{"id":"https://openalex.org/W44812467","doi":null,"title":"Structure, fonctions et localisation gonadique de l'aromatase equine","display_name":"Structure, fonctions et localisation gonadique de l'aromatase equine","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W44812467","mag":"44812467"},"language":"fr","primary_location":{"id":"mag:44812467","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/1995CAEN2040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"parent_works":[],"lineage":["https://openalex.org/W44812467"],"child_works_count":0,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073692544","display_name":"Jamal Almadhidi","orcid":"https://orcid.org/0000-0002-5258-3354","observed_orcids":["https://orcid.org/0000-0002-5258-3354"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jamal Almadhidi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5258-3354","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073692544"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0333000011742115,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13736","display_name":"Steroid Chemistry and Biochemistry","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nadph-cytochrome-p450-reductase","display_name":"NADPH-cytochrome P450 reductase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/enzyme-purification","display_name":"enzyme purification","score":0.4749999940395355},{"id":"https://openalex.org/keywords/deglycosylation","display_name":"deglycosylation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/polyclonal-antibodies","display_name":"polyclonal antibodies","score":0.7900000214576721},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.9070000052452087},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.925000011920929},{"id":"https://openalex.org/keywords/cryptorchidism","display_name":"cryptorchidism","score":0.7229999899864197},{"id":"https://openalex.org/keywords/ovary","display_name":"ovary","score":0.6859999895095825},{"id":"https://openalex.org/keywords/granulosa-cells","display_name":"granulosa cells","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.760048508644104},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7109345197677612},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4703251123428345},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34705376625061035},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.33054548501968384},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15192925930023193},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04430398344993591},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:44812467","doi":null,"is_oa":false,"landing_page_url":"https://www.theses.fr/1995CAEN2040","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W368598872","https://openalex.org/W31688679","https://openalex.org/W108346784","https://openalex.org/W2074217002","https://openalex.org/W2049597845","https://openalex.org/W847724726","https://openalex.org/W420543160","https://openalex.org/W2470120799","https://openalex.org/W2048006553","https://openalex.org/W151806806"],"abstract_inverted_index":{"L'aromatase":[0],"est":[1,24],"un":[2],"complexe":[3],"enzymatique":[4],"responsable":[5],"de":[6,17,31,42,72,77,79,99,153,170,191,211,231,234,247,254],"la":[7,50,69,164,167,180,227,232,255],"biosynthese":[8],"des":[9,13,83,112,142],"estrogenes":[10,113],"a":[11,21,119],"partir":[12],"androgenes.":[14],"La":[15,62],"purification":[16],"l'aromatase":[18,80,171],"testiculaire":[19],"equine":[20],"montre":[22,120],"qu'elle":[23],"constituee":[25],"d'une":[26],"nadph-cytochrome":[27],"p450":[28],"reductase":[29],"(reductase)":[30],"82":[32],"kda":[33,44],"apparemment":[34],"non":[35],"glycosylee":[36,45],"et":[37,68,82,151],"d'un":[38],"cytochrome":[39],"p450arom":[40],"(p450arom)":[41],"53":[43],"(de":[46],"2":[47],"kda).":[48],"Cependant,":[49],"deglycosylation":[51],"n'a":[52],"pas":[53,258],"affecte":[54],"son":[55],"activite":[56],"d'aromatisation":[57],"par":[58,126,148,159],"rapport":[59,127],"au":[60],"temoin.":[61],"composition":[63],"en":[64,90,97,114],"acides":[65],"amines":[66],"globale":[67],"sequence":[70],"n-terminale":[71],"l'ep450arom":[73,96,105,137],"sont":[74,213,220,265],"tres":[75,214],"proches":[76],"celle":[78],"humaine":[81],"autres":[84,219],"cytochromes":[85],"p450.":[86],"Nous":[87,156],"avons":[88,157],"mis":[89],"evidence":[91],"une":[92,121,160,238],"autre":[93],"fonction":[94,101],"pour":[95,124,163],"plus":[98],"sa":[100],"essentielle":[102],"dans":[103,172,184,244],"l'aromatisation,":[104],"apparait":[106],"catalyser":[107],"comme":[108],"chez":[109,141],"l'homme":[110],"l'hydroxylation":[111],"catecholestrogenes":[115],"in":[116],"vitro.":[117],"L'ep450arom":[118],"faible":[122,239],"affinite":[123],"l'estradiol":[125],"aux":[128],"substrats":[129],"androgeniques.":[130],"Des":[131],"anticorps":[132],"polyclonaux":[133],"specifiques":[134],"diriges":[135],"contre":[136],"ont":[138,145],"ete":[139,146],"produits":[140],"lapins.":[143],"Ils":[144],"testes":[147],"elisa,":[149],"immunoblot":[150],"inhibition":[152],"l'activite":[154],"aromatase.":[155],"etudie":[158],"technique":[161],"immunohistochimique,":[162],"premiere":[165],"fois,":[166],"distribution":[168],"cellulaire":[169],"les":[173,177,189,195,218,229,245,252],"gonades":[174],"equines.":[175],"Dans":[176,200],"testicules":[178],"normaux,":[179],"fluorescence":[181],"se":[182],"concentre":[183],"le":[185,201],"tissu":[186],"interstitiel":[187],"comprenant":[188],"cellules":[190,210,230,246,253,261],"leydig":[192,212],"tandis":[193],"que":[194,217,251],"tubules":[196],"seminiferes":[197],"apparaissent":[198],"negatifs.":[199],"testicule":[202],"abdominal":[203],"du":[204,262],"cheval":[205],"cryptorchide":[206],"etudie,":[207],"seules":[208],"quelques":[209],"positives":[215],"alors":[216,250],"soit":[221,224],"faiblement":[222],"reactives,":[223],"negatives.":[225],"Chez":[226],"jument,":[228],"granulosa":[233],"petit":[235],"follicule":[236],"presentent":[237],"reaction":[240],"positive":[241],"qui":[242],"s'intensifie":[243],"grand":[248],"follicule,":[249],"theque":[256],"n'apparaissent":[257],"fluorescentes.":[259],"Les":[260],"corps":[263],"jaune":[264],"toutes":[266],"fortement":[267],"immunoreactives":[268]},"counts_by_year":[],"updated_date":"2025-11-06T04:12:42.849631","created_date":"2016-06-24T00:00:00"}