{"id":"https://openalex.org/W44242156","doi":null,"title":"Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors.","display_name":"Development of antidepressant drugs. Fluoxetine (Prozac) and other selective serotonin uptake inhibitors.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W44242156","mag":"44242156","pmid":"https://pubmed.ncbi.nlm.nih.gov/7618533"},"language":"en","primary_location":{"id":"pmid:7618533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7618533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"D T Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D T Wong","raw_affiliation_strings":["Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110261041","display_name":"Frank P. Bymaster","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F P Bymaster","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8269,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.71149144,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"363","issue":null,"first_page":"77","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9589999914169312},{"id":"https://openalex.org/keywords/antidepressant-development","display_name":"antidepressant drug development","score":0.8019999861717224},{"id":"https://openalex.org/keywords/serotonin-uptake-inhibition","display_name":"serotonin uptake inhibition","score":0.6890000104904175},{"id":"https://openalex.org/keywords/norfluoxetine","display_name":"norfluoxetine","score":0.8679999709129333},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.9070000052452087},{"id":"https://openalex.org/keywords/paroxetine","display_name":"paroxetine","score":1.0},{"id":"https://openalex.org/keywords/tricyclic-antidepressants","display_name":"tricyclic antidepressants","score":0.8669999837875366},{"id":"https://openalex.org/keywords/norepinephrine-uptake","display_name":"norepinephrine uptake","score":0.8080000281333923},{"id":"https://openalex.org/keywords/monoamines","display_name":"monoamines","score":0.6179999709129333},{"id":"https://openalex.org/keywords/depression-treatment","display_name":"depression treatment","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.868647575378418},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.7292240262031555},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6673056483268738},{"id":"https://openalex.org/C42251903","wikidata":"https://www.wikidata.org/wiki/Q18391002","display_name":"Monoaminergic","level":4,"score":0.6449871063232422},{"id":"https://openalex.org/C2777828372","wikidata":"https://www.wikidata.org/wiki/Q408471","display_name":"Paroxetine","level":4,"score":0.6410908699035645},{"id":"https://openalex.org/C2777669559","wikidata":"https://www.wikidata.org/wiki/Q407617","display_name":"Sertraline","level":4,"score":0.6070070266723633},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.601242184638977},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.5733973383903503},{"id":"https://openalex.org/C2781081902","wikidata":"https://www.wikidata.org/wiki/Q3539074","display_name":"Tricyclic","level":2,"score":0.5140143632888794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5005764961242676},{"id":"https://openalex.org/C2910584757","wikidata":"https://www.wikidata.org/wiki/Q334477","display_name":"Serotonin Uptake Inhibitors","level":5,"score":0.46470940113067627},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4545449912548065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29108181595802307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22272807359695435},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09877470135688782},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08378145098686218},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.07470688223838806}],"mesh":[{"descriptor_ui":"D000929","descriptor_name":"Antidepressive Agents, Tricyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011437","descriptor_name":"Propylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011437","descriptor_name":"Propylamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013574","descriptor_name":"Synaptosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:7618533","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7618533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"},{"id":"mag:44242156","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7618533","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W51735324","https://openalex.org/W62399725","https://openalex.org/W64060380","https://openalex.org/W89369262","https://openalex.org/W121026993","https://openalex.org/W1238819995","https://openalex.org/W1505837991","https://openalex.org/W1850609236","https://openalex.org/W1885238897","https://openalex.org/W1913432089","https://openalex.org/W1964967660","https://openalex.org/W1965043512","https://openalex.org/W1966438430","https://openalex.org/W1967466543","https://openalex.org/W1968019882","https://openalex.org/W1970663885","https://openalex.org/W1971130009","https://openalex.org/W1974086238","https://openalex.org/W1976292997","https://openalex.org/W1979293025","https://openalex.org/W1980784555","https://openalex.org/W1981625242","https://openalex.org/W1986187211","https://openalex.org/W1986277865","https://openalex.org/W1986481868","https://openalex.org/W1986915649","https://openalex.org/W1987042430","https://openalex.org/W1989715191","https://openalex.org/W1989901803","https://openalex.org/W1990421313","https://openalex.org/W1994528708","https://openalex.org/W2000314099","https://openalex.org/W2000769865","https://openalex.org/W2002669946","https://openalex.org/W2002946197","https://openalex.org/W2008406610","https://openalex.org/W2008571936","https://openalex.org/W2008834514","https://openalex.org/W2010226712","https://openalex.org/W2012775663","https://openalex.org/W2012875919","https://openalex.org/W2013231063","https://openalex.org/W2013750681","https://openalex.org/W2017747690","https://openalex.org/W2018230108","https://openalex.org/W2021894419","https://openalex.org/W2023103015","https://openalex.org/W2023418528","https://openalex.org/W2024340541","https://openalex.org/W2024436146","https://openalex.org/W2028094236","https://openalex.org/W2031017946","https://openalex.org/W2034054527","https://openalex.org/W2035210985","https://openalex.org/W2036312254","https://openalex.org/W2036642842","https://openalex.org/W2037605443","https://openalex.org/W2039835536","https://openalex.org/W2040798945","https://openalex.org/W2040981420","https://openalex.org/W2043567599","https://openalex.org/W2044647088","https://openalex.org/W2045310324","https://openalex.org/W2046064455","https://openalex.org/W2047191222","https://openalex.org/W2052442115","https://openalex.org/W2052521265","https://openalex.org/W2064282880","https://openalex.org/W2065463514","https://openalex.org/W2065539656","https://openalex.org/W2067836800","https://openalex.org/W2070942143","https://openalex.org/W2072594850","https://openalex.org/W2074448465","https://openalex.org/W2079355643","https://openalex.org/W2079526280","https://openalex.org/W2084240947","https://openalex.org/W2085184575","https://openalex.org/W2087509729","https://openalex.org/W2090590696","https://openalex.org/W2092376330","https://openalex.org/W2092569285","https://openalex.org/W2092880342","https://openalex.org/W2114590805","https://openalex.org/W2125515805","https://openalex.org/W2142514218","https://openalex.org/W2144886680","https://openalex.org/W2155918730","https://openalex.org/W2164834056","https://openalex.org/W2169741270","https://openalex.org/W2238707608","https://openalex.org/W2246813284","https://openalex.org/W2277598528","https://openalex.org/W2288197714","https://openalex.org/W2289612860","https://openalex.org/W2289889955","https://openalex.org/W2322440347","https://openalex.org/W2341365624","https://openalex.org/W2402413962","https://openalex.org/W2408404749","https://openalex.org/W2408600311","https://openalex.org/W2411221764","https://openalex.org/W2411531910","https://openalex.org/W2417865122","https://openalex.org/W2426264332","https://openalex.org/W3072234959","https://openalex.org/W3212014441","https://openalex.org/W4407045131"],"related_works":["https://openalex.org/W51735324","https://openalex.org/W2080402976","https://openalex.org/W2398080393","https://openalex.org/W2408404749","https://openalex.org/W2042016713","https://openalex.org/W1598371539","https://openalex.org/W2441808454","https://openalex.org/W2021894419","https://openalex.org/W99295697","https://openalex.org/W1044665944"],"abstract_inverted_index":{"Active":[0],"uptake":[1,34,82,175,224],"processes":[2],"have":[3,55,180],"been":[4,43,181],"described":[5],"for":[6,58],"the":[7,44,74,78,87,103,153,169,193,203,209,230,239,242,248],"monoaminergic":[8],"neurotransmitters":[9],"including":[10],"serotonin":[11],"(5-hydroxytryptamine,":[12],"5-HT),":[13],"norepinephrine":[14],"(NE)":[15],"and":[16,24,28,37,94,109,124,128,132,136,156,165,178,199,208,213,222,238,247],"dopamine":[17],"(DA)":[18],"in":[19,39,47,86,142,152,157,225,236,255],"nervous":[20],"tissues":[21,41],"(Whitby,":[22],"Axelrod,":[23],"Weil-Malherbe,":[25],"1961;":[26],"Burgen":[27],"Iverson,":[29,31],"1965;":[30],"1971).":[32],"The":[33],"of":[35,50,60,73,106,112,116,120,192,206,211,220,232,257,262],"5-HT":[36,81,107,121,174,221,233,252],"NE":[38,223],"brain":[40],"has":[42,95,146],"target":[45],"sites":[46],"our":[48,197],"search":[49],"selective":[51,80,173,251],"inhibitors,":[52,176],"which":[53,195],"may":[54],"therapeutic":[56],"potential":[57],"treatment":[59],"depressive":[61],"disorders":[62],"(Wong":[63,90],"et":[64,91,161],"aI.,":[65,92,162],"1974;":[66],"1975a;":[67],"1993a).":[68],"Fluoxetine":[69],"[Prozac),":[70],"a":[71,98,110,148],"member":[72],"substituted":[75],"phenoxyphenylpropylamines,":[76],"was":[77],"first":[79],"inhibitor":[83],"to":[84,101],"appear":[85],"scientific":[88],"literature":[89],"1974)":[93],"served":[96],"as":[97,183,218],"useful":[99],"tool":[100],"establish":[102],"physiological":[104],"role":[105],"neurons":[108,122],"reference":[111],"pharmacological":[113],"responses":[114],"indicative":[115],"an":[117],"enhanced":[118],"transmission":[119],"(Fuller":[123],"Wong,":[125,137],"1977;":[126],"Wong":[127,131],"Fuller,":[129],"1987;":[130],"Murphy,":[133],"1989;":[134],"Fuller":[135],"1990).":[138],"After":[139],"its":[140,214],"introduction":[141],"1988,":[143],"fluoxetine":[144,212],"(Prozac)":[145],"become":[147],"major":[149,215],"antidepressant":[150,184,245],"drug":[151],"United":[154],"States":[155],"many":[158],"countries":[159],"(Beasley":[160],"1990;":[163],"Boyer":[164],"Feighner,":[166],"1991a).":[167],"In":[168,186],"U.S.,":[170],"two":[171],"other":[172],"sertraline":[177],"paroxetine,":[179],"introduced":[182],"drugs.":[185],"this":[187],"article,":[188],"we":[189],"present":[190,229],"some":[191,200],"background":[194],"attracted":[196],"attention,":[198],"studies":[201],"on":[202],"chemical":[204],"series":[205],"phenoxyphenylpropylamines":[207],"enantiomers":[210],"metabolite":[216],"norfluoxetine":[217],"inhibitors":[219,254],"vitro.":[226],"We":[227],"also":[228],"consequences":[231],"reuptake":[234,253],"inhibition":[235],"vivo,":[237],"contrast":[240],"between":[241],"classical":[243],"tricyclic":[244],"drugs":[246],"newly":[249],"developed":[250],"terms":[256],"their":[258],"interaction":[259],"with":[260],"receptors":[261],"neurotransmitters.":[263]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
