{"id":"https://openalex.org/W4417538528","doi":"https://doi.org/10.1088/1741-2552/aebb64","title":"Closed-loop neuroprosthetic control through spared neural activity enables proportional foot movements after spinal cord injury","display_name":"Closed-loop neuroprosthetic control through spared neural activity enables proportional foot movements after spinal cord injury","publication_year":2026,"publication_date":"2026-10-29","ids":{"openalex":"https://openalex.org/W4417538528","doi":"https://doi.org/10.1088/1741-2552/aebb64","pmid":"https://pubmed.ncbi.nlm.nih.gov/42956411"},"language":"en","primary_location":{"id":"doi:10.1088/1741-2552/aebb64","doi":"https://doi.org/10.1088/1741-2552/aebb64","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1741-2552/aebb64","pdf_url":"https://iopscience.iop.org/article/10.1088/1741-2552/aebb64/pdf","source":{"id":"https://openalex.org/S32898093","display_name":"Journal of Neural Engineering","issn_l":"1741-2552","issn":["1741-2552","1741-2560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://iopscience.iop.org/article/10.1088/1741-2552/aebb64/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Vlad Cnejevici","orcid":"https://orcid.org/0000-0003-2291-5941","observed_orcids":["https://orcid.org/0000-0003-2291-5941"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Vlad Cnejevici","raw_affiliation_strings":["Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":"https://orcid.org/0000-0003-2291-5941","affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matthias Ponfick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthias Ponfick","raw_affiliation_strings":["Krankenhaus Rummelsberg gGmbH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krankenhaus Rummelsberg gGmbH","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dietmar Fey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dietmar Fey","raw_affiliation_strings":["Friedrich-Alexander-Universitat Erlangen-Nurnberg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universitat Erlangen-Nurnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raul Constantin S\u00eempetru","orcid":"https://orcid.org/0000-0003-0455-0168","observed_orcids":["https://orcid.org/0000-0003-0455-0168"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Raul Constantin S\u00eempetru","raw_affiliation_strings":["Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg"],"raw_orcid":"https://orcid.org/0000-0003-0455-0168","affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":null,"display_name":"Alessandro Del Vecchio","orcid":"https://orcid.org/0000-0002-7118-5554","observed_orcids":["https://orcid.org/0000-0002-7118-5554"]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alessandro Del Vecchio","raw_affiliation_strings":["Friedrich-Alexander-Universitat Erlangen-Nurnberg"],"raw_orcid":"https://orcid.org/0000-0002-7118-5554","affiliations":[{"raw_affiliation_string":"Friedrich-Alexander-Universitat Erlangen-Nurnberg","institution_ids":["https://openalex.org/I181369854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181369854"],"apc_list":{"value":3325,"currency":"USD","value_usd":3325},"apc_paid":{"value":3325,"currency":"USD","value_usd":3325},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0032832,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.5508000254631042,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.3799000084400177,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10510","display_name":"Stroke Rehabilitation and Recovery","score":0.029200000688433647,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/functional-electrical-stimulation","display_name":"functional electrical stimulation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/neuroprosthetic-control","display_name":"neuroprosthetic control","score":0.7350000143051147},{"id":"https://openalex.org/keywords/surface-electromyography","display_name":"surface electromyography","score":0.9459999799728394},{"id":"https://openalex.org/keywords/feedback-control","display_name":"feedback control","score":0.7889999747276306},{"id":"https://openalex.org/keywords/lower-limb-motor-function","display_name":"lower limb motor function","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.7939000129699707},{"id":"https://openalex.org/C2777766275","wikidata":"https://www.wikidata.org/wiki/Q1327643","display_name":"Functional electrical stimulation","level":3,"score":0.7160000205039978},{"id":"https://openalex.org/C2781306077","wikidata":"https://www.wikidata.org/wiki/Q944758","display_name":"Tetraplegia","level":4,"score":0.6779999732971191},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6309999823570251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6172999739646912},{"id":"https://openalex.org/C2777515770","wikidata":"https://www.wikidata.org/wiki/Q507369","display_name":"Electromyography","level":2,"score":0.600600004196167},{"id":"https://openalex.org/C2778640784","wikidata":"https://www.wikidata.org/wiki/Q168002","display_name":"Ankle","level":2,"score":0.5230000019073486},{"id":"https://openalex.org/C137813230","wikidata":"https://www.wikidata.org/wiki/Q2996165","display_name":"Motor control","level":2,"score":0.4864000082015991},{"id":"https://openalex.org/C115076146","wikidata":"https://www.wikidata.org/wiki/Q1651051","display_name":"Foot (prosody)","level":2,"score":0.44279998540878296},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.3806999921798706},{"id":"https://openalex.org/C2781425072","wikidata":"https://www.wikidata.org/wiki/Q1889028","display_name":"Motor unit","level":2,"score":0.3443000018596649},{"id":"https://openalex.org/C197525751","wikidata":"https://www.wikidata.org/wiki/Q1431093","display_name":"Neuroprosthetics","level":2,"score":0.33820000290870667},{"id":"https://openalex.org/C60465272","wikidata":"https://www.wikidata.org/wiki/Q494478","display_name":"Range of motion","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C2778818304","wikidata":"https://www.wikidata.org/wiki/Q1819478","display_name":"Rehabilitation","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.30320000648498535},{"id":"https://openalex.org/C2777597760","wikidata":"https://www.wikidata.org/wiki/Q1049655","display_name":"Paraplegia","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C2776379899","wikidata":"https://www.wikidata.org/wiki/Q975054","display_name":"Tibialis anterior muscle","level":3,"score":0.2802000045776367},{"id":"https://openalex.org/C2776462017","wikidata":"https://www.wikidata.org/wiki/Q59744853","display_name":"Orthotics","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C3019108329","wikidata":"https://www.wikidata.org/wiki/Q1751327","display_name":"Movement control","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C39920418","wikidata":"https://www.wikidata.org/wiki/Q11476","display_name":"Kinematics","level":2,"score":0.25769999623298645},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.2524000108242035},{"id":"https://openalex.org/C2989316616","wikidata":"https://www.wikidata.org/wiki/Q6027402","display_name":"Lower limb","level":2,"score":0.25099998712539673}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1088/1741-2552/aebb64","doi":"https://doi.org/10.1088/1741-2552/aebb64","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1741-2552/aebb64","pdf_url":"https://iopscience.iop.org/article/10.1088/1741-2552/aebb64/pdf","source":{"id":"https://openalex.org/S32898093","display_name":"Journal of Neural Engineering","issn_l":"1741-2552","issn":["1741-2552","1741-2560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Engineering","raw_type":"journal-article"},{"id":"pmid:42956411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42956411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neural engineering","raw_type":"Journal Article"},{"id":"pmh:oai:arXiv.org:2506.16468","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/2506.16468","pdf_url":"https://arxiv.org/pdf/2506.16468","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.2506.16468","doi":"https://doi.org/10.48550/arxiv.2506.16468","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2506.16468","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.1088/1741-2552/aebb64","doi":"https://doi.org/10.1088/1741-2552/aebb64","is_oa":true,"landing_page_url":"https://doi.org/10.1088/1741-2552/aebb64","pdf_url":"https://iopscience.iop.org/article/10.1088/1741-2552/aebb64/pdf","source":{"id":"https://openalex.org/S32898093","display_name":"Journal of Neural Engineering","issn_l":"1741-2552","issn":["1741-2552","1741-2560"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neural Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3600303969","display_name":"A Direct Sensorimotor Connection with the Spared Neural Code of Movement to Regain Motor Function","funder_award_id":"101118089","funder_id":"https://openalex.org/F4320338453","funder_display_name":"HORIZON EUROPE European Research Council"},{"id":"https://openalex.org/G5066169911","display_name":"DeMOTUS: Entschl\u00fcsselung des exakten und repr\u00e4sentativen Outputs des spinalen motorischen Nervensystems des Menschen","funder_award_id":"523352235","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7868338874","display_name":null,"funder_award_id":"MV-2303-0006","funder_id":"https://openalex.org/F4320331012","funder_display_name":"Bayerische Staatsministerium f\u00fcr Wirtschaft, Landesentwicklung und Energie"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320331012","display_name":"Bayerische Staatsministerium f\u00fcr Wirtschaft, Landesentwicklung und Energie","ror":null},{"id":"https://openalex.org/F4320338453","display_name":"HORIZON EUROPE European Research Council","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417538528.pdf","grobid_xml":"https://content.openalex.org/works/W4417538528.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092163397","https://openalex.org/W4409284902","https://openalex.org/W2151138154","https://openalex.org/W2776350329","https://openalex.org/W7171437102","https://openalex.org/W1546411776","https://openalex.org/W2036473209","https://openalex.org/W2506440261","https://openalex.org/W7124911767","https://openalex.org/W7120463313"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Loss":[1],"of":[2,18,76,119,162,227,237,245],"voluntary":[3,242,275],"foot":[4,93,124,146,154,172,212,252,276],"movement":[5,55,125],"after":[6,24,60,80],"spinal":[7],"cord":[8],"injury":[9],"(SCI)":[10],"can":[11,57,82,184],"significantly":[12],"limit":[13],"independent":[14],"mobility":[15],"and":[16,85,115,147,157,202,225],"quality":[17],"life.":[19],"To":[20,178],"improve":[21],"motor":[22,150],"output":[23],"injury,":[25],"functional":[26,229],"electrical":[27,89],"stimulation":[28,34,90,249],"(FES)":[29],"is":[30,68],"used":[31,86,133,186,193],"to":[32,39,69,87,138,197,247],"deliver":[33],"pulses":[35],"through":[36],"the":[37,77,106,134,238],"skin":[38],"affected":[40,107,205],"muscles.":[41],"While":[42],"commercial":[43],"FES":[44,121,200,264],"systems":[45,265],"typically":[46],"use":[47],"motion-based":[48],"triggers,":[49],"prior":[50],"research":[51],"shows":[52],"that":[53,102,258],"spared":[54,73],"intent":[56],"be":[58,83,185],"decoded":[59,84,195],"SCI":[61,81,132],"using":[62,110],"surface":[63],"electromyography":[64],"(EMG).":[65],"Our":[66],"aim":[67],"assess":[70],"how":[71,180],"well":[72],"neural":[74,182],"signals":[75,183],"lower":[78,108],"limb":[79,109],"control":[88,118,136,198,244,273],"for":[91,123,153,187,219,270],"restoring":[92],"movement.":[94,277],"APPROACH:":[95],"We":[96],"developed":[97],"a":[98,111,142,228,267],"wearable":[99,259],"machine-learning-powered":[100],"neuroprosthetic":[101,189,272],"records":[103],"EMG":[104,260],"from":[105],"32-channel":[112],"electrode":[113],"bracelet":[114],"enables":[116],"closed-loop":[117,188,271],"an":[120,199,210],"device":[122,201],"restoration.":[126],"MAIN":[127],"RESULTS:":[128],"Five":[129],"participants":[130,164,192,239],"with":[131,144,174,263],"predicted":[135],"signal":[137],"follow":[139],"trajectories":[140],"on":[141,222],"screen":[143],"their":[145,194,204],"achieve":[148],"distinct":[149],"activation":[151,169],"patterns":[152],"flexion,":[155],"extension,":[156],"inversion":[158],"or":[159],"eversion.":[160],"Three":[161],"these":[163,181],"also":[165,240],"achieved":[166,241],"2":[167],"proportional":[168,243],"levels":[170,250],"during":[171,251],"flexion/extension":[173],">70%":[175],"overall":[176],"accuracy.":[177],"validate":[179],"control,":[190],"two":[191],"activity":[196],"stimulate":[203],"foot.":[206],"This":[207],"resulted":[208],"in":[209,215],"increased":[211],"flexion":[213],"range":[214],"every":[216],"stimulated":[217],"contraction":[218],"both":[220],"participants,":[221],"average":[223],"33.6%":[224],"40%":[226],"healthy":[230],"range,":[231],"respectively":[232],"(p":[233],"<":[234],"0.001).":[235],"One":[236],"up":[246],"6":[248],"flexion/extension.":[253],"SIGNIFICANCE:":[254],"These":[255],"results":[256],"suggest":[257],"decoding":[261],"coupled":[262],"provides":[266],"scalable":[268],"strategy":[269],"supporting":[274]},"counts_by_year":[],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-10-10T00:00:00"}
