{"id":"https://openalex.org/W44511826","doi":null,"title":"Strain difference in learning impairment in rats following lead administration during brain development.","display_name":"Strain difference in learning impairment in rats following lead administration during brain development.","publication_year":1986,"publication_date":"1986-10-01","ids":{"openalex":"https://openalex.org/W44511826","mag":"44511826","pmid":"https://pubmed.ncbi.nlm.nih.gov/3617108"},"language":"en","primary_location":{"id":"pmid:3617108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3617108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tokai journal of experimental and clinical medicine","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008730109","display_name":"Sadayoshi SHIGETA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Shigeta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"H Aikawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Aikawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043184611","display_name":"Tetsuo Misawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Misawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083608125","display_name":"Toshimichi Yoshida","orcid":"https://orcid.org/0000-0001-8935-8217","observed_orcids":["https://orcid.org/0000-0001-8935-8217"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yoshida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086386586","display_name":"Hiroshi Momotani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Momotani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113793397","display_name":"Kumiko Suzuki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Suzuki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.00530348,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"11","issue":"4","first_page":"241","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lead-acetate","display_name":"lead acetate","score":0.8100000023841858},{"id":"https://openalex.org/keywords/developmental-lead-exposure","display_name":"developmental lead exposure","score":0.6039999723434448},{"id":"https://openalex.org/keywords/learning-disabilities","display_name":"learning disabilities","score":0.8650000095367432},{"id":"https://openalex.org/keywords/avoidance-learning","display_name":"avoidance learning","score":0.9769999980926514},{"id":"https://openalex.org/keywords/wistar-rats","display_name":"Wistar rats","score":0.9729999899864197},{"id":"https://openalex.org/keywords/strain-differences","display_name":"strain differences","score":0.7829999923706055},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7229999899864197},{"id":"https://openalex.org/keywords/prenatal-lead-exposure","display_name":"prenatal lead exposure","score":0.6060000061988831},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.5809999704360962},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8746093511581421},{"id":"https://openalex.org/C2780655333","wikidata":"https://www.wikidata.org/wiki/Q333203","display_name":"Weaning","level":2,"score":0.6853817701339722},{"id":"https://openalex.org/C2779224224","wikidata":"https://www.wikidata.org/wiki/Q338810","display_name":"Lead acetate","level":3,"score":0.6815028190612793},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5359943509101868},{"id":"https://openalex.org/C3018023364","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Significant difference","level":2,"score":0.4844196140766144},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.47723960876464844},{"id":"https://openalex.org/C2777093003","wikidata":"https://www.wikidata.org/wiki/Q6508345","display_name":"Lead (geology)","level":2,"score":0.4533421993255615},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4449974000453949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3714309334754944},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.358461856842041},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.17323768138885498},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0667819082736969},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001362","descriptor_name":"Avoidance Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007854","descriptor_name":"Lead","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D007859","descriptor_name":"Learning Disabilities","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D007859","descriptor_name":"Learning Disabilities","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:3617108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3617108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tokai journal of experimental and clinical medicine","raw_type":"Comparative Study"},{"id":"mag:44511826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3617108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2316510145","https://openalex.org/W1527321575","https://openalex.org/W116473461","https://openalex.org/W1985643220","https://openalex.org/W2024297849","https://openalex.org/W1983867659","https://openalex.org/W7095767263","https://openalex.org/W2409435625","https://openalex.org/W2409643700","https://openalex.org/W3195836568"],"abstract_inverted_index":{"High":[0],"and":[1,9,38,44,63,75,107,117,137,155,159,184],"stable":[2],"avoidance":[3,150,165],"with":[4],"low":[5],"variability":[6],"(THA)":[7],"rats":[8,12,62,74,120,140,202],"non-select":[10],"Wistar":[11,73,123,143],"were":[13,50,56,85,111,166,188],"administered":[14],"2":[15],"mg/ml":[16],"lead":[17],"acetate":[18],"solution":[19],"(0.2-0.27":[20],"g/Kg/day":[21],"as":[22,51],"lead)":[23],"up":[24],"to":[25],"seven":[26],"weeks":[27],"of":[28,36,80,90,93,101,105,121,141,164,172],"age;":[29],"via":[30],"placenta":[31],"from":[32,39],"the":[33,60,64,67,72,81,91,94,115,118,122,126,135,138,142,146,169,173,177,194,199],"13th":[34],"day":[35],"gestation":[37],"maternal":[40],"milk":[41],"before":[42],"weaning,":[43],"per":[45],"os":[46],"after":[47],"weaning.":[48],"Results":[49],"follows.":[52],"1)":[53],"Significant":[54],"differences":[55],"not":[57],"observed":[58],"between":[59,134],"lead-exposed":[61],"controls":[65,92,116,136],"regarding":[66],"developmental":[68],"landmarks":[69],"in":[70,113,176,198],"both":[71,114],"THA":[76,148,179,200],"rats.":[77],"Body":[78],"weight":[79],"exposed":[82,119,139,178,201],"rats,":[83,149,180],"however,":[84],"significantly":[86],"less":[87],"than":[88],"that":[89,193],"two":[95],"rat":[96],"strains.":[97],"2)":[98],"Low":[99],"rate":[100],"avoidance,":[102],"slow":[103,181],"acquisition":[104,183],"learning":[106,151,182,195],"large":[108,185],"individual":[109,162,186],"variabilities":[110,163,187],"exhibited":[112],"strain":[124],"throughout":[125],"test":[127],"sessions.":[128],"No":[129],"significant":[130],"difference":[131],"was":[132,152,203],"indicated":[133],"strain.":[144],"In":[145],"control":[147],"acquired":[153],"rapidly,":[154],"a":[156],"high":[157],"level":[158],"very":[160],"small":[161],"demonstrated":[167],"during":[168],"latter":[170],"sessions":[171],"test.":[174],"Meanwhile,":[175],"displayed.":[189],"It":[190],"is":[191],"thought":[192],"impairment":[196],"appearing":[197],"induced":[204],"primarily":[205],"by":[206],"lead.":[207]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
