{"id":"https://openalex.org/W4417535329","doi":"https://doi.org/10.1007/s10753-025-02420-3","title":"Intestinal LGR4 Signalling Alters Bacterial translocation, Intrahepatic Microbiota composition, and Type 1 Interferon Expression in Murine Liver Fibrosis","display_name":"Intestinal LGR4 Signalling Alters Bacterial translocation, Intrahepatic Microbiota composition, and Type 1 Interferon Expression in Murine Liver Fibrosis","publication_year":2025,"publication_date":"2025-12-20","ids":{"openalex":"https://openalex.org/W4417535329","doi":"https://doi.org/10.1007/s10753-025-02420-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/41420724"},"language":"en","primary_location":{"id":"doi:10.1007/s10753-025-02420-3","doi":"https://doi.org/10.1007/s10753-025-02420-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10753-025-02420-3","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s10753-025-02420-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Junyan Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198959115","display_name":"Changzhi Medical College","ror":"https://ror.org/0340wst14","country_code":"CN","type":"education","lineage":["https://openalex.org/I198959115"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junyan Gao","raw_affiliation_strings":["Department of Basic Medicine, Changzhi Medical College, Changzhi, 046000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medicine, Changzhi Medical College, Changzhi, 046000, China","institution_ids":["https://openalex.org/I198959115"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bangtao Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bangtao Chen","raw_affiliation_strings":["Department of Dermatology, School of Medicine, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, 404000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, School of Medicine, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, 404000, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cheng Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Chen","raw_affiliation_strings":["Department of Gastroenterology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing, 400030, China","institution_ids":["https://openalex.org/I158842170","https://openalex.org/I4210154480"]}]},{"author_position":"last","author":{"id":null,"display_name":"Yanghui Bi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198959115","display_name":"Changzhi Medical College","ror":"https://ror.org/0340wst14","country_code":"CN","type":"education","lineage":["https://openalex.org/I198959115"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanghui Bi","raw_affiliation_strings":["Department of Basic Medicine, Changzhi Medical College, Changzhi, 046000, China. doctorYnh_b028@163.com","Department of Pathophysiology, Changzhi Medical College, Changzhi, 046000, China. doctorYnh_b028@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medicine, Changzhi Medical College, Changzhi, 046000, China. doctorYnh_b028@163.com","institution_ids":["https://openalex.org/I198959115"]},{"raw_affiliation_string":"Department of Pathophysiology, Changzhi Medical College, Changzhi, 046000, China. doctorYnh_b028@163.com","institution_ids":["https://openalex.org/I198959115"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I198959115"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":{"value":4790,"currency":"USD","value_usd":4790},"fwci":0.9933,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.79614272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"49","issue":"1","first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7616999745368958,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7616999745368958,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.1981000006198883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9150000214576721},{"id":"https://openalex.org/keywords/lgr4","display_name":"LGR4","score":0.8659999966621399},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.7459999918937683},{"id":"https://openalex.org/keywords/bacterial-translocation","display_name":"bacterial translocation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9419999718666077},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8190000057220459},{"id":"https://openalex.org/keywords/lactobacillus","display_name":"Lactobacillus","score":0.8859999775886536},{"id":"https://openalex.org/keywords/escherichia-shigella","display_name":"Escherichia-Shigella","score":0.9300000071525574},{"id":"https://openalex.org/keywords/klebsiella","display_name":"Klebsiella","score":0.9779999852180481},{"id":"https://openalex.org/keywords/acinetobacter","display_name":"Acinetobacter","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dubosiella","display_name":"Dubosiella","score":0.7549999952316284},{"id":"https://openalex.org/keywords/bifidobacterium","display_name":"Bifidobacterium","score":0.8980000019073486},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.8330000042915344},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.7089999914169312},{"id":"https://openalex.org/keywords/gut-liver-axis","display_name":"gut-liver axis","score":0.675000011920929},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.5649999976158142}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6180999875068665},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.5626999735832214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49320000410079956},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.46860000491142273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4625999927520752},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.4553999900817871},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4205999970436096},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.3758000135421753},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.34950000047683716},{"id":"https://openalex.org/C2780027724","wikidata":"https://www.wikidata.org/wiki/Q288892","display_name":"Ruminococcus","level":3,"score":0.34630000591278076},{"id":"https://openalex.org/C41260117","wikidata":"https://www.wikidata.org/wiki/Q668064","display_name":"Hepatology","level":2,"score":0.34200000762939453},{"id":"https://openalex.org/C102124568","wikidata":"https://www.wikidata.org/wiki/Q5009626","display_name":"CCL4","level":3,"score":0.3400000035762787},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.3294000029563904},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.31150001287460327},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3073999881744385},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.3005000054836273},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C2780749602","wikidata":"https://www.wikidata.org/wiki/Q425680","display_name":"Deoxycholic acid","level":3,"score":0.26969999074935913},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25999999046325684},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.25429999828338623}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007370","descriptor_name":"Interferon Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018988","descriptor_name":"Bacterial Translocation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10753-025-02420-3","doi":"https://doi.org/10.1007/s10753-025-02420-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10753-025-02420-3","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},{"id":"pmid:41420724","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41420724","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12722391","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12722391/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Inflammation","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10753-025-02420-3","doi":"https://doi.org/10.1007/s10753-025-02420-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10753-025-02420-3","pdf_url":null,"source":{"id":"https://openalex.org/S127393932","display_name":"Inflammation","issn_l":"0360-3997","issn":["0360-3997","1573-2576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1647640727","https://openalex.org/W1776390480","https://openalex.org/W2012559950","https://openalex.org/W2031723810","https://openalex.org/W2060117171","https://openalex.org/W2070352246","https://openalex.org/W2085959133","https://openalex.org/W2152163266","https://openalex.org/W2765808825","https://openalex.org/W2805379007","https://openalex.org/W2899741402","https://openalex.org/W2995998815","https://openalex.org/W3005755138","https://openalex.org/W3087672637","https://openalex.org/W3102967988","https://openalex.org/W3133991527","https://openalex.org/W3156543632","https://openalex.org/W3203654825","https://openalex.org/W4205791102","https://openalex.org/W4210579909","https://openalex.org/W4210622611","https://openalex.org/W4214823353","https://openalex.org/W4254379027","https://openalex.org/W4280573844","https://openalex.org/W4283826385","https://openalex.org/W4323543657","https://openalex.org/W4378953926","https://openalex.org/W4380576610","https://openalex.org/W4382988265","https://openalex.org/W4388832054","https://openalex.org/W4389615151","https://openalex.org/W4392470588","https://openalex.org/W4396664078","https://openalex.org/W4399809588","https://openalex.org/W4404645176","https://openalex.org/W4408285053"],"related_works":[],"abstract_inverted_index":{"Liver":[0,22],"fibrosis":[1],"(LF)":[2],"is":[3],"linked":[4],"to":[5,70],"decreased":[6,117,122,149,174,193],"type":[7],"1":[8],"interferon":[9],"(IFN1)":[10],"levels":[11],"at":[12],"steady-state,":[13],"intestinal":[14,19,36,41,49,86,108,112,240,247],"dysbacteriosis,":[15],"leaky":[16],"gut,":[17],"and":[18,35,54,60,114,121,129,148,155,173,197,204,253],"bacterial":[20,115,125],"translocation.":[21],"leucine-rich":[23],"repeats":[24],"containing":[25],"G":[26],"protein-coupled":[27],"receptor":[28,213],"4":[29],"(LGR4)":[30],"signalling":[31,51,242],"drives":[32],"LF":[33,53,72,105,137,189,244],"development,":[34],"LGR4":[37,50,109,241],"homeostasis":[38],"maintains":[39],"the":[40,46,158,210,215],"stem":[42],"cells.":[43],"To":[44],"explore":[45],"role":[47],"of":[48,64,83,124,143,152,160,185,209,218,221],"in":[52,73,85,107,133,165,169,181],"possible":[55],"relationships":[56],"with":[57,77,95,178,200,224],"intrahepatic":[58,118,141,150,171,194,202,250],"microbiota":[59,251],"IFN1,":[61],"intraperitoneal":[62],"injection":[63],"carbon":[65],"tetrachloride":[66],"(CCL4)":[67],"was":[68],"applied":[69],"induce":[71],"adult":[74],"C57BL/6J":[75],"mice":[76,91,177],"or":[78,226],"without":[79],"conditional":[80],"knockout":[81],"(cKO)":[82],"Lgr4":[84,131,163,179],"epithelial":[87],"cells":[88,223],"(IECs).":[89],"Fibrotic":[90],"were":[92],"simultaneously":[93],"treated":[94],"intragastric":[96,183],"bacteria":[97],"as":[98],"needed.":[99],"Results":[100],"showed":[101],"that":[102,238],"wild-type":[103],"murine":[104],"resulted":[106,168],"reduction,":[110],"increased":[111,140,170,201,230],"permeability":[113],"translocation,":[116],"IFN1":[119,205,212,256],"levels,":[120],"abundance":[123,142,151],"genera":[126,144],"Lactobacillus,":[127,153],"Dubosiella,":[128,154],"Bifidobacterium.":[130,156],"cKO":[132,164,180],"IECs":[134,166],"significantly":[135,187,192],"promoted":[136],"accompanied":[138,190],"by":[139,191,245],"Escherichia-Shigella,":[145,195],"Klebsiella,":[146,196],"Acinetobacter":[147,198],"In":[157,176],"absence":[159],"CCL4":[161],"challenge,":[162],"also":[167],"Escherichia-Shigella":[172],"Lactobacillus.":[175],"IECs,":[182],"administration":[184],"Lactobacillus":[186,203,225],"attenuated":[188],"along":[199],"levels;":[206],"however,":[207],"deletion":[208],"organismal":[211],"abolished":[214],"Lactobacillus-mediated":[216],"alleviation":[217],"LF.":[219],"Co-culture":[220],"DC2.4":[222],"its":[227],"genomic":[228],"DNA":[229],"supernatant":[231],"IFN-\u03b2":[232],"levels.":[233,257],"Overall,":[234],"this":[235],"study":[236],"demonstrates":[237],"weakened":[239],"facilitates":[243],"increasing":[246],"permeability,":[248],"altering":[249],"composition,":[252],"decreasing":[254],"liver":[255]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-12T09:15:50.089291","created_date":"2025-12-21T00:00:00"}