{"id":"https://openalex.org/W45177934","doi":null,"title":"The effect of CORM-3 on the inflammatory nature of haemorrhagic stroke","display_name":"The effect of CORM-3 on the inflammatory nature of haemorrhagic stroke","publication_year":2012,"publication_date":"2012-02-28","ids":{"openalex":"https://openalex.org/W45177934","mag":"45177934"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1344101","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1344101/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008618772","display_name":"Y. Yabluchanskiy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Y. Yabluchanskiy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008618772"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11848","display_name":"Heme Oxygenase-1 and Carbon Monoxide","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/corm-3","display_name":"CORM-3","score":0.9480000138282776},{"id":"https://openalex.org/keywords/carbon-monoxide-releasing-molecules","display_name":"carbon monoxide-releasing molecules","score":0.890999972820282},{"id":"https://openalex.org/keywords/intracerebral-hemorrhage","display_name":"intracerebral hemorrhage","score":0.9449999928474426},{"id":"https://openalex.org/keywords/hemorrhagic-stroke","display_name":"hemorrhagic stroke","score":0.9580000042915344},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8349999785423279},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7680000066757202},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8040000200271606},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8370000123977661},{"id":"https://openalex.org/keywords/timing-of-drug-administration","display_name":"timing of drug administration","score":0.7160000205039978},{"id":"https://openalex.org/keywords/brain-water-content","display_name":"brain water content","score":0.7310000061988831},{"id":"https://openalex.org/keywords/brain-injury","display_name":"brain injury","score":0.42500001192092896},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.5009999871253967},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.41100001335144043}],"concepts":[{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.7750881910324097},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6914043426513672},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6396936178207397},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.604432225227356},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.526034414768219},{"id":"https://openalex.org/C2777094939","wikidata":"https://www.wikidata.org/wiki/Q1368943","display_name":"Intracerebral hemorrhage","level":3,"score":0.5246163606643677},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5102801322937012},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.47198277711868286},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4449550211429596},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.4416991174221039},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43356406688690186},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.4135354459285736},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.413160115480423},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3556693494319916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3248063325881958},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31407952308654785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20250818133354187},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15016093850135803},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10696017742156982},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2777736543","wikidata":"https://www.wikidata.org/wiki/Q693442","display_name":"Subarachnoid hemorrhage","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1344101","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1344101/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:45177934","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/1344101/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":352,"referenced_works":["https://openalex.org/W38867221","https://openalex.org/W40061211","https://openalex.org/W49314355","https://openalex.org/W110942310","https://openalex.org/W125984928","https://openalex.org/W178069612","https://openalex.org/W186296382","https://openalex.org/W203545144","https://openalex.org/W211761701","https://openalex.org/W251020083","https://openalex.org/W257337194","https://openalex.org/W1237385790","https://openalex.org/W1485043634","https://openalex.org/W1492710735","https://openalex.org/W1493234464","https://openalex.org/W1496965652","https://openalex.org/W1507778094","https://openalex.org/W1509395915","https://openalex.org/W1522286249","https://openalex.org/W1529546987","https://openalex.org/W1536484729","https://openalex.org/W1541349172","https://openalex.org/W1545296694","https://openalex.org/W1545397496","https://openalex.org/W1551183882","https://openalex.org/W1562000342","https://openalex.org/W1562837156","https://openalex.org/W1581583656","https://openalex.org/W1594129908","https://openalex.org/W1679327448","https://openalex.org/W1706443485","https://openalex.org/W1766573027","https://openalex.org/W1786137152","https://openalex.org/W1838231017","https://openalex.org/W1937256964","https://openalex.org/W1963611639","https://openalex.org/W1964312134","https://openalex.org/W1964322102","https://openalex.org/W1964428139","https://openalex.org/W1965519239","https://openalex.org/W1966545151","https://openalex.org/W1967290285","https://openalex.org/W1967873263","https://openalex.org/W1968947739","https://openalex.org/W1969437735","https://openalex.org/W1970057053","https://openalex.org/W1970764391","https://openalex.org/W1970881264","https://openalex.org/W1971371657","https://openalex.org/W1972139210","https://openalex.org/W1972509721","https://openalex.org/W1972627268","https://openalex.org/W1973342003","https://openalex.org/W1973589135","https://openalex.org/W1973917792","https://openalex.org/W1974122593","https://openalex.org/W1975424513","https://openalex.org/W1975534403","https://openalex.org/W1976272968","https://openalex.org/W1976320302","https://openalex.org/W1976729036","https://openalex.org/W1978220518","https://openalex.org/W1980768356","https://openalex.org/W1980957114","https://openalex.org/W1980987756","https://openalex.org/W1981643724","https://openalex.org/W1982167041","https://openalex.org/W1982568851","https://openalex.org/W1983149176","https://openalex.org/W1983346181","https://openalex.org/W1983918745","https://openalex.org/W1984406225","https://openalex.org/W1984767608","https://openalex.org/W1984824436","https://openalex.org/W1986525923","https://openalex.org/W1986756462","https://openalex.org/W1986964828","https://openalex.org/W1989475128","https://openalex.org/W1989587423","https://openalex.org/W1990213295","https://openalex.org/W1990756467","https://openalex.org/W1991680271","https://openalex.org/W1991868475","https://openalex.org/W1992131118","https://openalex.org/W1996003447","https://openalex.org/W1996690550","https://openalex.org/W1997454513","https://openalex.org/W1997507706","https://openalex.org/W1998200062","https://openalex.org/W2000511986","https://openalex.org/W2000815286","https://openalex.org/W2003711453","https://openalex.org/W2004041535","https://openalex.org/W2004082031","https://openalex.org/W2005659566","https://openalex.org/W2005726985","https://openalex.org/W2005904261","https://openalex.org/W2006205771","https://openalex.org/W2008360623","https://openalex.org/W2008438640","https://openalex.org/W2008474919","https://openalex.org/W2009241327","https://openalex.org/W2009317009","https://openalex.org/W2009750871","https://openalex.org/W2010090192","https://openalex.org/W2010432106","https://openalex.org/W2011079660","https://openalex.org/W2011793103","https://openalex.org/W2013320354","https://openalex.org/W2014248364","https://openalex.org/W2016391008","https://openalex.org/W2018683277","https://openalex.org/W2019383506","https://openalex.org/W2021677811","https://openalex.org/W2023417206","https://openalex.org/W2023572242","https://openalex.org/W2024848348","https://openalex.org/W2028531319","https://openalex.org/W2030305474","https://openalex.org/W2030529426","https://openalex.org/W2031236369","https://openalex.org/W2031591420","https://openalex.org/W2032613630","https://openalex.org/W2033122418","https://openalex.org/W2035239697","https://openalex.org/W2035268298","https://openalex.org/W2035472812","https://openalex.org/W2037116004","https://openalex.org/W2037118856","https://openalex.org/W2037280078","https://openalex.org/W2037626563","https://openalex.org/W2038251576","https://openalex.org/W2038256604","https://openalex.org/W2039226390","https://openalex.org/W2040084521","https://openalex.org/W2040345927","https://openalex.org/W2041467804","https://openalex.org/W2041645861","https://openalex.org/W2041682003","https://openalex.org/W2042527026","https://openalex.org/W2043197363","https://openalex.org/W2044319350","https://openalex.org/W2044443383","https://openalex.org/W2044976491","https://openalex.org/W2045086791","https://openalex.org/W2045320558","https://openalex.org/W2045682687","https://openalex.org/W2046329404","https://openalex.org/W2047815625","https://openalex.org/W2049147335","https://openalex.org/W2049434003","https://openalex.org/W2049661372","https://openalex.org/W2050754416","https://openalex.org/W2050872369","https://openalex.org/W2050913584","https://openalex.org/W2052374786","https://openalex.org/W2054058695","https://openalex.org/W2054135378","https://openalex.org/W2054328493","https://openalex.org/W2054929937","https://openalex.org/W2055697807","https://openalex.org/W2055747781","https://openalex.org/W2056034889","https://openalex.org/W2056409142","https://openalex.org/W2056710153","https://openalex.org/W2057154892","https://openalex.org/W2058323075","https://openalex.org/W2060938349","https://openalex.org/W2061173173","https://openalex.org/W2061370133","https://openalex.org/W2061779392","https://openalex.org/W2064387526","https://openalex.org/W2065347265","https://openalex.org/W2065385172","https://openalex.org/W2066076668","https://openalex.org/W2066922686","https://openalex.org/W2067633386","https://openalex.org/W2067821134","https://openalex.org/W2068210940","https://openalex.org/W2068520577","https://openalex.org/W2068661103","https://openalex.org/W2068947040","https://openalex.org/W2070450284","https://openalex.org/W2070530740","https://openalex.org/W2070650972","https://openalex.org/W2070933761","https://openalex.org/W2071709068","https://openalex.org/W2072438077","https://openalex.org/W2072527522","https://openalex.org/W2073104240","https://openalex.org/W2073424392","https://openalex.org/W2074172712","https://openalex.org/W2074645936","https://openalex.org/W2074906955","https://openalex.org/W2075936299","https://openalex.org/W2076107212","https://openalex.org/W2076269811","https://openalex.org/W2077574201","https://openalex.org/W2077968233","https://openalex.org/W2078587582","https://openalex.org/W2080627140","https://openalex.org/W2082011284","https://openalex.org/W2082131420","https://openalex.org/W2084502927","https://openalex.org/W2084627525","https://openalex.org/W2085049977","https://openalex.org/W2085128625","https://openalex.org/W2085470941","https://openalex.org/W2085629151","https://openalex.org/W2086721674","https://openalex.org/W2087516645","https://openalex.org/W2088510868","https://openalex.org/W2090147463","https://openalex.org/W2090421059","https://openalex.org/W2090804892","https://openalex.org/W2090998371","https://openalex.org/W2091142824","https://openalex.org/W2091680030","https://openalex.org/W2092658609","https://openalex.org/W2093205075","https://openalex.org/W2093475762","https://openalex.org/W2094110602","https://openalex.org/W2094677029","https://openalex.org/W2094767574","https://openalex.org/W2094960332","https://openalex.org/W2095679373","https://openalex.org/W2095939380","https://openalex.org/W2097871217","https://openalex.org/W2097924742","https://openalex.org/W2098356781","https://openalex.org/W2098411167","https://openalex.org/W2099011527","https://openalex.org/W2100167607","https://openalex.org/W2103081912","https://openalex.org/W2103481051","https://openalex.org/W2103621310","https://openalex.org/W2103678102","https://openalex.org/W2103798426","https://openalex.org/W2104104806","https://openalex.org/W2104721556","https://openalex.org/W2105028929","https://openalex.org/W2105196489","https://openalex.org/W2105668545","https://openalex.org/W2105844738","https://openalex.org/W2107475094","https://openalex.org/W2107475246","https://openalex.org/W2107988171","https://openalex.org/W2109030151","https://openalex.org/W2110490571","https://openalex.org/W2110999346","https://openalex.org/W2111071161","https://openalex.org/W2112107066","https://openalex.org/W2112142763","https://openalex.org/W2113238081","https://openalex.org/W2113972465","https://openalex.org/W2115066467","https://openalex.org/W2115785602","https://openalex.org/W2116505148","https://openalex.org/W2118232718","https://openalex.org/W2119672318","https://openalex.org/W2121267737","https://openalex.org/W2122342801","https://openalex.org/W2125549595","https://openalex.org/W2125809720","https://openalex.org/W2126630207","https://openalex.org/W2126943377","https://openalex.org/W2127095655","https://openalex.org/W2128571597","https://openalex.org/W2128645063","https://openalex.org/W2129417796","https://openalex.org/W2131130086","https://openalex.org/W2131617036","https://openalex.org/W2132862382","https://openalex.org/W2132925738","https://openalex.org/W2134333028","https://openalex.org/W2136830984","https://openalex.org/W2139552889","https://openalex.org/W2139644186","https://openalex.org/W2139853268","https://openalex.org/W2142591538","https://openalex.org/W2143373778","https://openalex.org/W2144034260","https://openalex.org/W2145356173","https://openalex.org/W2145530136","https://openalex.org/W2145989829","https://openalex.org/W2146389866","https://openalex.org/W2147648389","https://openalex.org/W2148534328","https://openalex.org/W2148945403","https://openalex.org/W2149340306","https://openalex.org/W2151462874","https://openalex.org/W2151544350","https://openalex.org/W2153284962","https://openalex.org/W2157108937","https://openalex.org/W2157148912","https://openalex.org/W2158540635","https://openalex.org/W2160693812","https://openalex.org/W2161386375","https://openalex.org/W2161677223","https://openalex.org/W2163014707","https://openalex.org/W2163018412","https://openalex.org/W2163524393","https://openalex.org/W2166803343","https://openalex.org/W2167271707","https://openalex.org/W2168379311","https://openalex.org/W2168545543","https://openalex.org/W2169078693","https://openalex.org/W2169400952","https://openalex.org/W2170431734","https://openalex.org/W2170942810","https://openalex.org/W2171979283","https://openalex.org/W2176987607","https://openalex.org/W2294533161","https://openalex.org/W2312654759","https://openalex.org/W2325499359","https://openalex.org/W2330235342","https://openalex.org/W2338466016","https://openalex.org/W2366354702","https://openalex.org/W2368983351","https://openalex.org/W2395490072","https://openalex.org/W2396212888","https://openalex.org/W2396958085","https://openalex.org/W2399298219","https://openalex.org/W2400851843","https://openalex.org/W2401567177","https://openalex.org/W2403959990","https://openalex.org/W2405216392","https://openalex.org/W2405760433","https://openalex.org/W2406313143","https://openalex.org/W2410017280","https://openalex.org/W2411029623","https://openalex.org/W2411911695","https://openalex.org/W2412616133","https://openalex.org/W2414442663","https://openalex.org/W2415140927","https://openalex.org/W2416437117","https://openalex.org/W2416539531","https://openalex.org/W2418450073","https://openalex.org/W2418592423","https://openalex.org/W2418974357","https://openalex.org/W2422597986","https://openalex.org/W2424903899","https://openalex.org/W2427217946","https://openalex.org/W2440474512","https://openalex.org/W2460903080","https://openalex.org/W2462393612","https://openalex.org/W2463484420","https://openalex.org/W2498925443","https://openalex.org/W3028459116","https://openalex.org/W3135443006","https://openalex.org/W3176644452","https://openalex.org/W4313422295"],"related_works":["https://openalex.org/W2012206724","https://openalex.org/W3172823265","https://openalex.org/W2808916825","https://openalex.org/W2103481051","https://openalex.org/W2156467466","https://openalex.org/W7099186021","https://openalex.org/W3133546725","https://openalex.org/W4388948995","https://openalex.org/W1545844367","https://openalex.org/W4367302850"],"abstract_inverted_index":{"Objective\u2500":[0],"Intracerebral":[1],"hemorrhage":[2],"(ICH)":[3],"is":[4,16,275],"accompanied":[5],"by":[6,139],"a":[7,31,116,286],"pronounced":[8],"\\ninflammatory":[9],"response":[10,131],"that":[11],"mediates":[12],"brain":[13,42,75,121,153,193,223],"damage":[14],"but":[15],"also":[17],"essential":[18],"for":[19],"the":[20,27,150,197,246,265,291],"\\ntissue":[21],"reparative":[22],"process.":[23],"Here":[24],"we":[25],"assessed":[26],"effect":[28],"of":[29,69,199,248,267],"CORM-3,":[30],"water-soluble":[32],"\\ncarbon":[33],"monoxide-releasing":[34],"molecule":[35],"possessing":[36],"anti-inflammatory":[37],"properties,":[38],"on":[39,264],"\\ninflammation":[40],"and":[41,51,65,124,143,146,156,163,175,195,211,225,241],"injury":[43,224],"after":[44,103,109,137,219,234,261,282],"ICH.":[45,80],"\\nDesign\u2500":[46],"In":[47,228],"vivo,":[48],"in":[49,74,149],"vitro":[50],"ex":[52],"vivo":[53],"laboratory":[54],"study.":[55],"\\nSetting\u2500":[56],"Research":[57],"laboratory.":[58],"\\nSubjects\u2500":[59],"Male":[60],"Sprague-Dawley":[61],"rats,":[62],"250-350g.":[63],"\\nInterventions":[64],"Measurements\u2500":[66],"A":[67],"model":[68],"collagenase":[70,104,110,187,220,235],"injection":[71],"(2":[72],"\u03bcl)":[73],"\\nwas":[76],"established":[77],"to":[78,98,168,188],"induce":[79,189],"CORM-3":[81,230,256],"(4":[82],"or":[83,171,259,279],"8":[84],"mg/kg)":[85],"was":[86,113,132],"administered":[87],"i.v.":[88],"at":[89,134,180],"\\ndifferent":[90],"times":[91],"as":[92,115,285],"follows:":[93],"a)":[94],"5":[95],"min":[96],"prior":[97],"collagenase,":[99],"b)":[100],"3":[101,107,217,232,280],"hours":[102,218],"\\nand":[105],"c)":[106],"days":[108,233,281],"challenge.":[111],"Saline":[112],"used":[114],"negative":[117],"control.":[118],"\\nBrain":[119],"damage,":[120],"water":[122,154],"content":[123,155],"behavioural":[125],"assessment":[126],"were":[127,166,253],"evaluated.":[128],"\\nThe":[129],"inflammatory":[130,200,293],"determined":[133],"set":[135],"intervals":[136],"ICH":[138,151,190,262],"counting":[140],"\\nperipheral":[141],"neutrophils":[142,145],"lymphocytes,":[144],"activated":[147],"\\nmicroglia/macrophages":[148],"area,":[152],"measuring":[157],"plasma":[158,213],"\\nTNF-\u03b1":[159,226],"levels.":[160],"BV2":[161],"microglia":[162],"DI-TNC1":[164],"astrocytes":[165],"exposed":[167],"triton":[169],"(1%)":[170],"\\nCORM-3":[172,215,274],"(10-100":[173],"\u03bcM)":[174],"cytotoxicity":[176],"(LDH":[177],"assay)":[178],"measured":[179],"24":[181],"hours.":[182],"Main":[183],"Results\u2500":[184],"Challenge":[185],"with":[186,203],"caused":[191],"marked":[192],"\\ndamage":[194],"modified":[196],"levels":[198],"markers.":[201],"Pre-treatment":[202],"CORM-":[204],"\\n3":[205],"significantly":[206,221],"prevented":[207],"injury,":[208],"modulated":[209,239],"inflammation":[210,240],"reduced":[212],"TNF-\u03b1.":[214],"given":[216,231,276],"increased":[222],"production.":[227],"contrast,":[229],"afforded":[236],"\\npartial":[237],"protection,":[238],"decreased":[242],"TNF-\u03b1":[243],"starting":[244],"from":[245],"\\nday":[247],"application.":[249],"No":[250],"dose-dependent":[251],"effects":[252,270],"observed.":[254],"\\nConclusions\u2500":[255],"promotes":[257],"neuroprotection":[258],"neurotoxicity":[260],"\\ndepending":[263],"time":[266],"administration.":[268],"Beneficial":[269],"are":[271],"achieved":[272],"when":[273],"either":[277],"before":[278],"ICH,":[283],"namely,":[284],"prophylactic":[287],"agent":[288],"\\nor":[289],"during":[290],"post-acute":[292],"phase.":[294]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
