{"id":"https://openalex.org/W44215268","doi":"https://doi.org/10.1016/j.jacc.2004.06.079","title":"Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements","display_name":"Apparently normal mitral valves in patients with heart failure demonstrate biochemical and structural derangements","publication_year":2004,"publication_date":"2004-12-31","ids":{"openalex":"https://openalex.org/W44215268","doi":"https://doi.org/10.1016/j.jacc.2004.06.079","mag":"44215268","pmid":"https://pubmed.ncbi.nlm.nih.gov/15629373"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacc.2004.06.079","doi":"https://doi.org/10.1016/j.jacc.2004.06.079","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2004.06.079","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0735109704019576/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0735109704019576/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044710928","display_name":"Kathryn Jane Grande-Allen","orcid":"https://orcid.org/0000-0003-1533-3767","observed_orcids":["https://orcid.org/0000-0003-1533-3767"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K. Jane Grande-Allen","raw_affiliation_strings":["Bioengineering, Rice University, Houston, Texas 77251-7892, USA. grande@rice.edu","Bioengineering, Rice University, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering, Rice University, Houston, Texas 77251-7892, USA. grande@rice.edu","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Bioengineering, Rice University, Houston, Texas","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113477423","display_name":"Allen G. Borowski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allen G. Borowski","raw_affiliation_strings":["Cardiovascular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055346035","display_name":"Richard William Troughton","orcid":"https://orcid.org/0000-0001-7484-4036","observed_orcids":["https://orcid.org/0000-0001-7484-4036"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard W. Troughton","raw_affiliation_strings":["Cardiovascular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007375282","display_name":"Penny L. Houghtaling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Penny L. Houghtaling","raw_affiliation_strings":["Biostatistics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080099154","display_name":"Nicholas R. DiPaola","orcid":"https://orcid.org/0000-0003-3738-4995","observed_orcids":["https://orcid.org/0000-0003-3738-4995"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas R. DiPaola","raw_affiliation_strings":["Cardiovascular Medicine","Kaufman Center for Heart Failure"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine","institution_ids":[]},{"raw_affiliation_string":"Kaufman Center for Heart Failure","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012179922","display_name":"Christine Schomisch Moravec","orcid":"https://orcid.org/0000-0001-7369-1218","observed_orcids":["https://orcid.org/0000-0001-7369-1218"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine S. Moravec","raw_affiliation_strings":["Cardiovascular Medicine","Kaufman Center for Heart Failure"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine","institution_ids":[]},{"raw_affiliation_string":"Kaufman Center for Heart Failure","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033486502","display_name":"Ivan Vesel\u00fd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan Vesely","raw_affiliation_strings":["Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088924413","display_name":"Brian P. Griffin","orcid":"https://orcid.org/0000-0001-6831-8611","observed_orcids":["https://orcid.org/0000-0001-6831-8611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian P. Griffin","raw_affiliation_strings":["Cardiovascular Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044710928"],"corresponding_institution_ids":["https://openalex.org/I74775410"],"apc_list":{"value":7166,"currency":"USD","value_usd":7166},"apc_paid":null,"fwci":3.7027,"has_fulltext":true,"cited_by_count":134,"citation_normalized_percentile":{"value":0.92901747,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"1","first_page":"54","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitral-valve","display_name":"mitral valve","score":0.8399999737739563},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9459999799728394},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mitral-valve-fibrosis","display_name":"mitral valve fibrosis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.6489999890327454},{"id":"https://openalex.org/keywords/glycosaminoglycans","display_name":"glycosaminoglycans","score":0.9800000190734863},{"id":"https://openalex.org/keywords/dna-content","display_name":"DNA content","score":0.6779999732971191},{"id":"https://openalex.org/keywords/moisture-content","display_name":"moisture content","score":0.640999972820282},{"id":"https://openalex.org/keywords/dilated-cardiomyopathy","display_name":"dilated cardiomyopathy","score":0.7929999828338623},{"id":"https://openalex.org/keywords/ischemic-cardiomyopathy","display_name":"ischemic cardiomyopathy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.5509999990463257},{"id":"https://openalex.org/keywords/annular-diameter","display_name":"annular diameter","score":0.5709999799728394},{"id":"https://openalex.org/keywords/left-atrial-diameter","display_name":"left atrial diameter","score":0.7059999704360962},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8502381443977356},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7274510860443115},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7198233008384705},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6571981906890869},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.545124888420105},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.526059091091156},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.5111387372016907},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.509049117565155},{"id":"https://openalex.org/C2909944400","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Functional mitral regurgitation","level":4,"score":0.495003879070282},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.47269514203071594},{"id":"https://openalex.org/C2780870192","wikidata":"https://www.wikidata.org/wiki/Q1076385","display_name":"Chordae tendineae","level":3,"score":0.42465174198150635},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19017162919044495},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.171808123588562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08374100923538208},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005355","descriptor_name":"Fibrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006025","descriptor_name":"Glycosaminoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008943","descriptor_name":"Mitral Valve","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008943","descriptor_name":"Mitral Valve","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jacc.2004.06.079","doi":"https://doi.org/10.1016/j.jacc.2004.06.079","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2004.06.079","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0735109704019576/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},{"id":"pmid:15629373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15629373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jacc.2004.06.079","doi":"https://doi.org/10.1016/j.jacc.2004.06.079","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacc.2004.06.079","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0735109704019576/pdf","source":{"id":"https://openalex.org/S60865174","display_name":"Journal of the American College of Cardiology","issn_l":"0735-1097","issn":["0735-1097","1558-3597"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American College of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.5299999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2947295466","display_name":null,"funder_award_id":"F32-HL10228","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6961606339","display_name":"GLYCOSAMINOGLYCAN DISTRIBUTION IN MYXOID MITRAL VALVES","funder_award_id":"F32HL010228","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320310133","display_name":"Rice University","ror":"https://ror.org/008zs3103"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W44215268.pdf","grobid_xml":"https://content.openalex.org/works/W44215268.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W124243124","https://openalex.org/W1531049603","https://openalex.org/W1554286201","https://openalex.org/W1964954121","https://openalex.org/W1971372118","https://openalex.org/W1972282691","https://openalex.org/W1984590483","https://openalex.org/W2006411916","https://openalex.org/W2006565016","https://openalex.org/W2007182044","https://openalex.org/W2022034010","https://openalex.org/W2032709421","https://openalex.org/W2037407509","https://openalex.org/W2049009356","https://openalex.org/W2058548032","https://openalex.org/W2074270632","https://openalex.org/W2079248022","https://openalex.org/W2082197759","https://openalex.org/W2092244351","https://openalex.org/W2096743139","https://openalex.org/W2151800579","https://openalex.org/W2345695534","https://openalex.org/W2409387700","https://openalex.org/W2413734858","https://openalex.org/W2416443017","https://openalex.org/W2444214972","https://openalex.org/W4247517801"],"related_works":["https://openalex.org/W2015967500","https://openalex.org/W2064924056","https://openalex.org/W2306731125","https://openalex.org/W2203489985","https://openalex.org/W2053886543","https://openalex.org/W65221751","https://openalex.org/W4411622249","https://openalex.org/W2287290398","https://openalex.org/W1996927743","https://openalex.org/W2508978651"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
