{"id":"https://openalex.org/W44847642","doi":null,"title":"Immune insulitis and antibodies to nucleic acids induced with streptozotocin in mice.","display_name":"Immune insulitis and antibodies to nucleic acids induced with streptozotocin in mice.","publication_year":1981,"publication_date":"1981-02-01","ids":{"openalex":"https://openalex.org/W44847642","mag":"44847642","pmid":"https://pubmed.ncbi.nlm.nih.gov/6456098","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1537273"},"language":"en","primary_location":{"id":"pmid:6456098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6456098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1537273/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102720092","display_name":"Shaohua Huang","orcid":"https://orcid.org/0000-0002-7400-4632","observed_orcids":["https://orcid.org/0000-0002-7400-4632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S W Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113572667","display_name":"G. E. Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G E Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2035,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.44056692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"43","issue":"2","first_page":"425","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9120000004768372},{"id":"https://openalex.org/keywords/anti-ssdna-antibodies","display_name":"anti-ssDNA antibodies","score":0.597000002861023},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.9449999928474426},{"id":"https://openalex.org/keywords/islet-necrosis","display_name":"islet necrosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/mononuclear-cell-infiltration","display_name":"mononuclear cell infiltration","score":0.9290000200271606},{"id":"https://openalex.org/keywords/igg-deposition","display_name":"IgG deposition","score":0.8500000238418579},{"id":"https://openalex.org/keywords/type-1-diabetes-pathogenesis","display_name":"type 1 diabetes pathogenesis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/cd-1-mice","display_name":"ICR mice","score":0.6949999928474426},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2779511750","wikidata":"https://www.wikidata.org/wiki/Q922215","display_name":"Insulitis","level":4,"score":0.8373844027519226},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.6911100745201111},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5980006456375122},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5946383476257324},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5749204158782959},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5665448307991028},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5091795325279236},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.4932951331138611},{"id":"https://openalex.org/C167464567","wikidata":"https://www.wikidata.org/wiki/Q1775422","display_name":"Mononuclear cell infiltration","level":2,"score":0.45142096281051636},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.44650107622146606},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.4262602627277374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4137662947177887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32428160309791565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3182438611984253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11778345704078674}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000974","descriptor_name":"Antibodies, Antinuclear","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006943","descriptor_name":"Hyperglycemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013311","descriptor_name":"Streptozocin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:6456098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6456098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:1537273","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1537273/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"mag:44847642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6456098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1537273","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1537273/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W105060213","https://openalex.org/W193370619","https://openalex.org/W1989215599","https://openalex.org/W1995464415","https://openalex.org/W1997395929","https://openalex.org/W2010357177","https://openalex.org/W2019972832","https://openalex.org/W2033541880","https://openalex.org/W2046121022","https://openalex.org/W2054497664","https://openalex.org/W2090815691","https://openalex.org/W2118924566","https://openalex.org/W2416979810"],"related_works":["https://openalex.org/W2085146512","https://openalex.org/W105060213","https://openalex.org/W2161433268","https://openalex.org/W96982265","https://openalex.org/W1995464415","https://openalex.org/W7132358307","https://openalex.org/W1983469557","https://openalex.org/W1974222593","https://openalex.org/W2058082646","https://openalex.org/W2126871960"],"abstract_inverted_index":{"Streptozotocin":[0],"(STZ),":[1],"a":[2,9,14,21],"known":[3],"beta":[4],"cell":[5,115],"toxin,":[6],"given":[7],"in":[8,95,124,150,155,161,165,173,200,219,231,242],"single":[10],"injection":[11],"of":[12,51,64,74,82,93,103,110,121,130,146,152,158,171,183,240,245,248],"either":[13],"high":[15],"(100":[16],"mg/kg":[17,25],"body":[18,26],"weight)":[19,27],"or":[20,210],"low":[22],"dose":[23],"(60":[24],"to":[28,40,167,185,206,225],"young":[29],"(45":[30],"days":[31,79],"old)":[32],"CD-I":[33],"mice":[34,123,160],"induced":[35],"permanent":[36],"hyperglycaemia":[37,75],"which":[38],"led":[39],"insulin-dependent":[41],"diabetes":[42],"(IDD).":[43],"Further":[44],"study,":[45],"however,":[46],"revealed":[47],"that":[48,81],"the":[49,52,58,65,72,83,96,104,125,144,153,162,174,201,207,217,220,243,246],"course":[50],"disease":[53],"was":[54,76,86,148,197],"strikingly":[55],"different":[56],"between":[57],"groups.":[59],"The":[60,181],"average":[61],"latent":[62],"period":[63],"high-dose":[66,97,175,208],"group":[67,85,98,127,176,203,209,222],"(n":[68,89],"=":[69,90],"20)":[70],"before":[71],"development":[73],"only":[77,107,168],"3":[78],"while":[80],"low-dose":[84,126,163,202,221],"7":[87],"weeks":[88],"30).":[91],"Islets":[92],"pancreas":[94],"showed":[99],"extensive":[100],"acute":[101],"necrosis":[102],"islets":[105,132,154],"with":[106,135,233],"two":[108,169],"out":[109,120,157,170],"20":[111,119,172],"showing":[112],"limited":[113],"mononuclear":[114,136],"infiltration.":[116],"In":[117,142],"contrast,":[118],"30":[122,159],"had":[128],"45%":[129],"their":[131],"heavily":[133],"infiltrated":[134],"cells":[137],"(P":[138,177,212],"less":[139,178,213],"than":[140,179,214],"0.001).":[141],"addition,":[143],"deposition":[145],"IgG":[147],"found":[149],"40%":[151],"23":[156],"group,":[164],"contrast":[166],"0.005).":[180],"incidence":[182],"antibody":[184,196],"nucleic":[186],"acids,":[187],"polyadenylic-polyuridylic":[188],"acid,":[189,191],"polyinosinic-polycytidylic":[190],"single-stranded":[192],"DNA":[193],"and":[194,227],"anti-nuclear":[195],"significantly":[198],"higher":[199],"as":[204],"compared":[205],"controls":[211],"0.01).":[215],"Since":[216],"findings":[218],"are":[223],"similar":[224],"pathological":[226],"serological":[228],"changes":[229],"reported":[230],"man":[232],"recent-onset":[234],"IDD,":[235],"this":[236,249],"model":[237],"should":[238],"be":[239],"value":[241],"study":[244],"pathogenesis":[247],"disease.":[250]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}