{"id":"https://openalex.org/W44917060","doi":null,"title":"Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments.","display_name":"Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments.","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W44917060","mag":"44917060","pmid":"https://pubmed.ncbi.nlm.nih.gov/9286278"},"language":"en","primary_location":{"id":"pmid:9286278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9286278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"X Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X Guo","raw_affiliation_strings":["Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036867662","display_name":"Abboud J. Ghalayini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A J Ghalayini","raw_affiliation_strings":["Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"H Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Chen","raw_affiliation_strings":["Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111439830","display_name":"Robert E. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R E Anderson","raw_affiliation_strings":["Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, USA","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I49332381"],"apc_list":null,"apc_paid":null,"fwci":0.5624,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.60624932,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"38","issue":"9","first_page":"1873","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.6323000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.17569999396800995,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.07970000058412552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rod-outer-segments","display_name":"rod outer segments","score":0.8619999885559082},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.875},{"id":"https://openalex.org/keywords/light-adaptation","display_name":"light adaptation","score":0.531000018119812},{"id":"https://openalex.org/keywords/p85-regulatory-subunit","display_name":"p85 regulatory subunit","score":0.7620000243186951},{"id":"https://openalex.org/keywords/p110-catalytic-subunit","display_name":"p110 catalytic subunit","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":0.6840000152587891},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-phosphate","display_name":"phosphatidylinositol 3-phosphate","score":0.7609999775886536},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-4-bisphosphate","display_name":"phosphatidylinositol 3,4-bisphosphate","score":0.9079999923706055},{"id":"https://openalex.org/keywords/retinal-membranes","display_name":"retinal membranes","score":0.367000013589859},{"id":"https://openalex.org/keywords/bovine-retina","display_name":"bovine retina","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.8399238586425781},{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.7997215390205383},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6944648027420044},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.661112904548645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5603287816047668},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.5312820672988892},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.5206724405288696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5123163461685181},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.5076178312301636},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40965986251831055},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3548611104488373},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13430488109588623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003623","descriptor_name":"Dark Adaptation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010775","descriptor_name":"Photic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010786","descriptor_name":"Photoreceptor Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9286278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9286278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:44917060","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9286278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5509712900","display_name":"Second Messengers in the Retina","funder_award_id":"R01EY000871","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G781448320","display_name":"Lipid Metabolism in the Retina","funder_award_id":"R01EY004149","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1509623942","https://openalex.org/W1549868924","https://openalex.org/W1974014017","https://openalex.org/W1975642651","https://openalex.org/W1997772006","https://openalex.org/W2005536723","https://openalex.org/W2017499074","https://openalex.org/W2038816853","https://openalex.org/W2063117678","https://openalex.org/W2088532612"],"related_works":["https://openalex.org/W1978053922","https://openalex.org/W2467054703","https://openalex.org/W2070468104","https://openalex.org/W2131029602","https://openalex.org/W2002441761","https://openalex.org/W107785049","https://openalex.org/W2409004740","https://openalex.org/W1968716331","https://openalex.org/W2409187892","https://openalex.org/W1968886069"],"abstract_inverted_index":{"PURPOSE:":[0],"Phosphatidylinositol":[1],"3-kinase":[2,29,99,126,150,221],"(PI":[3],"3-kinase)":[4],"plays":[5],"important":[6],"roles":[7],"in":[8,20,32,81,100,123,152,179,182,224,236],"mitogenesis,":[9],"vesicular":[10],"trafficking,":[11],"actin":[12],"rearrangement,":[13],"and":[14,36,48,60,84,102,119,135,200,210,229],"prevention":[15],"of":[16,74,97,109,117,144,163,186,198,206],"apoptotic":[17],"cell":[18],"death":[19],"nonocular":[21],"tissues.":[22],"This":[23],"investigation":[24],"looked":[25],"for":[26],"whether":[27],"PI":[28,75,98,125,132,149,164,220],"is":[30,222],"present":[31,223],"bovine":[33,58,225],"rod":[34,51,226],"photoreceptors":[35],"if":[37],"light":[38],"has":[39],"any":[40,216],"effect":[41],"on":[42,203],"its":[43,230],"activity.":[44],"METHODS:":[45],"Bleached":[46],"(BROS)":[47],"dark-adapted":[49],"(DROS)":[50],"outer":[52,227],"segments":[53,228],"were":[54,88],"prepared":[55],"from":[56],"frozen":[57],"retinas":[59],"immunoblotted":[61],"or":[62,70],"immunoprecipitated":[63,127],"with":[64],"antibodies":[65],"against":[66],"the":[67,82,85,115,145,193],"regulatory":[68],"(p85)":[69],"catalytic":[71],"(p110)":[72],"subunits":[73],"3-kinase.":[76],"Kinase":[77],"activity":[78,151,175,231],"was":[79,105,156],"measured":[80],"immunoprecipitates":[83],"reaction":[86],"products":[87],"identified":[89],"by":[90,107,128,141],"high-performance":[91],"liquid":[92],"chromatography":[93],"(HPLC).":[94],"The":[95,148,184],"amount":[96],"membrane":[101],"cytosol":[103,191,212],"fractions":[104],"determined":[106,140],"densitometry":[108],"immunoblots.":[110],"RESULTS:":[111],"Immunoblot":[112],"analysis":[113,143],"showed":[114,174],"presence":[116],"85":[118],"110":[120],"kDa":[121],"proteins":[122],"ROS.":[124],"anti-p85":[129,199],"antibody":[130],"converted":[131],"to":[133,137,158,233],"PI-3-P":[134],"PI-4-P":[136],"PI-3,4-P2,":[138],"as":[139,177,181],"HPLC":[142],"deacylated":[146],"products.":[147],"these":[153],"ROS":[154,187,208,211],"preparations":[155],"sensitive":[157],"wortmannin,":[159],"a":[160],"potent":[161],"inhibitor":[162],"3-kinase,":[165],"at":[166],"low":[167],"concentrations":[168],"(IC50":[169],"3":[170],"nM).":[171],"Immunoprecipitates":[172],"(IPs)":[173],"twice":[176],"high":[178],"BROS":[180],"DROS.":[183],"IPs":[185],"membranes":[188],"but":[189],"not":[190,214],"maintained":[192],"light-dark":[194,217],"difference.":[195],"However,":[196],"measurement":[197],"anti-p110":[201],"immunoreactivities":[202],"western":[204],"blots":[205],"ROS,":[207],"membranes,":[209],"did":[213],"show":[215],"differences.":[218],"CONCLUSIONS:":[219],"appears":[232],"be":[234],"greater":[235],"light-adapted":[237],"retinas.":[238]},"counts_by_year":[{"year":2020,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
