{"id":"https://openalex.org/W4507422","doi":"https://doi.org/10.17077/etd.dbmqnenp","title":"Degradation of human \u03b1- and \u03b2-defensins by culture supernatants of Porphyromonas gingivalis","display_name":"Degradation of human \u03b1- and \u03b2-defensins by culture supernatants of Porphyromonas gingivalis","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W4507422","doi":"https://doi.org/10.17077/etd.dbmqnenp","mag":"4507422"},"language":"en","primary_location":{"id":"doi:10.17077/etd.dbmqnenp","doi":"https://doi.org/10.17077/etd.dbmqnenp","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.dbmqnenp","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730691780002771/13730714950002771","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001928502","display_name":"Matthew David Carlisle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matthew David Carlisle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001928502"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.7836999893188477,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.1973000019788742,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porphyromonas-gingivalis","display_name":"Porphyromonas gingivalis","score":0.996999979019165},{"id":"https://openalex.org/keywords/human-beta-defensins","display_name":"human beta-defensins","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bacterial-proteases","display_name":"bacterial proteases","score":0.9089999794960022},{"id":"https://openalex.org/keywords/culture-supernatant","display_name":"culture supernatant","score":0.9049999713897705},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.800000011920929},{"id":"https://openalex.org/keywords/periodontal-pathogens","display_name":"periodontal pathogens","score":0.6890000104904175},{"id":"https://openalex.org/keywords/antimicrobial-peptides","display_name":"antimicrobial peptides","score":0.9110000133514404}],"concepts":[{"id":"https://openalex.org/C2780183776","wikidata":"https://www.wikidata.org/wiki/Q3214147","display_name":"Porphyromonas gingivalis","level":3,"score":0.9778190851211548},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.9272653460502625},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7672158479690552},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5957438349723816},{"id":"https://openalex.org/C2776498113","wikidata":"https://www.wikidata.org/wiki/Q412820","display_name":"Defensin","level":3,"score":0.5326331257820129},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.5197712779045105},{"id":"https://openalex.org/C129437159","wikidata":"https://www.wikidata.org/wiki/Q4897294","display_name":"Beta defensin","level":4,"score":0.5150222778320312},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.48890700936317444},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.47446686029434204},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.44795313477516174},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4227452874183655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39250648021698},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37522637844085693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2597607374191284},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2523092031478882},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1695042848587036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1687454879283905},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.17077/etd.dbmqnenp","doi":"https://doi.org/10.17077/etd.dbmqnenp","is_oa":false,"landing_page_url":"https://doi.org/10.17077/etd.dbmqnenp","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"University of Iowa","raw_type":"dissertation"},{"id":"pmh:oai:alma.01IOWA_INST:11730691790002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/graduate/Degradation-of-human-\u03b1--and-\u03b2-defensins/9983777130302771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730691780002771/13730714950002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"},{"id":"pmh:oai:ir.uiowa.edu:etd-1836","doi":null,"is_oa":false,"landing_page_url":"https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1836&context=etd","pdf_url":null,"source":{"id":"https://openalex.org/S4377196317","display_name":"Iowa Research Online (University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations","raw_type":"thesis"}],"best_oa_location":{"id":"pmh:oai:alma.01IOWA_INST:11730691790002771","doi":null,"is_oa":true,"landing_page_url":"https://iro.uiowa.edu/esploro/outputs/graduate/Degradation-of-human-\u03b1--and-\u03b2-defensins/9983777130302771","pdf_url":"https://iro.uiowa.edu/view/delivery/01IOWA_INST/12730691780002771/13730714950002771","source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4507422.pdf","grobid_xml":"https://content.openalex.org/works/W4507422.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W1485007640","https://openalex.org/W1691524838","https://openalex.org/W1733288684","https://openalex.org/W1861428035","https://openalex.org/W1929493432","https://openalex.org/W1931391884","https://openalex.org/W1964703096","https://openalex.org/W1965204107","https://openalex.org/W1966126294","https://openalex.org/W1970314831","https://openalex.org/W1970434698","https://openalex.org/W1972350252","https://openalex.org/W1974652468","https://openalex.org/W1975364766","https://openalex.org/W1977241485","https://openalex.org/W1980968411","https://openalex.org/W1982034461","https://openalex.org/W1983077597","https://openalex.org/W1985550744","https://openalex.org/W1988092678","https://openalex.org/W1989998611","https://openalex.org/W1990025846","https://openalex.org/W1992579069","https://openalex.org/W1992840253","https://openalex.org/W1993022619","https://openalex.org/W1999714531","https://openalex.org/W2001535938","https://openalex.org/W2001760147","https://openalex.org/W2001850809","https://openalex.org/W2006440275","https://openalex.org/W2013245073","https://openalex.org/W2015027028","https://openalex.org/W2018793626","https://openalex.org/W2019094601","https://openalex.org/W2020137152","https://openalex.org/W2023967578","https://openalex.org/W2027183942","https://openalex.org/W2030387250","https://openalex.org/W2030728478","https://openalex.org/W2031799142","https://openalex.org/W2039217428","https://openalex.org/W2039378017","https://openalex.org/W2042792856","https://openalex.org/W2044292829","https://openalex.org/W2044559815","https://openalex.org/W2045457193","https://openalex.org/W2046226423","https://openalex.org/W2047128020","https://openalex.org/W2048615673","https://openalex.org/W2056039068","https://openalex.org/W2057198053","https://openalex.org/W2057389581","https://openalex.org/W2058223359","https://openalex.org/W2060660430","https://openalex.org/W2061496011","https://openalex.org/W2065141838","https://openalex.org/W2071463327","https://openalex.org/W2072849913","https://openalex.org/W2073313072","https://openalex.org/W2074225999","https://openalex.org/W2081537251","https://openalex.org/W2087976424","https://openalex.org/W2097098774","https://openalex.org/W2098786490","https://openalex.org/W2099494881","https://openalex.org/W2099730204","https://openalex.org/W2100819581","https://openalex.org/W2104713845","https://openalex.org/W2105295803","https://openalex.org/W2107715779","https://openalex.org/W2109630790","https://openalex.org/W2111299301","https://openalex.org/W2112311397","https://openalex.org/W2113949809","https://openalex.org/W2114774693","https://openalex.org/W2115622227","https://openalex.org/W2117440442","https://openalex.org/W2120591497","https://openalex.org/W2122456003","https://openalex.org/W2123850573","https://openalex.org/W2123905657","https://openalex.org/W2124497317","https://openalex.org/W2128791999","https://openalex.org/W2129867662","https://openalex.org/W2131322694","https://openalex.org/W2131353762","https://openalex.org/W2132663081","https://openalex.org/W2134570303","https://openalex.org/W2138207315","https://openalex.org/W2140151651","https://openalex.org/W2143609157","https://openalex.org/W2144475669","https://openalex.org/W2148067829","https://openalex.org/W2149801449","https://openalex.org/W2150119287","https://openalex.org/W2152978370","https://openalex.org/W2156271214","https://openalex.org/W2157107389","https://openalex.org/W2157473561","https://openalex.org/W2157569508","https://openalex.org/W2158198131","https://openalex.org/W2159457641","https://openalex.org/W2159694093","https://openalex.org/W2160554488","https://openalex.org/W2161180045","https://openalex.org/W2161560597","https://openalex.org/W2168301435","https://openalex.org/W2168874564","https://openalex.org/W2168989126","https://openalex.org/W2190152688","https://openalex.org/W2280718905","https://openalex.org/W2343892901"],"related_works":["https://openalex.org/W6980969151","https://openalex.org/W2006440275","https://openalex.org/W1977892990","https://openalex.org/W2157252661","https://openalex.org/W1968713515","https://openalex.org/W2042792856","https://openalex.org/W1974652468","https://openalex.org/W2168989126","https://openalex.org/W2029995817","https://openalex.org/W1980476380"],"abstract_inverted_index":{"Porphyromonas":[0],"gingivalis":[1,22,46],"produces":[2],"proteases":[3,43],"capable":[4],"of":[5],"degrading":[6],"cytokines,":[7],"host":[8],"heme":[9],"proteins,":[10],"and":[11,33,49],"some":[12],"antimicrobial":[13],"peptides.":[14],"In":[15],"this":[16,50],"work,":[17],"I":[18],"show":[19],"that":[20,42],"P.":[21,45],"culture":[23],"supernatants":[24],"fully":[25],"or":[26],"partially":[27],"degrade":[28,47],"human":[29,34],"neutrophil":[30],"peptide":[31],"alpha-defensins":[32],"beta-defensins":[35],"after":[36],"30":[37],"minutes.":[38],"This":[39],"observation":[40],"suggests":[41],"from":[44],"defensins":[48],"activity":[51],"could":[52],"abrogate":[53],"defensin-related":[54],"innate":[55],"immune":[56],"functions.":[57]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
