{"id":"https://openalex.org/W45029812","doi":null,"title":"Determinants of exacerbation frequency in COPD","display_name":"Determinants of exacerbation frequency in COPD","publication_year":2010,"publication_date":"2010-06-28","ids":{"openalex":"https://openalex.org/W45029812","mag":"45029812"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:20188","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/20188/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044010239","display_name":"Jennifer Kathleen Quint","orcid":"https://orcid.org/0000-0003-0149-4869","observed_orcids":["https://orcid.org/0000-0003-0149-4869"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jennifer K Quint","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0149-4869","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5044010239"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/acute-exacerbation-of-copd","display_name":"COPD exacerbations","score":0.8840000033378601},{"id":"https://openalex.org/keywords/frequent-exacerbators","display_name":"frequent exacerbators","score":0.8119999766349792},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.5419999957084656},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.6919999718666077},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6050000190734863},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.9850000143051147},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.7360000014305115},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9829999804496765},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.7699999809265137},{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.8809999823570251},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.5289999842643738},{"id":"https://openalex.org/keywords/sputum","display_name":"sputum","score":0.5899999737739563},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.7649999856948853},{"id":"https://openalex.org/keywords/endobronchial-biopsy","display_name":"bronchial biopsy","score":0.7870000004768372},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.8742738962173462},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.8627299666404724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7241035103797913},{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.5694476962089539},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4980628490447998},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45236676931381226},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43867599964141846},{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.42689359188079834},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3847349286079407},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2553333342075348},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12712615728378296},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10405421257019043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08874467015266418},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:20188","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/20188/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:45029812","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/20188/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":342,"referenced_works":["https://openalex.org/W15219517","https://openalex.org/W19198940","https://openalex.org/W163605352","https://openalex.org/W188982345","https://openalex.org/W1489649750","https://openalex.org/W1508470956","https://openalex.org/W1509525329","https://openalex.org/W1512185800","https://openalex.org/W1571712967","https://openalex.org/W1575652676","https://openalex.org/W1595955343","https://openalex.org/W1607601839","https://openalex.org/W1640024993","https://openalex.org/W1727599135","https://openalex.org/W1776775909","https://openalex.org/W1873207088","https://openalex.org/W1907868111","https://openalex.org/W1920721512","https://openalex.org/W1933597658","https://openalex.org/W1964519011","https://openalex.org/W1966224713","https://openalex.org/W1966416156","https://openalex.org/W1966637039","https://openalex.org/W1967095109","https://openalex.org/W1968282511","https://openalex.org/W1970094565","https://openalex.org/W1970194636","https://openalex.org/W1972148439","https://openalex.org/W1972512435","https://openalex.org/W1973588393","https://openalex.org/W1973742535","https://openalex.org/W1974786556","https://openalex.org/W1975184169","https://openalex.org/W1975317389","https://openalex.org/W1976271106","https://openalex.org/W1979518810","https://openalex.org/W1980829155","https://openalex.org/W1980875416","https://openalex.org/W1981602900","https://openalex.org/W1981681632","https://openalex.org/W1982820261","https://openalex.org/W1984086633","https://openalex.org/W1985558958","https://openalex.org/W1985626796","https://openalex.org/W1986083986","https://openalex.org/W1987404181","https://openalex.org/W1987555297","https://openalex.org/W1988008315","https://openalex.org/W1989497089","https://openalex.org/W1989501142","https://openalex.org/W1990674750","https://openalex.org/W1991265445","https://openalex.org/W1991648511","https://openalex.org/W1993396326","https://openalex.org/W1993402824","https://openalex.org/W1994258927","https://openalex.org/W1995660065","https://openalex.org/W1996287932","https://openalex.org/W1997438374","https://openalex.org/W1999128589","https://openalex.org/W1999661685","https://openalex.org/W1999957902","https://openalex.org/W2000784101","https://openalex.org/W2001079134","https://openalex.org/W2001803608","https://openalex.org/W2002962300","https://openalex.org/W2003165120","https://openalex.org/W2003855023","https://openalex.org/W2004635533","https://openalex.org/W2005334676","https://openalex.org/W2005936777","https://openalex.org/W2006103746","https://openalex.org/W2007122289","https://openalex.org/W2007543639","https://openalex.org/W2009180025","https://openalex.org/W2010652028","https://openalex.org/W2012163833","https://openalex.org/W2012519534","https://openalex.org/W2012968700","https://openalex.org/W2013040399","https://openalex.org/W2013120001","https://openalex.org/W2014062301","https://openalex.org/W2014819850","https://openalex.org/W2015037737","https://openalex.org/W2015327085","https://openalex.org/W2018773303","https://openalex.org/W2018938924","https://openalex.org/W2018963759","https://openalex.org/W2019558876","https://openalex.org/W2019558888","https://openalex.org/W2020378082","https://openalex.org/W2021409342","https://openalex.org/W2021460354","https://openalex.org/W2022665256","https://openalex.org/W2022912717","https://openalex.org/W2022934710","https://openalex.org/W2026801927","https://openalex.org/W2027494943","https://openalex.org/W2027696560","https://openalex.org/W2027907793","https://openalex.org/W2028433125","https://openalex.org/W2028979096","https://openalex.org/W2029610924","https://openalex.org/W2031033693","https://openalex.org/W2033286451","https://openalex.org/W2033336070","https://openalex.org/W2034772723","https://openalex.org/W2035328265","https://openalex.org/W2035483021","https://openalex.org/W2037118583","https://openalex.org/W2037833734","https://openalex.org/W2037904353","https://openalex.org/W2038350718","https://openalex.org/W2040861245","https://openalex.org/W2040884453","https://openalex.org/W2043619238","https://openalex.org/W2044860515","https://openalex.org/W2045303683","https://openalex.org/W2045708487","https://openalex.org/W2048053168","https://openalex.org/W2048660493","https://openalex.org/W2051011390","https://openalex.org/W2051682127","https://openalex.org/W2052977441","https://openalex.org/W2053157117","https://openalex.org/W2054685659","https://openalex.org/W2055342544","https://openalex.org/W2055415548","https://openalex.org/W2056032598","https://openalex.org/W2056539055","https://openalex.org/W2057099776","https://openalex.org/W2057826604","https://openalex.org/W2062971761","https://openalex.org/W2063613980","https://openalex.org/W2064052128","https://openalex.org/W2064066776","https://openalex.org/W2064095640","https://openalex.org/W2066984712","https://openalex.org/W2067027353","https://openalex.org/W2068394637","https://openalex.org/W2069079702","https://openalex.org/W2073144273","https://openalex.org/W2073463392","https://openalex.org/W2075419054","https://openalex.org/W2075788257","https://openalex.org/W2075944120","https://openalex.org/W2077395343","https://openalex.org/W2077523026","https://openalex.org/W2078520607","https://openalex.org/W2079342260","https://openalex.org/W2079427948","https://openalex.org/W2079787591","https://openalex.org/W2080065572","https://openalex.org/W2080650328","https://openalex.org/W2082099782","https://openalex.org/W2082728971","https://openalex.org/W2084296671","https://openalex.org/W2085243564","https://openalex.org/W2085866528","https://openalex.org/W2086872426","https://openalex.org/W2089022749","https://openalex.org/W2090110893","https://openalex.org/W2090340366","https://openalex.org/W2091249799","https://openalex.org/W2092514627","https://openalex.org/W2093206323","https://openalex.org/W2093426283","https://openalex.org/W2093783163","https://openalex.org/W2094124704","https://openalex.org/W2094354458","https://openalex.org/W2095666112","https://openalex.org/W2095918859","https://openalex.org/W2096710347","https://openalex.org/W2097749677","https://openalex.org/W2097941784","https://openalex.org/W2097969332","https://openalex.org/W2098115046","https://openalex.org/W2098369481","https://openalex.org/W2098505771","https://openalex.org/W2099004448","https://openalex.org/W2100405281","https://openalex.org/W2100662719","https://openalex.org/W2101182707","https://openalex.org/W2102157578","https://openalex.org/W2102354280","https://openalex.org/W2102516680","https://openalex.org/W2103024679","https://openalex.org/W2103193127","https://openalex.org/W2103375939","https://openalex.org/W2104411528","https://openalex.org/W2105491536","https://openalex.org/W2107529421","https://openalex.org/W2107829061","https://openalex.org/W2108225039","https://openalex.org/W2108679807","https://openalex.org/W2108983987","https://openalex.org/W2110265450","https://openalex.org/W2110282870","https://openalex.org/W2110378267","https://openalex.org/W2110554565","https://openalex.org/W2110947112","https://openalex.org/W2110988425","https://openalex.org/W2112162293","https://openalex.org/W2112282811","https://openalex.org/W2112334970","https://openalex.org/W2112441234","https://openalex.org/W2112484139","https://openalex.org/W2112692443","https://openalex.org/W2112778345","https://openalex.org/W2114301704","https://openalex.org/W2115268884","https://openalex.org/W2115908657","https://openalex.org/W2115987911","https://openalex.org/W2116340286","https://openalex.org/W2116522708","https://openalex.org/W2117263637","https://openalex.org/W2117302340","https://openalex.org/W2117393897","https://openalex.org/W2117837864","https://openalex.org/W2117840930","https://openalex.org/W2117857396","https://openalex.org/W2118756794","https://openalex.org/W2118939220","https://openalex.org/W2119189176","https://openalex.org/W2119398778","https://openalex.org/W2120241921","https://openalex.org/W2120444921","https://openalex.org/W2120629366","https://openalex.org/W2120751909","https://openalex.org/W2120845288","https://openalex.org/W2120902800","https://openalex.org/W2121102190","https://openalex.org/W2121531941","https://openalex.org/W2122748935","https://openalex.org/W2123169409","https://openalex.org/W2123545513","https://openalex.org/W2124070987","https://openalex.org/W2124501756","https://openalex.org/W2124580054","https://openalex.org/W2125522165","https://openalex.org/W2125605790","https://openalex.org/W2125827623","https://openalex.org/W2125968371","https://openalex.org/W2126535440","https://openalex.org/W2127062009","https://openalex.org/W2127327473","https://openalex.org/W2127820302","https://openalex.org/W2127951128","https://openalex.org/W2128042779","https://openalex.org/W2128252542","https://openalex.org/W2128723998","https://openalex.org/W2128833564","https://openalex.org/W2129724566","https://openalex.org/W2130462780","https://openalex.org/W2131446449","https://openalex.org/W2131454732","https://openalex.org/W2131829840","https://openalex.org/W2132704570","https://openalex.org/W2132880751","https://openalex.org/W2133119676","https://openalex.org/W2135007745","https://openalex.org/W2135374245","https://openalex.org/W2135435097","https://openalex.org/W2136335199","https://openalex.org/W2136593482","https://openalex.org/W2136789440","https://openalex.org/W2137240228","https://openalex.org/W2137266781","https://openalex.org/W2137355020","https://openalex.org/W2137754661","https://openalex.org/W2137890862","https://openalex.org/W2137969357","https://openalex.org/W2138610809","https://openalex.org/W2138695842","https://openalex.org/W2139415488","https://openalex.org/W2140264378","https://openalex.org/W2140971802","https://openalex.org/W2141620979","https://openalex.org/W2141885489","https://openalex.org/W2142284998","https://openalex.org/W2142724633","https://openalex.org/W2142910120","https://openalex.org/W2143341326","https://openalex.org/W2143550118","https://openalex.org/W2143891168","https://openalex.org/W2144400988","https://openalex.org/W2144766427","https://openalex.org/W2144792692","https://openalex.org/W2145466675","https://openalex.org/W2145964444","https://openalex.org/W2146257741","https://openalex.org/W2146323311","https://openalex.org/W2146660032","https://openalex.org/W2146831688","https://openalex.org/W2147064547","https://openalex.org/W2147404147","https://openalex.org/W2148562709","https://openalex.org/W2149297476","https://openalex.org/W2149849734","https://openalex.org/W2150311411","https://openalex.org/W2151518917","https://openalex.org/W2151757809","https://openalex.org/W2152132747","https://openalex.org/W2152443104","https://openalex.org/W2153483837","https://openalex.org/W2153971243","https://openalex.org/W2154098294","https://openalex.org/W2155171964","https://openalex.org/W2155172180","https://openalex.org/W2155228191","https://openalex.org/W2155341981","https://openalex.org/W2155523942","https://openalex.org/W2155665090","https://openalex.org/W2155845033","https://openalex.org/W2156958204","https://openalex.org/W2158651030","https://openalex.org/W2159803589","https://openalex.org/W2160050642","https://openalex.org/W2160067099","https://openalex.org/W2160443208","https://openalex.org/W2160585439","https://openalex.org/W2161162490","https://openalex.org/W2162340140","https://openalex.org/W2162918753","https://openalex.org/W2164597973","https://openalex.org/W2166432084","https://openalex.org/W2168347562","https://openalex.org/W2169896557","https://openalex.org/W2170814415","https://openalex.org/W2171066639","https://openalex.org/W2172098606","https://openalex.org/W2181887661","https://openalex.org/W2299801952","https://openalex.org/W2313510870","https://openalex.org/W2317936986","https://openalex.org/W2326755306","https://openalex.org/W2333081132","https://openalex.org/W2410103014","https://openalex.org/W2415159896","https://openalex.org/W2744987950","https://openalex.org/W2745254043","https://openalex.org/W3215119582"],"related_works":["https://openalex.org/W2041092088","https://openalex.org/W2991618326","https://openalex.org/W2952884403","https://openalex.org/W2765326832","https://openalex.org/W2906682362","https://openalex.org/W2772694277","https://openalex.org/W2104105274","https://openalex.org/W3025352392","https://openalex.org/W2522002951","https://openalex.org/W2126416499"],"abstract_inverted_index":{"Background:":[0],"Chronic":[1],"obstructive":[2],"pulmonary":[3],"disease":[4,19,247],"(COPD)":[5],"is":[6,20,234],"a":[7,67],"heterogeneous":[8],"collection":[9],"of":[10,25,43,52,70,75,138,239],"conditions":[11],"characterized":[12],"by":[13],"irreversible":[14],"expiratory":[15],"airflow":[16],"limitation.":[17],"The":[18,228],"interspersed":[21],"with":[22,245],"exacerbations;":[23],"periods":[24],"acute":[26],"symptomatic,":[27],"physiological":[28],"and":[29,57,72,104,113,116,124,134,148,164,176,206,242],"functional":[30],"deterioration.":[31],"There":[32,185,233],"are":[33,66],"large":[34],"differences":[35,210],"in":[36,92,95,120,168,189,196,211],"yearly":[37],"exacerbation":[38,80,153,240],"incidence":[39],"rates":[40],"between":[41,204,223],"patients":[42,99,139,161],"similar":[44],"COPD":[45,88],"severity":[46],"giving":[47],"rise":[48],"to":[49,107,158,179],"the":[50,76,86,93,108,121,224],"concept":[51],"two":[53,225],"distinct":[54,68],"phenotypes;":[55],"frequent":[56,64,163,205,229],"infrequent":[58,165,183,207],"exacerbators.":[59,184,208],"This":[60],"thesis":[61],"hypothesizes":[62],"that":[63,78],"exacerbators":[65,166,172],"phenotype":[69,231],"COPD,":[71],"identifies":[73],"some":[74],"factors":[77],"influence":[79],"frequency.":[81],"\\nMethod:":[82],"356":[83],"individuals":[84],"from":[85],"London":[87],"cohort":[89],"were":[90,118,128,173,221],"included":[91],"analyses":[94],"different":[96],"subgroups.":[97],"All":[98],"completed":[100],"daily":[101],"diary":[102],"cards":[103],"reported":[105,152],"exacerbations":[106],"study":[109],"team":[110],"for":[111,130,144],"sampling":[112],"treatment.":[114],"Blood":[115],"sputum":[117],"collected":[119],"stable":[122],"state":[123],"at":[125],"exacerbation.":[126],"Samples":[127],"processed":[129],"cytokines,":[131],"genetic":[132,212],"polymorphisms":[133,213],"viruses.":[135],"A":[136],"subset":[137],"also":[140],"had":[141],"endobronchial":[142],"biopsies":[143],"epithelial":[145],"cell":[146],"work":[147],"immunohistochemistry.":[149],"\\nResults:":[150],"Patient":[151],"frequency":[154],"can":[155],"be":[156,180],"used":[157],"accurately":[159],"stratify":[160],"into":[162],"groups":[167],"subsequent":[169],"years.":[170],"Frequent":[171],"more":[174,177],"depressed":[175],"likely":[178],"female":[181],"then":[182],"was":[186],"no":[187],"difference":[188],"social":[190],"contacts,":[191],"HRV":[192],"positivity":[193],"or":[194,201],"load":[195],"sputum,":[197],"Vitamin":[198],"D":[199],"levels,":[200],"cytokine":[202],"variability":[203],"No":[209],"(ICAM-1,":[214],"IL-6,":[215],"IL-8,":[216],"VDR,":[217],"Taq1":[218],"\u03b11":[219],"\u2013antitrypsin)":[220],"identified":[222],"groups.":[226],"\\nConclusions:":[227],"exacerbator":[230],"exists.":[232],"not":[235],"one":[236],"single":[237],"determinant":[238],"frequency,":[241],"determinants":[243],"vary":[244],"underlying":[246],"severity.":[248]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}