{"id":"https://openalex.org/W4417536886","doi":"https://doi.org/10.31351/vol34iss4pp66-75","title":"Molecular Docking,Synthesis and Preliminary Anti-microbial Evaluation of Some New Sulfonohydrazide and 1,3,4-Oxadiaxzole Derivatives of Flurbiprofen","display_name":"Molecular Docking,Synthesis and Preliminary Anti-microbial Evaluation of Some New Sulfonohydrazide and 1,3,4-Oxadiaxzole Derivatives of Flurbiprofen","publication_year":2025,"publication_date":"2025-12-20","ids":{"openalex":"https://openalex.org/W4417536886","doi":"https://doi.org/10.31351/vol34iss4pp66-75"},"language":"en","primary_location":{"id":"doi:10.31351/vol34iss4pp66-75","doi":"https://doi.org/10.31351/vol34iss4pp66-75","is_oa":true,"landing_page_url":"https://doi.org/10.31351/vol34iss4pp66-75","pdf_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3867/1554","source":{"id":"https://openalex.org/S2764399167","display_name":"Iraqi Journal of Pharmaceutical Sciences","issn_l":"1683-3597","issn":["1683-3597","2521-3512"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3867/1554","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hawraa Yusur Jassim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103044","display_name":"Ministry of Health","ror":"https://ror.org/01b1c8m98","country_code":"IQ","type":"government","lineage":["https://openalex.org/I4210103044"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Hawraa Yusur Jassim","raw_affiliation_strings":["Iraqi Ministry of Health, Department of Health in Baghdad,Russafa, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Iraqi Ministry of Health, Department of Health in Baghdad,Russafa, Baghdad, Iraq","institution_ids":["https://openalex.org/I4210103044"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mohammed Kamil Hadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135120706","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21","country_code":"IQ","type":"education","lineage":["https://openalex.org/I135120706"]}],"countries":["IQ"],"is_corresponding":false,"raw_author_name":"Mohammed Kamil Hadi","raw_affiliation_strings":["Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq","institution_ids":["https://openalex.org/I135120706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":250000,"currency":"IQD","value_usd":null},"apc_paid":null,"fwci":0.298,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50683023,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"34","issue":"4","first_page":"66","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12410","display_name":"Structural and Chemical Analysis of Organic and Inorganic Compounds","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-3-4-oxadiazoles","display_name":"1,3,4-oxadiazoles","score":0.9800000190734863},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.6869999766349792},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/antifungal-activity","display_name":"antifungal activity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/candida-albicans","display_name":"Candida albicans","score":0.9810000061988831},{"id":"https://openalex.org/keywords/streptococcus-pyogenes","display_name":"Streptococcus pyogenes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9990000128746033},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9950000047683716},{"id":"https://openalex.org/keywords/admet-properties","display_name":"ADMET properties","score":0.718999981880188},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8485000133514404},{"id":"https://openalex.org/C2781000538","wikidata":"https://www.wikidata.org/wiki/Q419890","display_name":"Flurbiprofen","level":2,"score":0.8299000263214111},{"id":"https://openalex.org/C2779204102","wikidata":"https://www.wikidata.org/wiki/Q424825","display_name":"Ethyl chloroacetate","level":3,"score":0.57669997215271},{"id":"https://openalex.org/C2776300020","wikidata":"https://www.wikidata.org/wiki/Q422423","display_name":"Bromide","level":2,"score":0.5188999772071838},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4943000078201294},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.46070000529289246},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4287000000476837},{"id":"https://openalex.org/C2777093645","wikidata":"https://www.wikidata.org/wiki/Q420258","display_name":"Cyanogen bromide","level":4,"score":0.41929998993873596},{"id":"https://openalex.org/C87906975","wikidata":"https://www.wikidata.org/wiki/Q899114","display_name":"Sulfonyl","level":3,"score":0.3939000070095062},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.39239999651908875},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.3822999894618988},{"id":"https://openalex.org/C505241676","wikidata":"https://www.wikidata.org/wiki/Q688","display_name":"Chlorine","level":2,"score":0.37560001015663147},{"id":"https://openalex.org/C2779607818","wikidata":"https://www.wikidata.org/wiki/Q243354","display_name":"Carbon disulfide","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C2776597398","wikidata":"https://www.wikidata.org/wiki/Q5954496","display_name":"Hydrazine (antidepressant)","level":2,"score":0.3662000000476837},{"id":"https://openalex.org/C2781060337","wikidata":"https://www.wikidata.org/wiki/Q462174","display_name":"Hydrate","level":2,"score":0.3659999966621399},{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.34299999475479126},{"id":"https://openalex.org/C2778746504","wikidata":"https://www.wikidata.org/wiki/Q417897","display_name":"Norfloxacin","level":4,"score":0.3393000066280365},{"id":"https://openalex.org/C2779906673","wikidata":"https://www.wikidata.org/wiki/Q414413","display_name":"Enrofloxacin","level":4,"score":0.3253999948501587},{"id":"https://openalex.org/C2779448499","wikidata":"https://www.wikidata.org/wiki/Q1227206","display_name":"Oxadiazole","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3165999948978424},{"id":"https://openalex.org/C28800991","wikidata":"https://www.wikidata.org/wiki/Q15634405","display_name":"Hydrolysate","level":3,"score":0.3160000145435333},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.310699999332428},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.30379998683929443},{"id":"https://openalex.org/C2779751237","wikidata":"https://www.wikidata.org/wiki/Q411258","display_name":"Chloroacetyl chloride","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.288100004196167},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.2870999872684479},{"id":"https://openalex.org/C2781283055","wikidata":"https://www.wikidata.org/wiki/Q139199","display_name":"Triethylamine","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.27720001339912415},{"id":"https://openalex.org/C2778695967","wikidata":"https://www.wikidata.org/wiki/Q44791900","display_name":"Chloride","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C2777682936","wikidata":"https://www.wikidata.org/wiki/Q408908","display_name":"Pyrazole","level":2,"score":0.266400009393692},{"id":"https://openalex.org/C2775896084","wikidata":"https://www.wikidata.org/wiki/Q425597","display_name":"Hydroxide","level":2,"score":0.25609999895095825},{"id":"https://openalex.org/C175528265","wikidata":"https://www.wikidata.org/wiki/Q500256","display_name":"Chemical structure","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C2994600331","wikidata":"https://www.wikidata.org/wiki/Q193124","display_name":"Aerobic bacteria","level":3,"score":0.2531000077724457}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.31351/vol34iss4pp66-75","doi":"https://doi.org/10.31351/vol34iss4pp66-75","is_oa":true,"landing_page_url":"https://doi.org/10.31351/vol34iss4pp66-75","pdf_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3867/1554","source":{"id":"https://openalex.org/S2764399167","display_name":"Iraqi Journal of Pharmaceutical Sciences","issn_l":"1683-3597","issn":["1683-3597","2521-3512"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:46201164c7da4e9c9f5954df6ad4fa03","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/46201164c7da4e9c9f5954df6ad4fa03","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences, Vol 34, Iss 4 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.31351/vol34iss4pp66-75","doi":"https://doi.org/10.31351/vol34iss4pp66-75","is_oa":true,"landing_page_url":"https://doi.org/10.31351/vol34iss4pp66-75","pdf_url":"https://bijps.uobaghdad.edu.iq/index.php/bijps/article/download/3867/1554","source":{"id":"https://openalex.org/S2764399167","display_name":"Iraqi Journal of Pharmaceutical Sciences","issn_l":"1683-3597","issn":["1683-3597","2521-3512"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319170","host_organization_name":"University of Baghdad","host_organization_lineage":["https://openalex.org/P4310319170"],"host_organization_lineage_names":["University of Baghdad"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iraqi Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310603","display_name":"University of Baghdad","ror":"https://ror.org/007f1da21"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417536886.pdf","grobid_xml":"https://content.openalex.org/works/W4417536886.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"A":[0],"new":[1],"series":[2],"of":[3,40,76,111,133],"compounds":[4,30,136],"were":[5,48,84],"derived":[6],"from":[7],"2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoic":[8],"acid":[9],"by":[10],"reacting":[11],"flurbiprofen":[12,20],"ethyl":[13],"ester":[14],"with":[15,25,60,142,154],"hydrazine":[16],"hydrate":[17],"to":[18,50,66],"get":[19],"hydrazid(III)":[21],"which":[22,56],"then":[23],"reacted":[24,49,59],"three":[26],"different":[27],"sulfonyl":[28],"chloride":[29],"(Benzenesulfonyl":[31],"Chloride,":[32,34],"4-toleunesulfonyl":[33],"4-chlorosulfonyl":[35],"Chloride)":[36],"in":[37],"the":[38,68,77,134,160],"existence":[39],"triethylamine.":[41],"Additionally,":[42],"compound":[43],"(III)":[44],"and":[45,63,81,109,123,126],"carbon":[46],"disulfide":[47],"yield":[51,67],"oxadiazole":[52],"2-thione":[53],"(compound":[54],"V),":[55],"was":[57,90],"subsequently":[58],"4-chlorophenacyl":[61],"bromide":[62,65],"4-bromophenacyl":[64],"final":[69,78,88],"products":[70],"(Va":[71],"&":[72],"Vb).":[73],"For":[74],"characterization":[75],"compounds,":[79],"FT-IR":[80],"1H-NMR":[82],"spectroscopy":[83],"used":[85],".":[86],"Each":[87],"compound(IVa-c,Va-b)":[89],"examined":[91],"for":[92],"their":[93],"Anti-Microbial":[94],"activity":[95,120],"against":[96,121],"G(+)ve":[97,124],"bacteria":[98,104,125],"(Streptococcus":[99],"pyogenes,":[100],"Staphylococcus":[101],"aureus),":[102],"G(-)ve":[103,122],"(Escherichia":[105],"coli,":[106],"Klebsiella":[107],"pneumoniae)":[108],"strain":[110],"fungi":[112],"(Candida":[113],"albicans).":[114],"Compound":[115],"(IVc)":[116],"showed":[117],"highest":[118],"antimicrobial":[119],"Candida":[127],"albicans":[128],"fungi.":[129],"The":[130],"ADMET":[131],"study":[132],"resulting":[135],"exhibited":[137],"desirable":[138],"pharmacokinetic":[139],"properties":[140],"along":[141],"acceptable":[143],"estimated":[144],"drug-like":[145],"properties.":[146],"molecular":[147,151],"docking":[148,152],"revealed":[149],"good":[150],"results":[153],"target":[155],"protein":[156],"using":[157],"ciprofloxacin":[158],"as":[159],"reference.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2025-12-21T00:00:00"}
