138],"activities":[139],"obtained":[141,171],"time-activity":[144],"curves":[145],"regions":[147],"interest":[149],"drawn":[150],"source":[153],"fed":[157],"into":[158],"OLINDA":[159],"organ":[161,211],"level":[162],"dosimetry.":[163],"Parameters":[164],"urinary":[167],"bladder":[168,175,186,232],"model":[169],"fitting":[173],"data":[176,199],"images":[180],"assuming":[182],"subjects":[183],"voiding":[184,233],"at":[187],"regular":[188],"intervals.":[189],"The":[190,268],"dose":[191,225],"blood/red-marrow":[194],"estimated":[196],"lumbar":[202],"vertebra.":[203],"Results":[205],"Table":[207],"shows":[209],"doses":[212,246],"standard":[215,218,254,263],"male":[216,255],"female":[219],"effective":[224,245],"according":[226],"ICRP":[228],"103.":[229],"For":[230],"interval":[234],"45":[236],"minutes,":[237],"agreement":[239],"patient":[241],"scanning":[242],"protocol,":[243],"14.3":[248],"\u00b1":[249,258],"0.4":[250,259],"\u03bcSv/MBq":[251,260],"18.0":[257],"female.":[264],"Conclusions":[266],"new":[269],"tracer":[271],"BAY86-9596":[272],"showed":[273],"favorable":[275],"radiation":[276],"dosimetry":[277],"ED":[280],"being":[281],"comparable":[282],"[18F]-FDG":[286]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2016-06-24T00:00:00"}