{"id":"https://openalex.org/W44631927","doi":null,"title":"Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats.","display_name":"Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats.","publication_year":2004,"publication_date":"2004-03-01","ids":{"openalex":"https://openalex.org/W44631927","mag":"44631927","pmid":"https://pubmed.ncbi.nlm.nih.gov/15000880"},"language":"en","primary_location":{"id":"pmid:15000880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15000880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051904035","display_name":"Qing-junHUANG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qing-jun Huang","raw_affiliation_strings":["Psychoneuroimmunolgy Laboratory, Bethune Military Medical College, Shijiazhuang 050081, China. stone89@heinfo.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychoneuroimmunolgy Laboratory, Bethune Military Medical College, Shijiazhuang 050081, China. stone89@heinfo.net","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013655198","display_name":"HongJIANG","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Jiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043577395","display_name":"Kin-lingHAO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin-ling Hao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5063548049","display_name":"ThomasRMINOP","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas R Minor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1392,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.42408377,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"25","issue":"3","first_page":"293","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/depression-like-behavior","display_name":"depression-like behavior","score":0.9380000233650208},{"id":"https://openalex.org/keywords/interleukin-1-receptor-antagonist","display_name":"interleukin-1 receptor antagonist","score":0.7850000262260437},{"id":"https://openalex.org/keywords/porsolt-forced-swim-test","display_name":"Porsolt forced swim test","score":0.8569999933242798},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7770000100135803},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9340000152587891},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.7059999704360962},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2777842393","wikidata":"https://www.wikidata.org/wiki/Q407841","display_name":"Reserpine","level":2,"score":0.9858722686767578},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6983640193939209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6131662130355835},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6044691205024719},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5701913237571716},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.5308334231376648},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.5270288586616516},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4768434762954712},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4130121171474457},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37823545932769775},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32055312395095825},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.30435115098953247},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012795","descriptor_name":"Sialoglycoproteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053590","descriptor_name":"Interleukin 1 Receptor Antagonist Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15000880","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15000880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:206618267","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15000880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:44631927","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95561A/200403/9650365.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W64241676","https://openalex.org/W2014484891","https://openalex.org/W2134144722"],"related_works":["https://openalex.org/W206618267","https://openalex.org/W2391157227","https://openalex.org/W3029234323","https://openalex.org/W2024783932","https://openalex.org/W2350855150","https://openalex.org/W2366089011","https://openalex.org/W3031077049","https://openalex.org/W2064780317","https://openalex.org/W3029357989","https://openalex.org/W2049468229"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"investigate":[2],"the":[3,24,55,78,133],"mechanism":[4],"of":[5,26,35,42,69,80,119,129],"brain":[6,36,145],"interleukin-1":[7,146],"beta":[8,71,106,121,147],"(IL-1":[9],"beta)":[10],"in":[11,15,23,33,54,59,64,83,111],"reserpine-induced":[12],"behavioral":[13,141],"depression":[14,142],"rats.":[16,65],"METHODS:":[17],"Porsult":[18,56,84],"swim":[19,57,85],"test":[20,58,86],"was":[21,31],"used":[22,32],"measurement":[25,34],"depressive":[27],"behavior":[28],"and":[29,47,89,99,115,131],"ELISA":[30],"IL-1":[37,70,105,120],"beta.":[38],"RESULTS:":[39],"Intraperitoneal":[40],"injection":[41,67,128],"reserpine":[43,93,109,130],"(0,":[44],"4,":[45],"6,":[46],"8":[48],"mg/kg,":[49],"ip)":[50],"increased":[51,107],"floating":[52,81],"time":[53,82],"a":[60],"dose-and":[61],"time-dependent":[62],"manner":[63],"Intracerebroventricular":[66],"(icv)":[68],"receptor":[72],"antagonist":[73],"(IL-1ra,":[74],"6":[75],"mg/kg)":[76],"blocked":[77],"increment":[79],"at":[87,97,124,135],"48":[88,136],"72":[90],"h":[91,101],"after":[92,102,108,127],"injection,":[94],"but":[95],"not":[96],"1":[98],"24":[100,125],"injection.":[103],"Brain":[104],"treatment":[110],"posterior":[112],"cortex,":[113],"hippocampus,":[114],"hypothalamus.":[116],"The":[117],"increase":[118],"concentration":[122],"starts":[123],"hours":[126],"reached":[132],"peak":[134],"h.":[137],"CONCLUSION:":[138],"Reserpine":[139],"induced":[140],"partially":[143],"via":[144],"generation.":[148]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}