{"id":"https://openalex.org/W44971806","doi":null,"title":"THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS","display_name":"THE ROLE OF NUCLEAR RECEPTOR COACTIVATOR AIB1/SRC3 IN NORMAL AND BREAST CANCER STROMAL FUNCTIONS","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W44971806","mag":"44971806"},"language":"en","primary_location":{"id":"pmh:oai:pqdtoai.proquest.com:3505253","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3505253","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3505253","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10822/557904","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042969990","display_name":"Maram Alotaibi","orcid":"https://orcid.org/0000-0002-6383-2301","observed_orcids":["https://orcid.org/0000-0002-6383-2301"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maram Alotaibi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6383-2301","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042969990"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9315999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.019600000232458115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.01759999990463257,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nuclear-receptor-coactivators","display_name":"nuclear receptor coactivators","score":0.8769999742507935},{"id":"https://openalex.org/keywords/breast-cancer-stroma","display_name":"breast cancer stroma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.871999979019165},{"id":"https://openalex.org/keywords/fgf2-signaling","display_name":"FGF2 signaling","score":0.8240000009536743},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.6650000214576721},{"id":"https://openalex.org/keywords/epithelial-stromal-crosstalk","display_name":"stromal-epithelial crosstalk","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mammary-tumors","display_name":"mammary tumors","score":0.6980000138282776},{"id":"https://openalex.org/keywords/fgf10","display_name":"FGF10","score":0.6100000143051147},{"id":"https://openalex.org/keywords/fgfr2b","display_name":"FGFR2b","score":0.6510000228881836},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.7540000081062317},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C203966977","wikidata":"https://www.wikidata.org/wiki/Q14914599","display_name":"Nuclear receptor coactivator 3","level":5,"score":0.8911041021347046},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.836193323135376},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7075647711753845},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.5118722319602966},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.48410308361053467},{"id":"https://openalex.org/C124170894","wikidata":"https://www.wikidata.org/wiki/Q14914591","display_name":"Nuclear receptor coactivator 2","level":5,"score":0.48218193650245667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42874765396118164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41642600297927856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39826610684394836},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3588736057281494},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.341578871011734},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2928895056247711},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.08652624487876892},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08476510643959045},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07651317119598389},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.05773618817329407}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pqdtoai.proquest.com:3505253","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3505253","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=3505253","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:repository.library.georgetown.edu:10822/557904","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10822/557904","pdf_url":"http://hdl.handle.net/10822/557904","source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tumor Biology","raw_type":"thesis"},{"id":"mag:44971806","doi":null,"is_oa":false,"landing_page_url":"https://repository.library.georgetown.edu/handle/10822/557904","pdf_url":null,"source":{"id":"https://openalex.org/S2764685317","display_name":"Georgetown University-Graduate School of Arts & Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4323970070","host_organization_name":"Georgetown University","host_organization_lineage":["https://openalex.org/P4323970070"],"host_organization_lineage_names":["Georgetown University"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Georgetown University-Graduate School of Arts & Sciences","raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.library.georgetown.edu:10822/557904","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10822/557904","pdf_url":"http://hdl.handle.net/10822/557904","source":{"id":"https://openalex.org/S4306402467","display_name":"DigitalGeorgetown (Georgetown University Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210145449","host_organization_name":"Center for Security and Emerging Technology","host_organization_lineage":["https://openalex.org/I4210145449"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tumor Biology","raw_type":"thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W44971806.pdf","grobid_xml":"https://content.openalex.org/works/W44971806.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1493268813","https://openalex.org/W1495287184","https://openalex.org/W1573363574","https://openalex.org/W1591852023","https://openalex.org/W1613446635","https://openalex.org/W1783580437","https://openalex.org/W1906108187","https://openalex.org/W1922704711","https://openalex.org/W1966972759","https://openalex.org/W1967060514","https://openalex.org/W1967468131","https://openalex.org/W1969481087","https://openalex.org/W1973759139","https://openalex.org/W1975545468","https://openalex.org/W1977027014","https://openalex.org/W1978893041","https://openalex.org/W1981022538","https://openalex.org/W1989021197","https://openalex.org/W1990529844","https://openalex.org/W1995461379","https://openalex.org/W1996454474","https://openalex.org/W1996825254","https://openalex.org/W1997941797","https://openalex.org/W1999563094","https://openalex.org/W2000307014","https://openalex.org/W2004203209","https://openalex.org/W2004459567","https://openalex.org/W2005973091","https://openalex.org/W2006181492","https://openalex.org/W2016296831","https://openalex.org/W2021012077","https://openalex.org/W2025439263","https://openalex.org/W2032769992","https://openalex.org/W2037001386","https://openalex.org/W2041016208","https://openalex.org/W2041591721","https://openalex.org/W2043852388","https://openalex.org/W2046905172","https://openalex.org/W2055861133","https://openalex.org/W2057845792","https://openalex.org/W2060128629","https://openalex.org/W2061619516","https://openalex.org/W2064956340","https://openalex.org/W2068113812","https://openalex.org/W2083416363","https://openalex.org/W2086159554","https://openalex.org/W2094465857","https://openalex.org/W2095223509","https://openalex.org/W2097134216","https://openalex.org/W2097281052","https://openalex.org/W2098752185","https://openalex.org/W2099520227","https://openalex.org/W2101546624","https://openalex.org/W2104147399","https://openalex.org/W2104200252","https://openalex.org/W2111650618","https://openalex.org/W2120483851","https://openalex.org/W2120621109","https://openalex.org/W2130201056","https://openalex.org/W2130229338","https://openalex.org/W2133244267","https://openalex.org/W2134404166","https://openalex.org/W2138662986","https://openalex.org/W2141815918","https://openalex.org/W2154453972","https://openalex.org/W2155556340","https://openalex.org/W2156016303","https://openalex.org/W2159391346","https://openalex.org/W2160240347","https://openalex.org/W2163018106","https://openalex.org/W2167787018","https://openalex.org/W2168649860","https://openalex.org/W2172256092","https://openalex.org/W2314203153","https://openalex.org/W2398689688","https://openalex.org/W4252769738"],"related_works":["https://openalex.org/W4255764289","https://openalex.org/W4247091263","https://openalex.org/W1544221717","https://openalex.org/W2098103041","https://openalex.org/W753596956","https://openalex.org/W2079149091","https://openalex.org/W171297582","https://openalex.org/W1512338825","https://openalex.org/W4230960930","https://openalex.org/W4253824244"],"abstract_inverted_index":{"The":[0,334],"nuclear":[1],"receptor":[2],"coactivator":[3],"amplified":[4],"in":[5,14,20,32,39,69,72,101,123,135,282,308,315,326,341],"breast":[6,316],"cancer":[7,21],"1":[8],"(AIB1/SRC3)":[9],"has":[10,53,322],"a":[11,56,160,171,211,323],"well-defined":[12],"role":[13,325],"steroid":[15],"and":[16,22,42,98,116,179,195,206,242,246,257,273,294,311],"growth":[17],"factor":[18],"signaling":[19,131],"normal":[23],"epithelial":[24,310],"cells.":[25],"Less":[26],"is":[27,37,268],"known":[28],"about":[29],"its":[30,152],"function":[31,91],"stromal":[33,96,312,328],"cells,":[34],"though":[35],"AIB1/SRC3":[36,60,73,88,138,143,158,180,207,283,307,321,340],"upregulated":[38],"tumor":[40,47,62,332],"stroma":[41,63,343],"may":[43],"thus":[44],"contribute":[45],"to":[46,186,270,275],"angiogenesis.":[48,300],"In":[49,76,177],"addition,":[50],"our":[51],"lab":[52],"demonstrated":[54],"previously":[55],"potential":[57],"impact":[58,146,151],"of":[59,87,92,95,108,132,170,173,215,231,239,260,289,299,306,336,339],"on":[61,89,99,129,163],"as":[64],"reduced":[65,191,237,287],"angiogenesis":[66],"was":[67],"observed":[68,127,156],"mammary":[70,331],"tumors":[71],"knockout":[74],"mice.":[75],"this":[77,202,232],"study,":[78],"we":[79,302],"report":[80],"for":[81,226],"the":[82,85,90,167,183,261,265,304,309,327,342],"first":[83],"time":[84],"effect":[86,162],"two":[93,193],"types":[94],"cells":[97,134,241],"keratinocytes":[100],"vitro.":[102],"Endothelial":[103],"cell":[104,174],"functions":[105],"including":[106],"formation":[107],"tube":[109],"like":[110],"structures,":[111],"monolayer":[112],"formation,":[113],"migration,":[114],"proliferation":[115,165],"apoptosis":[117],"were":[118,140,190,224],"all":[119],"inhibited":[120],"by":[121,192],"reduction":[122,128],"AIB1.":[124],"We":[125,154,318],"also":[126,155],"FGF2-induced":[130],"endothelial":[133],"vitro":[136],"when":[137],"levels":[139],"reduced.":[141],"Moreover,":[142],"did":[144,150,199],"not":[145,200,274],"fibroblast":[147],"proliferation,":[148],"but":[149],"migration.":[153],"that":[157,221,264,320],"had":[159],"significant":[161],"keratinocyte":[164],"through":[166],"up":[168],"regulation":[169],"number":[172],"cycle":[175],"molecules.":[176],"AIB1/SRC3+/-":[178,205],"-/-":[181,208],"mice,":[182],"angiogenic":[184],"responses":[185],"subcutaneous":[187],"Matrigel":[188],"implants":[189],"thirds":[194],"exogenously":[196],"added":[197],"FGF2":[198],"overcome":[201],"deficiency.":[203],"Furthermore,":[204],"mice":[209,285],"showed":[210,236,286],"similarly":[212],"delayed":[213,345],"healing":[214,235,267],"full-thickness":[216],"excisional":[217],"skin":[218],"wounds":[219,281],"indicating":[220],"both":[222],"alleles":[223],"required":[225],"proper":[227],"tissue":[228],"repair.":[229],"Analysis":[230],"defective":[233,266,276],"wound":[234],"recruitment":[238],"inflammatory":[240],"macrophages,":[243],"cytokine":[244],"induction":[245],"metalloprotease":[247],"activity.":[248],"Skin":[249],"grafts":[250,262],"from":[251],"animals":[252],"with":[253],"different":[254],"AIB1":[255],"genotype":[256],"subsequent":[258],"wounding":[259],"revealed":[263],"attributable":[269],"local":[271,297],"factors":[272],"bone":[277],"marrow":[278],"responses.":[279],"Indeed,":[280],"+/-":[284],"expression":[288],"FGF10,":[290],"FGFBP3,":[291],"FGFR1,":[292],"FGFR2b":[293],"FGFR3,":[295],"major":[296],"drivers":[298],"Further,":[301],"examined":[303],"influence":[305],"cross":[313],"talk":[314],"cancer.":[317],"reported":[319],"critical":[324],"compartment":[329],"during":[330],"development.":[333],"loss":[335],"one":[337],"allele":[338],"significantly":[344],"tumorigenesis.":[346]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
