{"id":"https://openalex.org/W4417455132","doi":"https://doi.org/10.3390/pathogens14121298","title":"Development of a Novel Sandwich ELISA Test for the Detection of Antibodies Against Rickettsia","display_name":"Development of a Novel Sandwich ELISA Test for the Detection of Antibodies Against Rickettsia","publication_year":2025,"publication_date":"2025-12-18","ids":{"openalex":"https://openalex.org/W4417455132","doi":"https://doi.org/10.3390/pathogens14121298","pmid":"https://pubmed.ncbi.nlm.nih.gov/41471253"},"language":"en","primary_location":{"id":"doi:10.3390/pathogens14121298","doi":"https://doi.org/10.3390/pathogens14121298","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens14121298","pdf_url":"https://www.mdpi.com/2076-0817/14/12/1298/pdf?version=1766041314","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2076-0817/14/12/1298/pdf?version=1766041314","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018224337","display_name":"Marco Quevedo-D\u00edaz","orcid":"https://orcid.org/0009-0006-0011-3680","observed_orcids":["https://orcid.org/0009-0006-0011-3680"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4210164364","display_name":"Institute of Virology of the Slovak Academy of Sciences","ror":"https://ror.org/04xrjem68","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]}],"countries":["SK"],"is_corresponding":true,"raw_author_name":"Marco Quevedo-Diaz","raw_affiliation_strings":["Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0009-0006-0011-3680","affiliations":[{"raw_affiliation_string":"Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120842654","display_name":"Semen Kaliukanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4210164364","display_name":"Institute of Virology of the Slovak Academy of Sciences","ror":"https://ror.org/04xrjem68","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]},{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":true,"raw_author_name":"Semen Kaliukanov","raw_affiliation_strings":["Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","Faculty of Natural Science, Department of Microbiology and Virology, Comenius University, Ilkovi\u010dova 3278/6, 84104 Bratislava, Slovakia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]},{"raw_affiliation_string":"Faculty of Natural Science, Department of Microbiology and Virology, Comenius University, Ilkovi\u010dova 3278/6, 84104 Bratislava, Slovakia","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052629668","display_name":"Franti\u0161ek Csicsay","orcid":"https://orcid.org/0009-0005-8845-5855","observed_orcids":["https://orcid.org/0009-0005-8845-5855"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4210164364","display_name":"Institute of Virology of the Slovak Academy of Sciences","ror":"https://ror.org/04xrjem68","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Frantisek Csicsay","raw_affiliation_strings":["Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0009-0005-8845-5855","affiliations":[{"raw_affiliation_string":"Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021252266","display_name":"Diana Hopkov\u00e1","orcid":"https://orcid.org/0000-0002-7515-6734","observed_orcids":["https://orcid.org/0000-0002-7515-6734"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4210164364","display_name":"Institute of Virology of the Slovak Academy of Sciences","ror":"https://ror.org/04xrjem68","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Diana Hopkova","raw_affiliation_strings":["Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0000-0002-7515-6734","affiliations":[{"raw_affiliation_string":"Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086353622","display_name":"\u013dudov\u00edt \u0160kult\u00e9ty","orcid":"https://orcid.org/0000-0002-9830-6459","observed_orcids":["https://orcid.org/0000-0002-9830-6459"]},"institutions":[{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I4210123996","display_name":"Biomedical Research Center of the Slovak Academy of Sciences","ror":"https://ror.org/02s3ds748","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996"]},{"id":"https://openalex.org/I4210164364","display_name":"Institute of Virology of the Slovak Academy of Sciences","ror":"https://ror.org/04xrjem68","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Ludovit Skultety","raw_affiliation_strings":["Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","National Reference Centre for Surveillance and Laboratory Diagnosis of Rickettsioses Bansk\u00e1 Bystrica, Performance Workplace Institute of Virology, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia"],"raw_orcid":"https://orcid.org/0000-0002-9830-6459","affiliations":[{"raw_affiliation_string":"Department of Rickettsiology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364"]},{"raw_affiliation_string":"National Reference Centre for Surveillance and Laboratory Diagnosis of Rickettsioses Bansk\u00e1 Bystrica, Performance Workplace Institute of Virology, D\u00fabravsk\u00e1 Cesta 9, 84505 Bratislava, Slovakia","institution_ids":["https://openalex.org/I4210164364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018224337","https://openalex.org/A5120842654"],"corresponding_institution_ids":["https://openalex.org/I207624831","https://openalex.org/I4210123996","https://openalex.org/I4210164364","https://openalex.org/I74788687"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36213528,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":"12","first_page":"1298","last_page":"1298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10296","display_name":"Vector-borne infectious diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12833","display_name":"Bartonella species infections research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11899","display_name":"Brucella: diagnosis, epidemiology, treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rickettsia","display_name":"Rickettsia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rickettsial-diseases","display_name":"rickettsial infection","score":0.8809999823570251},{"id":"https://openalex.org/keywords/sandwich-elisa","display_name":"sandwich ELISA","score":0.8619999885559082},{"id":"https://openalex.org/keywords/serological-diagnosis","display_name":"serological diagnosis","score":0.7319999933242798},{"id":"https://openalex.org/keywords/recombinant-antigen","display_name":"recombinant antigen","score":0.843999981880188},{"id":"https://openalex.org/keywords/igg-detection","display_name":"IgG detection","score":0.656000018119812},{"id":"https://openalex.org/keywords/igm-antibody-detection","display_name":"IgM antibody detection","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cross-reactivity","display_name":"cross-reactivity","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.7918000221252441},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6639999747276306},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6061000227928162},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5360999703407288},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5286999940872192},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.49399998784065247},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.48739999532699585},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4860000014305115},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.44679999351501465},{"id":"https://openalex.org/C2983449737","wikidata":"https://www.wikidata.org/wiki/Q177719","display_name":"Clinical diagnosis","level":2,"score":0.40389999747276306},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.4025000035762787},{"id":"https://openalex.org/C2780414542","wikidata":"https://www.wikidata.org/wiki/Q627992","display_name":"Rickettsia","level":3,"score":0.33320000767707825},{"id":"https://openalex.org/C3017456870","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Specific antibody","level":3,"score":0.32519999146461487},{"id":"https://openalex.org/C2780367336","wikidata":"https://www.wikidata.org/wiki/Q4808618","display_name":"Assay sensitivity","level":3,"score":0.3075000047683716},{"id":"https://openalex.org/C2780261877","wikidata":"https://www.wikidata.org/wiki/Q3519062","display_name":"Rapid diagnostic test","level":3,"score":0.2973000109195709},{"id":"https://openalex.org/C2984894117","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Indirect immunofluorescence","level":3,"score":0.2883000075817108},{"id":"https://openalex.org/C3020067899","wikidata":"https://www.wikidata.org/wiki/Q1163564","display_name":"Screening test","level":2,"score":0.2822999954223633},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.28220000863075256},{"id":"https://openalex.org/C98246554","wikidata":"https://www.wikidata.org/wiki/Q5280334","display_name":"Direct fluorescent antibody","level":3,"score":0.2808000147342682},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27379998564720154}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003429","descriptor_name":"Cross Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007075","descriptor_name":"Immunoglobulin M","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012281","descriptor_name":"Rickettsia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012281","descriptor_name":"Rickettsia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012281","descriptor_name":"Rickettsia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012281","descriptor_name":"Rickettsia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012281","descriptor_name":"Rickettsia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012282","descriptor_name":"Rickettsia Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/pathogens14121298","doi":"https://doi.org/10.3390/pathogens14121298","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens14121298","pdf_url":"https://www.mdpi.com/2076-0817/14/12/1298/pdf?version=1766041314","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},{"id":"pmid:41471253","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41471253","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1c066205a2154c5387be4c7964c22aba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1c066205a2154c5387be4c7964c22aba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pathogens, Vol 14, Iss 12, p 1298 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12736059","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12736059/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pathogens","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.3390/pathogens14121298","doi":"https://doi.org/10.3390/pathogens14121298","is_oa":true,"landing_page_url":"https://doi.org/10.3390/pathogens14121298","pdf_url":"https://www.mdpi.com/2076-0817/14/12/1298/pdf?version=1766041314","source":{"id":"https://openalex.org/S4210239906","display_name":"Pathogens","issn_l":"2076-0817","issn":["2076-0817"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1900011353","display_name":"Elimin\u00e1cia klie\u0161\u0165ami pren\u00e1\u0161an\u00fdch infekci\u00ed bez pou\u017eitia antibiot\u00edk","funder_award_id":"APVV-23-0325","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"},{"id":"https://openalex.org/G8088548421","display_name":null,"funder_award_id":"APVV-23-","funder_id":"https://openalex.org/F4320323251","funder_display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja"}],"funders":[{"id":"https://openalex.org/F4320323251","display_name":"Agent\u00fara na Podporu V\u00fdskumu a V\u00fdvoja","ror":"https://ror.org/037nx0e70"},{"id":"https://openalex.org/F4320323641","display_name":"Vedeck\u00e1 Grantov\u00e1 Agent\u00fara M\u0160VVa\u0160 SR a SAV","ror":"https://ror.org/044gwpv05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417455132.pdf","grobid_xml":"https://content.openalex.org/works/W4417455132.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1980019871","https://openalex.org/W1996393629","https://openalex.org/W2038680047","https://openalex.org/W2112913332","https://openalex.org/W2144049958","https://openalex.org/W2166984210","https://openalex.org/W2168784969","https://openalex.org/W2354086895","https://openalex.org/W2621508059","https://openalex.org/W2765228684","https://openalex.org/W2781855246","https://openalex.org/W2803637580","https://openalex.org/W2979516843","https://openalex.org/W3019726578","https://openalex.org/W3041346262","https://openalex.org/W3087244600","https://openalex.org/W3109013292","https://openalex.org/W3138077599","https://openalex.org/W3207193255","https://openalex.org/W4226420065","https://openalex.org/W4292608371","https://openalex.org/W4303633806","https://openalex.org/W4407273816"],"related_works":[],"abstract_inverted_index":{"Diagnosis":[0],"of":[1,13,44,107,111,133,163,188],"rickettsial":[2,189],"infections":[3],"is":[4],"challenging":[5],"due":[6],"to":[7,49,131],"nonspecific":[8],"clinical":[9,96,179],"symptoms":[10],"and":[11,27,37,51,70,76,94,109,151,172,185],"limitations":[12],"current":[14],"diagnostic":[15,127,156,174],"methods.":[16],"Molecular":[17],"assays":[18],"allow":[19],"early":[20,42,184],"detection":[21,60,187],"but":[22,121],"are":[23],"limited":[24],"by":[25],"cost":[26],"technical":[28],"demands,":[29],"whereas":[30],"conventional":[31],"serological":[32],"tests":[33],"often":[34],"exhibit":[35],"cross-reactivity":[36,141],"low":[38],"sensitivity":[39,106,119],"during":[40],"the":[41,161,183],"stages":[43],"infection.":[45],"This":[46],"study":[47],"aimed":[48],"develop":[50],"evaluate":[52],"a":[53,134,177],"recombinant-antigen":[54],"sandwich":[55],"ELISA":[56,100,167],"for":[57,78,181],"improved":[58],"antibody":[59],"against":[61],"Rickettsia":[62,65],"spp.":[63],"Three":[64],"akari":[66],"proteins,":[67],"rGroEL,":[68],"rDnaK,":[69],"rA8GP63":[71,152],"(uncharacterized":[72],"protein),":[73],"were":[74],"produced":[75],"validated":[77],"immunogenicity.":[79],"The":[80,98,126],"assay":[81],"was":[82,129],"evaluated":[83],"using":[84],"94":[85],"patient":[86],"serum":[87],"samples,":[88],"including":[89],"those":[90],"with":[91,104,139,147,176],"positive,":[92],"negative,":[93],"unknown":[95],"course.":[97],"optimized":[99],"demonstrated":[101],"high":[102],"reproducibility,":[103],"IgG":[105],"89.47\u201395.39%":[108],"specificity":[110,124],"90%.":[112],"IgM":[113],"detection,":[114],"also":[115],"assessed,":[116],"showed":[117],"lower":[118],"(42.11\u201382.89%)":[120],"maintained":[122],"strong":[123],"(83.33%).":[125],"performance":[128],"comparable":[130],"that":[132],"commercial":[135],"indirect":[136],"immunofluorescence":[137],"assay,":[138],"no":[140],"detected":[142],"in":[143],"sera":[144],"from":[145],"patients":[146],"unrelated":[148],"infections.":[149,190],"rDnaK":[150],"represent":[153],"newly":[154],"explored":[155],"candidates.":[157],"These":[158],"findings":[159],"highlight":[160],"potential":[162],"this":[164],"recombinant":[165],"protein-based":[166],"as":[168],"an":[169],"accessible,":[170],"sensitive":[171],"specific":[173],"tool,":[175],"meaningful":[178],"impact":[180],"improving":[182],"accurate":[186]},"counts_by_year":[],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-12-18T00:00:00"}
