{"id":"https://openalex.org/W44503468","doi":null,"title":"Optimal sequence of anthracyclines and taxanes as adjuvant breast cancer treatment.","display_name":"Optimal sequence of anthracyclines and taxanes as adjuvant breast cancer treatment.","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W44503468","mag":"44503468","pmid":"https://pubmed.ncbi.nlm.nih.gov/19169608"},"language":"en","primary_location":{"id":"pmid:19169608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19169608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Clinica terapeutica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010531543","display_name":"Patrizia Vici","orcid":"https://orcid.org/0000-0001-7528-9783","observed_orcids":["https://orcid.org/0000-0001-7528-9783"]},"institutions":[{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Vici","raw_affiliation_strings":["Istituto Nazionale Tumori Regina Elena, Roma. pvici@ifo.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Nazionale Tumori Regina Elena, Roma. pvici@ifo.it","institution_ids":["https://openalex.org/I4387152244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033656633","display_name":"Giuditta Viola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Viola","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"S Rossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Rossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019614566","display_name":"Claudio Botti","orcid":"https://orcid.org/0000-0002-5814-6876","observed_orcids":["https://orcid.org/0000-0002-5814-6876"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Botti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055054012","display_name":"Carlo Vitucci","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Vitucci","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026439843","display_name":"Domenico Sergi","orcid":"https://orcid.org/0000-0002-8639-5378","observed_orcids":["https://orcid.org/0000-0002-8639-5378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Sergi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"F R Ferranti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F R Ferranti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056121618","display_name":"Elena Saracca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Saracca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107840765","display_name":"Luigi Di Lauro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Di Lauro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015445323","display_name":"Serena Corsetti","orcid":"https://orcid.org/0000-0003-1351-9568","observed_orcids":["https://orcid.org/0000-0003-1351-9568"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Corsetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Foggi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Foggi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047667701","display_name":"Silvia Ileana Fattoruso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S I S Fattoruso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111948408","display_name":"M L\u00f3pez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Lopez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3332,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.60599706,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"159","issue":"6","first_page":"453","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.6547999978065491,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.34380000829696655,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthracyclines","display_name":"anthracyclines","score":0.8980000019073486},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":1.0},{"id":"https://openalex.org/keywords/drug-sequence","display_name":"drug sequence","score":0.5360000133514404},{"id":"https://openalex.org/keywords/sequential-chemotherapy","display_name":"sequential chemotherapy","score":0.43299999833106995},{"id":"https://openalex.org/keywords/cross-resistance","display_name":"cross-resistance","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.49399998784065247},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7390000224113464},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9900000095367432}],"concepts":[{"id":"https://openalex.org/C2777511904","wikidata":"https://www.wikidata.org/wiki/Q425227","display_name":"Taxane","level":4,"score":0.9465689659118652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9049440622329712},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.8103946447372437},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.7075371146202087},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.6507906913757324},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6274352669715881},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5706377029418945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5511993765830994},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5333932042121887},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.41462060809135437},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3755425214767456},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35151606798171997}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017024","descriptor_name":"Chemotherapy, Adjuvant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017322","descriptor_name":"Clinical Trials, Phase II as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:19169608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19169608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Clinica terapeutica","raw_type":"Journal Article"},{"id":"mag:44503468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19169608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131065012","https://openalex.org/W2768511567","https://openalex.org/W1974504826","https://openalex.org/W2140460875","https://openalex.org/W2805411247","https://openalex.org/W2167922617","https://openalex.org/W3029703039","https://openalex.org/W3131640721","https://openalex.org/W1993318634","https://openalex.org/W1972595386"],"abstract_inverted_index":{"Results":[0],"from":[1,131],"randomized":[2,189],"trials":[3,60,77,141,166],"evaluating":[4,167],"taxane":[5,152],"versus":[6],"non-taxane":[7],"containing":[8],"regimens":[9],"in":[10,18,31,36,90,110,175],"adjuvant":[11,176],"breast":[12,177],"cancer":[13,178],"treatment":[14],"indicate":[15],"an":[16,155,186],"advantage":[17],"DFS":[19],"and":[20,97,130,162,173,185],"OS":[21],"for":[22],"the":[23,26,45,56,62,79,107,111,114,144,160,168],"taxane-arms,":[24],"but":[25],"best":[27,145,169],"schedule":[28],"of":[29,58,88,113,126,139,171,181],"administration,":[30],"combination":[32],"with":[33,65,82,134],"anthracyclines":[34,172],"or":[35,92],"sequence,":[37,64,81],"is":[38,106,193],"still":[39],"a":[40,127,135,151],"debated":[41],"issue,":[42],"even":[43],"if":[44],"sequential":[46],"strategy":[47,146],"appears":[48],"to":[49,54,103,116,119,149,154,159],"be":[50,104,148],"less":[51],"toxic.":[52],"Up":[53],"now,":[55],"majority":[57],"clinical":[59,132],"employed":[61],"\"standard\"":[63],"anthracycline-based":[66],"combinations":[67],"fi":[68,85],"rst,":[69,86],"followed":[70],"by":[71,124],"taxanes.":[72],"Few":[73],"small":[74,182],"phase":[75,190],"II":[76],"evaluated":[78],"reverse":[80],"taxanes":[83,174],"administered":[84],"most":[87],"them":[89],"metastatic":[91],"neoadjuvant":[93],"setting,":[94],"suggesting":[95],"efficacy":[96],"lower":[98],"toxicity.":[99],"An":[100],"important":[101],"issue":[102],"considered":[105],"hypothesized":[108],"differences":[109],"ability":[112],"drugs":[115],"induce":[117],"cross-resistance":[118],"each":[120],"other,":[121],"as":[122],"suggested":[123],"data":[125],"preclinical":[128],"study,":[129],"study":[133],"cross-over":[136],"design;":[137],"results":[138],"these":[140],"suggest":[142],"that":[143],"would":[147],"administer":[150],"prior":[153],"anthracycline,":[156],"also":[157],"according":[158],"Norton":[161],"Simon":[163],"hypothesis.":[164],"Moreover,":[165],"sequence":[170],"setting":[179],"are":[180,198],"sample":[183],"size,":[184],"adequately":[187],"powered":[188],"III":[191],"trial":[192],"needed":[194],"before":[195],"definitive":[196],"conclusions":[197],"reached.":[199]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}