{"id":"https://openalex.org/W4417536896","doi":"https://doi.org/10.31351/vol34iss4pp125-140","title":"Design, Development, and Optimization of Spanlastics for Delivery of Rizatriptan Benzoate","display_name":"Design, Development, and Optimization of Spanlastics for Delivery of Rizatriptan Benzoate","publication_year":2025,"publication_date":"2025-12-20","ids":{"openalex":"https://openalex.org/W4417536896","doi":"https://doi.org/10.31351/vol34iss4pp125-140"},"language":"en","primary_location":{"id":"doi:10.31351/vol34iss4pp125-140","doi":"https://doi.org/10.31351/vol34iss4pp125-140","is_oa":true,"landing_page_url":"https://doi.org/10.31351/vol34iss4pp125-140","pdf_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3733/1559","source":{"id":"https://openalex.org/S2764399167","display_name":"Iraqi Journal of Pharmaceutical Sciences","issn_l":"1683-3597","issn":["1683-3597","2521-3512"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3733/1559","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rajaa A. Dahash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103044","display_name":"Ministry of Health","ror":"https://ror.org/01b1c8m98","country_code":"IQ","type":"government","lineage":["https://openalex.org/I4210103044"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Rajaa A. Dahash","raw_affiliation_strings":["Ministry of Health, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Health, Baghdad, Iraq","institution_ids":["https://openalex.org/I4210103044"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mowafaq M. Ghareeb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135120706","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21","country_code":"IQ","type":"education","lineage":["https://openalex.org/I135120706"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mowafaq M. Ghareeb","raw_affiliation_strings":["Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq","institution_ids":["https://openalex.org/I135120706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":250000,"currency":"IQD","value_usd":null},"apc_paid":null,"fwci":0.6937,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70622413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"34","issue":"4","first_page":"125","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.49559998512268066,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.49559998512268066,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.20909999310970306,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.19629999995231628,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spanlastics","display_name":"spanlastics","score":0.847000002861023},{"id":"https://openalex.org/keywords/rizatriptan-benzoate","display_name":"rizatriptan benzoate","score":0.9929999709129333},{"id":"https://openalex.org/keywords/span-60","display_name":"Span 60","score":0.9020000100135803},{"id":"https://openalex.org/keywords/vesicle-formulation-optimization","display_name":"vesicle formulation optimization","score":0.6330000162124634},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.7390000224113464},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ethanol-injection","display_name":"ethanol injection","score":0.5740000009536743},{"id":"https://openalex.org/keywords/vesicle-morphology","display_name":"vesicle morphology","score":0.6779999732971191},{"id":"https://openalex.org/keywords/drug-excipient-compatibility","display_name":"drug-excipient compatibility","score":0.7350000143051147},{"id":"https://openalex.org/keywords/amorphous-drug-state","display_name":"amorphous drug state","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.7329999804496765},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.6809999942779541},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.6227999925613403},{"id":"https://openalex.org/C169222746","wikidata":"https://www.wikidata.org/wiki/Q4116558","display_name":"Factorial experiment","level":2,"score":0.6075999736785889},{"id":"https://openalex.org/C92397422","wikidata":"https://www.wikidata.org/wiki/Q5062082","display_name":"Central composite design","level":3,"score":0.5685999989509583},{"id":"https://openalex.org/C104628117","wikidata":"https://www.wikidata.org/wiki/Q3964828","display_name":"Sonication","level":2,"score":0.5350000262260437},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5091999769210815},{"id":"https://openalex.org/C150077022","wikidata":"https://www.wikidata.org/wiki/Q3136137","display_name":"Response surface methodology","level":2,"score":0.5059000253677368},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.44769999384880066},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.4404999911785126},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4268999993801117},{"id":"https://openalex.org/C160892712","wikidata":"https://www.wikidata.org/wiki/Q901559","display_name":"Fourier transform infrared spectroscopy","level":2,"score":0.4088999927043915},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3228999972343445},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C2983812674","wikidata":"https://www.wikidata.org/wiki/Q134808","display_name":"Delivery system","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C3019981671","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Immediate release","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C204320433","wikidata":"https://www.wikidata.org/wiki/Q7268772","display_name":"Quality by Design","level":3,"score":0.2897999882698059},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.2831000089645386},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2825999855995178},{"id":"https://openalex.org/C2778648169","wikidata":"https://www.wikidata.org/wiki/Q967768","display_name":"Compatibility (geochemistry)","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.2653000056743622},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2599000036716461},{"id":"https://openalex.org/C129446986","wikidata":"https://www.wikidata.org/wiki/Q542419","display_name":"Thermal analysis","level":3,"score":0.2574000060558319}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31351/vol34iss4pp125-140","doi":"https://doi.org/10.31351/vol34iss4pp125-140","is_oa":true,"landing_page_url":"https://doi.org/10.31351/vol34iss4pp125-140","pdf_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3733/1559","source":{"id":"https://openalex.org/S2764399167","display_name":"Iraqi Journal of Pharmaceutical Sciences","issn_l":"1683-3597","issn":["1683-3597","2521-3512"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:0ae662a2071a4435993f27ebe174c8d1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0ae662a2071a4435993f27ebe174c8d1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences, Vol 34, Iss 4 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31351/vol34iss4pp125-140","doi":"https://doi.org/10.31351/vol34iss4pp125-140","is_oa":true,"landing_page_url":"https://doi.org/10.31351/vol34iss4pp125-140","pdf_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3733/1559","source":{"id":"https://openalex.org/S2764399167","display_name":"Iraqi Journal of Pharmaceutical Sciences","issn_l":"1683-3597","issn":["1683-3597","2521-3512"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310603","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417536896.pdf","grobid_xml":"https://content.openalex.org/works/W4417536896.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Spanlastics":[0,15],"are":[1],"nanovascular":[2],"drug":[3,269],"delivery":[4,301],"systems":[5,302],"that":[6,246,260,289],"use":[7],"surfactants,":[8],"including":[9],"hydrophilic":[10],"and":[11,25,42,80,83,95,111,126,150,185,203,217],"hydrophobic":[12],"medicines":[13,20],".":[14,33,57,99,117,132,208,220,228,241,265,282,303],"enhance":[16],"the":[17,23,48,67,71,139,215,251,256,268,286,292],"ability":[18],"of":[19,40,50,55,73,197,201,206,236,255],"to":[21,46,62,137,273,294],"enter":[22],"body":[24],"provide":[26],"a":[27,37,64,143,151,194,199,211,297],"continuous":[28],"release":[29,165,235],"over":[30,238],"extended":[31],"periods":[32],"These":[34],"vesicles":[35],"possess":[36],"high":[38,152],"degree":[39],"elasticity":[41],"flexibility":[43],",":[44,76,87,91,147,167,173,267,285],"enabling":[45],"improve":[47],"transportation":[49],"medications":[51],"through":[52],"different":[53],"methods":[54],"administrations":[56],"Box-behnken":[58],"design":[59,110,125],"was":[60,224,262,271],"utilized":[61],"establish":[63],"relationship":[65],"between":[66,214],"formulation":[68,192],"parameters,":[69],"specifically":[70],"amount":[72],"Span":[74],"60":[75],"cremophor":[77],"EL":[78],"40":[79],"sonication":[81],"time":[82],"important":[84],"quality":[85],"attributes":[86],"namely":[88],"particle":[89,145,195],"size":[90,146,196],"polydispersity":[92],"index":[93],"(PDI)":[94],"entrapment":[96],"efficiency":[97],"(EE%)":[98],"The":[100,118,133,154,221,229,242],"spanlastic":[101,280,290],"formulations":[102,134],"were":[103,135],"developed":[104,119],"using":[105,113,120,128,160],"response":[106,121],"surface":[107,122],"central":[108,123],"composite":[109,124],"formulated":[112,127],"an":[114,129,204,233,276],"ethanol":[115,130],"injection":[116,131],"analyzed":[136],"identify":[138],"optimal":[140],"formula":[141,156,231,281],"with":[142,250],"tiny":[144],"lower":[148],"PDI":[149,200],"EE%.":[153],"optimized":[155],"underwent":[157],"additional":[158],"analysis":[159,244],"zeta":[161,222],"potential":[162,223],"measurement":[163],"in-vitro":[164],"profile":[166],"Fourier":[168],"Transform":[169],"Infrared":[170],"(FTIR)":[171],"Analysis":[172,183,188],"Field":[174],"Emission":[175],"Scanning":[176,181],"Electron":[177],"Microscopy":[178],"(FESEM)":[179],",Differential":[180],"Calorimetry":[182],"(DSC)":[184],"X-ray":[186],"Diffraction":[187],"(XRD)":[189],".The":[190],"improved":[191],"exhibited":[193],"(84,98)nm,":[198],"0.1993":[202],"EE%":[205],"(53.69)%":[207],"There":[209],"is":[210,248],"little":[212],"discrepancy":[213],"observed":[216],"predicated":[218],"values":[219],"-":[225],"22.":[226],"37":[227],"optimum":[230],"showed":[232],"appropriate":[234],"88.5%":[237],"8":[239],"hr":[240],"compatibility":[243],"demonstrated":[245,288],"RNB":[247],"compatible":[249],"other":[252],"excipients":[253],".Analysis":[254],"vesicle":[257],"shape":[258],"revealed":[259],"it":[261],"nearly":[263],"spherical":[264],"Furthermore":[266],"molecule":[270],"seen":[272],"exist":[274],"in":[275],"amorphous":[277],"condition":[278],"within":[279],"In":[283],"summary":[284],"result":[287],"have":[291],"capacity":[293],"serve":[295],"as":[296],"carrier":[298],"for":[299],"medicine":[300]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2025-12-21T00:00:00"}
