{"id":"https://openalex.org/W4417415430","doi":"https://doi.org/10.1016/j.synbio.2026.10.011","title":"Computational and experimental analysis for the mismatched DNA recognition mechanism of TaqMutS","display_name":"Computational and experimental analysis for the mismatched DNA recognition mechanism of TaqMutS","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W4417415430","doi":"https://doi.org/10.1016/j.synbio.2026.10.011"},"language":"en","primary_location":{"id":"doi:10.1016/j.synbio.2026.10.011","doi":"https://doi.org/10.1016/j.synbio.2026.10.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.synbio.2026.10.011","pdf_url":null,"source":{"id":"https://openalex.org/S2898462621","display_name":"Synthetic and Systems Biotechnology","issn_l":"2097-1206","issn":["2097-1206","2405-805X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic and Systems Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.synbio.2026.10.011","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008833674","display_name":"Wenyang Jiang","orcid":"https://orcid.org/0000-0003-1255-5452","observed_orcids":["https://orcid.org/0000-0003-1255-5452","https://orcid.org/0000-0001-5898-1460"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyan Jiang","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043814966","display_name":"Yiyang Ding","orcid":"https://orcid.org/0000-0001-6031-1263","observed_orcids":["https://orcid.org/0000-0001-6031-1263"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiyang Ding","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028699064","display_name":"Haojie Sun","orcid":"https://orcid.org/0009-0004-0874-3543","observed_orcids":["https://orcid.org/0009-0004-0874-3543"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haojie Sun","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160638448","display_name":"Yuxuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuxuan Li","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006086141","display_name":"Xiao Huan Liang","orcid":"https://orcid.org/0000-0002-9423-9201","observed_orcids":["https://orcid.org/0000-0002-9423-9201"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Liang","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043546888","display_name":"Quanshun Li","orcid":"https://orcid.org/0000-0002-4115-7552","observed_orcids":["https://orcid.org/0000-0002-4115-7552","https://orcid.org/0000-0003-0548-6073"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quanshun Li","raw_affiliation_strings":["Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China"],"raw_orcid":"https://orcid.org/0000-0002-4115-7552","affiliations":[{"raw_affiliation_string":"Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun, 130012, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006086141","https://openalex.org/A5043546888","https://openalex.org/A5160638448"],"corresponding_institution_ids":["https://openalex.org/I194450716"],"apc_list":{"value":1500,"currency":"USD","value_usd":1500},"apc_paid":{"value":1500,"currency":"USD","value_usd":1500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0083709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":null,"first_page":"124","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.24279999732971191,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.22190000116825104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muts","display_name":"MutS","score":0.7519999742507935},{"id":"https://openalex.org/keywords/dna-mismatch-recognition","display_name":"DNA mismatch recognition","score":0.9509999752044678},{"id":"https://openalex.org/keywords/dna-mismatch-repair","display_name":"DNA mismatch repair","score":0.5350000262260437},{"id":"https://openalex.org/keywords/pi-pi-stacking","display_name":"\u03c0-\u03c0 stacking","score":0.8450000286102295},{"id":"https://openalex.org/keywords/protein-dna-interactions","display_name":"protein-DNA interactions","score":0.6050000190734863},{"id":"https://openalex.org/keywords/electrostatic-interactions","display_name":"electrostatic interactions","score":0.7519999742507935},{"id":"https://openalex.org/keywords/nonspecific-binding","display_name":"non-specific binding","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6869999766349792},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6054999828338623},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5174000263214111},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4733000099658966},{"id":"https://openalex.org/C60748783","wikidata":"https://www.wikidata.org/wiki/Q2984243","display_name":"DNA mismatch repair","level":4,"score":0.4253000020980835},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3995000123977661},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.3546000123023987},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.34220001101493835},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.3086000084877014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3021000027656555},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2809999883174896},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C191961535","wikidata":"https://www.wikidata.org/wiki/Q2360205","display_name":"A-DNA","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C2775862295","wikidata":"https://www.wikidata.org/wiki/Q2660911","display_name":"Dissection (medical)","level":2,"score":0.25600001215934753}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.synbio.2026.10.011","doi":"https://doi.org/10.1016/j.synbio.2026.10.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.synbio.2026.10.011","pdf_url":null,"source":{"id":"https://openalex.org/S2898462621","display_name":"Synthetic and Systems Biotechnology","issn_l":"2097-1206","issn":["2097-1206","2405-805X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic and Systems Biotechnology","raw_type":"journal-article"},{"id":"doi:10.64898/2025.12.16.694542","doi":"https://doi.org/10.64898/2025.12.16.694542","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2025.12.16.694542","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/12/16/2025.12.16.694542.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1016/j.synbio.2026.10.011","doi":"https://doi.org/10.1016/j.synbio.2026.10.011","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.synbio.2026.10.011","pdf_url":null,"source":{"id":"https://openalex.org/S2898462621","display_name":"Synthetic and Systems Biotechnology","issn_l":"2097-1206","issn":["2097-1206","2405-805X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synthetic and Systems Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2025148830","display_name":null,"funder_award_id":"32271319","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4574427219","display_name":null,"funder_award_id":"32301051","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5676526665","display_name":null,"funder_award_id":"2025T180729","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G6394399298","display_name":null,"funder_award_id":"U24A20365","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7019178536","display_name":null,"funder_award_id":"2023C015","funder_id":"https://openalex.org/F4320316081","funder_display_name":"Jilin Province Development and Reform Commission"},{"id":"https://openalex.org/G975092767","display_name":null,"funder_award_id":"2020YFA0907000","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320316081","display_name":"Jilin Province Development and Reform Commission","ror":"https://ror.org/0331mqm40"},{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320251","display_name":"Royal Society of Chemistry","ror":"https://ror.org/025sbr097"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4417415430.pdf","grobid_xml":"https://content.openalex.org/works/W4417415430.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1992939232","https://openalex.org/W2009233699","https://openalex.org/W2031383532","https://openalex.org/W2106826690","https://openalex.org/W2115072804","https://openalex.org/W2136615212","https://openalex.org/W2136913070","https://openalex.org/W2390421705","https://openalex.org/W2613468548","https://openalex.org/W2952420859","https://openalex.org/W3009456429","https://openalex.org/W3093968171","https://openalex.org/W3174189678","https://openalex.org/W4380758629","https://openalex.org/W4387965309","https://openalex.org/W4392907096","https://openalex.org/W4404909281","https://openalex.org/W4405197330"],"related_works":["https://openalex.org/W7027653637","https://openalex.org/W4391656922","https://openalex.org/W2094223041","https://openalex.org/W6887888806","https://openalex.org/W3166822173","https://openalex.org/W3169029288","https://openalex.org/W4380758629","https://openalex.org/W2106826690","https://openalex.org/W7024826406","https://openalex.org/W2411236243"],"abstract_inverted_index":{"By":[0],"sensing":[1],"local":[2],"conformational":[3],"strains":[4],"in":[5],"DNA,":[6,32],"Taq":[7,47],"MutS":[8,48],"utilizes":[9],"a":[10],"push-pull":[11],"mechanism":[12],"via":[13],"the":[14,26],"synergy":[15],"of":[16,46],"residues":[17,39],"S57":[18],"and":[19,31,41],"D472":[20],"to":[21],"modulate":[22],"\u03c0-stacking":[23],"interactions":[24],"between":[25],"key":[27],"recognition":[28],"residue":[29],"F39":[30],"thereby":[33],"achieving":[34],"specific":[35],"mismatch-site":[36],"recognition.":[37],"Meanwhile,":[38],"K61":[40],"R473":[42],"fine-tune":[43],"non-specific":[44],"binding":[45],"through":[49],"electrostatic":[50],"synergy.":[51]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2025-12-17T00:00:00"}
