{"id":"https://openalex.org/W4434567","doi":"https://doi.org/10.1054/bjoc.2001.2114","title":"A three-arm phase III randomised trial assessing, in patients with extensive-disease small-cell lung cancer, accelerated chemotherapy with support of haematological growth factor or oral antibiotics","display_name":"A three-arm phase III randomised trial assessing, in patients with extensive-disease small-cell lung cancer, accelerated chemotherapy with support of haematological growth factor or oral antibiotics","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W4434567","doi":"https://doi.org/10.1054/bjoc.2001.2114","mag":"4434567","pmid":"https://pubmed.ncbi.nlm.nih.gov/11720426","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363948"},"language":"en","primary_location":{"id":"doi:10.1054/bjoc.2001.2114","doi":"https://doi.org/10.1054/bjoc.2001.2114","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2001.2114","pdf_url":null,"source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1054/bjoc.2001.2114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"for the European Lung Cancer Working Party","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"for the European Lung Cancer Working Party","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112868364","display_name":"Sculier Jp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J P Sculier","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, B-1000 Bruxelles, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, B-1000 Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109896328","display_name":"M Paesmans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M Paesmans","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111939411","display_name":"J. Lecomte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J Lecomte","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111384581","display_name":"Oswald Van Cutsem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"O Van Cutsem","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111448054","display_name":"Jean\u2010Jacques Lafitte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J J Lafitte","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108496840","display_name":"Th. Berghmans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"T Berghmans","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002166354","display_name":"George Koumakis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"G Koumakis","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029328492","display_name":"M Florin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M C Florin","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040574645","display_name":"Jacques Thiriaux","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J Thiriaux","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111669758","display_name":"J. Michel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J Michel","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":null,"display_name":"V Giner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"V Giner","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113573484","display_name":"M.C. Berchier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"M C Berchier","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109871601","display_name":"P. Mommen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"P Mommen","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008474060","display_name":"Vincent Ninane","orcid":"https://orcid.org/0000-0002-8686-0591","observed_orcids":["https://orcid.org/0000-0002-8686-0591"]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"V Ninane","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]},{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, Bruxelles, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082455844","display_name":"Jean A. Klastersky","orcid":"https://orcid.org/0000-0002-7941-2387","observed_orcids":["https://orcid.org/0000-0002-7941-2387"]},"institutions":[{"id":"https://openalex.org/I2801838318","display_name":"Institut Jules Bordet","ror":"https://ror.org/05e8s8534","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801838318"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J Klastersky","raw_affiliation_strings":["Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Institut Jules Bordet, 1rue H\u00e9ger-Bordet, Bruxelles, B-1000, Belgium","institution_ids":["https://openalex.org/I2801838318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801838318"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":2.3545,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.87612554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"85","issue":"10","first_page":"1444","last_page":"1451"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extensive-stage-small-cell-lung-cancer","display_name":"extensive-stage small cell lung cancer","score":0.9120000004768372},{"id":"https://openalex.org/keywords/oral-antibiotics","display_name":"oral antibiotics","score":0.8809999823570251},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9570000171661377},{"id":"https://openalex.org/keywords/dose-intensity","display_name":"dose intensity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8790000081062317},{"id":"https://openalex.org/keywords/infection-risk","display_name":"infection risk","score":0.6169999837875366},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5720000267028809},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.788392961025238},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6352445483207703},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6280516982078552},{"id":"https://openalex.org/C2777506904","wikidata":"https://www.wikidata.org/wiki/Q418560","display_name":"Ifosfamide","level":4,"score":0.6173713803291321},{"id":"https://openalex.org/C2780835546","wikidata":"https://www.wikidata.org/wiki/Q425122","display_name":"Epirubicin","level":4,"score":0.5395111441612244},{"id":"https://openalex.org/C2779321808","wikidata":"https://www.wikidata.org/wiki/Q416660","display_name":"Vindesine","level":5,"score":0.5364177227020264},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5140377283096313},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5015707015991211},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4775479733943939},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.47595497965812683},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.42206886410713196},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.411730021238327},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.314431369304657},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.22235479950904846},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.16401150822639465},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.08357641100883484},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007069","descriptor_name":"Ifosfamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014751","descriptor_name":"Vindesine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D023381","descriptor_name":"Endpoint Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1054/bjoc.2001.2114","doi":"https://doi.org/10.1054/bjoc.2001.2114","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2001.2114","pdf_url":null,"source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1506898","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363948","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2363948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2363948","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:11720426","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11720426","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Clinical Trial"},{"id":"pmh:oai:dial.uclouvain.be:boreal:101754","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2078.2/101754","pdf_url":null,"source":{"id":"https://openalex.org/S4306401974","display_name":"DIAL (Catholic University of Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The British journal of cancer, Vol. 85, no. 10, p. 1444-1451 (2001)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/85459","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/85459","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Cancer, 85 (10","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1054/bjoc.2001.2114","doi":"https://doi.org/10.1054/bjoc.2001.2114","is_oa":true,"landing_page_url":"https://doi.org/10.1054/bjoc.2001.2114","pdf_url":null,"source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W41701363","https://openalex.org/W1681457064","https://openalex.org/W1828901577","https://openalex.org/W1856289993","https://openalex.org/W1876445714","https://openalex.org/W1894342532","https://openalex.org/W1900393559","https://openalex.org/W1905406155","https://openalex.org/W1978116379","https://openalex.org/W1995804719","https://openalex.org/W2037672311","https://openalex.org/W2041808533","https://openalex.org/W2074454485","https://openalex.org/W2085054454","https://openalex.org/W2085757096","https://openalex.org/W2108113897","https://openalex.org/W2133495180","https://openalex.org/W2139727577","https://openalex.org/W2165254830","https://openalex.org/W2173643829","https://openalex.org/W2200116273","https://openalex.org/W2226490553","https://openalex.org/W2268765260","https://openalex.org/W2330558238","https://openalex.org/W2336367159","https://openalex.org/W2340678921","https://openalex.org/W2341557816","https://openalex.org/W2341745217","https://openalex.org/W3005498893"],"related_works":["https://openalex.org/W4234028285","https://openalex.org/W797955708","https://openalex.org/W2077378016","https://openalex.org/W833562105","https://openalex.org/W7061127109","https://openalex.org/W811107277","https://openalex.org/W2412795043","https://openalex.org/W4248781733","https://openalex.org/W2392669888","https://openalex.org/W4245550164"],"abstract_inverted_index":{"The":[0,130],"European":[1],"Lung":[2],"Cancer":[3],"Working":[4],"Party":[5],"(ELCWP)":[6],"designed":[7],"a":[8,222],"3-arm":[9],"phase":[10],"III":[11],"randomised":[12,31],"trial":[13,216],"to":[14,141,218],"determine":[15],"the":[16,33,113],"role":[17],"of":[18,43,115,160,196,225],"accelerated":[19,101],"chemotherapy":[20,39,69,81,226],"in":[21,102,112,136,139,188,203,212,220],"extensive-disease":[22],"(ED)":[23],"small-cell":[24],"lung":[25],"cancer":[26],"(SCLC).":[27],"Eligible":[28],"patients":[29,94],"were":[30,95,200,209],"between":[32],"3":[34,50],"following":[35],"arms:":[36],"(A)":[37],"Standard":[38],"with":[40,70,82,105,153],"6":[41],"courses":[42],"EVI":[44,71,83],"(epirubicin":[45],"60":[46],"mg":[47,51],"m(-2),":[48,52],"vindesine":[49],"ifosfamide":[53],"5":[54],"g":[55],"m(-2);":[56],"all":[57],"drugs":[58],"given":[59],"on":[60],"day":[61],"1":[62],"repeated":[63],"every":[64,73],"three":[65],"weeks.":[66],"(B)":[67],"Accelerated":[68,80],"administered":[72],"2":[74],"weeks":[75],"and":[76,84,124,128,157,163,170,175,178,206],"GM-CSF":[77,230],"support.":[78,231],"(C)":[79],"oral":[85],"antibiotics":[86],"(cotrimoxazole).":[87],"Primary":[88],"endpoint":[89],"was":[90,133],"survival.":[91],"233":[92],"eligible":[93],"randomised.":[96],"Chemotherapy":[97],"could":[98],"be":[99],"significantly":[100,134],"arm":[103,121,137,142,166,173,181,189,204,213],"B":[104,123,138,174,190,205],"increased":[106,194],"absolute":[107],"dose-intensity.":[108],"Best":[109],"response":[110,131],"rates,":[111],"population":[114],"evaluable":[116],"patients,":[117],"were,":[118],"respectively":[119],"for":[120,165,172,180],"A,":[122,167],"C,":[125],"59%,":[126],"76%":[127],"70%.":[129],"rate":[132,159,195],"higher":[135],"comparison":[140],"A":[143],"(P":[144],"=":[145],"0.04).":[146],"There":[147],"was,":[148],"however,":[149],"no":[150],"survival":[151,223],"difference":[152],"respective":[154],"median":[155],"duration":[156],"2-year":[158],"286":[161],"days":[162,169,177],"5%":[164],"264":[168,176],"6%":[171,179],"C.":[182,214],"Severe":[183],"thrombopenia":[184],"occurred":[185],"more":[186,201],"frequently":[187],"but":[191],"without":[192],"an":[193],"bleeding.":[197],"Non-severe":[198],"infections":[199,208],"frequent":[202,211],"severe":[207],"less":[210],"Our":[215],"failed":[217],"demonstrate,":[219],"ED-SCLC,":[221],"benefit":[224],"acceleration":[227],"by":[228],"using":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}