{"id":"https://openalex.org/W44728641","doi":"https://doi.org/10.1152/ajpheart.1999.277.1.h50","title":"Oxygen delivery does not limit cardiac performance during high work states","display_name":"Oxygen delivery does not limit cardiac performance during high work states","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W44728641","doi":"https://doi.org/10.1152/ajpheart.1999.277.1.h50","mag":"44728641","pmid":"https://pubmed.ncbi.nlm.nih.gov/10409181"},"language":"en","primary_location":{"id":"doi:10.1152/ajpheart.1999.277.1.h50","doi":"https://doi.org/10.1152/ajpheart.1999.277.1.h50","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1999.277.1.h50","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030985040","display_name":"Jianyi Jay Zhang","orcid":"https://orcid.org/0000-0002-3955-6554","observed_orcids":["https://orcid.org/0000-0002-3955-6554"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianyi Zhang","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110067870","display_name":"Yo Murakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yo Murakami","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100388018","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0001-5263-5823","observed_orcids":["https://orcid.org/0000-0001-5263-5823"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103392217","display_name":"Yong Kwon Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yong K Cho","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675695","display_name":"Yun Ye","orcid":"https://orcid.org/0000-0002-0286-7359","observed_orcids":["https://orcid.org/0000-0002-0286-7359"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Ye","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050687867","display_name":"Guangrong Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangrong Gong","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088329368","display_name":"Robert J. Bache","orcid":"https://orcid.org/0000-0003-3988-0677","observed_orcids":["https://orcid.org/0000-0003-3988-0677"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert J. Bache","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054800712","display_name":"K\u01cemil U\u01e7urbil","orcid":"https://orcid.org/0000-0002-8475-9334","observed_orcids":["https://orcid.org/0000-0002-8475-9334"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K\u00e2mil U\u011furbil","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112682244","display_name":"Arthur H. L. From","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4210140408","display_name":"Minneapolis VA Medical Center","ror":"https://ror.org/032b8d361","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210117246","https://openalex.org/I4210117924","https://openalex.org/I4210140408"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur H. L. From","raw_affiliation_strings":["Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Biochemistry, Radiology, and the Center for Magnetic Resonance Research, University of Minnesota Health Sciences Center, Minneapolis 55455; and Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4210140408"]},{"raw_affiliation_string":"Department of Veterans Affairs Medical Center, Minneapolis, Minnesota 55417","institution_ids":["https://openalex.org/I4210140408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5423,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.8815425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"277","issue":"1","first_page":"H50","last_page":"H57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.3158999979496002,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.13500000536441803,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.10989999771118164,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocardial-oxygenation","display_name":"myocardial oxygenation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/high-energy-phosphates","display_name":"high-energy phosphates","score":0.847000002861023},{"id":"https://openalex.org/keywords/phosphocreatine","display_name":"phosphocreatine","score":0.7979999780654907},{"id":"https://openalex.org/keywords/myocardial-energy-metabolism","display_name":"myocardial energy metabolism","score":0.5720000267028809},{"id":"https://openalex.org/keywords/deoxymyoglobin","display_name":"deoxymyoglobin","score":0.746999979019165},{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.5730000138282776},{"id":"https://openalex.org/keywords/coronary-stenosis","display_name":"coronary artery stenosis","score":0.7160000205039978},{"id":"https://openalex.org/keywords/dobutamine","display_name":"dobutamine","score":0.6480000019073486},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.8840000033378601},{"id":"https://openalex.org/keywords/oxygen-delivery","display_name":"oxygen delivery","score":0.5580000281333923},{"id":"https://openalex.org/keywords/31p-nmr-spectroscopy","display_name":"31P NMR","score":0.8130000233650208},{"id":"https://openalex.org/keywords/1h-magnetic-resonance-spectroscopy","display_name":"1H magnetic resonance spectroscopy","score":0.8560000061988831},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.699999988079071},{"id":"https://openalex.org/keywords/coronary-artery-occlusion","display_name":"coronary artery occlusion","score":0.6119999885559082},{"id":"https://openalex.org/keywords/rate-pressure-product","display_name":"rate-pressure product","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.598545253276825},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.5825434327125549},{"id":"https://openalex.org/C151201525","wikidata":"https://www.wikidata.org/wiki/Q177239","display_name":"Limit (mathematics)","level":2,"score":0.5709077715873718},{"id":"https://openalex.org/C2994142871","wikidata":"https://www.wikidata.org/wiki/Q7873","display_name":"Oxygen delivery","level":3,"score":0.5549328923225403},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.34270966053009033},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32054001092910767},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2597959637641907},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.15366780757904053},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12602448463439941},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.06319239735603333},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpheart.1999.277.1.h50","doi":"https://doi.org/10.1152/ajpheart.1999.277.1.h50","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpheart.1999.277.1.h50","pdf_url":null,"source":{"id":"https://openalex.org/S87338489","display_name":"American Journal of Physiology-Heart and Circulatory Physiology","issn_l":"0363-6135","issn":["0363-6135","1522-1539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Heart and Circulatory Physiology","raw_type":"journal-article"},{"id":"pmid:10409181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10409181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G161044043","display_name":null,"funder_award_id":"HL 33600","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G46320104","display_name":null,"funder_award_id":"HL 21872","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5212922728","display_name":null,"funder_award_id":"HL-40570","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5796549174","display_name":"Myocardial Perfusion in the Hypertrophied Heart","funder_award_id":"R01HL021872","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7777615473","display_name":"NMR STUDIES OF MYOCARDIAL METABOLISM","funder_award_id":"R01HL033600","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W253796813","https://openalex.org/W347748731","https://openalex.org/W623999939","https://openalex.org/W1662116282","https://openalex.org/W1914953015","https://openalex.org/W1931991697","https://openalex.org/W1935060748","https://openalex.org/W1994197068","https://openalex.org/W2003598390","https://openalex.org/W2015798899","https://openalex.org/W2018165658","https://openalex.org/W2033665082","https://openalex.org/W2034140315","https://openalex.org/W2046333906","https://openalex.org/W2048433042","https://openalex.org/W2053116782","https://openalex.org/W2060128407","https://openalex.org/W2074243670","https://openalex.org/W2082531877","https://openalex.org/W2087245704","https://openalex.org/W2087673691","https://openalex.org/W2094655709","https://openalex.org/W2114101618","https://openalex.org/W2122065610","https://openalex.org/W2135250420","https://openalex.org/W2139575438","https://openalex.org/W2143020642","https://openalex.org/W2150512485","https://openalex.org/W2172613969","https://openalex.org/W2175985062","https://openalex.org/W2270876567","https://openalex.org/W2291803512","https://openalex.org/W2396936483","https://openalex.org/W2403096848","https://openalex.org/W2404332614","https://openalex.org/W2408389579","https://openalex.org/W2410054595","https://openalex.org/W2411804586","https://openalex.org/W2418955264","https://openalex.org/W2467172072","https://openalex.org/W2473227467"],"related_works":["https://openalex.org/W2101317960","https://openalex.org/W2206954463","https://openalex.org/W2114000470","https://openalex.org/W2008721894","https://openalex.org/W2187968194","https://openalex.org/W2410054595","https://openalex.org/W2408872949","https://openalex.org/W2057237531","https://openalex.org/W2188166915","https://openalex.org/W2153985164"],"abstract_inverted_index":{"This":[0,150],"study":[1],"tested":[2],"the":[3,6,56,65,70,141,161,172,180,227,269,285,288,305,309,316,320],"hypothesis":[4,286],"that":[5,237,262,287],"loss":[7],"of":[8,58,67,74,107,226,246,255,271,311,318,322],"myocardial":[9,68,135,256,289],"high-energy":[10],"phosphates":[11],"(HEP),":[12],"which":[13,118],"occurs":[14],"during":[15,104,145,171,179,230,244],"high":[16,181,265,294],"cardiac":[17],"work":[18,182,266,295],"states":[19,267,296],"[J.":[20],"Zhang,":[21,28],"D.":[22],"J.":[23,45],"Duncker,":[24],"Y.":[25,27],"Xu,":[26],"G.":[29],"Path,":[30],"H.":[31,36],"Merkle,":[32],"K.":[33,42],"Hendrich,":[34],"A.":[35],"L.":[37],"From,":[38],"R.":[39],"Bache,":[40],"and":[41,103,109,134,307],"U\u011furbil.":[43],"Am.":[44],"Physiol.":[46,50],"268:":[47],"(Heart":[48],"Circ.":[49],"37):":[51],"H1891-H1905,":[52],"1995],":[53],"is":[54,239],"not":[55,275,298],"result":[57],"insufficient":[59],"intracellular":[60],"O(2)":[61,302],"availability.":[62],"To":[63],"evaluate":[64],"state":[66,174,183],"oxygenation,":[69],"proximal":[71],"histidine":[72],"signal":[73],"deoxymyoglobin":[75],"(Mb-delta)":[76],"was":[77,130,138,212],"determined":[78],"with":[79,90,277],"(1)H":[80],"nuclear":[81],"magnetic":[82],"resonance":[83,143,152],"spectroscopy":[84],"(MRS),":[85],"whereas":[86,187],"HEP":[87,201,260,290,313],"were":[88,98],"examined":[89],"(31)P":[91],"MRS.":[92],"Normal":[93],"dogs":[94],"(n":[95],"=":[96],"11)":[97],"studied":[99],"under":[100],"basal":[101,173],"conditions":[102],"combined":[105],"infusion":[106],"dobutamine":[108],"dopamine":[110],"(20":[111],"micrograms":[112],".":[113],"kg(-1).":[114],"min(-1)":[115],"iv":[116],"each),":[117],"increased":[119,189],"rate-pressure":[120],"products":[121],"to":[122,140,175,192,214,251,300,304],">50,000":[123],"mmHg.":[124],"beats.":[125],"min(-1).":[126],"Creatine":[127],"phosphate":[128],"(CP)":[129],"expressed":[131],"as":[132],"CP/ATP,":[133,220],"myoglobin":[136],"desaturation":[137],"normalized":[139],"Mb-delta":[142,151,203,221,238,280],"present":[144,229],"total":[146,231],"coronary":[147,210,232,247,272],"artery":[148],"occlusion.":[149,233],"appeared":[153],"at":[154,264,293],"71":[155],"parts":[156],"per":[157],"million":[158],"downfield":[159],"from":[160,166,190],"water":[162],"resonance.":[163,281],"CP/ATP":[164],"decreased":[165],"2.":[167],"22":[168],"+/-":[169,177,194,224],"0.12":[170],"1.83":[176],"0.09":[178],"(P":[184,196],"<":[185,197],"0.01),":[186],"DeltaP(i)/CP":[188],"0":[191],"0.21":[193],"0.04":[195],"0.01).":[198],"Despite":[199],"these":[200],"changes,":[202],"remained":[204],"undetectable.":[205],"In":[206],"contrast,":[207],"when":[208],"a":[209,216,253,278],"stenosis":[211],"applied":[213],"produce":[215],"similar":[217,259],"decrease":[218,254],"in":[219,242,268,315],"reached":[222],"0.38":[223],"0.10":[225],"value":[228],"These":[234],"data":[235],"demonstrate":[236],"readily":[240],"detected":[241],"vivo":[243],"limitation":[245],"blood":[248],"flow":[249],"sufficient":[250],"cause":[252],"CP/ATP.":[257],"However,":[258],"changes":[261,291],"occur":[263],"absence":[270,317],"occlusion":[273],"are":[274,297],"associated":[276],"detectable":[279],"The":[282],"findings":[283],"support":[284],"observed":[292],"due":[299],"inadequate":[301],"availability":[303],"mitochondria":[306],"emphasize":[308],"limitations":[310],"interpreting":[312],"alterations":[314],"knowing":[319],"level":[321],"myocyte":[323],"oxygenation.":[324]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
