{"id":"https://openalex.org/W44640728","doi":null,"title":"Insulin resistance and fertility in polycystic ovary syndrome.","display_name":"Insulin resistance and fertility in polycystic ovary syndrome.","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W44640728","mag":"44640728","pmid":"https://pubmed.ncbi.nlm.nih.gov/20108521","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3018970"},"language":"en","primary_location":{"id":"pmid:20108521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20108521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicine and life","raw_type":"Journal Article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3018970/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042340054","display_name":"Simona Vasilica Fica","orcid":"https://orcid.org/0000-0002-9676-7497","observed_orcids":["https://orcid.org/0000-0002-9676-7497"]},"institutions":[{"id":"https://openalex.org/I162051807","display_name":"Carol Davila University of Medicine and Pharmacy","ror":"https://ror.org/04fm87419","country_code":"RO","type":"education","lineage":["https://openalex.org/I162051807"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Simona Fica","raw_affiliation_strings":["Endocrinology Department, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology Department, \"Carol Davila\" University of Medicine and Pharmacy, Bucharest, Romania","institution_ids":["https://openalex.org/I162051807"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064144205","display_name":"Alice Ioana Albu","orcid":"https://orcid.org/0000-0002-5544-1212","observed_orcids":["https://orcid.org/0000-0002-5544-1212"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice Albu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048130050","display_name":"M\u0103dd\u0103lina Constantin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M\u0103dd\u0103lina Constantin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066331121","display_name":"Georgiana Alina Dobri","orcid":"https://orcid.org/0000-0001-5199-4023","observed_orcids":["https://orcid.org/0000-0001-5199-4023"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgiana Alina Dobri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0465,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.01428571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1","issue":"4","first_page":"415","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9860000014305115},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":1.0},{"id":"https://openalex.org/keywords/female-infertility","display_name":"female infertility","score":0.7599999904632568},{"id":"https://openalex.org/keywords/anovulation","display_name":"anovulation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/thiazolidinediones","display_name":"thiazolidinediones","score":0.8980000019073486},{"id":"https://openalex.org/keywords/ovulation-induction","display_name":"ovulation induction","score":0.828000009059906},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7960000038146973},{"id":"https://openalex.org/keywords/insulin-sensitizing-drugs","display_name":"insulin-sensitizing drugs","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.7200000286102295},{"id":"https://openalex.org/keywords/miscarriage","display_name":"miscarriage","score":0.6119999885559082},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.8149999976158142},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9750000238418579}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.8567763566970825},{"id":"https://openalex.org/C2780323712","wikidata":"https://www.wikidata.org/wiki/Q19484","display_name":"Metformin","level":3,"score":0.8032039403915405},{"id":"https://openalex.org/C2780853582","wikidata":"https://www.wikidata.org/wiki/Q25556","display_name":"Anovulation","level":5,"score":0.7735850811004639},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.7537685632705688},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7474377751350403},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.7194059491157532},{"id":"https://openalex.org/C2780186808","wikidata":"https://www.wikidata.org/wiki/Q10529545","display_name":"Hyperandrogenism","level":5,"score":0.7085697650909424},{"id":"https://openalex.org/C2781230225","wikidata":"https://www.wikidata.org/wiki/Q3150564","display_name":"Ovulation induction","level":4,"score":0.5216384530067444},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.47140052914619446},{"id":"https://openalex.org/C2777702977","wikidata":"https://www.wikidata.org/wiki/Q187082","display_name":"Ovulation","level":3,"score":0.44211283326148987},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.43871641159057617},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.42022591829299927},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.4151563346385956},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.41479191184043884},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3648020923137665},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35965093970298767},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.11628949642181396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11614638566970825},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.07032456994056702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077154","descriptor_name":"Rosiglitazone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D011085","descriptor_name":"Polycystic Ovary Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045162","descriptor_name":"Thiazolidinediones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:20108521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20108521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicine and life","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3018970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3018970/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Life","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.292.7889","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.292.7889","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c2/e1/J_Med_Life_2008_Nov_15_1(4)_415-422.tar.gz","raw_type":"text"},{"id":"mag:44640728","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3018970","pdf_url":null,"source":{"id":"https://openalex.org/S2755172410","display_name":"Journal of Medicine and Life","issn_l":"1844-122X","issn":["1844-122X","1844-3117"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320337","host_organization_name":"Carol Davila University of Medicine and Pharmacy Publishing House","host_organization_lineage":["https://openalex.org/P4310320337"],"host_organization_lineage_names":["Carol Davila University of Medicine and Pharmacy Publishing House"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicine and Life","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3018970","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3018970/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Life","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W90218097","https://openalex.org/W1888335775","https://openalex.org/W1970941152","https://openalex.org/W1984254712","https://openalex.org/W1984926244","https://openalex.org/W1985157643","https://openalex.org/W1991146639","https://openalex.org/W1992614785","https://openalex.org/W1994494139","https://openalex.org/W1996272298","https://openalex.org/W1996806039","https://openalex.org/W2005004639","https://openalex.org/W2014416979","https://openalex.org/W2014686801","https://openalex.org/W2015159617","https://openalex.org/W2025155805","https://openalex.org/W2025511406","https://openalex.org/W2035630142","https://openalex.org/W2037405534","https://openalex.org/W2040235690","https://openalex.org/W2042858996","https://openalex.org/W2043289274","https://openalex.org/W2070732543","https://openalex.org/W2079672855","https://openalex.org/W2081877349","https://openalex.org/W2085223433","https://openalex.org/W2088868617","https://openalex.org/W2091336289","https://openalex.org/W2093478778","https://openalex.org/W2096257807","https://openalex.org/W2109580294","https://openalex.org/W2114124243","https://openalex.org/W2114250093","https://openalex.org/W2119823280","https://openalex.org/W2123925343","https://openalex.org/W2126438731","https://openalex.org/W2137352589","https://openalex.org/W2138595862","https://openalex.org/W2147127250","https://openalex.org/W2159152234","https://openalex.org/W2159852002","https://openalex.org/W2165523894","https://openalex.org/W2166956316","https://openalex.org/W2171439516","https://openalex.org/W2240382524","https://openalex.org/W2314633857","https://openalex.org/W2328114156","https://openalex.org/W2347050486","https://openalex.org/W2418642995"],"related_works":["https://openalex.org/W1993622528","https://openalex.org/W2003449006","https://openalex.org/W115865598","https://openalex.org/W2757330944","https://openalex.org/W4387327241","https://openalex.org/W1999009046","https://openalex.org/W3186382899","https://openalex.org/W3112945068","https://openalex.org/W2361207264","https://openalex.org/W941340229"],"abstract_inverted_index":{"Polycystic":[0],"Ovary":[1],"Syndrome":[2],"(PCOS)":[3],"represents":[4],"a":[5,34,89,105,138,227],"common":[6],"endocrinopathy,":[7],"with":[8,42,65,127,142,182,250],"anovulation":[9],"and":[10,32,58,107,117,124,155,242],"hyperandrogenism":[11],"as":[12,46,88,226],"cardinal":[13],"symptoms.":[14],"In":[15,201],"recent":[16],"years":[17],"it":[18],"has":[19,69],"been":[20,70],"recognized":[21],"that":[22],"insulin":[23,63,78,83,205],"resistance":[24,64,79,206],"is":[25,40],"an":[26],"intrinsec":[27],"feature":[28],"of":[29,51,62,77,140,204,223,248],"the":[30,221,245],"disorder":[31],"plays":[33],"central":[35],"role":[36],"in":[37,80,94,114,137,177,213],"pathogenesis.":[38],"PCOS":[39,81,95,115,214],"associated":[41],"important":[43],"reproductive":[44,67,112],"morbidity":[45],"shown":[47],"by":[48],"high":[49],"prevalence":[50],"anovulatory":[52],"infertility,":[53],"spontaneous":[54],"abortion,":[55],"gestational":[56],"diabetes":[57],"preeclampsia.":[59],"The":[60],"association":[61],"this":[66,163,256],"pathology":[68],"well":[71],"documented.":[72],"Due":[73],"to":[74,103,110,121,132,171,197,209,219,238,243,253,255],"major":[75],"implication":[76],"pathogenesis,":[82],"reduction":[84,203],"strategies":[85],"were":[86],"studied":[87,162],"possible":[90],"treatment":[91,176],"for":[92,153,174,188,230],"infertility":[93,175,231],"patients.":[96],"Weight":[97],"loss,":[98],"even":[99],"modest":[100],"was":[101,130,207],"proved":[102,208],"be":[104,119],"simple":[106],"efficient":[108],"method":[109],"improve":[111],"parameters":[113],"patients":[116,126,141,249],"should":[118],"recommended":[120],"all":[122],"overweight":[123],"obese":[125],"infertility.":[128],"Metformin":[129],"showed":[131],"induce":[133],"ovulation,":[134],"at":[135],"least":[136],"subset":[139],"PCOS,":[143],"but":[144,191,216],"there":[145,166],"are":[146,167,195,232,236],"not":[147,168],"unequivocal":[148],"proves":[149],"concerning":[150],"its":[151],"efficacy":[152,187],"pregnancies":[154],"live-birth":[156],"rate,":[157],"mainly":[158],"because":[159],"few":[160],"trials":[161],"aspect.":[164],"Therefore":[165],"enough":[169],"evidences":[170,218],"recommend":[172],"metformin":[173],"PCOS.":[178],"Few":[179],"small":[180],"studies":[181,194,235],"newer":[183],"thiazolidindiones":[184],"suggest":[185],"their":[186],"ovulation":[189,211],"induction,":[190],"further":[192],"extensive":[193],"needed":[196,237],"confirm":[198],"these":[199,240],"results.":[200],"conclusion,":[202],"ameliorate":[210],"rate":[212],"patients,":[215],"strong":[217],"sustain":[220],"utility":[222],"insulin-sensitizing":[224],"drugs":[225],"therapeutic":[228],"option":[229],"lacking.":[233],"Future":[234],"elucidate":[239],"aspects":[241],"characterize":[244],"particular":[246],"subtype":[247],"higher":[251],"probability":[252],"respond":[254],"treatment.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
