{"id":"https://openalex.org/W4417455263","doi":"https://doi.org/10.1002/cbf.70151","title":"Mitochondrial Dysfunction Drives Oxidative Stress and Energy Imbalance in a Murine Model of Spondyloarthritis","display_name":"Mitochondrial Dysfunction Drives Oxidative Stress and Energy Imbalance in a Murine Model of Spondyloarthritis","publication_year":2025,"publication_date":"2025-12-01","ids":{"openalex":"https://openalex.org/W4417455263","doi":"https://doi.org/10.1002/cbf.70151","pmid":"https://pubmed.ncbi.nlm.nih.gov/41410024"},"language":"en","primary_location":{"id":"doi:10.1002/cbf.70151","doi":"https://doi.org/10.1002/cbf.70151","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbf.70151","pdf_url":null,"source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rodrigo Prieto\u2010Carrasco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142652706","display_name":"Autonomous University of Chihuahua","ror":"https://ror.org/04mrrw205","country_code":"MX","type":"education","lineage":["https://openalex.org/I142652706"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Rodrigo Prieto\u2010Carrasco","raw_affiliation_strings":["PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico","institution_ids":["https://openalex.org/I142652706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019753987","display_name":"Susana Aide\u00e9 Gonz\u00e1lez\u2010Ch\u00e1vez","orcid":"https://orcid.org/0000-0002-1779-296X","observed_orcids":["https://orcid.org/0000-0002-1779-296X"]},"institutions":[{"id":"https://openalex.org/I142652706","display_name":"Autonomous University of Chihuahua","ror":"https://ror.org/04mrrw205","country_code":"MX","type":"education","lineage":["https://openalex.org/I142652706"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Susana Aide\u00e9 Gonz\u00e1lez\u2010Ch\u00e1vez","raw_affiliation_strings":["PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico"],"raw_orcid":"https://orcid.org/0000-0002-1779-296X","affiliations":[{"raw_affiliation_string":"PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico","institution_ids":["https://openalex.org/I142652706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034031629","display_name":"Eduardo Chaparro-Barrera","orcid":"https://orcid.org/0000-0001-7246-4451","observed_orcids":["https://orcid.org/0000-0001-7246-4451"]},"institutions":[{"id":"https://openalex.org/I142652706","display_name":"Autonomous University of Chihuahua","ror":"https://ror.org/04mrrw205","country_code":"MX","type":"education","lineage":["https://openalex.org/I142652706"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Eduardo Chaparro\u2010Barrera","raw_affiliation_strings":["PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico","institution_ids":["https://openalex.org/I142652706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118214776","display_name":"Mario Loya-Rivera","orcid":"https://orcid.org/0009-0001-8096-8745","observed_orcids":["https://orcid.org/0009-0001-8096-8745"]},"institutions":[{"id":"https://openalex.org/I142652706","display_name":"Autonomous University of Chihuahua","ror":"https://ror.org/04mrrw205","country_code":"MX","type":"education","lineage":["https://openalex.org/I142652706"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Mario Loya\u2010Rivera","raw_affiliation_strings":["PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico","institution_ids":["https://openalex.org/I142652706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092626256","display_name":"Bel\u00e9n Cuevas-L\u00f3pez","orcid":"https://orcid.org/0009-0000-8762-7874","observed_orcids":["https://orcid.org/0009-0000-8762-7874"]},"institutions":[{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]},{"id":"https://openalex.org/I59361560","display_name":"Instituto Polit\u00e9cnico Nacional","ror":"https://ror.org/059sp8j34","country_code":"MX","type":"education","lineage":["https://openalex.org/I59361560"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Bel\u00e9n Cuevas\u2010L\u00f3pez","raw_affiliation_strings":["CECyT 6, Instituto Polit\u00e9cnico Nacional Mexico City Mexico","Department of Cardio\u2010Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CECyT 6, Instituto Polit\u00e9cnico Nacional Mexico City Mexico","institution_ids":["https://openalex.org/I59361560"]},{"raw_affiliation_string":"Department of Cardio\u2010Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City Mexico","institution_ids":["https://openalex.org/I4210157394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088064451","display_name":"Fernando E. Garc\u00eda\u2010Arroyo","orcid":"https://orcid.org/0000-0003-1545-9765","observed_orcids":["https://orcid.org/0000-0003-1545-9765"]},"institutions":[{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Fernando E. Garc\u00eda\u2010Arroyo","raw_affiliation_strings":["Department of Cardio\u2010Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City Mexico"],"raw_orcid":"https://orcid.org/0000-0003-1545-9765","affiliations":[{"raw_affiliation_string":"Department of Cardio\u2010Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City Mexico","institution_ids":["https://openalex.org/I4210157394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003333186","display_name":"Omar Emiliano Aparicio\u2010Trejo","orcid":"https://orcid.org/0000-0002-7701-4537","observed_orcids":["https://orcid.org/0000-0002-7701-4537"]},"institutions":[{"id":"https://openalex.org/I4210157394","display_name":"Instituto Nacional de Cardiolog\u00eda","ror":"https://ror.org/046e90j34","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210157394"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Omar Emiliano Aparicio\u2010Trejo","raw_affiliation_strings":["Department of Cardio\u2010Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardio\u2010Renal Pathophysiology National Institute of Cardiology \u201cIgnacio Ch\u00e1vez\u201d Mexico City Mexico","institution_ids":["https://openalex.org/I4210157394"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024454450","display_name":"C\u00e9sar Pacheco\u2010Tena","orcid":"https://orcid.org/0000-0002-0793-8988","observed_orcids":["https://orcid.org/0000-0002-0793-8988"]},"institutions":[{"id":"https://openalex.org/I142652706","display_name":"Autonomous University of Chihuahua","ror":"https://ror.org/04mrrw205","country_code":"MX","type":"education","lineage":["https://openalex.org/I142652706"]}],"countries":["MX"],"is_corresponding":true,"raw_author_name":"C\u00e9sar Pacheco\u2010Tena","raw_affiliation_strings":["PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico"],"raw_orcid":"https://orcid.org/0000-0002-0793-8988","affiliations":[{"raw_affiliation_string":"PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences Autonomous University of Chihuahua Chihuahua Mexico","institution_ids":["https://openalex.org/I142652706"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024454450"],"corresponding_institution_ids":["https://openalex.org/I142652706"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24155253,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"43","issue":"12","first_page":"e70151","last_page":"e70151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8398000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.10239999741315842,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spondyloarthritis","display_name":"spondyloarthritis","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9950000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.7429999709129333},{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.8059999942779541},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":0.9629999995231628},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/synovial-fibroblasts","display_name":"synovial fibroblasts","score":0.9150000214576721},{"id":"https://openalex.org/keywords/joint-inflammation","display_name":"joint inflammation","score":0.7429999709129333},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.6539999842643738},{"id":"https://openalex.org/keywords/4-hydroxynonenal","display_name":"4-hydroxynonenal","score":0.8560000061988831},{"id":"https://openalex.org/keywords/pink1","display_name":"PINK1","score":0.6620000004768372},{"id":"https://openalex.org/keywords/pgc-1alpha","display_name":"PGC-1\u03b1","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dba-1-mice","display_name":"DBA/1 mice","score":0.7239999771118164},{"id":"https://openalex.org/keywords/synovial-transcriptome","display_name":"synovial transcriptome","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7161999940872192},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.7056999802589417},{"id":"https://openalex.org/C2777755479","wikidata":"https://www.wikidata.org/wiki/Q18039927","display_name":"FIS1","level":5,"score":0.6676999926567078},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6481000185012817},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.5788999795913696},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.5625},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5187000036239624},{"id":"https://openalex.org/C2777591492","wikidata":"https://www.wikidata.org/wiki/Q18041951","display_name":"MFN1","level":5,"score":0.5156000256538391},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.505299985408783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.505299985408783},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4999000132083893},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.4697999954223633},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.46860000491142273},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.46399998664855957},{"id":"https://openalex.org/C111491248","wikidata":"https://www.wikidata.org/wiki/Q18033821","display_name":"DNAJA3","level":5,"score":0.4271000027656555},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3935999870300293},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.38909998536109924},{"id":"https://openalex.org/C2777092462","wikidata":"https://www.wikidata.org/wiki/Q15334407","display_name":"MFN2","level":5,"score":0.38019999861717224},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3517000079154968},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32359999418258667},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.3089999854564667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3043999969959259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30059999227523804},{"id":"https://openalex.org/C169415338","wikidata":"https://www.wikidata.org/wiki/Q18031951","display_name":"TFAM","level":4,"score":0.29429998993873596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2858000099658966},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.2800000011920929},{"id":"https://openalex.org/C2776804853","wikidata":"https://www.wikidata.org/wiki/Q18045837","display_name":"PINK1","level":5,"score":0.26409998536109924},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.2567000091075897}],"mesh":[{"descriptor_ui":"D000070918","descriptor_name":"Synoviocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000070918","descriptor_name":"Synoviocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000070918","descriptor_name":"Synoviocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000070918","descriptor_name":"Synoviocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025241","descriptor_name":"Spondylarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025241","descriptor_name":"Spondylarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D025241","descriptor_name":"Spondylarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D025241","descriptor_name":"Spondylarthritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cbf.70151","doi":"https://doi.org/10.1002/cbf.70151","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbf.70151","pdf_url":null,"source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},{"id":"pmid:41410024","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41410024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biochemistry and function","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1518086527","https://openalex.org/W1524129710","https://openalex.org/W1884950180","https://openalex.org/W1971794940","https://openalex.org/W2029195231","https://openalex.org/W2036013589","https://openalex.org/W2090711760","https://openalex.org/W2101315321","https://openalex.org/W2146607274","https://openalex.org/W2229506676","https://openalex.org/W2270832141","https://openalex.org/W2395249393","https://openalex.org/W2414591521","https://openalex.org/W2526217474","https://openalex.org/W2547436731","https://openalex.org/W2790553047","https://openalex.org/W2894565780","https://openalex.org/W2927266107","https://openalex.org/W3009647858","https://openalex.org/W3034112560","https://openalex.org/W3039656228","https://openalex.org/W3093863156","https://openalex.org/W3107527779","https://openalex.org/W3118492427","https://openalex.org/W3156622295","https://openalex.org/W3157501418","https://openalex.org/W3157593766","https://openalex.org/W3189213208","https://openalex.org/W4210470594","https://openalex.org/W4281744141","https://openalex.org/W4282968194","https://openalex.org/W4285041315","https://openalex.org/W4294131694","https://openalex.org/W4297989882","https://openalex.org/W4310356800","https://openalex.org/W4311376539","https://openalex.org/W4385247054","https://openalex.org/W4388024297","https://openalex.org/W4392762572","https://openalex.org/W4399133757","https://openalex.org/W4399284286","https://openalex.org/W4402773474","https://openalex.org/W4411349166"],"related_works":[],"abstract_inverted_index":{"Joint":[0],"inflammation":[1],"and":[2,30,46,61,72,74,77,83,107,115,129,143,153],"structural":[3],"damage":[4],"in":[5,22,34,56,96,133,173,197,210,235],"spondyloarthritis":[6],"(SpA)":[7],"are":[8],"not":[9],"fully":[10],"explained":[11],"by":[12,100,140],"known":[13],"immune":[14],"mechanisms.":[15],"While":[16],"mitochondrial":[17,54,69,88,94,123,187,195,208,226],"dysfunction":[18,95,209],"has":[19],"been":[20],"implicated":[21],"other":[23],"rheumatic":[24],"diseases,":[25],"such":[26],"as":[27,218],"rheumatoid":[28],"arthritis":[29,44],"lupus,":[31],"its":[32],"role":[33,193],"SpA":[35],"remains":[36],"poorly":[37],"understood.":[38],"Male":[39],"DBA/1":[40],"mice":[41,49],"with":[42,87,111],"spontaneous":[43],"(SpAD)":[45],"healthy":[47],"BALB/c":[48],"were":[50,171],"compared":[51],"to":[52,121,186,205],"assess":[53],"alterations":[55],"joint":[57,97,223],"tissues,":[58],"isolated":[59],"mitochondria":[60],"cultured":[62,174],"fibroblast-like":[63],"synoviocytes":[64],"(FLS).":[65],"Analyses":[66],"focused":[67],"on":[68],"dynamics":[70],"(fission":[71],"fusion)":[73],"turnover":[75,109],"(biogenesis":[76],"mitophagy),":[78],"bioenergetic":[79],"function,":[80,188],"oxidative":[81,134],"stress,":[82],"transcriptomic":[84],"changes":[85,170],"associated":[86],"function.":[89],"SpAD":[90,198],"induced":[91],"a":[92,130,160,163,211,219],"coordinated":[93],"tissues":[98],"characterized":[99],"increased":[101],"fission":[102],"(Drp1),":[103],"reduced":[104,126],"fusion":[105],"(Mfn2),":[106],"dysregulated":[108],"processes":[110],"elevated":[112,148],"mitophagy":[113],"(PINK1)":[114],"biogenesis":[116],"(PGC-1\u03b1).":[117],"This":[118,200],"imbalance":[119],"led":[120],"dysregulation":[122,196],"complexes":[124],"activity,":[125,147,152],"ATP":[127],"production,":[128],"pronounced":[131],"increase":[132],"stress.":[135],"The":[136],"latter":[137],"was":[138],"evidenced":[139],"decreased":[141],"catalase":[142],"glutathione":[144],"peroxidase":[145],"(Gpx)":[146],"superoxide":[149],"dismutase":[150],"(SOD)":[151],"accumulation":[154],"of":[155,194,214,222],"4":[156],"hydroxynonenal":[157],"(4-HNE),":[158],"highlighting":[159],"shift":[161],"toward":[162],"chronic":[164],"pro-oxidative":[165],"environment.":[166],"Similar":[167],"gene":[168],"expression":[169],"observed":[172],"FLS.":[175],"Transcriptomic":[176],"analysis":[177],"identified":[178],"6,673":[179],"differentially":[180],"expressed":[181],"genes,":[182],"including":[183],"139":[184],"related":[185],"which":[189],"reinforces":[190],"the":[191,203],"central":[192],"pathophysiology.":[199],"study":[201],"is":[202],"first":[204],"comprehensively":[206],"characterize":[207],"murine":[212],"model":[213],"SpA,":[215],"identifying":[216],"it":[217],"potential":[220],"driver":[221],"damage.":[224],"Targeting":[225],"pathways":[227],"may":[228],"offer":[229],"novel":[230],"strategies":[231],"for":[232],"disease":[233],"modification":[234],"spondyloarthritis.":[236]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-12-18T00:00:00"}