{"id":"https://openalex.org/W44326176","doi":null,"title":"Menopausal bone loss and estrogen replacement.","display_name":"Menopausal bone loss and estrogen replacement.","publication_year":1976,"publication_date":"1976-07-01","ids":{"openalex":"https://openalex.org/W44326176","mag":"44326176","pmid":"https://pubmed.ncbi.nlm.nih.gov/972014"},"language":"en","primary_location":{"id":"pmid:972014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/972014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Israel journal of medical sciences","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113711447","display_name":"Silvia Meema","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Meema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112103485","display_name":"H. E. Meema","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H E Meema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.5005,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.97746698,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"12","issue":"7","first_page":"601","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.5770999789237976,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.413100004196167,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-replacement-therapy","display_name":"estrogen replacement therapy","score":0.9779999852180481},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8550000190734863},{"id":"https://openalex.org/keywords/bone-mineral-mass","display_name":"bone mineral mass","score":0.9449999928474426},{"id":"https://openalex.org/keywords/radius","display_name":"radius","score":0.8339999914169312},{"id":"https://openalex.org/keywords/oophorectomy","display_name":"oophorectomy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/castration","display_name":"castration","score":0.777999997138977},{"id":"https://openalex.org/keywords/cortical-thickness","display_name":"cortical thickness","score":0.7419999837875366},{"id":"https://openalex.org/keywords/estrogen-therapy","display_name":"estrogen therapy","score":0.31700000166893005}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8767474889755249},{"id":"https://openalex.org/C2778562196","wikidata":"https://www.wikidata.org/wiki/Q177708","display_name":"Menopause","level":2,"score":0.7870625257492065},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6889419555664062},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.5227898955345154},{"id":"https://openalex.org/C2993253760","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone mass","level":3,"score":0.5138909816741943},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4648854434490204},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4478394687175751},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44121798872947693},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.44102567434310913},{"id":"https://openalex.org/C2780712178","wikidata":"https://www.wikidata.org/wiki/Q25326559","display_name":"Peak bone mass","level":4,"score":0.4302123486995697},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34301072359085083},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002369","descriptor_name":"Castration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008903","descriptor_name":"Minerals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:972014","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/972014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Israel journal of medical sciences","raw_type":"Journal Article"},{"id":"mag:44326176","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/972014","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2085899477","https://openalex.org/W2066226218","https://openalex.org/W2047366838","https://openalex.org/W3187058077","https://openalex.org/W1462198039","https://openalex.org/W4249757590","https://openalex.org/W145113570","https://openalex.org/W636729433","https://openalex.org/W2411767540","https://openalex.org/W2092791248"],"abstract_inverted_index":{"Throughout":[0],"adult":[1],"life":[2],"the":[3,8,37,42,51,59,65,70,99,116,126],"bone":[4,63,80,95,110,158,175],"mineral":[5,81],"mass":[6,96,111],"of":[7,24,45,50,62,72,79,88,94,101,115,125,157],"radius":[9,127],"is":[10,39,91],"greater":[11],"in":[12,15,27,64,84,122,130],"males":[13],"than":[14,58,112],"females.":[16],"In":[17,138],"males,":[18],"it":[19,29],"decreases":[20,30],"after":[21,103,136],"60":[22],"years":[23,102],"age,":[25,89],"while":[26,83,160],"females,":[28],"earlier,":[31],"at":[32],"approximately":[33],"50":[34,73],"years,":[35,47],"and":[36],"loss":[38,93,156],"greater.":[40],"At":[41],"average":[43,118],"age":[44,71],"67":[46],"one":[48],"half":[49],"normal":[52,60],"white":[53],"female":[54],"population":[55],"has":[56],"less":[57,109],"amount":[61],"radius.":[66],"Premenopausal":[67],"women":[68,106,114,132,145,163],"over":[69],"do":[74],"not":[75],"show":[76],"any":[77],"decline":[78],"mass,":[82,159],"postmenopausal":[85,144,162,174],"women,":[86],"regardless":[87],"there":[90],"a":[92,139,147,154],"related":[97],"to":[98,172],"number":[100],"menopause.":[104],"Castrated":[105],"have":[107],"significantly":[108],"premenopausal":[113],"same":[117],"age.":[119],"No":[120],"decrease":[121],"cortical":[123],"thickness":[124],"was":[128],"found":[129],"oophorectomized":[131],"treated":[133],"with":[134],"estrogens":[135],"castration.":[137],"long-term,":[140],"follow-up":[141],"study,":[142],"untreated":[143],"(after":[146],"natural":[148],"or":[149],"an":[150],"artifical":[151],"menopause)":[152],"showed":[153,164],"significant":[155],"estrogen-treated,":[161],"no":[165],"such":[166],"loss.":[167,176],"Estrogen":[168],"treatment":[169],"thus":[170],"appears":[171],"prevent":[173]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}