{"id":"https://openalex.org/W44253919","doi":"https://doi.org/10.4049/jimmunol.182.supp.137.25","title":"Constitutive expression of Foxp3 in conventional T cells reduces cellular proliferation and alleviates autoimmune arthritis (137.25)","display_name":"Constitutive expression of Foxp3 in conventional T cells reduces cellular proliferation and alleviates autoimmune arthritis (137.25)","publication_year":2009,"publication_date":"2009-04-01","ids":{"openalex":"https://openalex.org/W44253919","doi":"https://doi.org/10.4049/jimmunol.182.supp.137.25","mag":"44253919"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.182.supp.137.25","doi":"https://doi.org/10.4049/jimmunol.182.supp.137.25","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.137.25","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111606257","display_name":"Linjie Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linjie Guo","raw_affiliation_strings":["Immunology, Baylor College of Medicine , Houston, TX","1Immunology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Baylor College of Medicine , Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"1Immunology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087012625","display_name":"Biao Q Zheng","orcid":"https://orcid.org/0000-0002-0216-1022","observed_orcids":["https://orcid.org/0000-0002-0216-1022"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Biao Zheng","raw_affiliation_strings":["Immunology, Baylor College of Medicine , Houston, TX","1Immunology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Baylor College of Medicine , Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"1Immunology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011730809","display_name":"Shuhua Han","orcid":"https://orcid.org/0000-0003-3824-0539","observed_orcids":["https://orcid.org/0000-0003-3824-0539"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuhua Han","raw_affiliation_strings":["Immunology, Baylor College of Medicine , Houston, TX","1Immunology, Baylor College of Medicine, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology, Baylor College of Medicine , Houston, TX","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"1Immunology, Baylor College of Medicine, Houston, TX","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"182","issue":"Supplement_1","first_page":"137.25","last_page":"137.25"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":1.0},{"id":"https://openalex.org/keywords/conventional-t-cells","display_name":"conventional T cells","score":0.7960000038146973},{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.75},{"id":"https://openalex.org/keywords/autoimmune-arthritis","display_name":"autoimmune arthritis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8519999980926514},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.8510000109672546},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7429999709129333},{"id":"https://openalex.org/keywords/t-cell-unresponsiveness","display_name":"T cell hyporesponsiveness","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.9175679683685303},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.7186610698699951},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.554603099822998},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.539032518863678},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4775015711784363},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4297317862510681},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4274025559425354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42613548040390015},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42249369621276855},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.3821903169155121},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.359037309885025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.182.supp.137.25","doi":"https://doi.org/10.4049/jimmunol.182.supp.137.25","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.182.supp.137.25","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.75,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6422103","https://openalex.org/W2065825731","https://openalex.org/W2470900108","https://openalex.org/W2056024588","https://openalex.org/W2053257624","https://openalex.org/W1916063112","https://openalex.org/W7144312922","https://openalex.org/W2095091733","https://openalex.org/W1964819336","https://openalex.org/W2895243890"],"abstract_inverted_index":{"Abstract":[0],"The":[1,65,84,132],"forkhead":[2],"family":[3],"transicrption":[4],"factor":[5],"Foxp3":[6,22,38,55,68,88,106,116,139,158,168,198],"is":[7,69,170],"critically":[8],"important":[9,202],"for":[10],"the":[11,25,59,72],"development":[12,26],"and":[13,76,123,145,208,214],"function":[14],"of":[15,21,27,61,74,87,157,183,217],"regulatory":[16,47],"T":[17,44,48,78,90,151,185,219],"cells":[18,45,79,91,152,186],"(Tregs).":[19],"Lack":[20],"leads":[23],"to":[24,46,112,128,174],"fatal":[28],"autoimmune":[29],"lymphoproliferative":[30],"diseases.":[31],"Previously":[32],"studies":[33],"have":[34,52,190],"shown":[35,164],"that":[36,105,165,187,197],"ectopic":[37,85],"expression":[39,86,169],"can":[40],"phenotypically":[41],"convert":[42],"effector":[43],"cells.":[49,220],"However,":[50],"we":[51,103],"recently":[53],"generated":[54],"transgenic":[56,107],"mice":[57,108,118],"under":[58],"control":[60],"lck":[62],"distal":[63],"promoter.":[64],"transgene":[66],"(Tg)":[67],"expressed":[70],"in":[71,138,150,166,179,204],"majority":[73],"CD4+":[75],"CD8+":[77],"but":[80,93,177],"at":[81],"modulate":[82],"levels.":[83],"renders":[89],"hyporesponsive":[92],"conferred":[94],"neither":[95],"Treg":[96],"phenotype":[97],"nor":[98],"suppressive":[99,191],"function.":[100],"In":[101],"addition,":[102],"found":[104],"exhibit":[109],"reduced":[110,137],"susceptibility":[111],"collagen-induced":[113],"arthritis":[114,126],"(CIA).":[115],"Tg":[117,140,159],"had":[119],"delayed":[120],"disease":[121],"onset":[122],"developed":[124],"milder":[125],"compare":[127],"wild":[129],"type":[130],"controls.":[131],"serum":[133],"autoantibody":[134],"levels":[135],"were":[136,148],"mice.":[141,160],"Both":[142],"cytokine":[143,215],"production":[144,216],"antigen-specific":[146,218],"proliferation":[147],"decreased":[149],"from":[153],"draining":[154],"lymph":[155],"nodes":[156],"It":[161],"has":[162],"been":[163],"human":[167],"not":[171,189],"only":[172],"confined":[173],"CD4+CD25+":[175],"Tregs":[176],"also":[178],"a":[180],"high":[181],"percentage":[182],"activated":[184],"do":[188],"capabilities.":[192],"Thus,":[193],"our":[194],"results":[195],"indicate":[196],"may":[199],"play":[200],"an":[201],"role":[203],"regulating":[205],"immune":[206],"responses":[207,213],"inflammation":[209],"by":[210],"attenuating":[211],"proliferative":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
